scholarly journals Clinical significance of post-surgical residual tumor burden and radiation therapy in treating patients with lacrimal adenoid cystic carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (37) ◽  
pp. 60639-60646 ◽  
Author(s):  
Jae Myoung Noh ◽  
Eonju Lee ◽  
Yong Chan Ahn ◽  
Dongryul Oh ◽  
Yoon-Duck Kim ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Adenoid Cystic Carcinoma ◽  
Clinical Significance ◽  
Residual Tumor ◽  
Tumor Burden ◽  
Adenoid Cystic

Adenoid Cystic Carcinoma with Intracranial Extension: Report of Three Cases

Neurosurgery ◽  
1990 ◽  
Vol 26 (6) ◽  
pp. 1060-1065 ◽  
Author(s):  
Shinichiro Wakisaka ◽  
Akitsugu Nonaka ◽  
Yoshihiro Morita ◽  
Masashi Fukui ◽  
Kazuo Kinoshita
Keyword(s):  
Radiation Therapy ◽  
Adenoid Cystic Carcinoma ◽  
Residual Tumor ◽  
Middle Cranial Fossa ◽  
Intracranial Extension ◽  
Gasserian Ganglion ◽  
The Third ◽  
Orbital Roof ◽  
Adenoid Cystic ◽  
Cranial Fossa

Abstract Adenoid cystic carcinoma (cylindroma) usually arises from the salivary, lacrimal, or other exocrine glands, and is rarely encountered by neurosurgeons. The authors describe three cases involving intracranial extension. An intraorbital tumor in a 71-year-old man extended directly into the epidural space of the frontal base and destroyed the orbital roof. In a 53-year-old woman, the tumor arose from the area adjacent to the eustachian tube and invaded the Gasserian ganglion. In the third patient, a 58-year-old man, the tumor originated in the maxillary sinus and extended directly into the middle cranial fossa. In all these cases, the tumors were removed to the fullest extent possible. Although residual tumor was markedly reduced by radiation therapy, recurrence and metastases occurred within a few years. Thus, adenoid cystic carcinoma appears to be radiosensitive, but not curable by irradiation. In treating a recurrent tumor in one patient, we applied the so-called “two-route” chemotherapy (cisplatin and its antidote) in combination with radiation therapy. The tumor responded well to this therapy, although multiple pulmonary and bone metastases eventually led to the patient's death.

Patterns of Care and Outcomes of Primary Adenoid Cystic Carcinoma of the Trachea

2021 ◽  
pp. 000348942110081
Author(s):  
Sara Behbahani ◽  
Gregory L. Barinsky ◽  
David Wassef ◽  
Boris Paskhover ◽  
Rachel Kaye
Keyword(s):  
Radiation Therapy ◽  
Adenoid Cystic Carcinoma ◽  
Surgical Resection ◽  
Proportional Hazards ◽  
Invasive Disease ◽  
Cox Proportional Hazards ◽  
Tumor Diameter ◽  
Adenoid Cystic ◽  
Cox Proportional Hazards Models ◽  
Age Of Diagnosis

Objective: Primary tracheal malignancies are relatively rare cancers, representing 0.1% to 0.4% of all malignancies. Adenoid cystic carcinoma (ACC) is the second most common histology of primary tracheal malignancy, after squamous cell carcinoma. This study aims to analyze demographic characteristics and potential influencing factors on survival of tracheal ACC (TACC). Methods: This was a retrospective cohort study utilizing the National Cancer Database (NCDB). The NCDB was queried for all cases of TACC diagnosed from 2004 to 2016 (n = 394). Kaplan-Meier (KM) and Cox proportional-hazards models were used to determine clinicopathological and treatment factors associated with survival outcomes. Results: Median age of diagnosis was 56 (IQR: 44.75-66.00). Females were affected slightly more than males (53.8% vs 46.2%). The most prevalent tumor diameter range was 20 to 39 mm (34.8%) followed by greater than 40 mm in diameter (17.8%). Median overall survival (OS) was 9.72 years with a 5- and 10-year OS of 70% and 47.5%, respectively. Localized disease was not associated with a survival benefit over invasive disease ( P = .388). The most common intervention was surgery combined with radiation therapy (RT) at 46.2%, followed by surgery alone (16.8%), and standalone RT (8.9%). When adjusting for confounders, surgical resection was independently associated with improved OS (HR 0.461, 95% CI 0.225-0.946). Tumor size greater than 40 mm was independently associated with worse OS (HR 2.808; 95% CI 1.096-7.194). Conclusion: Our data suggests that surgical resection, possibly in conjunction with radiation therapy, is associated with improved survival, and tumor larger than 40 mm are associated with worse survival.

scholarly journals Fatty Acid Binding Protein 7 Is a Molecular Marker in Adenoid Cystic Carcinoma of the Salivary Glands: Implications for Clinical Significance

2014 ◽  
Vol 7 (6) ◽  
pp. 780-787 ◽  
Author(s):  
Janyaporn Phuchareon ◽  
Jonathan B. Overdevest ◽  
Frank McCormick ◽  
David W. Eisele ◽  
Annemieke van Zante ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Molecular Marker ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Clinical Significance ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Adenoid Cystic

Impact of Radiation Therapy Volumes on Skull Base Recurrence in Adenoid Cystic Carcinoma in the Head and Neck

2014 ◽  
Vol 90 (1) ◽  
pp. S545-S546
Author(s):  
J. Kim ◽  
J. Lee ◽  
H. Wu ◽  
M. Sung ◽  
T. Kown ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Skull Base ◽  
Adenoid Cystic

Adjuvant radiation therapy and survival for adenoid cystic carcinoma of the breast

The Breast ◽  
2017 ◽  
Vol 31 ◽  
pp. 214-218 ◽  
Author(s):  
Jia-Yuan Sun ◽  
San-Gang Wu ◽  
Shan-Yu Chen ◽  
Feng-Yan Li ◽  
Huan-Xin Lin ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Adenoid Cystic Carcinoma ◽  
Adjuvant Radiation ◽  
Carcinoma Of The Breast ◽  
Adjuvant Radiation Therapy ◽  
Adenoid Cystic

scholarly journals Particle Beam Radiation Therapy for Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses

2020 ◽  
Vol 10 ◽  
Author(s):  
Weixu Hu ◽  
Jiyi Hu ◽  
Qingting Huang ◽  
Jing Gao ◽  
Jing Yang ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Nasal Cavity ◽  
Adenoid Cystic Carcinoma ◽  
Paranasal Sinuses ◽  
Particle Beam ◽  
Beam Radiation ◽  
Adenoid Cystic

A Case of Adenoid Cystic Carcinoma of the Mandible Which Responded to Radiation Therapy

2020 ◽  
Vol 113 (12) ◽  
pp. 815-819
Author(s):  
Misato Suzumura ◽  
Kazuhiko Takeuchi
Keyword(s):  
Radiation Therapy ◽  
Adenoid Cystic Carcinoma ◽  
Adenoid Cystic

Expression and clinical significance of FAK, ILK, and PTEN in salivary adenoid cystic carcinoma

2012 ◽  
Vol 133 (2) ◽  
pp. 203-208 ◽  
Author(s):  
Dong Chen ◽  
Bin Zhang ◽  
Jian Kang ◽  
Xiaofeng Ma ◽  
Yan Lu ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Clinical Significance ◽  
Salivary Adenoid Cystic Carcinoma ◽  
Adenoid Cystic
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