Monoclonal antibodies in the treatment of bronchial asthma

Questions of bronchial asthma heterogeneity, approaches to allocation of various phenotypes on the basis of clinical signs, biological and genetic markers and endotypes taking into account an etiology and pathophysiology of the disease are considered in the article. Allocation of phenotypes / endotypes promote the best understanding of essence of a disease and it is expedient for development of an individual approach to therapy as some options of a current OH can differ the resistant answer to standard treatment.

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The Application of Monoclonal Antibodies for the Definition of Genetic Markers of Human Red Cells

Advances in Forensic Haemogenetics ◽

10.1007/978-3-642-73330-7_56 ◽

1988 ◽

pp. 268-283 ◽

Cited By ~ 2

Author(s):

D. Voak ◽

D. Davies ◽

H. Sonneborn ◽

J. Moulds ◽

A. Fletcher ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Genetic Markers ◽

Red Cells ◽

Definition Of ◽

Human Red Cells

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Risk Factors of Postprocedural Hypotension following Carotid Artery Stenting

Rivista di Neuroradiologia ◽

10.1177/197140099500800637 ◽

1995 ◽

Vol 8 (6) ◽

pp. 205-210

Author(s):

T. Nonaka ◽

S. Oka ◽

S. Miyata ◽

T. Baba ◽

T. Mikami ◽

...

Keyword(s):

Risk Factors ◽

Carotid Artery ◽

Clinical Characteristics ◽

Carotid Bifurcation ◽

Carotid Stenting ◽

Neurological Deficits ◽

Occurrence Rate ◽

Patients At Risk ◽

Selection Of Patients ◽

Selection Of

This study is performed to investigate risk factors of hypotension in response to elective carotid stenting. Forty-four lesions of 40 consecutive patients (mean age 70.4 ± 8.2 years) were retrospectively analyzed. Easy Wall stent was applied in 15 lesions and SMART stent in 29 lesions. We investigated correlations between the occurrence rate of postoperative hypotension below 90 mmHg and persisting over three hours and findings of preoperative angiograms, ultrasonograms and clinical characteristics. Postprocedural hypotension occurred in 19 patients (47.5%) and medical treatment (intravenous administration of catecholamines) was required in eleven patients (27.5%). Although there was no permanent neurological deficits related with postprocedural hypotension, transient neurological deficits were found in three patients. Risk factors of prolonged postprocedural hypotension were statistically analyzed. On angiographic characteristics; 1) distance between the carotid bifurcation and the lesion with maximum stenosis (≦10 mm vs. >10 mm: p = 0.031), 2) type of stenosis (eccentric vs. concentric: p = 0.014) On ultrasonographic characteristics; 1) calcifications at the carotid bifurcation (present vs. absent: p<0.001). Other variables, including age and degree of stenosis, were not associated with postprocedural hypotension after carotid stenting. These angiographic and ultrasonographic variables can be used to identify patients at risk for postprocedural hypotension after carotid stenting. Such identification may help in selection of patients who will benefit from appropriate pharmacological treatment.

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The modern significant of the bronchial asthma

Vestnik of Russian military medical Academy ◽

10.17816/brmma50078 ◽

2020 ◽

Vol 22 (2) ◽

pp. 227-234

Author(s):

V. V. Salukhov ◽

M. A. Kharitonov ◽

A. A. Zaycev ◽

K. A. Ramazanova ◽

K. V. Asyamov

Keyword(s):

Bronchial Asthma ◽

Diagnostic Algorithm ◽

Detailed Examination ◽

Phenotypic Characteristics ◽

Treatment And Prevention ◽

Flexible Dosing ◽

Mechanisms Of Development ◽

Prophylactic Method ◽

Selection Of Patients ◽

Selection Of

A review of modern literature on the diagnostic algorithm of bronchial asthma and a detailed examination of all its stages is presented. It is known that bronchial asthma is the most common form of the disease, prone to progression to more severe forms, but fraught with the development of exacerbations, even fatal. Often, general practitioners perceive bronchial asthma as a manageable, understandable disease, for the successful treatment of which it is enough to identify and isolate the allergen, as well as prescribe therapy. Understanding the mechanisms of development of bronchial asthma helps to increase the effectiveness of the diagnosis and treatment of asthma, preferably taking into account the phenotype. Determining the phenotypic characteristics of bronchial asthma is a requirement of the time, because personalized medicine does not yet require the creation of a separate drug, diagnostic or prophylactic method for each individual patient, but it requires the selection of patients (allocation of subpopulations / clusters / phenotypes of bronchial asthma) that are most responsive to a particular drug, a method for diagnosing or preventing a disease. The essence of phenotyping in medicine is the optimization of diagnosis, treatment and prevention. The central and most studied links of the pathogenetic mechanism and its variants of development are described, phenotypes of bronchial asthma are discussed, as well as options for basic and targeted therapy of bronchial asthma. The necessity of studying personalized therapy and flexible dosing of drugs used in the treatment of bronchial asthma is emphasized.

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Risk Factors of Postprocedural Hypotension following Carotid Artery Stenting

Interventional Neuroradiology ◽

10.1177/15910199060120s137 ◽

2006 ◽

Vol 12 (1_suppl) ◽

pp. 205-210 ◽

Cited By ~ 3

Author(s):

T. Nonaka ◽

S. Oka ◽

S. Miyata ◽

T. Baba ◽

T. Mikami ◽

...

