scholarly journals THE ISSUE OF USE PARALLELISM FACTOR METHOD AND INDEX OF CIRCULATING NTICOAGULANT IN DIAGNOSTIC ALGORITHM DEFICITY OF COAGULATION FACTORS

2019 ◽  
Vol 64 (2) ◽  
pp. 83-88
Author(s):  
V. V. Potylitsina ◽  
V. V. Samoilenko ◽  
S. M. Lobanova ◽  
I. A. Olkhovskiy ◽  
I. V. Palgova
Keyword(s):  
Diagnostic Algorithm ◽  
Coagulation Factors ◽  
Diagnostic Value ◽  
Laboratory Method ◽  
Activity Factor ◽  
Confirmation Test ◽  
Prolonged Aptt ◽  
Definition Of ◽  
Selection Of Patients ◽  
Selection Of

The paper presents the comparative use of algorithms to identify the causes of deficiency of coagulation factors in patients with a prolonged APTT, including the definition of the index of circulating anticoagulant (ICA) and the factor-parallelism (FP) method. The results obtained in children with hereditary hemophilia and adults with acquired hemophilia. It is shown that ICA is an effective method for pre-selection of patients with hereditary hemophilia if you suspect an inhibitor to subsequent confirmation test Bethesda. The method the FP has just proved itself in the diagnosis of acquired forms of hemophilia. The use of FP method is most expedient at the stage of screening to identify inhibitors in the laboratory. Method FP loses diagnostic value if the results of the activity factor in all dilutions is close to zero, which is characteristic for individual variants of hereditary hemophilia.

scholarly journals The modern significant of the bronchial asthma

2020 ◽  
Vol 22 (2) ◽  
pp. 227-234
Author(s):  
V. V. Salukhov ◽  
M. A. Kharitonov ◽  
A. A. Zaycev ◽  
K. A. Ramazanova ◽  
K. V. Asyamov
Keyword(s):  
Bronchial Asthma ◽  
Diagnostic Algorithm ◽  
Detailed Examination ◽  
Phenotypic Characteristics ◽  
Treatment And Prevention ◽  
Flexible Dosing ◽  
Mechanisms Of Development ◽  
Prophylactic Method ◽  
Selection Of Patients ◽  
Selection Of

A review of modern literature on the diagnostic algorithm of bronchial asthma and a detailed examination of all its stages is presented. It is known that bronchial asthma is the most common form of the disease, prone to progression to more severe forms, but fraught with the development of exacerbations, even fatal. Often, general practitioners perceive bronchial asthma as a manageable, understandable disease, for the successful treatment of which it is enough to identify and isolate the allergen, as well as prescribe therapy. Understanding the mechanisms of development of bronchial asthma helps to increase the effectiveness of the diagnosis and treatment of asthma, preferably taking into account the phenotype. Determining the phenotypic characteristics of bronchial asthma is a requirement of the time, because personalized medicine does not yet require the creation of a separate drug, diagnostic or prophylactic method for each individual patient, but it requires the selection of patients (allocation of subpopulations / clusters / phenotypes of bronchial asthma) that are most responsive to a particular drug, a method for diagnosing or preventing a disease. The essence of phenotyping in medicine is the optimization of diagnosis, treatment and prevention. The central and most studied links of the pathogenetic mechanism and its variants of development are described, phenotypes of bronchial asthma are discussed, as well as options for basic and targeted therapy of bronchial asthma. The necessity of studying personalized therapy and flexible dosing of drugs used in the treatment of bronchial asthma is emphasized.

