scholarly journals NLRC5 attenuates inflammatory response in IL-1β-stimulated human osteoarthritis chondrocytes through the NF-κB signaling pathway

Aging ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 20651-20660
Author(s):  
Yiping Mu ◽  
Yang Zhang ◽  
Jie Wu ◽  
Qi Li
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Osteoarthritis Chondrocytes

scholarly journals Retraction: Salvianolic acid B inhibits inflammatory response and cell apoptosis via the PI3K/Akt signaling pathway in IL-1β-induced osteoarthritis chondrocytes

RSC Advances ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 4441-4441
Author(s):  
Laura Fisher
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Cell Apoptosis ◽  
Akt Signaling ◽  
Salvianolic Acid B ◽  
Signalling Pathway ◽  
Akt Signaling Pathway ◽  
Salvianolic Acid ◽  
Osteoarthritis Chondrocytes

Retraction of ‘Salvianolic acid B inhibits inflammatory response and cell apoptosis via the PI3K/Akt signalling pathway in IL-1β-induced osteoarthritis chondrocytes’ by Bin Zhu et al., RSC Adv., 2018, 8, 36422–36429, DOI: 10.1039/C8RA02418A.

scholarly journals Resveratrol inhibit interleukin-1β induced inflammatory response in human osteoarthritis chondrocytes through NF-κB signaling pathway

2020 ◽  
Author(s):  
Xiao-Fei Shen ◽  
Yi Cheng ◽  
Qi-Rong Dong ◽  
Min-Qian Zheng
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Interleukin 1Β ◽  
Osteoarthritis Chondrocytes

Abstract The authors have withdrawn this preprint due to author disagreement.

scholarly journals Sesamin inhibits IL-1β-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway

Oncotarget ◽  
2016 ◽  
Vol 7 (50) ◽  
pp. 83720-83726 ◽  
Author(s):  
Pengyu Kong ◽  
Guanghua Chen ◽  
Anlong Jiang ◽  
Yufu Wang ◽  
Chengchao Song ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Nrf2 Signaling Pathway ◽  
Osteoarthritis Chondrocytes

Stachydrine attenuates IL-1β-induced inflammatory response in osteoarthritis chondrocytes through the NF-κB signaling pathway

2020 ◽  
Vol 326 ◽  
pp. 109136 ◽  
Author(s):  
Haojie Wu ◽  
Minghui Zhang ◽  
Weihua Li ◽  
Shutao Zhu ◽  
Dengfeng Zhang
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Osteoarthritis Chondrocytes

scholarly journals Salvianolic acid B inhibits inflammatory response and cell apoptosis via the PI3K/Akt signaling pathway in IL-1β-induced osteoarthritis chondrocytes

RSC Advances ◽  
2018 ◽  
Vol 8 (64) ◽  
pp. 36422-36429 ◽  
Author(s):  
Bin Zhu ◽  
Xuejian Wang ◽  
Jiawen Teng
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Elderly People ◽  
Cell Apoptosis ◽  
Akt Signaling ◽  
Salvianolic Acid B ◽  
Joint Disease ◽  
Akt Signaling Pathway ◽  
Salvianolic Acid ◽  
Osteoarthritis Chondrocytes

Osteoarthritis (OA) is the most common joint disease among late middle-aged or elderly people.

Glycyrrhizic acid attenuates the inflammatory response after spinal cord injury by inhibiting HMGB1 through the p38/JNK signaling pathway

2021 ◽  
Author(s):  
Zhiwu Wu ◽  
Zhihua Wang ◽  
Zhiping Xie ◽  
Huaxin Zhu ◽  
Chengcai Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Inflammatory Response ◽  
Signaling Pathway ◽  
Glycyrrhizic Acid ◽  
Jnk Signaling ◽  
Cord Injury ◽  
Jnk Signaling Pathway

LncRNA-Cox2 regulates macrophage polarization and inflammatory response through the CREB-C/EBPβ signaling pathway in septic mice

2021 ◽  
pp. 108347
Author(s):  
Qi Wang ◽  
Yun Xie ◽  
Qian He ◽  
Yan Geng ◽  
Jiru Xu
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Macrophage Polarization

Plantamajoside attenuates inflammatory response in LPS-stimulated human gingival fibroblasts by inhibiting PI3K/AKT signaling pathway

2019 ◽  
Vol 127 ◽  
pp. 208-211 ◽  
Author(s):  
Fei Liu ◽  
Xin Huang ◽  
Jing-jun He ◽  
Ci Song ◽  
Ling Peng ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Human Gingival Fibroblasts ◽  
Gingival Fibroblasts ◽  
Akt Signaling Pathway

scholarly journals Cichoric Acid Ameliorates Monosodium Urate-Induced Inflammatory Response by Reducing NLRP3 Inflammasome Activation via Inhibition of NF-kB Signaling Pathway

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Qi Wang ◽  
Bingfeng Lin ◽  
Zhifeng Li ◽  
Jie Su ◽  
Yulin Feng
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Nlrp3 Inflammasome ◽  
Gouty Arthritis ◽  
Inflammasome Activation ◽  
Cichoric Acid ◽  
Monosodium Urate ◽  
Protein Levels ◽  
Nlrp3 Inflammasome Activation ◽  
Tnf Α

Gouty arthritis is characterized by the deposition of monosodium urate (MSU) within synovial joints and tissues due to increased urate concentrations. Here, we elucidated the role of the natural compound cichoric acid (CA) on the MSU crystal-stimulated inflammatory response. The THP-1-derived macrophages (THP-Ms) were pretreated with CA and then stimulated with MSU suspensions. The protein levels of p65 and IκBα, the activation of the NF-κB signaling pathway by measuring the expression of its downstream inflammatory cytokines, and the activity of NLRP3 inflammasome were measured by western blotting and ELISA. CA treatment markedly inhibited the degradation of IκBα and the activation of NF-κB signaling pathway and reduced the levels of its downstream inflammatory genes such as IL-1β, TNF-α, COX-2, and PGE2 in the MSU-stimulated THP-M cells. Therefore, we infer that CA effectively alleviated MSU-induced inflammation by suppressing the degradation of IκBα, thereby reducing the activation of the NF-κB signaling pathway and the NLRP3 inflammasome. These results suggest that CA could be a novel therapeutic strategy in averting acute episodes of gout.

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