scholarly journals Multimodal brain magnetic resonance imaging and perfusion computer assisted tomography scanning in evaluation of cerebroprotective efficacy of antihypertensive therapy

2009 ◽  
Vol 15 (3) ◽  
pp. 280-284
Author(s):  
E. V. Fedorenko ◽  
H. -J. Wittsack ◽  
A. M. Russina ◽  
N. L. Afanasieva ◽  
V. M. Gulyaev ◽  
...  

A multimodal diagnostic study of the brain was carried out in 22 patients with arterial hypertension (mean systolic blood pressure 152,8 ± 7,6 mm Hg, mean diastolic blood pressure 94,6 ± 5,2 mm Hg), without cardiovascular events in anamnesis. Magnetic resonance imaging (MRI) imaging and dynamic contrast-enhanced perfusion X-ray computer assisted tomography scan (DynCT) of the brain were performed at admission and after six months of antihypertensive treatment. Based on the MRI and DynCT visual data the extent of periventricular oedema, dimensions of liquor system and regional cerebral blood flow (as ml/min/100 g tissue) were quantified. The quantitative MRI and DynCT indices were analyzed regarding the decrease of blood pressure. Significant decrease of periventricular oedema and improvement in perfusion of basal ganglii area were observed in patients demonstrated decrease in systolic blood pressure for 12-28 mm Hg. The degree of the blood pressure decrease was not associated with the significant MRI and DynCT data improvement. Hencefore, we conclude that the brain MRI and perfusion DynCT data can be employed for evaluation of cerebroprotective effects of antihypertensive therapy.

Root Methods ◽  
2000 ◽  
pp. 343-363 ◽  
Author(s):  
S. Asseng ◽  
L. A. G. Aylmore ◽  
J. S. MacFall ◽  
J. W. Hopmans ◽  
P. J. Gregory

2018 ◽  
Vol 7 (3) ◽  
pp. 217-221
Author(s):  
E. V. Shevchenko ◽  
G. R. Ramazanov ◽  
S. S. Petrikov

Background Acute dizziness may be the only symptom of stroke. Prevalence of this disease among patients with isolated dizziness differs significantly and depends on study design, inclusion criteria and diagnostic methods. In available investigations, we did not find any prospective studies where magnetic resonance imaging, positional maneuvers, and Halmagyi-Curthoys test had been used to clarify a pattern of diseases with isolated acute dizziness and suspected stroke.Aim of study To clarify the pattern of the causes of dizziness in patients with suspected acute stroke.Material and methods We examined 160 patients admitted to N.V. Sklifosovsky Research Institute for Emergency Medicine with suspected stroke and single or underlying complaint of dizziness. All patients were examined with assessment of neurological status, Dix-Hollpike and Pagnini-McClure maneuvers, HalmagyiCurthoys test, triplex scans of brachiocephalic arteries, transthoracic echocardiography, computed tomography (CT) and magnetic resonance imaging (MRI) of the brain with magnetic field strength 1.5 T. MRI of the brain was performed in patients without evidence of stroke by CT and in patients with stroke of undetermined etiology according to the TOAST classification.Results In 16 patients (10%), the cause of dizziness was a disease of the brain: ischemic stroke (n=14 (88%)), hemorrhage (n=1 (6%)), transient ischemic attack (TIA) of posterior circulation (n=1 (6%)). In 70.6% patients (n=113), the dizziness was associated with peripheral vestibulopathy: benign paroxysmal positional vertigo (n=85 (75%)), vestibular neuritis (n=19 (17%)), Meniere’s disease (n=7 (6%)), labyrinthitis (n=2 (1,3%)). In 6.9% patients (n=11), the cause of dizziness was hypertensive encephalopathy, 1.9% of patients (n=3) had heart rhythm disturbance, 9.4% of patients (n=15) had psychogenic dizziness, 0.6% of patients (n=1) had demyelinating disease, and 0.6% of patients (n=1) had hemic hypoxia associated with iron deficiency anemia.Conclusion In 70.6% patients with acute dizziness, admitted to hospital with a suspected stroke, peripheral vestibulopathy was revealed. Only 10% of patients had a stroke as a cause of dizziness.


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