scholarly journals Efficacy of the antimicrobial peptide TP4 against Helicobacter pylori infection: in vitro membrane perturbation via micellization and in vivo suppression of host immune responses in a mouse model

Oncotarget ◽  
2015 ◽  
Vol 6 (15) ◽  
pp. 12936-12954 ◽  
Author(s):  
Jayaram Lakshmaiah Narayana ◽  
Han-Ning Huang ◽  
Chang-Jer Wu ◽  
Jyh-Yih Chen
Keyword(s):  
Helicobacter Pylori ◽  
Mouse Model ◽  
Immune Responses ◽  
Antimicrobial Peptide ◽  
Helicobacter Pylori Infection ◽  
Host Immune Responses ◽  
Membrane Perturbation

scholarly journals Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0148353 ◽  
Author(s):  
Sílvia Fontenete ◽  
Marina Leite ◽  
Davie Cappoen ◽  
Rita Santos ◽  
Chris Van Ginneken ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Mouse Model ◽  
Helicobacter Pylori Infection

The role of cytosolic phospholipase A2 in gastric damage induced by helicobacter pylori infection: in vivo and in vitro studies

2000 ◽  
Vol 118 (4) ◽  
pp. A732-A733
Author(s):  
Gerardo Nardone ◽  
Eileen Holicky ◽  
Jim R. Uhl ◽  
Vittorio Colantuoni ◽  
Lina Sabatino ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Phospholipase A2 ◽  
Cytosolic Phospholipase A2 ◽  
In Vitro Studies ◽  
Helicobacter Pylori Infection ◽  
Gastric Damage ◽  
Cytosolic Phospholipase

scholarly journals The Synthetic Antimicrobial Peptide Pexiganan and Its Nanoparticles (PNPs) Exhibit the Anti-Helicobacter pylori Activity in Vitro and in Vivo

Molecules ◽  
2015 ◽  
Vol 20 (3) ◽  
pp. 3972-3985 ◽  
Author(s):  
Xiao-Lin Zhang ◽  
An-Min Jiang ◽  
Zhong-You Ma ◽  
Xian-Bao Li ◽  
You-Yi Xiong ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Antimicrobial Peptide

Effect of vaccination against Helicobacter pylori infection and its immune responses in experimental mouse model

1998 ◽  
Vol 114 ◽  
pp. A987
Author(s):  
T. Gotoh ◽  
A. Nishizono ◽  
J. Ikewaki ◽  
M. Kimoto ◽  
K. Mifune ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Mouse Model ◽  
Immune Responses ◽  
Helicobacter Pylori Infection ◽  
Experimental Mouse Model ◽  
Experimental Mouse

In vivo and in vitro activation of caspase-8 and -3 associated with Helicobacter pylori infection

2002 ◽  
Vol 4 (7) ◽  
pp. 713-722 ◽  
Author(s):  
Hassan Ashktorab ◽  
Mattew Neapolitano ◽  
Chandara Bomma ◽  
Cornel Allen ◽  
Amel Ahmed ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
Caspase 8 ◽  
In Vitro Activation

Factors Affecting the Validity of the 13C-Urea Breath Test for In Vivo Determination of Helicobacter pylori Infection Status in a Mouse Model

Helicobacter ◽  
1999 ◽  
Vol 4 (4) ◽  
pp. 260-265 ◽  
Author(s):  
Paul D. Hammond ◽  
Fred J. Stutzenberger ◽  
Ross N. Butler ◽  
Leanna C. Read ◽  
Geoffrey P. Davidson
Keyword(s):  
Helicobacter Pylori ◽  
Mouse Model ◽  
Breath Test ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
Infection Status ◽  
Factors Affecting ◽  
13C Urea Breath Test

scholarly journals Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease

2021 ◽  
Author(s):  
Vivian Vasconcelos Costa ◽  
Michelle A Sugimoto ◽  
Josy Hubner ◽  
Caio S Bonilha ◽  
Celso Martins Queiroz-Junior ◽  
...  
Keyword(s):  
Immune Responses ◽  
Denv Infection ◽  
Annexin A1 ◽  
Cytokine Storm ◽  
Dengue Disease ◽  
Host Immune Responses ◽  
Inflammation Resolution ◽  
Circulating Levels

Host immune responses contribute to dengue's pathogenesis and severity, yet the possibility that failure in endogenous inflammation resolution pathways could characterise the disease has not been contemplated. The pro-resolving protein Annexin A1 (AnxA1) is known to counterbalance overexuberant inflammation and mast cell (MC) activation. We hypothesised that inadequate AnxA1 engagement underlies the cytokine storm and vascular pathologies associated with dengue disease. Levels of AnxA1 were examined in the plasma of dengue patients and infected mice. Immunocompetent, IFNα/βR-/-, AnxA1-/- and FPR2/ALX-/- mice were infected with Dengue virus (DENV) and treated with the AnxA1 mimetic peptide Ac2-26 for analysis. Additionally, the effect of Ac2-26 on DENV-induced MC degranulation was assessed in vitro and in vivo. We observed that circulating levels of AnxA1 were reduced in dengue patients and DENV-infected mice. While the absence of AnxA1 or its receptor FPR2/ALX aggravated illness in infected mice, treatment with AnxA1 agonistic peptide attenuated disease manifestations. Both clinical outcomes were attributed to modulation of DENV-mediated viral load-independent MC degranulation. We have thereby identified that altered levels of the pro-resolving mediator AnxA1 are of pathological relevance in DENV infection, suggesting FPR2/ALX agonists as a therapeutic target for dengue disease.

MicroRNA-155 Expression With Brucella Infection in vitro and in vivo and Decreased Serum Levels of MicroRNA-155 in Patients With Brucellosis

2021 ◽  
Author(s):  
Xi Zhang ◽  
Jingjing Chen ◽  
Huimin Cheng ◽  
Jinying Zhu ◽  
Qiao Dong ◽  
...  
Keyword(s):  
Immune Responses ◽  
Early Stage ◽  
Serum Levels ◽  
Human Brucellosis ◽  
Host Immune Responses ◽  
Contrasting Effect ◽  
Antibody Titers ◽  
Unique Mechanism

Abstract Infection by Brucella is characterized by the inhibition of host immune responses. MicroRNA-155 (miR-155) has been implicated in the immune response to many diseases. In this study, miR-155 expression during Brucella 16M infection of macrophages and mice were analyzed. Expression of miR-155 was significantly induced in macrophages at 24 hours post infection. Analysis of infected mice showed that miR-155 was inhibited at 7 and 14 days, but induced at 28 days. Very interestingly, the induction or inhibition trend was reversed at 7 and 14 days in 16M△virB-infected mice. This suggested that decreased expression of miR-155 at an early stage of infection was dependent on intracellular replication. In humans with brucellosis, serum levels of miR-155 were significantly decreased compared to those without brucellosis and healthy volunteers. Significant correlations were observed between serum level of miR-155 and serum anti-Brucella antibody titers and symptom of sweat. The decrease in miR-155 with Brucella infection contrasts with the increase in miR-155 observed in Mycobacterium tuberculosis infection. This contrasting effect suggests that Brucella interferes with miR-155-regulated immune responses through a unique mechanism. Taken together, data from this study indicate that Brucella infection affects miR-155 expression, and that human brucellosis patients show decreased serum levels of miR-155.

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