scholarly journals MiR-23a modulates X-linked inhibitor of apoptosis-mediated autophagy in human luminal breast cancer cell lines

Oncotarget ◽  
2017 ◽  
Vol 8 (46) ◽  
pp. 80709-80721 ◽  
Author(s):  
Ping Chen ◽  
Yin-Huan He ◽  
Xing Huang ◽  
Si-Qi Tao ◽  
Xiao-Nan Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Inhibitor Of Apoptosis ◽  
Luminal Breast Cancer ◽  
Luminal Breast Cancer Cell

scholarly journals Luminal Breast Cancer Cell Lines Overexpressing ZNF703 Are Resistant to Tamoxifen through Activation of Akt/mTOR Signaling

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72053 ◽  
Author(s):  
Xi Zhang ◽  
Xin Mu ◽  
Ou Huang ◽  
Zuoquan Xie ◽  
Min Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Mtor Signaling ◽  
Breast Cancer Cell Lines ◽  
Luminal Breast Cancer ◽  
Luminal Breast Cancer Cell

scholarly journals MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines

2020 ◽  
Vol 21 (15) ◽  
pp. 5458
Author(s):  
Yong-Chul Kim ◽  
Mary L. Cutler
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
P38 Map Kinase ◽  
Breast Cancer Cell Lines ◽  
Luminal Breast Cancer ◽  
Control Of Gene Expression ◽  
Luminal Breast Cancer Cell

(1) Background: The microRNA (miR)-directed control of gene expression is correlated with numerous physiological processes as well as the pathological features of tumors. The focus of this study is on the role of miRs in the regulation of RSU1 and proteins in the IPP (integrin linked kinase, PINCH and parvin) complex. Because the IPP adaptor proteins link β integrins to actin cytoskeleton, and the RSU1 signaling protein connects the complex to the activation of cJun, ATF2 and the transcription of PTEN, their reduction by miRs has the potential to alter both adhesion and survival signaling. (2) Methods: Multiple database analyses were used to identify miRs that target RSU1 and PINCH1. miR transfection validated the effects of miRs on RSU1, PINCH1 and downstream targets in breast cancer cell lines. (3) Results: The miRs targeting RSU1 mRNA include miR-182-5p, -409-3p, -130a-3p, -221-3p, -744-5p and -106b-5p. Data show that miR-182-5p and -409-3p reduce RSU1, PINCH1 and inhibit the ATF2 activation of PTEN expression. miR-221-3p and miR-130a-3p target RSU1 and PINCH1 and, conversely, RSU1 depletion increases miR-221-3p and miR-130a-3p. (4) Conclusions: miRs targeting RSU1 and PINCH1 in mammary epithelial or luminal breast cancer cell lines reduced RSU1 signaling to p38 MAP kinase and ATF2, inhibiting the expression of PTEN. miR-221-3p, known to target PTEN and cell cycle regulators, also targets RSU1 and PINCH1 in luminal breast cancer cell lines.

scholarly journals Establishment and characterization of highly osteolytic luminal breast cancer cell lines by intracaudal arterial injection

2020 ◽  
Vol 25 (2) ◽  
pp. 111-123 ◽  
Author(s):  
Yuxuan Han ◽  
Jun Nakayama ◽  
Yusuke Hayashi ◽  
Seongmoon Jeong ◽  
Mitsuru Futakuchi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Luminal Breast Cancer ◽  
Luminal Breast Cancer Cell

Abstract 3012: Single-cell transcriptomic characterization of luminal breast cancer cell lines with acquired resistance to the CDK4/6 inhibitor palbociclib

2019 ◽  
Author(s):  
Matteo Benelli ◽  
Giulia Boccalini ◽  
Dario Romagnoli ◽  
Martina Bonechi ◽  
Chiara Biagioni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Cell ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Acquired Resistance ◽  
Breast Cancer Cell Lines ◽  
Luminal Breast Cancer ◽  
Luminal Breast Cancer Cell

Abstract 3012: Single-cell transcriptomic characterization of luminal breast cancer cell lines with acquired resistance to the CDK4/6 inhibitor palbociclib

2019 ◽  
Author(s):  
Matteo Benelli ◽  
Giulia Boccalini ◽  
Dario Romagnoli ◽  
Martina Bonechi ◽  
Chiara Biagioni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Cell ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Acquired Resistance ◽  
Breast Cancer Cell Lines ◽  
Luminal Breast Cancer ◽  
Luminal Breast Cancer Cell

The effects of phytoestrogen extracts isolated from elder flower on hormone production and proliferation of trophoblast tumour and breast cancer cell lines

2014 ◽  
Vol 74 (S 01) ◽  
Author(s):  
L Schröder ◽  
B Piechulla ◽  
M Chorbak ◽  
C Kuhn ◽  
S Schulze ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Hormone Production

Cytotoxic activity and anti-cancer potential of Ontario grown onion extracts against breast cancer cell lines

2018 ◽  
Vol 8 (3) ◽  
pp. 159 ◽  
Author(s):  
Meghan Fragis ◽  
Abdulmonem I. Murayyan ◽  
Suresh Neethirajan
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Cytotoxic Activities ◽  
Cancer Line ◽  
Mcf 7

Background: Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer deaths among Canadian women. Cancer management through changes in lifestyle, such as increased intake of foods rich in dietary flavonoids, have been shown to decrease the risk associated with breast, liver, colorectal, and upper-digestive cancers in epidemiologic studies. Onions are high in flavonoid content and one of the most common vegetables. Additionally, onions are used in most Canadian cuisines.Methods: We investigated the effect of five prominent Ontario grown onion (Stanley, Ruby Ring, LaSalle, Fortress, and Safrane) extracts on two subtypes of breast cancer cell lines: a triple negative breast cancer line MDA-MB-231 and an ER+ breast cancer line MCF-7.Results: These onion extracts elicited strong anti-proliferative, anti-migratory, and cytotoxic activities on both the cancer cell lines. Flavonoids present in these onion extracts induced apoptosis, cell cycle arrest in the G2/M phase, and a reduction in mitochondrial membrane potential at dose-dependent concentrations. Onion extracts were more effective against MDA-MB-231 compared to the MCF-7 cell line. Conclusion: In this study, we investigated the extracts synthesized from Ontario-grown onion varieties in inducing anti-migratory, cytostatic, and cytotoxic activities in two sub-types of human breast cancer cell lines. Anti-tumor activity of these extracts depends upon the varietal and can be formulated into nutraceuticals and functional foods for the wellbeing of cancer patients. Overall, the results suggest that onion extracts are a good source of flavonoids with anti-cancerous properties.Keywords: onion extracts; flavonoids; anti-proliferative; breast cancer; cytotoxic activity

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