scholarly journals Down-regulation of NTCP expression by cyclin D1 in hepatitis B virus-related hepatocellular carcinoma has clinical significance

Oncotarget ◽  
2016 ◽  
Vol 8 (34) ◽  
pp. 56041-56050 ◽  
Author(s):  
Jingting Kang ◽  
Jie Wang ◽  
Jin Cheng ◽  
Zhiliang Cao ◽  
Ran Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Cyclin D1 ◽  
Clinical Significance ◽  
Down Regulation ◽  
B Virus

scholarly journals Clinical significance of hepatitis B virus-DNA in hepatocellular carcinoma negative for hepatitis B virus surface antigen

2010 ◽  
Vol 1 (2) ◽  
pp. 343-346
Author(s):  
SHINPEI TATEIWA ◽  
YOSHIHIKO YANO ◽  
YASUSHI SEO ◽  
AKIRA MIKI ◽  
KAWANO YUUKI ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clinical Significance ◽  
Surface Antigen ◽  
Virus Surface ◽  
Virus Surface Antigen ◽  
Hepatitis B Virus Dna ◽  
B Virus

Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis

2014 ◽  
Vol 92 (2) ◽  
pp. 152-162 ◽  
Author(s):  
Yanrui Sheng ◽  
Shijia Ding ◽  
Ke Chen ◽  
Juan Chen ◽  
Sen Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Promoter Activity ◽  
Down Regulation ◽  
B Virus ◽  
And Migration ◽  
Hcc Cells ◽  
Proliferation And Migration

MicroRNA-101(miR-101) has been shown to be down-regulated in hepatocellular carcinoma (HCC). The hepatitis B virus (HBV) is a major risk factor in the development and progression of HCC. However, the correlation between HBV and miR-101 has not yet been fully elucidated. In this study, we reported that HBV could repress miR-101-3p by inhibiting its promoter activity and identified the potential effects of miR-101-3p on some important biological properties of HCC cells by targeting Rap1b. Dual-luciferase reporter assays showed that HBV down-regulated miR-101-3p by inhibiting its promoter activity. Down-regulation of miR-101-3p promoted cell proliferation, migration, and reduced apoptosis, and resulted in up-regulation of Rap1b, while overexpression of miR-101-3p inhibited these processes. Moreover, overexpression of Rap1b was able to reverse the suppressed cell proliferation and migration mediated by miR-101-3p. Our data showed that HBV down-regulated miR-101-3p expression by inhibiting its promoter activity, which resulted in up-regulation of Rap1b, and down-regulation of miR-101-3p or up-regulation of Rap1b promoted proliferation and migration of HCC cells. This provides a new understanding of the mechanism of HBV-related HCC pathogenesis and the potential application of miR-101-3p in cancer therapy.

Clinical significance of antibody against hepatitis B virus core antigen in patients with hepatitis C virus-related hepatocellular carcinoma

2003 ◽  
Vol 23 (4) ◽  
pp. 227-231 ◽  
Author(s):  
Yoichi Yano ◽  
Fumihiko Yamashita ◽  
Shuji Sumie ◽  
Kotaro Kuwaki ◽  
Hiroshi Yamamoto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clinical Significance ◽  
Core Antigen ◽  
Virus Core ◽  
B Virus
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