scholarly journals High blood sugar levels but not diabetes mellitus significantly enhance oxaliplatin chemoresistance in patients with stage III colorectal cancer receiving adjuvant FOLFOX6 chemotherapy

2019 ◽  
Vol 11 ◽  
pp. 175883591986696 ◽  
Author(s):  
I-Ping Yang ◽  
Zhi-Feng Miao ◽  
Ching-Wen Huang ◽  
Hsiang-Lin Tsai ◽  
Yung-Sung Yeh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Colorectal Cancer ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Stage Iii ◽  
Health Concern ◽  
Prognostic Impact ◽  
Glucose Administration ◽  
High Blood Sugar ◽  
Sugar Levels

Background: The high prevalence of type 2 diabetes mellitus (DM) among patients with colorectal cancer (CRC) is becoming a serious public health concern worldwide. FOLFOX4 chemotherapy is one of the most widely used adjuvant therapies in patients with stage III colon cancer after surgical resection. However, chemotherapy resistance is associated with a poor prognosis. The prognostic impact of high blood sugar levels on oxaliplatin resistance in CRC patients is an unexplored topic. Methods: In total, 157 patients with stage III CRC were classified according to their fasting blood sugar level (⩾126 or <126 mg/dl). Clinicopathological features and oxaliplatin chemoresistance/survival outcome of the two groups were compared. In vitro cell proliferation assay was performed through d-(+)-glucose administration. Results: Multivariate analysis results revealed that high blood sugar level was a significantly independent prognostic factor of disease-free survival and overall survival (both p < 0.05), but not DM history. After metformin administration, enhanced proliferation of CRC cells (HT-29, HCT-116, SW480, and SW620) with d-(+)-glucose administration could be reversed and oxaliplatin chemosensitivity considerably increased ( p < 0.05). Furthermore, phosphorylation of two glycolysis-related target proteins, SMAD3 and MYC, notably increased under high glucose concentration. Conclusions: Hyperglycemia can affect clinical outcomes in stage III CRC patients receiving adjuvant chemotherapy, and the mechanism underlying oxaliplatin resistance is possibly associated with increased phosphorylation of SMAD3 and MYC and upregulation of EHMT2 expression.

High-serum blood sugar level significantly enhances oxaliplatin resistance in stage III colorectal cancer patients.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 532-532
Author(s):  
Jaw-Yuan Wang
Keyword(s):  
Clinical Outcomes ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Chemotherapy Resistance ◽  
Resistance Mechanism ◽  
High Serum ◽  
Stage Iii ◽  
Prognostic Impact ◽  
Glucose Administration

532 Background: FOLFOX4 chemotherapy is one of the most widely used adjuvant therapies in patients with stage III colon cancer after surgical resection. However, chemotherapy resistance is associated with a poor prognosis. The prognostic impact of high blood sugar levels on oxaliplatin resistance in CRC patients is an unexplored topic. Methods: A total of 157 patients with stage III CRC were classified according to their serum blood sugar level (≥ 126 or < 126 mg/dL). Clinicopathological features and clinical outcomes (oxaliplatin resistance) of the two groups were analyzed. Results: Through multivariate analysis, both disease-free and overall survival of CRC patients was found to be significantly associated with serum blood glucose levels (both P < 0.05) but not DM history. In vitro cell proliferation assay was performed through D-(+)-glucose administration. After metformin administration, enhanced proliferation of CRC cells with D-(+)-glucose administration could be reversed and oxaliplatin sensitivity considerably increased ( P < 0.05). Furthermore, phosphorylation of two glycolysis-related target proteins, SMAD3 and MYC, notably increased with high glucose concentration. Conclusions: In summary, hyperglycemia could affect clinical outcomes in CRC patients receiving adjuvant chemotherapy, with the underlying oxaliplatin resistance mechanism possibly associated with increasing phosphorylation of SMAD3 and MYC and upregulation of G9A expression.

scholarly journals LEVELS OF DIABETES BLOOD SUGAR WITH TYPE OF CATARACT

2019 ◽  
Vol 3 (1) ◽  
pp. 7-13
Author(s):  
Indah Lestari ◽  
Fifiyahpuahsari Fifiyahpuahsari
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Chemical Exposure ◽  
Diabetic Patients ◽  
Nuclear Cataract ◽  
High Blood Glucose ◽  
High Blood Sugar ◽  
Sugar Levels ◽  
The Impact

