Preparation and Property of Antibacterial Nucleus with the Combination of Nano-Silver and Antibiotics

To improve the yield and quality of pearls in freshwater pearl culture and the survival rates after nucleus implanting surgery, pearl farmers used artificial pearl nuclear transplantation techniques to raise pearls. To address the common problem of Staphylococcus aureus and Escherichia coli infection in oyster farming, a new prophylactic method by using compound antibiotics to prepare the medicine coated pearl nucleus was put forward based on existing research results of the nanosilver antibacterial nucleus. Single-factor experiment, multi-factor experiment, orthogonal experiment, SPSS analysis of variance was used to optimize the antibacterial formulation on the assumption that the contaminated probability of these two pathogenic bacteria was the same. The result showed that the optimal ratio of compound antibiotics was 0.0075g/ml of the flavomycin solution and 0.01g/mL of the terramycin solution; the inhibition zones diameter of both pathogenic bacteria was more than 2.6cm in vitro, which was higher than the nanosilver antibacterial nucleus of 0.9cm in vitro. Indicating that the addition of this compound antibiotic formula for the nanosilver antibacterial nucleus could reduce the usage of antibiotics under the premise of maintaining antibacterial effectiveness, and could preferably inhibit the pathogenic microorganisms in the postoperative infection period. This also indicates that compound antibiotics coated antibacterial nanosilver nucleus would be applied more widely.

REPORTE DE ECTOPARÁSITOS EN AVES DE CAUTIVERIO, Y SU CONTROL

Mexico is found in the top 10 countries worldwide that export wild birds. While there is an increasing demand for owning birds among Mexicans, there is insufficient information on how to appropriately care for them. Mexico is home to approximately 1,060 ofthe world’s bird species, roughly 10%. Removal of these birds from their natural habitat for commercial purposes without regulation is a practice widely undertaken in the country. As a result of he lack of knowledge and irresponsible practices while keeping these birds in captivity, their well-being is not maintained. They therefore become susceptible to the proliferation of external arthropod parasites, called ectoparasites. Ectoparasites can cause disease in humans, domestic and wild animals by acting as a reservoir for important pathogens that can transmit zoonotic infections. In this work, clinical cases of domestic birds obtained from Veterinarians of the Metropolitan Area of Guadalajara that were infected by ectoparasites were reviewed. In all the cases analyzed, the presence of the ectoparasite Knemidokoptesspp., cause of scabies, was found. The most commonly used treatment for elimination ofparasitosis is topical Ivermectin, and the main risk factor identified is the lack of cleanliness in bird housing. A timely treatment for these parasitic infections is able to prevent the death of these birds. Additionally, a proper diet and carrying out a necessary prophylactic method for each species will improve their quality of life in captivity.

The management of migraine through Acupuncture: a literature review

Background: Migraine is one of the most disabling conditions worldwide, and acupuncture can be used as prophylaxis. This practice is indicated to relieve tension, stress, induce analgesia, and has been gaining space due to its A level evidence. Objectives: Investigate the impact of acupuncture on the management of migraine disorders. Design and Settings: literature review. Methods: After searching the MEDLINE database for “migraine disorders OR headache”, “acupuncture” and “integrative medicine OR alternative medicine”, 271 articles were found and 6 used. Only those with full text available and published between 2011-2021 were included. Those that addressed a specific type of migraine were excluded. Results: Acupuncture was analyzed in 4 studies as prophylaxis for migraine, in which there was a general reduction in symptoms and 50% reduction in frequency of episodes (p <0.05), with its effects comparable to drugs such as Depakene, Topamax, Metoprolol and Flunarizine. A meta-analysis involving 39 clinical trials showed that the acupuncture group obtained better results than the control group (p <0.001), these results were sustained when analyzing pain after randomization, in agreement with another study that demonstrated pain reduction in the group that used simulated acupuncture (p=0.002). It should be noted that, although some patients report adverse effects, it’s safe and as effective than drugs used in the treatment of migraine. Conclusions: Acupuncture is a good prophylactic method for migraine. It reduces pain episodes and has less adverse effects when compared to conventional methods. However, further studies on this therapy are needed.

Etiopathogenetic specificity and prospects of phage therapy in infectious keratoconjunctivitis in cattle

Infectious bovine keratoconjunctivitis (IBK) is a bacterial eye disease affecting cattle worldwide. The main etiological role in IBK belongs to Moraxella spp. (including in associations with Staphylococcus spp., Streptococcus spp., Pseudomonas aeruginosa, E. coli, Proteus). Persistence factors and antimicrobial resistance of these bacteria, reduce the effectiveness of traditional treatment measures for IBK. New strategies for combating bacterial infections set up prospects for the use of bacteriophages. The paper presents data substantiating the relevance of the development of a therapeutic and prophylactic method of phage processing and an agent based on lytically properties of bacteriophages to combat infectious keratoconjunctivitis in cattle.