Keyword(s):

Risk Factors ◽

Carotid Artery ◽

Clinical Characteristics ◽

Carotid Bifurcation ◽

Carotid Stenting ◽

Neurological Deficits ◽

Occurrence Rate ◽

Patients At Risk ◽

Selection Of Patients ◽

Selection Of

This study is performed to investigate risk factors of hypotension in response to elective carotid stenting. Forty-four lesions of 40 consecutive patients (mean age 70.4 ± 8.2 years) were retrospectively analyzed. Easy Wall stent was applied in 15 lesions and SMART stent in 29 lesions. We investigated correlations between the occurrence rate of postoperative hypotension below 90 mmHg and persisting over three hours and findings of preoperative angiograms, ultrasonograms and clinical characteristics. Postprocedural hypotension occurred in 19 patients (47.5%) and medical treatment (intravenous administration of catecholamines) was required in eleven patients (27.5%). Although there was no permanent neurological deficits related with postprocedural hypotension, transient neurological deficits were found in three patients. Risk factors of prolonged postprocedural hypotension were statistically analyzed. On angiographic characteristics; 1) distance between the carotid bifurcation and the lesion with maximum stenosis (≦10 mm vs. >10 mm: p = 0.031), 2) type of stenosis (eccentric vs. concentric: p = 0.014) On ultrasonographic characteristics; 1) calcifications at the carotid bifurcation (present vs. absent: p<0.001). Other variables, including age and degree of stenosis, were not associated with postprocedural hypotension after carotid stenting. These angiographic and ultrasonographic variables can be used to identify patients at risk for postprocedural hypotension after carotid stenting. Such identification may help in selection of patients who will benefit from appropriate pharmacological treatment.

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New therapy options for patients with eosinophilic type of severe bronchial asthma

Medical Council ◽

10.21518/2079-701x-2019-21-111-116 ◽

2020 ◽

pp. 111-116

Author(s):

G. L. Ignatova ◽

V. N. Antonov ◽

E. V. Blinova ◽

I. V. Grebneva ◽

E. V. Sheklanova

Keyword(s):

Decision Making ◽

Severe Asthma ◽

Bronchial Asthma ◽

Clinical Studies ◽

Clinical Characteristics ◽

Biological Therapy ◽

Efficacy And Safety ◽

Therapy Options ◽

New Therapy ◽

Chelyabinsk Region

The article provides data on the epidemiology of severe asthma. It defines the phenotype and endotype of bronchial asthma and classifies BA according to phenotype/endotype. The features of the eosinophilic phenotype of severe bronchial asthma are considered. Clinical characteristics of the patient corresponding to the prescription of benralizumab are presented. The algorithm of decision making by a doctor-therapist about patients’ referral to a pulmonologist for consideration of the biological therapy issue is given. The results of the main clinical studies to assess the efficacy and safety of benralizumab in patients with severe eosinophilic bronchial asthma: SIROCCO, CALIMA, ZONDA, BORA are described. The experience of using various biological preparations for the treatment of severe asthma in Chelyabinsk and the Chelyabinsk Region has also been summarized.

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THE ISSUE OF USE PARALLELISM FACTOR METHOD AND INDEX OF CIRCULATING NTICOAGULANT IN DIAGNOSTIC ALGORITHM DEFICITY OF COAGULATION FACTORS

Russian Clinical Laboratory Diagnostics ◽

10.18821/0869-2084-2019-64-2-83-88 ◽

2019 ◽

Vol 64 (2) ◽

pp. 83-88

Author(s):

V. V. Potylitsina ◽

V. V. Samoilenko ◽

S. M. Lobanova ◽

I. A. Olkhovskiy ◽

I. V. Palgova

Keyword(s):

Diagnostic Algorithm ◽

Coagulation Factors ◽

Diagnostic Value ◽

Laboratory Method ◽

Activity Factor ◽

Confirmation Test ◽

Prolonged Aptt ◽

Definition Of ◽

Selection Of Patients ◽

Selection Of

The paper presents the comparative use of algorithms to identify the causes of deficiency of coagulation factors in patients with a prolonged APTT, including the definition of the index of circulating anticoagulant (ICA) and the factor-parallelism (FP) method. The results obtained in children with hereditary hemophilia and adults with acquired hemophilia. It is shown that ICA is an effective method for pre-selection of patients with hereditary hemophilia if you suspect an inhibitor to subsequent confirmation test Bethesda. The method the FP has just proved itself in the diagnosis of acquired forms of hemophilia. The use of FP method is most expedient at the stage of screening to identify inhibitors in the laboratory. Method FP loses diagnostic value if the results of the activity factor in all dilutions is close to zero, which is characteristic for individual variants of hereditary hemophilia.

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Selection and Preparation of Specific Tissue Regions For Tem Using Large Epoxy-Embedded Blocks

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010007206x ◽

1973 ◽

Vol 31 ◽

pp. 324-325 ◽

Cited By ~ 1

Author(s):

P. M. Lowrie ◽

W. S. Tyler

Keyword(s):

Electron Microscopy ◽

Anatomical Structures ◽

Ultrastructural Studies ◽

Transmission Electron ◽

Microscopic Evaluation ◽

Embedded Blocks ◽

Specific Tissue ◽

Definition Of ◽

Areas Of Interest ◽

Selection Of

The importance of examining stained 1 to 2μ plastic sections by light microscopy has long been recognized, both for increased definition of many histologic features and for selection of specimen samples to be used in ultrastructural studies. Selection of specimens with specific orien ation relative to anatomical structures becomes of critical importance in ultrastructural investigations of organs such as the lung. The uantity of blocks necessary to locate special areas of interest by random sampling is large, however, and the method is lacking in precision. Several methods have been described for selection of specific areas for electron microscopy using light microscopic evaluation of paraffin, epoxy-infiltrated, or epoxy-embedded large blocks from which thick sections were cut. Selected areas from these thick sections were subsequently removed and re-embedded or attached to blank precasted blocks and resectioned for transmission electron microscopy (TEM).

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