scholarly journals PIM kinase inhibitor, AZD1208, inhibits protein translation and induces autophagy in primary chronic lymphocytic leukemia cells

Oncotarget ◽  
2019 ◽  
Vol 10 (29) ◽  
pp. 2793-2809 ◽  
Author(s):  
Fabiola Cervantes-Gomez ◽  
Christine M. Stellrecht ◽  
Mary L. Ayres ◽  
Michael J. Keating ◽  
William G. Wierda ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Kinase Inhibitor ◽  
Protein Translation ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Primary Chronic Lymphocytic Leukemia

scholarly journals Interaction with Vascular Endothelium Enhances Survival in Primary Chronic Lymphocytic Leukemia Cells via NF-κB Activation and De novo Gene Transcription

2010 ◽  
Vol 70 (19) ◽  
pp. 7523-7533 ◽  
Author(s):  
Andrea G.S. Buggins ◽  
Chris Pepper ◽  
Piers E.M. Patten ◽  
Saman Hewamana ◽  
Satyen Gohil ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Gene Transcription ◽  
Vascular Endothelium ◽  
De Novo ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
De Novo Gene ◽  
Primary Chronic Lymphocytic Leukemia

scholarly journals Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells

Leukemia ◽  
2010 ◽  
Vol 25 (1) ◽  
pp. 89-100 ◽  
Author(s):  
U Kruse ◽  
C P Pallasch ◽  
M Bantscheff ◽  
D Eberhard ◽  
L Frenzel ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Kinase Inhibitors ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Target Deconvolution ◽  
Primary Chronic Lymphocytic Leukemia

scholarly journals Comparison of Acalabrutinib, A Selective Bruton Tyrosine Kinase Inhibitor, with Ibrutinib in Chronic Lymphocytic Leukemia Cells

2016 ◽  
Vol 23 (14) ◽  
pp. 3734-3743 ◽  
Author(s):  
Viralkumar Patel ◽  
Kumudha Balakrishnan ◽  
Elena Bibikova ◽  
Mary Ayres ◽  
Michael J. Keating ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Bruton Tyrosine Kinase

scholarly journals p65 Activity and ZAP-70 Status Predict the Sensitivity of Chronic Lymphocytic Leukemia Cells to the Selective IκB Kinase Inhibitor BMS-345541

2009 ◽  
Vol 15 (8) ◽  
pp. 2767-2776 ◽  
Author(s):  
Mónica López-Guerra ◽  
Gaël Roué ◽  
Patricia Pérez-Galán ◽  
Roberto Alonso ◽  
Neus Villamor ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Kinase Inhibitor ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Iκb Kinase

scholarly journals Genetic modification of primary chronic lymphocytic leukemia cells with a lentivirus expressing CD38

Haematologica ◽  
2010 ◽  
Vol 95 (3) ◽  
pp. 514-517 ◽  
Author(s):  
L. Pearce ◽  
L. Morgan ◽  
T. T. Lin ◽  
S. Hewamana ◽  
R. J. Matthews ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Genetic Modification ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Primary Chronic Lymphocytic Leukemia

scholarly journals Evaluation of bendamustine in combination with fludarabine in primary chronic lymphocytic leukemia cells

Blood ◽  
2014 ◽  
Vol 123 (24) ◽  
pp. 3780-3789 ◽  
Author(s):  
Amal A. El-Mabhouh ◽  
Mary L. Ayres ◽  
Elizabeth J. Shpall ◽  
Veerabhadran Baladandayuthapani ◽  
Michael J. Keating ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Dna Synthesis ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Unscheduled Dna Synthesis ◽  
Key Points ◽  
Primary Chronic Lymphocytic Leukemia

Key Points The fludarabine and bendamustine combination is cytotoxic to CLL cells even in the presence of a protective microenvironment. H2AX activation was maximum with the combination, and unscheduled DNA synthesis induced by bendamustine was blocked by fludarabine.

scholarly journals Rapid and efficient nonviral gene delivery of CD154 to primary chronic lymphocytic leukemia cells

2005 ◽  
Vol 13 (2) ◽  
pp. 215-224 ◽  
Author(s):  
L H Li ◽  
E Biagi ◽  
C Allen ◽  
R Shivakumar ◽  
J M Weiss ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Gene Delivery ◽  
Lymphocytic Leukemia ◽  
Nonviral Gene Delivery ◽  
Leukemia Cells ◽  
Primary Chronic Lymphocytic Leukemia

scholarly journals Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells

Leukemia ◽  
2004 ◽  
Vol 18 (4) ◽  
pp. 747-755 ◽  
Author(s):  
I N Hahntow ◽  
F Schneller ◽  
M Oelsner ◽  
K Weick ◽  
I Ringshausen ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Kinase Inhibitor ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor
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