Diabetes mellitus was a disease with macro and micro risk of angiopathy, which includes the impact of causing cataracts. Diabetic patients with high sugar levels have a greater chance of developing cataracts at a younger age and certain tendencies towards cataract type. The aim of the study was to analyze the correlation between diabetes blood sugar levels and cataract type. The research design was correlation analysis with Cross-Sectional approach. Samples in the study were some cataract patients who had a history of diabetes mellitus in Surabaya Undaan Eye Hospital as many as 125 people, it was taken using consecutive sampling technique, and fulfilling the criteria of the study (age range 45 - 65 years, have complete medical records related to the continuity of sugar examination results in blood, the incidence of cataracts is not caused by congenital cataracts, juveniles, due to trauma, chemical exposure to UV radiation). Independent variable was the blood sugar level of Diabetes mellitus and the Dependent variable was cataract type. The instruments used were laboratory tests related to blood sugar levels, and medical diagnosis related to cataract type. Data were analyzed by Spearman rho, with a significant value <0.05. The results showed a close association between diabetes and cataracts, where as many as 47.2% with high blood sugar levels, 40% with nuclear cataract type and from 59 respondents with high blood sugar levels 26 people experienced nuclear cataract type, with rho value = 0.001. The mechanism of glucose toxicity in Diabetes Mellitus which causes cataracts can go through three paths: increased activity of the aldose reductase enzyme which causes the formation of sugar alcohol, sorbitol and galactitol in crystalline lenses; through the non-enzymatic replication process; and at high blood glucose levels a glucose oxidation process will occur which causes oxidative stress conditions. Maintenance of managing blood sugar levels must be a concern for diabetics.   Keywords: Blood Sugar Level, Diabetes Mellitus, Type of Cataract  

scholarly journals LEVELS OF DIABETES BLOOD SUGAR WITH TYPE OF CATARACT

2019 ◽  
Vol 3 (1) ◽  
pp. 7-13
Author(s):  
Indah Lestari ◽  
Fifiyahpuahsari Fifiyahpuahsari
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Chemical Exposure ◽  
Diabetic Patients ◽  
Nuclear Cataract ◽  
High Blood Glucose ◽  
High Blood Sugar ◽  
Sugar Levels ◽  
The Impact

Diabetes mellitus was a disease with macro and micro risk of angiopathy, which includes the impact of causing cataracts. Diabetic patients with high sugar levels have a greater chance of developing cataracts at a younger age and certain tendencies towards cataract type. The aim of the study was to analyze the correlation between diabetes blood sugar levels and cataract type. The research design was correlation analysis with Cross-Sectional approach. Samples in the study were some cataract patients who had a history of diabetes mellitus in Surabaya Undaan Eye Hospital as many as 125 people, it was taken using consecutive sampling technique, and fulfilling the criteria of the study (age range 45 - 65 years, have complete medical records related to the continuity of sugar examination results in blood, the incidence of cataracts is not caused by congenital cataracts, juveniles, due to trauma, chemical exposure to UV radiation). Independent variable was the blood sugar level of Diabetes mellitus and the Dependent variable was cataract type. The instruments used were laboratory tests related to blood sugar levels, and medical diagnosis related to cataract type. Data were analyzed by Spearman rho, with a significant value <0.05. The results showed a close association between diabetes and cataracts, where as many as 47.2% with high blood sugar levels, 40% with nuclear cataract type and from 59 respondents with high blood sugar levels 26 people experienced nuclear cataract type, with rho value = 0.001. The mechanism of glucose toxicity in Diabetes Mellitus which causes cataracts can go through three paths: increased activity of the aldose reductase enzyme which causes the formation of sugar alcohol, sorbitol and galactitol in crystalline lenses; through the non-enzymatic replication process; and at high blood glucose levels a glucose oxidation process will occur which causes oxidative stress conditions. Maintenance of managing blood sugar levels must be a concern for diabetics.   Keywords: Blood Sugar Level, Diabetes Mellitus, Type of Cataract  

scholarly journals Pengaruh Edukasi Senam Kaki Diabetes Mellitus Berbahasa Tetum Terhadap Sirkulasi Ekstremitas Bawah Dan Kadar Gula Darah Sewaktu Di Centru Saude Comoro, Dili, Timor Leste.

