The isoform A of reticulon-4 (Nogo-A) in cerebrospinal fluid of primary brain tumor patients: influencing factors

Purpose: To describe our population of primary brain tumor (PBT) patients, a subgroup of cancer patients whose intensive care unit (ICU) outcomes are understudied. Methods: Retrospective analysis of PBT patients admitted to an ICU between 2013 to 2018 for an unplanned need. Using descriptive analyses, we characterized our population and their outcomes. Results: Fifty-nine PBT patients were analyzed. ICU mortality was 19% (11/59). The most common indication for admission was seizures (n = 16, 27%). Conclusion: Our ICU mortality of PBT patients was comparable to other solid tumor patients and the general ICU population and better than patients with hematological malignancies. Further study of a larger population would inform guidelines for triaging PBT patients who would most benefit from ICU-level care.

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QLIF-41. UNDERSTANDING EMOTIONAL DISTRESS IN PRIMARY BRAIN TUMOR PATIENTS: IS THERE A RELATIONSHIP WITH FEAR OF DEATH?

Neuro-Oncology ◽

10.1093/neuonc/nox168.849 ◽

2017 ◽

Vol 19 (suppl_6) ◽

pp. vi210-vi210

Author(s):

Ashlee Loughan ◽

Sarah Braun

Keyword(s):

Brain Tumor ◽

Emotional Distress ◽

Primary Brain Tumor ◽

Fear Of Death ◽

Tumor Patients

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Executive dysfunction in neuro-oncology: Behavior Rating Inventory of Executive Function in adult primary brain tumor patients

Applied Neuropsychology Adult ◽

10.1080/23279095.2018.1553175 ◽

2019 ◽

Vol 27 (5) ◽

pp. 393-402 ◽

Cited By ~ 2

Author(s):

Ashlee R. Loughan ◽

Sarah E. Braun ◽

Autumn Lanoye

Keyword(s):

Brain Tumor ◽

Executive Function ◽

Executive Dysfunction ◽

Primary Brain Tumor ◽

Behavior Rating ◽

Tumor Patients ◽

Behavior Rating Inventory

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Gender difference in relation to depression and quality of life among patients with a primary brain tumor

European Psychiatry ◽

10.1016/j.eurpsy.2005.05.008 ◽

2006 ◽

Vol 21 (3) ◽

pp. 194-199 ◽

Cited By ~ 54

Author(s):

Arja Mainio ◽

Helinä Hakko ◽

Asko Niemelä ◽

John Koivukangas ◽

Pirkko Räsänen

Keyword(s):

Quality Of Life ◽

Brain Tumor ◽

Functional Status ◽

Primary Brain Tumor ◽

Karnofsky Performance Scale ◽

Tumor Patients ◽

The Relationship ◽

Depressive Patients ◽

Performance Scale

AbstractObjective. –We studied the relationship between depressive symptoms and quality of life (QOL) as well as functional status in primary brain tumor patients at recurrent measurements. Differences in QOL between depressive and non-depressive samples by gender were controlled for tumor characteristics and patients' psychosocial factors.Materials and methods. –The data consisted of 77 patients with a primary brain tumor, 30 males and 47 females. Depression of the patients was assessed by Beck Depression Inventory (BDI) and Crown-Crisp Experiential Index (CCEI), functional status by Karnofsky Performance scale (KPS) and QOL by Sintonen's 15D before tumor operation as well as at 3 months and at 1 year from surgical operation of the tumor.Results.The level of QOL in females was lower compared to that of males. Depression was the main predictor for worse QOL in the patients at all measurements. Depressive patients with a benign brain tumor had significantly worse QOL versus non-depressive ones.Discussion and conclusion. –Decreased QOL was strongly related to depression, especially among patients with a benign brain tumor. Further studies are needed to find whether sufficient depression therapy improves the QOL of patients.

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Cerebrospinal Fluid MicroRNA Signatures as Diagnostic Biomarkers in Brain Tumors

Cancers ◽

10.3390/cancers11101546 ◽

2019 ◽

Vol 11 (10) ◽

pp. 1546 ◽

Cited By ~ 8

Author(s):

Alena Kopkova ◽

Jiri Sana ◽

Tana Machackova ◽

Marek Vecera ◽

Lenka Radova ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Brain Tumor ◽

Brain Tumors ◽

Low Grade ◽

Tumor Type ◽

Tumor Patients ◽

Primary Tumors ◽

Mirna Profiling ◽

Tumor Types ◽

Cns Malignancies

Central nervous system (CNS) malignancies include primary tumors that originate within the CNS as well as secondary tumors that develop as a result of metastatic spread. Circulating microRNAs (miRNAs) were found in almost all human body fluids including cerebrospinal fluid (CSF), and they seem to be highly stable and resistant to even extreme conditions. The overall aim of our study was to identify specific CSF miRNA patterns that could differentiate among brain tumors. These new biomarkers could potentially aid borderline or uncertain imaging results onto diagnosis of CNS malignancies, avoiding most invasive procedures such as stereotactic biopsy or biopsy. In total, 175 brain tumor patients (glioblastomas, low-grade gliomas, meningiomas and brain metastases), and 40 non-tumor patients with hydrocephalus as controls were included in this prospective monocentric study. Firstly, we performed high-throughput miRNA profiling (Illumina small RNA sequencing) on a discovery cohort of 70 patients and 19 controls and identified specific miRNA signatures of all brain tumor types tested. Secondly, validation of 9 candidate miRNAs was carried out on an independent cohort of 105 brain tumor patients and 21 controls using qRT-PCR. Based on the successful results of validation and various combination patterns of only 5 miRNA levels (miR-30e, miR-140, let-7b, mR-10a and miR-21-3p) we proposed CSF-diagnostic scores for each tumor type which enabled to distinguish them from healthy donors and other tumor types tested. In addition to this primary diagnostic tool, we described the prognostic potential of the combination of miR-10b and miR-196b levels in CSF of glioblastoma patients. In conclusion, we performed the largest study so far focused on CSF miRNA profiling in patients with brain tumors, and we believe that this new class of biomarkers have a strong potential as a diagnostic and prognostic tool in these patients.

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