scholarly journals High blood sugar levels significantly impact the prognosis of colorectal cancer patients through down-regulation of microRNA-16 by targeting Myb and VEGFR2

Oncotarget ◽  
2016 ◽  
Vol 7 (14) ◽  
pp. 18837-18850 ◽  
Author(s):  
I-Ping Yang ◽  
Hsiang-Lin Tsai ◽  
Ching-Wen Huang ◽  
Chien-Yu Lu ◽  
Zhi-Feng Miao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Blood Sugar ◽  
Down Regulation ◽  
High Blood Sugar ◽  
Sugar Levels ◽  
Colorectal Cancer Patients

scholarly journals Down-Regulation of HLA-A Expression Correlates with a Better Prognosis in Colorectal Cancer Patients

2002 ◽  
Vol 82 (12) ◽  
pp. 1725-1733 ◽  
Author(s):  
Anand G Menon ◽  
Hans Morreau ◽  
Rob A E M Tollenaar ◽  
E Alphenaar ◽  
Marjo van Puijenbroek ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Down Regulation ◽  
Colorectal Cancer Patients

scholarly journals High blood sugar levels but not diabetes mellitus significantly enhance oxaliplatin chemoresistance in patients with stage III colorectal cancer receiving adjuvant FOLFOX6 chemotherapy

2019 ◽  
Vol 11 ◽  
pp. 175883591986696 ◽  
Author(s):  
I-Ping Yang ◽  
Zhi-Feng Miao ◽  
Ching-Wen Huang ◽  
Hsiang-Lin Tsai ◽  
Yung-Sung Yeh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Colorectal Cancer ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Stage Iii ◽  
Health Concern ◽  
Prognostic Impact ◽  
Glucose Administration ◽  
High Blood Sugar ◽  
Sugar Levels

Background: The high prevalence of type 2 diabetes mellitus (DM) among patients with colorectal cancer (CRC) is becoming a serious public health concern worldwide. FOLFOX4 chemotherapy is one of the most widely used adjuvant therapies in patients with stage III colon cancer after surgical resection. However, chemotherapy resistance is associated with a poor prognosis. The prognostic impact of high blood sugar levels on oxaliplatin resistance in CRC patients is an unexplored topic. Methods: In total, 157 patients with stage III CRC were classified according to their fasting blood sugar level (⩾126 or <126 mg/dl). Clinicopathological features and oxaliplatin chemoresistance/survival outcome of the two groups were compared. In vitro cell proliferation assay was performed through d-(+)-glucose administration. Results: Multivariate analysis results revealed that high blood sugar level was a significantly independent prognostic factor of disease-free survival and overall survival (both p < 0.05), but not DM history. After metformin administration, enhanced proliferation of CRC cells (HT-29, HCT-116, SW480, and SW620) with d-(+)-glucose administration could be reversed and oxaliplatin chemosensitivity considerably increased ( p < 0.05). Furthermore, phosphorylation of two glycolysis-related target proteins, SMAD3 and MYC, notably increased under high glucose concentration. Conclusions: Hyperglycemia can affect clinical outcomes in stage III CRC patients receiving adjuvant chemotherapy, and the mechanism underlying oxaliplatin resistance is possibly associated with increased phosphorylation of SMAD3 and MYC and upregulation of EHMT2 expression.

Associations of daily partner responses with fatigue interference and relationship satisfaction in colorectal cancer patients.

2018 ◽  
Vol 37 (11) ◽  
pp. 1015-1024
Author(s):  
Fabiola Müller ◽  
Marrit A. Tuinman ◽  
Ellen Stephenson ◽  
Ans Smink ◽  
Anita DeLongis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Relationship Satisfaction ◽  
Cancer Patients ◽  
Colorectal Cancer Patients

Safety and Quality of Life in the Treatment of Non-metastasic Colorectal Cancer Patients: 5-fluorouracil Versus Capecitabine

2019 ◽  
Author(s):  
Julia Sánchez-Gundín ◽  
Cristina Martín-Sabroso ◽  
Ana M. Fernández-Carballido ◽  
D. Barreda-Hernández ◽  
Ana I. Torres-Suárez
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Cancer Patients ◽  
Colorectal Cancer Patients
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