P.16.1 DIAGNOSTIC VALUE OF EUS IN THE SELECTION OF PATIENTS WITH GASTRIC CANCER ELIGIBLE FOR A NEOADJUVANT CHEMOTHERAPY

2013 ◽  
Vol 45 ◽  
pp. S198
Author(s):  
F. Antonini ◽  
W. Siquini ◽  
S. Piergallini ◽  
V. Belfiori ◽  
B. Marraccini ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Diagnostic Value ◽  
Selection Of Patients ◽  
Selection Of

scholarly journals Monoclonal antibodies in the treatment of bronchial asthma

2018 ◽  
Vol 15 (3) ◽  
pp. 5-15
Author(s):  
N I Ilina ◽  
O M Kurbacheva
Keyword(s):  
Monoclonal Antibodies ◽  
Genetic Markers ◽  
Bronchial Asthma ◽  
Clinical Characteristics ◽  
Standard Treatment ◽  
Biological Therapy ◽  
Resistance Response ◽  
Definition Of ◽  
Selection Of Patients ◽  
Selection Of

The article discusses different phenotypes of heterogeneous bronchial asthma (BA), methods of identification of patients with severe bronchial asthma, based on clinical characteristics, biological and genetic markers. Definition of phenotypes/ endotypes of BA contributes to better understanding of the nature of the disease and is feasible for development of an individual approach to therapy, because some types of BA may differ in resistance response to the standard treatment. The article gives an overview of modern research focused on the use of monoclonal antibodies in the treatment of BA. It discusses the algorithm of selection of patients with severe BA for prescribing of biological therapy.

Selection and Preparation of Specific Tissue Regions For Tem Using Large Epoxy-Embedded Blocks

1973 ◽  
Vol 31 ◽  
pp. 324-325 ◽  
Author(s):  
P. M. Lowrie ◽  
W. S. Tyler
Keyword(s):  
Electron Microscopy ◽  
Anatomical Structures ◽  
Ultrastructural Studies ◽  
Transmission Electron ◽  
Microscopic Evaluation ◽  
Embedded Blocks ◽  
Specific Tissue ◽  
Definition Of ◽  
Areas Of Interest ◽  
Selection Of

The importance of examining stained 1 to 2μ plastic sections by light microscopy has long been recognized, both for increased definition of many histologic features and for selection of specimen samples to be used in ultrastructural studies. Selection of specimens with specific orien ation relative to anatomical structures becomes of critical importance in ultrastructural investigations of organs such as the lung. The uantity of blocks necessary to locate special areas of interest by random sampling is large, however, and the method is lacking in precision. Several methods have been described for selection of specific areas for electron microscopy using light microscopic evaluation of paraffin, epoxy-infiltrated, or epoxy-embedded large blocks from which thick sections were cut. Selected areas from these thick sections were subsequently removed and re-embedded or attached to blank precasted blocks and resectioned for transmission electron microscopy (TEM).

Selection of patients for portal-systemic shunts

JAMA ◽  
1966 ◽  
Vol 196 (12) ◽  
pp. 1039-1044 ◽  
Author(s):  
R. E. Hermann
Keyword(s):  
Selection Of Patients ◽  
Selection Of

Perioperative acute internal carotid thrombosis after general surgery

2020 ◽  
Vol 99 (3) ◽  
pp. 136-140
Keyword(s):  
Cardiac Surgery ◽  
Internal Carotid ◽  
Right Hemicolectomy ◽  
Diagnostic Assessment ◽  
Left Carotid Artery ◽  
Perioperative Stroke ◽  
Internal Carotid Occlusion ◽  
Acute Brain Ischemia ◽  
Selection Of Patients ◽  
Selection Of

Introduction: The average incidence of perioperative stroke during major non-cardiac surgery is less than 1%, suggesting that it is rarely a major problem for the vast majority of patients. Methods: In our paper we present a 46-year-old patient undergoing acute right hemicolectomy who developed right-sided hemiparesis in the perioperative setting. Immediate CTAg examination showed an ischemic stroke in the left hemisphere as a result of left internal carotid thrombosis. A surgical procedure to recanalize the left carotid artery was performed 14 hours from the onset of neurological symptomatology and the neurological deficit gradually recovered fully. Conclusion: Our case report supports studies showing that a thorough diagnostic assessment allows the selection of patients who may benefit from urgent revascularization of acute internal carotid occlusion during the phase of acute brain ischemia.

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