scholarly journals PIM kinase inhibitor, AZD1208, inhibits protein translation and induces autophagy in primary chronic lymphocytic leukemia cells

Oncotarget ◽  
2019 ◽  
Vol 10 (29) ◽  
pp. 2793-2809 ◽  
Author(s):  
Fabiola Cervantes-Gomez ◽  
Christine M. Stellrecht ◽  
Mary L. Ayres ◽  
Michael J. Keating ◽  
William G. Wierda ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Kinase Inhibitor ◽  
Protein Translation ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Primary Chronic Lymphocytic Leukemia

scholarly journals Comparison of Acalabrutinib, A Selective Bruton Tyrosine Kinase Inhibitor, with Ibrutinib in Chronic Lymphocytic Leukemia Cells

2016 ◽  
Vol 23 (14) ◽  
pp. 3734-3743 ◽  
Author(s):  
Viralkumar Patel ◽  
Kumudha Balakrishnan ◽  
Elena Bibikova ◽  
Mary Ayres ◽  
Michael J. Keating ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Bruton Tyrosine Kinase

scholarly journals p65 Activity and ZAP-70 Status Predict the Sensitivity of Chronic Lymphocytic Leukemia Cells to the Selective IκB Kinase Inhibitor BMS-345541

2009 ◽  
Vol 15 (8) ◽  
pp. 2767-2776 ◽  
Author(s):  
Mónica López-Guerra ◽  
Gaël Roué ◽  
Patricia Pérez-Galán ◽  
Roberto Alonso ◽  
Neus Villamor ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Kinase Inhibitor ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Iκb Kinase

scholarly journals Genetic modification of primary chronic lymphocytic leukemia cells with a lentivirus expressing CD38

Haematologica ◽  
2010 ◽  
Vol 95 (3) ◽  
pp. 514-517 ◽  
Author(s):  
L. Pearce ◽  
L. Morgan ◽  
T. T. Lin ◽  
S. Hewamana ◽  
R. J. Matthews ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Genetic Modification ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Primary Chronic Lymphocytic Leukemia

scholarly journals Evaluation of bendamustine in combination with fludarabine in primary chronic lymphocytic leukemia cells

Blood ◽  
2014 ◽  
Vol 123 (24) ◽  
pp. 3780-3789 ◽  
Author(s):  
Amal A. El-Mabhouh ◽  
Mary L. Ayres ◽  
Elizabeth J. Shpall ◽  
Veerabhadran Baladandayuthapani ◽  
Michael J. Keating ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Dna Synthesis ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Unscheduled Dna Synthesis ◽  
Key Points ◽  
Primary Chronic Lymphocytic Leukemia

Key Points The fludarabine and bendamustine combination is cytotoxic to CLL cells even in the presence of a protective microenvironment. H2AX activation was maximum with the combination, and unscheduled DNA synthesis induced by bendamustine was blocked by fludarabine.

scholarly journals Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells

Leukemia ◽  
2004 ◽  
Vol 18 (4) ◽  
pp. 747-755 ◽  
Author(s):  
I N Hahntow ◽  
F Schneller ◽  
M Oelsner ◽  
K Weick ◽  
I Ringshausen ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Kinase Inhibitor ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor
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