2020 ◽  
Vol 5 (1) ◽  
pp. 16-24
Author(s):  
Carmelita Barros ◽  
Fitri Arofiati
Keyword(s):  
Diabetes Mellitus ◽  
Lower Extremity ◽  
Blood Sugar ◽  
Blood Circulation ◽  
Blood Sugar Level ◽  
Statistical Tests ◽  
Wilcoxon Test ◽  
Timor Leste ◽  
Post Test ◽  
Sugar Levels

ABSTRACT Diabetes mellitus (DM) in Indonesia is better known as diabetes and in Timor Leste DM known as Ra'an Midar has become a very serious health problem, and is the most common endocrine disease. Diabetes mellitus is a degenerative disease that is characterized by metabolic disorders or pancreatic damage so that the pancreas is unable to produce enough insulin to the maximum so that it can cause insulin deficiency in the body both absolute and relative can increase blood sugar levels or hyperglycemia. Data from the Dili District Health Office in 2018 showed that there were 2690 patients with diabetes mellitus, so that diabetic foot exercises were needed. The purpose of this study was to determine the effect of Tetum Language Diabetes Foot Gymnastic Education on Lower Circulation and Lower Blood Sugar Levels at the Saude Comoro Center, Dili, Timor Leste. Method : using the Pre-Experiment method. Independent variable: Education of Tetum Language Diabetes Foot Gymnastics Education, dependent variable: Circulation of Lower Extremity and Blood Sugar Level at a Time. Population 100 people, sample 28 people, sample technique: simple random, data collection: Examination of blood sugar levels, blood circulation, statistical tests: Wilcoxon Test. Results : Most respondents who had good blood circulation were 15 pre- test (53.6%) and 18 post-test (64.3%). And the majority of respondents whose blood sugar levels were good were 14 people pre-test (50.0%) and 20 people post test (71.4%). Based on the results of statistical tests using the Wilcoxon Signed Rank Test, the value of blood circulation is a significant level of 0.005 and the blood sugar level is at a significant level of 0,000. Conclusion : Conclusion there is the influence of Education on Tetun Language Diabetes Foot Gymnastics on Lower Extracurricular Circulation and Blood Sugar Levels At the Saude Comoro Center, Dili, Timor Leste.  Keyword: Leg exercise, lower extremity bloodd circulation, Blood sugar levels, Diabetes mellitus.

scholarly journals Senam Prolanis Dm Dan Jalan Kaki Terhadap Penurunan Kadar Gula Darah Pada Penderita Diabetes Millitus Tipe II Di Klinik UMP Purwokerto

2021 ◽  
Vol 6 (2) ◽  
pp. 94
Author(s):  
Agus Sutiono ◽  
Dedy Purwito
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
The Body ◽  
Rank Test ◽  
Type Ii ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Sugar Levels ◽  
Blood Glucose Monitor

Diabetes mellitus is one of cronical degenerative disease. The prevalence of sufferers continues to increase every year, one of the non-pharmacological therapies is exercise such as gymnastics prolanis DM and walking exercises to decrease the glucose level by the body muscles during the physical body. Objective this research is to find out the effectiveness of Prolanis and walking exercises in reducing blood sugar levels in DM patients type II. Method this study uses the Quasi experiment with pre and post with two group design. The study population was 92 DM patients type II with a sample of 82 people. Glucometer (Auto check blood glucose monitor) is used to collect the data. Wiloxon Test is used to analyze the statistical data. Results the research shows that the value of Prolanis Exercises (DM) is p=0.002 which means a significant influence on decrease of the sugar level of DM patients type II. Meanwhile the value of walking exercises is p=0.001. From the statistic test of WIlconxon Signed Rank Test, It obtained Z correlation = 7.886. It means that there is a significant correlation between Prolanis and walking exercises towards the decrease of blood sugar level of Diabetes Mellitus patients type II. Physical activities done regularly, measurably, and correctly are suggested to be considered as non-pharmacological therapies for Diabetes Mellitus patients type II to decrease blood sugar level. Keywords: Prolanis Exercises (DM), Walking, sugar blood level.

