scholarly journals WITHDRAWN: IFN-γ and IL-1β treated-human placenta-derived mesenchymal stromal cells enhance the generation of IL-10+T cells by upregulating PDLs expressions and ameliorate experimental autoimmune encephalomyelitis

Oncotarget ◽  
2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Zhuoya Wang ◽  
Zhuoya Wang ◽  
Weiwei Wang ◽  
Weiwei Wang ◽  
Yun Hou ◽  
...  
Keyword(s):  
T Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Mesenchymal Stromal Cells ◽  
Human Placenta ◽  
Stromal Cells ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

scholarly journals Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Inhibiting CD4 Th17 T Cells in a CC Chemokine Ligand 2-Dependent Manner

2009 ◽  
Vol 182 (10) ◽  
pp. 5994-6002 ◽  
Author(s):  
Moutih Rafei ◽  
Philippe M. Campeau ◽  
Adriana Aguilar-Mahecha ◽  
Marguerite Buchanan ◽  
Patrick Williams ◽  
...  
Keyword(s):  
T Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Dependent Manner ◽  
Autoimmune Encephalomyelitis ◽  
Chemokine Ligand ◽  
Cc Chemokine Ligand 2 ◽  
Chemokine Ligand 2 ◽  
Experimental Autoimmune

Neuroprotective effects of placenta-derived mesenchymal stromal cells in a rat model of experimental autoimmune encephalomyelitis

Cytotherapy ◽  
2016 ◽  
Vol 18 (9) ◽  
pp. 1100-1113 ◽  
Author(s):  
Assmaa O. Selim ◽  
Sally A. Selim ◽  
Sally M. Shalaby ◽  
Hala Mosaad ◽  
Taisir Saber
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Mesenchymal Stromal Cells ◽  
Rat Model ◽  
Stromal Cells ◽  
Autoimmune Encephalomyelitis ◽  
Neuroprotective Effects ◽  
Experimental Autoimmune

scholarly journals Characterization of myelin oligodendrocyte glycoprotein (MOG)35–55-specific CD8+ T cells in experimental autoimmune encephalomyelitis

2019 ◽  
Vol 132 (24) ◽  
pp. 2934-2940
Author(s):  
Yong Peng ◽  
Fei-Zhou Zhu ◽  
Zhi-Xing Chen ◽  
Jian-Xiong Zhou ◽  
Lu Gan ◽  
...  
Keyword(s):  
T Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Cd8 T Cells ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

scholarly journals Chloroquine Treatment Enhances Regulatory T Cells and Reduces the Severity of Experimental Autoimmune Encephalomyelitis

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65913 ◽  
Author(s):  
Rodolfo Thomé ◽  
Adriel S. Moraes ◽  
André Luis Bombeiro ◽  
Alessandro dos Santos Farias ◽  
Carolina Francelin ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Autoimmune Encephalomyelitis ◽  
Chloroquine Treatment ◽  
Experimental Autoimmune

scholarly journals The Disease-Ameliorating Function of Autoregulatory CD8 T Cells Is Mediated by Targeting of Encephalitogenic CD4 T Cells in Experimental Autoimmune Encephalomyelitis

2013 ◽  
Vol 191 (1) ◽  
pp. 117-126 ◽  
Author(s):  
Sterling B. Ortega ◽  
Venkatesh P. Kashi ◽  
Andrew F. Tyler ◽  
Khrishen Cunnusamy ◽  
Jason P. Mendoza ◽  
...  
Keyword(s):  
T Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

scholarly journals Mgat5 Deficiency in T Cells and Experimental Autoimmune Encephalomyelitis

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Ani Grigorian ◽  
Michael Demetriou
Keyword(s):  
T Cells ◽  
T Cell ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Demyelinating Disease ◽  
Cell Receptor ◽  
Protein Glycosylation ◽  
Autoimmune Encephalomyelitis ◽  
Glycosylation Pathway ◽  
Experimental Autoimmune ◽  
Surface Glycoproteins

Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease initiated by autoreactive T cells. Mgat5, a gene in the Asn (N-) linked protein glycosylation pathway, associates with MS severity and negatively regulates experimental autoimmune encephalomyelitis (EAE) and spontaneous inflammatory demyelination in mice. N-glycan branching by Mgat5 regulates interaction of surface glycoproteins with galectins, forming a molecular lattice that differentially controls the concentration of surface glycoproteins. T-cell receptor signaling, T-cell proliferation, TH1 differentiation, and CTLA-4 endocytosis are inhibited by Mgat5 branching. Non-T cells also contribute to MS pathogenesis and express abundant Mgat5 branched N-glycans. Here we explore whether Mgat5 deficiency in myelin-reactive T cells is sufficient to promote demyelinating disease. Adoptive transfer of myelin-reactive Mgat5−/− T cells into Mgat5+/+ versus Mgat5−/− recipients revealed more severe EAE in the latter, suggesting that Mgat5 branching deficiency in recipient naive T cells and/or non-T cells contribute to disease pathogenesis.

scholarly journals 4-1BB Triggering Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating the Balance between Th17 and Regulatory T Cells

2011 ◽  
Vol 187 (3) ◽  
pp. 1120-1128 ◽  
Author(s):  
Young H. Kim ◽  
Beom K. Choi ◽  
Su M. Shin ◽  
Chang H. Kim ◽  
Ho S. Oh ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

Cathepsin L regulates pathogenic CD4 T cells in experimental autoimmune encephalomyelitis

2021 ◽  
Vol 93 ◽  
pp. 107425
Author(s):  
Miho Shibamura-Fujiogi ◽  
Koichi Yuki ◽  
Lifei Hou
Keyword(s):  
T Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Cd4 T Cells ◽  
Cathepsin L ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune
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