scholarly journals Bovine Herpesvirus Types 5 (BoHV5): A New and Emerging Threat in Indian Cattle

2021 ◽  
Author(s):  
K.D. Rawat ◽  
K.K. Chaubey
Keyword(s):  
Sexually Transmitted Diseases ◽  
Bovine Herpesvirus ◽  
Laboratory Animals ◽  
Test Protocol ◽  
Experimental Animals ◽  
Sexually Transmitted ◽  
The Central Nervous System ◽  
Indian Cattle ◽  
Subtype A ◽  
First Time

Bovine herpesvirus 5 (BoHV-5) belongs to the genus varicellovirus family herpesviridae and is a causative agent of meningo-encephalitis in cattle. BoHV-5 can replicates in the central nervous system (CNS) to cause encephalitis and establishes latency in the trigeminal ganglion of either naturally infected cattle or experimentally inoculated laboratory animals. BoHV 5 was first time reported in Australia in 1962 and subsequently reported in Latin Ameican countries Argentina, Brazil and Uruguay. Few cases of BoHV5 infection has also been reported in USA and Europe. Recently, the BoHV5 infection was reported in Indian cattle for the first time. The BoHV5 was isolated from aborted cattle and characterized as BoHV5 subtype A and this finding may necessitate inclusion of BoHV5 test protocol in testing of semen for sexually transmitted diseases. Because BoHV5 infection in cattle recently reported in India so, it is needed to explore the similarity of the isolates with earlier reported isolates and to check it’s pathogenicity to cause encephalitis in natural host and in experimental animals like rabbits, rat, guniea pig etc. Beside this, we have to explore the information about co-infection of BoHV5 with other viral, bacterial, fungal as well as parasitic agents.

scholarly journals Isolation and characterization of bovine herpes virus 5 (BHV5) from cattle in India

2020 ◽  
Author(s):  
Naveen Kumar ◽  
Yogesh Chander ◽  
Thachamvally Riyesh ◽  
Nitin Khandelwal ◽  
Ram Kumar ◽  
...  
Keyword(s):  
Nucleotide Sequencing ◽  
South American ◽  
Serum Samples ◽  
Test Protocol ◽  
Sexually Transmitted ◽  
Cytopathic Effects ◽  
Isolation And Characterization ◽  
Mdbk Cells ◽  
Subtype A ◽  
First Time

AbstractBovine herpesvirus 1 (BHV1) and 5 (BHV5) are genetically and antigenically related alphaherpesviruses. Infection with one virus induces protective immunity against the other. However, disease associated with BHV1 and BHV5 varies significantly; whereas BHV1 infection is usually associated with rhinotracheitis and abortion, BHV5 causes encephalitis in cattle. BHV5 outbreaks are sporadic and mainly restricted to the South American countries. We report BHV5 infection for the first time from aborted cattle in India. Based on the characteristic cytopathic effects in MDBK cells, amplification of the viral genome in PCR, differential PCR for BHV1/BHV5, nucleotide sequencing and restriction endonuclease patterns, identity of the virus was confirmed as BHV5 subtype A. Serum samples from the aborted cattle strongly neutralized both BHV1 and BHV5 suggesting an active viral infection in the herd. Upon UL27, UL44 and UL54 gene-based sequence and phylogenetic analysis, the isolated virus clustered with BHV5 strains and showed highest similarity with the Brazilian BHV5 strains.Author SummaryBHV5 causes fatal meningoencephalitis that may result in a mortality rate of up to 100% in cattle. BHV5 is rarely associated with abortion and its distribution is restricted to South American countries. Only a few cases of this disease have been reported from other countries. For the first time, we provide a strong evidence of BHV5 infection from aborted cattle in India. The finding may necessitate inclusion of BHV5 test protocol in testing of semen for sexually transmitted diseases. Also, the isolated virus would be useful for developing diagnostic, prophylactic and therapeutic agents to combat BHV5 disease in the country.

Features of the sensitivity of the central nervous system of the organism of experimental animals to the effects of certain psychotropic drugs and their combinations against the background of chronic alcohol intoxication in a chronopharmacological experiment

2020 ◽  
pp. 56-62
Author(s):  
E.V. Filippova
Keyword(s):  
Alcohol Intoxication ◽  
Laboratory Animals ◽  
Histological Structure ◽  
Chronic Alcohol ◽  
Behavioral Reactions ◽  
Experimental Animals ◽  
Chronic Alcohol Intoxication ◽  
Psychotropic Action ◽  
Adaptive Effect ◽  
The Central Nervous System

In a chronopharmacological experiment, the effect of two drugs with psychotropic action in combinations on the behavior of laboratory animals subjected to chronic alcohol intoxication was examined. Against the background of a deprimating agent, a decrease in the threshold of sensitivity to electrical irritation and the duration of an aggressive reaction was revealed; an increase in these indicators was established with a combination of a deprimating drug with an antioxidant. It has been shown that the antioxidant has a desynchronizing effect on the behavioral reactions of laboratory animals for two days, which indicates a pronounced adaptive effect. In the case of using combinations of a deprimating agent with an antioxidant, a decrease in the destruction of the histological structure of the myocardium against the background of chronic alcoholization was established.