MODERN CONCEPT OF RENDERING AID TO WOMEN WITH OVARIAN HEMORRHAGES

Aim: Analysis of modern medical care for women with ovarian hemorrhage, determination of the main diagnostic criteria that influence the choice of treatment tactics and further prognosis of the outcome of treatment of ovarian apoplexy. Material and methods: The provision of medical care to 888 women with ovarian apoplexy. Depending on the volume of hemoperitoneum, all patients were divided into three groups.: Group I – 480 (54.0%) women in whom intraabdominal bleeding did not exceed 200 ml; Group II – 283 (31.8%) patients with hemoperitoneum ranged from 200 to 500 ml; Group III – 125 (14.1%) patients with hemoperitoneum volume greater than 500 ml. Results: According to the data of the transvaginal US , a linear dependence was observed between the level of free liquid and the volume of hemoperitoneum (r=0.63, p<0.05). In 792 (89.2%) patients the diagnosis of apoplexy of the ovary and intraperitoneal hemorrhage was made to surgical intervention- on the basis of clinical picture and US data. The most frequently performed hemostatic operation was resection of the ovary – 477 (77.2%) interventions. The average volume of hemoperitoneum discovered in patients with AO, in absence of the adhesive process was (273.5±21.3) ml, whereas in patients with the expressed adhesive process of the small pelvis organs it was (141.4±35.5) ml. The cause of AO was the corpus luteum or cyst of the corpus luteum in more than the half of the cases – 348 (56.3%). Conclusions: The manifestation of the clinical symptoms in apoplexy of the ovaries depends on the volume of intraperitoneal hemorrhage. The application of laparoscopy as a main therapeutic and prophylactic method in AO allows to preserve, and sometimes to restore the reproductive function of a woman and to reduce the rate of the disease relapse development.

The modern significant of the bronchial asthma

A review of modern literature on the diagnostic algorithm of bronchial asthma and a detailed examination of all its stages is presented. It is known that bronchial asthma is the most common form of the disease, prone to progression to more severe forms, but fraught with the development of exacerbations, even fatal. Often, general practitioners perceive bronchial asthma as a manageable, understandable disease, for the successful treatment of which it is enough to identify and isolate the allergen, as well as prescribe therapy. Understanding the mechanisms of development of bronchial asthma helps to increase the effectiveness of the diagnosis and treatment of asthma, preferably taking into account the phenotype. Determining the phenotypic characteristics of bronchial asthma is a requirement of the time, because personalized medicine does not yet require the creation of a separate drug, diagnostic or prophylactic method for each individual patient, but it requires the selection of patients (allocation of subpopulations / clusters / phenotypes of bronchial asthma) that are most responsive to a particular drug, a method for diagnosing or preventing a disease. The essence of phenotyping in medicine is the optimization of diagnosis, treatment and prevention. The central and most studied links of the pathogenetic mechanism and its variants of development are described, phenotypes of bronchial asthma are discussed, as well as options for basic and targeted therapy of bronchial asthma. The necessity of studying personalized therapy and flexible dosing of drugs used in the treatment of bronchial asthma is emphasized.

Efficacy of the staged endoscopic ligature of the varicose veins in children, suffering portal hypertension

Objective. To estimate the efficacy of first procedure of endoscopic ligature for the varicose esophageal veins in children, suffering portal hypertension in accordance to data of endoscopic examination. Materials and methods. Endoscopic ligature of the varicose esophageal veins was performed in 24 patients, suffering portal hypertension, aiming at prophylaxis of hemorrhage from the varicose veins. Results. Reduction of the varicose veins degree after first ligature procedure was observed in 14 (58.33%) children, eradication of the varicose veins - in 5 (20.83%) of them. In 1 (4.17%) patient a complication (hemorrhage) have occurred in a moment of a ligature application. In 2 (8.33%) patients a hemorrhage from the varicose veins of stomach have occurred. Conclusion. Endoscopic ligature constitutes a secure and effective prophylactic method for hemorrhage from the esophageal varicose in children, suffering portal hypertension, and permits to control the varicose degree on stages of the portal hypertension treatment. Even after first procedure of endoscopic ligature the esophageal varicose degree have had reduced at average (p < 0.05). After endoscopic ligature the hemorrhage occurrence risk have reduced: p=0.05, and the risks ratio constitutes 0.14 (95% CI 0.04-0.56).

Tick exposure and prevalence of Borrelia burgdorferi antibodies among hunters and other individuals exposed to vector ticks in eastern Poland

Background. Lyme borreliosis is the most frequent tick-borne disease in Europe and North America, and the number of registered cases is on the increase. Frequent presence in the habitats of ticks enhances the risk of tick bites and possible infection with Borrelia burgdorferi spirochetes. Objective. The aim of the study was to assess the risk of B. burgdorferi infection posed to hunters and other individuals exposed to activity-related contact with ticks. Material and methods. The study was carried out in the northern part of the Lublin Province (eastern Poland) and involved 150 individuals exposed to tick bites (110 hunters and 40 individuals exposed to activity-related contact with ticks). The analysis of sera for the presence of B. burgdorferi IgM and IgG antibodies was carried out. All 150 individuals were tested with the ELISA assay, and positive and borderline results of the assay were verified with the Western blot test. All study participants completed a questionnaire, which provided information about exposure to ticks, application of prophylactic measures, and awareness of Lyme borreliosis. Results. The ELISA assay revealed a positive or borderline result in at least one of the classes of B. burgdorferi antibodies in 63.3% (95/150) of the individuals (IgM 14.0%, IgG 63.3%). Verification carried out with the Western blot test showed a positive or borderline result in at least one of the antibody classes in 38.0% (57/150) of the examined persons (IgM 2.7%, IgG 36.7%). Abdomen (56.0%) and legs (53.7%) were the most frequently bitten body regions. Tick bites on the abdomen were significantly more frequently declared by hunters. Inspection of the body after returning from natural areas was more popular prophylactic method than use of repellents. Inspection of the body was significantly more often used in the group of the hunters. Conclusions. The risk of B. burgdorferi infection among hunters and other individuals undertaking activities associated with exposure to tick bites in the study area is high.