scholarly journals Enrichment of branched chain amino acid transaminase 1 correlates with multiple biological processes and contributes to poor survival of IDH1 wild-type gliomas

Aging ◽  
2021 ◽  
Author(s):  
Li Yi ◽  
Xiaoguang Fan ◽  
Jiabo Li ◽  
Feng Yuan ◽  
Jian Zhao ◽  
...  
Keyword(s):  
Amino Acid ◽  
Biological Processes ◽  
Wild Type ◽  
Poor Survival ◽  
Branched Chain Amino Acid ◽  
Branched Chain

Repression of the Branched-Chain Amino Acid Biosynthetic Enzymes in Developing Conidia and Mycelia of Neurospora

1974 ◽  
Vol 52 (10) ◽  
pp. 822-829 ◽  
Author(s):  
Andrés J. Jobbágy ◽  
Robert P. Wagner
Keyword(s):  
Amino Acid ◽  
Neurospora Crassa ◽  
Enzymic Activity ◽  
Logarithmic Phase ◽  
Biosynthetic Enzymes ◽  
Wild Type ◽  
Isoleucine Leucine ◽  
Branched Chain Amino Acid ◽  
End Products ◽  
Branched Chain

During germination of the conidia of wild type Neurospora crassa, the enzymes of the isoleucine–valine pathway increase in activity. This increase is partially repressed in the presence of a combination of exogenous isoleucine, leucine, and valine. Repressed levels of enzymic activity are also observed in mycelium during the logarithmic phase of growth. In both cases, isoleucine and leucine together are almost as effective without valine as when the three are present together. The synthesis of these enzymes does appear to be affected by their end products but not to the extent exhibited in bacteria.

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