scholarly journals “Japanese Ants (Tenebrio Molitor) Stabilize Blood Sugar Levels For Diabetics”: The Current Issue OF Herbal Medicine In Indonesia"

2018 ◽  
Vol 2 (02) ◽  
pp. 164-168
Author(s):  
Asirotul Marifah Marifah
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Sampling Technique ◽  
Lower Blood ◽  
Patients With Diabetes ◽  
Independent Variable ◽  
Sugar Levels ◽  
The Relationship ◽  
Different Doses

There are still many of our people who have never heard or even seen the shape of the Japanese ants, so sometimes people consume Japanese ants with different doses between people with each other and even some who consume Japanese ants are not appropriate doses because they want to get well soon. The purpose of research to know the relationship between consumption patterns of Japanese ants and blood sugar levels of people with diabetes mellitus. The design of this study is correlational analytic with crossectional approach. Variables of this research there are two that is the pattern of consumption of Japanese ants as an independent variable and blood sugar levels as the dependent variable. The population of this study was all patients with diabetes Mellitus who had suffered > 5 years who consumed Japanese ants in Grinting Village Karangjeruk Village Jatirejo Subdistrict Mojokerto regency as many as 10 respondents. in the sampling of researchers using total sampling technique. Data collection with an observation sheet of Japanese ant consumption and blood sugar level. The result of the research showed that most of the respondents consume Japanese ants regularly as much as 6 respondents (60%) and most respondents have blood sugar level in the normal category that is between 100-125 mg/dl as many as 6 respondents (60%). Consumption Japanese ants can routinely lower blood sugar levels of people with diabetes mellitus because ants contain enzymes that can keep blood sugar levels diabetics.

scholarly journals “Japanese Ants (Tenebrio Molitor) Stabilize Blood Sugar Levels For Diabetics”: The Current Issue OF Herbal Medicine In Indonesia"

2018 ◽  
Vol 2 (02) ◽  
pp. 164-168
Author(s):  
Asirotul Marifah Marifah
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Sampling Technique ◽  
Lower Blood ◽  
Patients With Diabetes ◽  
Independent Variable ◽  
Sugar Levels ◽  
The Relationship ◽  
Different Doses

There are still many of our people who have never heard or even seen the shape of the Japanese ants, so sometimes people consume Japanese ants with different doses between people with each other and even some who consume Japanese ants are not appropriate doses because they want to get well soon. The purpose of research to know the relationship between consumption patterns of Japanese ants and blood sugar levels of people with diabetes mellitus. The design of this study is correlational analytic with crossectional approach. Variables of this research there are two that is the pattern of consumption of Japanese ants as an independent variable and blood sugar levels as the dependent variable. The population of this study was all patients with diabetes Mellitus who had suffered > 5 years who consumed Japanese ants in Grinting Village Karangjeruk Village Jatirejo Subdistrict Mojokerto regency as many as 10 respondents. in the sampling of researchers using total sampling technique. Data collection with an observation sheet of Japanese ant consumption and blood sugar level. The result of the research showed that most of the respondents consume Japanese ants regularly as much as 6 respondents (60%) and most respondents have blood sugar level in the normal category that is between 100-125 mg/dl as many as 6 respondents (60%). Consumption Japanese ants can routinely lower blood sugar levels of people with diabetes mellitus because ants contain enzymes that can keep blood sugar levels diabetics.

CLINICAL STUDY TO EVALUATE EFFICACY OF NISHA AMALAKI CHURNA IN NEWLY DIAGNOSED PRAMEHA TYPE II DIABETES MELLITUS.

