scholarly journals Enhanced efficacy with reduced toxicity of chemotherapy drug 5-fluorouracil by synergistic treatment with Abnormal Savda Munziq from Uyghur medicine

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Tao Yang ◽  
Mutalifu Aimaiti ◽  
Deqi Su ◽  
Weiwei Miao ◽  
Bin Zhou ◽  
...  
Keyword(s):  
Chemotherapy Drug ◽  
Abnormal Savda ◽  
Abnormal Savda Munziq ◽  
Reduced Toxicity

scholarly journals Enhanced antitumor efficacy and reduced toxicity of Abnormal Savda Munziq on tumor bearing mice treated with chemotherapy

Oncotarget ◽  
2017 ◽  
Vol 8 (54) ◽  
pp. 92682-92698
Author(s):  
Tao Yang ◽  
Wenhui Shi ◽  
Zukereguli Wumaierniyazi ◽  
Lianlian Shan ◽  
Weiwei Miao ◽  
...  
Keyword(s):  
Antitumor Efficacy ◽  
Tumor Bearing ◽  
Abnormal Savda ◽  
Abnormal Savda Munziq ◽  
Reduced Toxicity

Investigations into cytotoxic effects of the herbal preparation Abnormal Savda Munziq

2015 ◽  
Author(s):  
Harald Kühnel ◽  
Abulimiti Adilijiang ◽  
Agnes Dadak ◽  
Matthias Wieser ◽  
Halmurat Upur ◽  
...  
Keyword(s):  
Herbal Preparation ◽  
Cytotoxic Effects ◽  
Abnormal Savda ◽  
Abnormal Savda Munziq

scholarly journals Inhibition of Cell Growth and Cellular Protein, DNA and RNA Synthesis in Human Hepatoma (HepG2) Cells by Ethanol Extract of Abnormal Savda Munziq of Traditional Uighur Medicine

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Halmurat Upur ◽  
Abdiryim Yusup ◽  
Isabelle Baudrimont ◽  
Anwar Umar ◽  
Benedicte Berke ◽  
...  
Keyword(s):  
Rna Synthesis ◽  
Ethanol Extract ◽  
Cellular Protein ◽  
Time Dependent ◽  
Dependent Manner ◽  
Human Hepatoma ◽  
Dna And Rna ◽  
Dna And Rna Synthesis ◽  
Abnormal Savda ◽  
Abnormal Savda Munziq

Abnormal Savda Munziq (ASMq) is a traditional Uighur medicinal herbal preparation, commonly used for the treatment and prevention of cancer. We tested the effects of ethanol extract of ASMq on cultured human hepatoma cells (HepG2) to explore the mechanism of its putative anticancer properties, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) bromide, neutral red and lactate dehydrogenase (LDH) leakage assays, testing the incorporation of3[H]-leucine and3[H]-nucleosides into protein, DNA and RNA, and quantifying the formation of malondialdehyde-thiobarbituric acid (MDA) adducts. ASMq ethanol extract significantly inhibited the growth of HepG2 and cell viability, increased the leakage of LDH after 48 hours or 72 hours treatment, in a concentration- and time-dependent manner (P< .05). Cellular protein, DNA and RNA synthesis were inhibited in a concentration- and time-dependent manner (P< .05). No significant MDA release in culture medium and no lipid peroxidation in cells were observed. The results suggest that the cytotoxic effects of ASMq ethanol extract might be related to inhibition of cancer cell growth, alteration of cell membrane integrity and inhibition of cellular protein, DNA and RNA synthesis.

scholarly journals Abnormal Savda Munziq, an Herbal Preparation of Traditional Uighur Medicine, May Prevent 1,2-dimethylhydrazine-Induced Rat Colon Carcinogenesis

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Abdiryim Yusup ◽  
Halmurat Upur ◽  
Anwar Umar ◽  
Benedicte Berke ◽  
Dilxat Yimit ◽  
...  
Keyword(s):  
Body Weight ◽  
Normal Saline ◽  
Colon Carcinogenesis ◽  
Ethanol Extract ◽  
Negative Control ◽  
Aberrant Crypt Foci ◽  
Rat Colon ◽  
Preneoplastic Lesions ◽  
Abnormal Savda ◽  
Abnormal Savda Munziq

The study tried to assess the chemoprotective effect of abnormal Savda Munziq (ASMq) on 1,2-dimethylhydrazine (DMH)-induced rat colon carcinogenesis. Male F344 rats were randomized into eight groups: Group 1 was served as control, no DMH injection was given and treated daily with normal saline. Rats in Groups 2–8 were given a single intraperitoneal injection of DMH (20 mg/kg body weight) at the beginning of the study. Group 2 was served as negative control, administered with normal saline until the end of the experiment after the single DMH injection. Groups 3–5 were served as pretreatment group, administered with ASMq ethanol extract at 400, 800 and 1600 mg/kg body weight, respectively, until the 45th day, continued by normal saline administration for another 45 days. Groups 6–8 were served as the treatment group, administered with normal saline for the first 45 days from the day of DMH injection, ASMq ethanol extract at three different doses to be administered until the end of the second 45th day. All rats were sacrificed at 91st day and the colons were analyzed for aberrant crypt foci (ACF) formation and crypt multiplicity. Results showed that ASMq ethanol extract reduced the number of ACF, AC and crypt multiplicity significantly (P< .05). It suggested that ASMq ethanol extract had chemoprotective effects on DMH-induced colon carcinogenesis, by suppressing the development of preneoplastic lesions, and probably exerted protection against the initiation and promotion steps of colon carcinogenesis.

scholarly journals Behavioral, Neurochemical and Neuroendocrine Effects of Abnormal Savda Munziq in the Chronic Stress Mice

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Nurmuhammat Amat ◽  
Parida Hoxur ◽  
Dang Ming ◽  
Aynur Matsidik ◽  
Anake Kijjoa ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Serum Levels ◽  
Latency Time ◽  
Enhancing Effect ◽  
Traditional Uighur Medicine ◽  
Y Maze ◽  
Abnormal Savda ◽  
Abnormal Savda Munziq ◽  
The Brain ◽  
Memory Enhancing

Oral administration of Abnormal Savda Munsiq (ASMq), a herbal preparation used in Traditional Uighur Medicine, was found to exert a memory-enhancing effect in the chronic stressed mice, induced by electric foot-shock. The memory improvement of the stressed mice was shown by an increase of the latency time in the step-through test and the decrease of the latency time in the Y-maze test. Treatment with ASMq was found to significantly decrease the serum levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT) and -endorphin (-EP) as well as the brain and serum level of norepinephrine (NE). Furthermore, ASMq was able to significantly reverse the chronic stress by decreasing the brain and serum levels of the monoamine neurotransmitters dopamine (DA), 5-hydroxytryptamine (5-HT) and 3,4-dihydroxyphenylalanine (DOPAC). The results obtained from this study suggested that the memory-enhancing effect of ASMq was mediated through regulations of neurochemical and neuroendocrine systems.

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