scholarly journals Professor V.A. Waldman and his family: a contribution to Russian medicine

2020 ◽  
Vol 11 (3) ◽  
pp. 125-134
Author(s):  
Dmitry V. Baram ◽  
Natalya Ya. Dzeranova ◽  
Vladimir A. Isakov ◽  
Yuri R. Kovalev ◽  
Nina S. Parfyonova
Keyword(s):  
Hormonal Regulation ◽  
Laboratory Animals ◽  
Medical Institute ◽  
Experimental Medicine ◽  
Enteric Infection ◽  
Medical Sciences ◽  
System A ◽  
Union Institute ◽  
The Central Nervous System ◽  
First Time

Outstanding representatives of the St. Petersburg medical dynasty from the Waldman family: V.A. Waldman, his son A.V. Waldman and sister A.A. Waldman made a huge contribution to the health care of our country. The founder and first head of the department of faculty therapy at the Leningrad State Pediatric Medical Institute, Viktor A. Waldman, is an outstanding therapist, cardiologist, rheumatologist, classic of domestic medicine, a successor to the best traditions of the Botkin school. Cardiovascular pathology was studied clinically and experimentally by him and his staff, the pathogenesis of various forms of rheumatism was studied, methods for its diagnosis and treatment were developed. He did a great job of creating the rheumatological service of the city, for the first time founded in Leningrad cardiac rheumatology rooms at large enterprises, and later on a cardiac rheumatology clinic. Arthur V. Waldman son of V.A. Waldman, a prominent pharmacologist, head of the department of pharmacology of the 1st Leningrad Medical Institute named after academician I.P. Pavlov, academician of the Academy of Medical Sciences of the USSR made a significant contribution to the study of the mechanism of action of various pharmacological substances on synaptic transmission of excitation in the central nervous system. A large series of works by A.V. Waldman is devoted to the pharmacology of emotional stress, the problem of the experimental study of emotions and means of controlling them. Alisa A. Valdman sister of V.A. Waldman, a pathologist, an employee of the All-Union Institute of Experimental Medicine, studied the role of nervous and hormonal regulation in the development of the infectious process, which she studied on a paratyphoid model for enteric infection in laboratory animals.

Features of the sensitivity of the central nervous system of the organism of experimental animals to the effects of certain psychotropic drugs and their combinations against the background of chronic alcohol intoxication in a chronopharmacological experiment

2020 ◽  
pp. 56-62
Author(s):  
E.V. Filippova
Keyword(s):  
Alcohol Intoxication ◽  
Laboratory Animals ◽  
Histological Structure ◽  
Chronic Alcohol ◽  
Behavioral Reactions ◽  
Experimental Animals ◽  
Chronic Alcohol Intoxication ◽  
Psychotropic Action ◽  
Adaptive Effect ◽  
The Central Nervous System

In a chronopharmacological experiment, the effect of two drugs with psychotropic action in combinations on the behavior of laboratory animals subjected to chronic alcohol intoxication was examined. Against the background of a deprimating agent, a decrease in the threshold of sensitivity to electrical irritation and the duration of an aggressive reaction was revealed; an increase in these indicators was established with a combination of a deprimating drug with an antioxidant. It has been shown that the antioxidant has a desynchronizing effect on the behavioral reactions of laboratory animals for two days, which indicates a pronounced adaptive effect. In the case of using combinations of a deprimating agent with an antioxidant, a decrease in the destruction of the histological structure of the myocardium against the background of chronic alcoholization was established.

Chronopharmacological sensitivity of the central nervous system of the organism of experimental animals to the action of certain psychotropic drugs against the background of chronic alcohol intoxication

2020 ◽  
pp. 63-68
Author(s):  
E. V. Philippova
Keyword(s):  
Central Nervous System ◽  
Alcohol Intoxication ◽  
Laboratory Animals ◽  
Chronic Alcohol ◽  
Behavioral Reactions ◽  
Experimental Animals ◽  
Chronic Alcohol Intoxication ◽  
Psychotropic Action ◽  
Adaptive Effect ◽  
The Central Nervous System

The behavior of experimental animals under the influence of two drugs with psychotropic action and their combination against the background of chronic alcohol intoxication in a chronopharmacological experiment was studied. A decrease in the threshold of sensitivity to electrical irritation was revealed against the background of the use of a deprimating agent and an increase in these indicators when this drug was combined with an antioxylant. The pronounced adaptive effect of the antioxidant is evidenced by its desyn chronizing effect on the behavioral reactions of laboratory animals for two days.

Sign in / Sign up

Export Citation Format

Share Document