2021 ◽  
pp. 42-43
Author(s):  
Neena Damle
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Type Ii Diabetes ◽  
Blood Sugar Level ◽  
Type Ii Diabetes Mellitus ◽  
Fasting Blood Sugar ◽  
Type Ii ◽  
Newly Diagnosed ◽  
Sugar Levels ◽  
Hba1c Levels

During the last few years India have maximum increase of Type II diabetes mellitus . The prevalence of type 2 diabetes mellitus is 2.4% in rural population and 11.6% in urban population[1] . In this study total 10 Subjects of newly diagnosed type II Diabetes Mellitus, who fullled below criteria were selected from D.Y. Patil Ayurvedic Hospital Nerul Navi Mumbai OPD No.1. a) HbA1c level more than 6.5% b) Fasting blood Sugar level (FBS) more than 126 mg/dL (7 mmol/L) c) 2-hour Post Prandial Blood Sugar level (PPBS) more than 200 mg/dL (11.1 mmol/L). All 10 subjects treated with Nisha Amalaki Churna 3gms BD one hour before breakfast and before dinner with warm water for three months. Data of subjective parameters and physical examination of subjects was recorded in CRF during three visits 30 days apart. For Statistical Analysis Wilcoxon matched-pairs signed-ranks test was used to assess Subjective parameters and Paired t-Test was used to compare Fasting Blood Sugar level, two hour post prandial blood sugar levels and HbA1C levels BT and AT. The study showed signicant results in most of the subjective parameters at the level of signicance (P<0.05). Nisha Amalaki Churna reduced Fasting blood sugar levels and post Prandial blood sugar levels signicantly at level of signicance p<0.01. Nisha Amalaki Churna also reduced HbA1C levels signicantly at level of signicance p<0.01.The Ayurvedic mixture Nisha Amalaki Churna was signicantly effective in newly diagnosed Type II Diabetes Mellitus subjects.

scholarly journals High blood sugar levels significantly impact the prognosis of colorectal cancer patients through down-regulation of microRNA-16 by targeting Myb and VEGFR2

Oncotarget ◽  
2016 ◽  
Vol 7 (14) ◽  
pp. 18837-18850 ◽  
Author(s):  
I-Ping Yang ◽  
Hsiang-Lin Tsai ◽  
Ching-Wen Huang ◽  
Chien-Yu Lu ◽  
Zhi-Feng Miao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Blood Sugar ◽  
Down Regulation ◽  
High Blood Sugar ◽  
Sugar Levels ◽  
Colorectal Cancer Patients

scholarly journals Resistant starch, amylose, and amylopectin content in breadfruit cookies as an alternative snack for individuals with diabetes mellitus

Food Research ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 394-400
Author(s):  
Z.A. Fitriani ◽  
F.F. Dieny ◽  
A. Margawati ◽  
F.F. Jauharany
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Resistant Starch ◽  
Blood Sugar Level ◽  
Friedman Test ◽  
Lifestyle Management ◽  
Diet Management ◽  
Sugar Levels ◽  
The One ◽  
One Way Anova

Uncontrolled hyperglycaemia in individuals with diabetes mellitus can increase the risk factors for disease complications. Therefore, lifestyle management becomes a vital measure for those individuals, especially in diet management, to control their blood sugar level. Breadfruit starch-based cookies contain resistant starch, amylose, and amylopectin that can inhibit the increment of blood sugar levels. Hence, these cookies can be used as an alternative snack for those individuals. This study was aimed to analyse the content of resistant starch, amylose, and amylopectin, as well as the acceptability level of breadfruit starch-based cookies. We used a completely randomised experiment using four formulations with various breadfruit flour content: 25%, 50%, 75% and 100%. The breadfruit formulation containing breadfruit flour (BF) and wheat flour (WF). Formula 25% (25% BF 75% WF, 50% (50% BF and WF), 75% (75% BF 25% WF), and 100% BF. The one-way ANOVA was used to compare the content of resistant starch, amylose, and amylopectin among the cookies. Furthermore, the Friedman test was used to analyse the acceptance level of the cookies, which includes colour, odour, texture, and flavour. The cookies contain 19.38-20.51% of resistant starch, 13.55-16.60% of amylose, and 83.39- 86.44% of amylopectin. The highest resistant starch and amylose contents were found in cookies with 100% breadfruit flour content, while the highest amylopectin content was found in the 25% formulation. The acceptability level of the cookies included colour, odour, texture, and flavour. Cookies made with 100% breadfruit flour contained the highest resistant starch and amylose, but the lowest amylopectin. It also received the highest acceptability among the panellists.

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