Position Paper and Clinical Guidelines Update

Differentiated thyroid cancer (DTC) is the most common endocrine cancer and its incidence has increased in recent decades. Initial treatment usually consists of total thyroidectomy followed by ablation of thyroid remnants by iodine-131. As thyroid cells are assumed to be the only source of thyroglobulin (Tg) in the human body, circulating Tg serves as a biochemical marker of persistent or recurrent disease in DTC follow-up. Currently, standard follow-up for DTC comprises Tg measurement and neck ultrasound combined, when indicated, with an additional radioiodine scan. Measurement of Tg after stimulation by endogenous or exogenous TSH is recommended by current clinical guidelines to detect occult disease with a maximum sensitivity due to the suboptimal sensitivity of older Tg assays. However, the development of new highly sensitive Tg assays with improved analytical sensitivity and precision at low concentrations now allows detection of very low Tg concentrations reflecting minimal amounts of thyroid tissue without the need for TSH stimulation. Use of these highly sensitive Tg assays has not yet been incorporated into clinical guidelines but they will, we believe, be used by physicians caring for patients with DTC. The aim of this clinical position paper is, therefore, to offer advice on the various aspects and implications of using these highly sensitive Tg assays in the clinical care of patients with DTC.

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Supporting a person-centred approach in clinical guidelines. A position paper of the Allied Health Community - Guidelines International Network (G-I-N)

Health Expectations ◽

10.1111/hex.12144 ◽

2013 ◽

Vol 18 (5) ◽

pp. 1543-1558 ◽

Cited By ~ 18

Author(s):

Simone A. van Dulmen ◽

Sue Lukersmith ◽

Josephine Muxlow ◽

Elaine Santa Mina ◽

Maria W.G. Nijhuis-van der Sanden ◽

...

Keyword(s):

Clinical Guidelines ◽

Allied Health ◽

Position Paper ◽

International Network ◽

Health Community

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Patient-centered approach in clinical guidelines; a position paper of the guideline international network (G-I-N) allied health community

Physiotherapy ◽

10.1016/j.physio.2015.03.1578 ◽

2015 ◽

Vol 101 ◽

pp. e1575-e1576

Author(s):

S.A. van Dulmen ◽

P.J. van der Wees ◽

M.W.G. Nijhuis-Van der Sanden

Keyword(s):

Clinical Guidelines ◽

Allied Health ◽

Position Paper ◽

Patient Centered ◽

International Network ◽

Health Community

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What Role Can Process Mining Play in Recurrent Clinical Guidelines Issues? A Position Paper

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17186616 ◽

2020 ◽

Vol 17 (18) ◽

pp. 6616

Author(s):

Roberto Gatta ◽

Mauro Vallati ◽

Carlos Fernandez-Llatas ◽

Antonio Martinez-Millana ◽

Stefania Orini ◽

...

Keyword(s):

Medical Informatics ◽

Clinical Guidelines ◽

Process Mining ◽

State Of The Art ◽

Position Paper ◽

Evidence Based ◽

The Past ◽

Relevant Role ◽

Indispensable Tool ◽

Based Medicine

In the age of Evidence-Based Medicine, Clinical Guidelines (CGs) are recognized to be an indispensable tool to support physicians in their daily clinical practice. Medical Informatics is expected to play a relevant role in facilitating diffusion and adoption of CGs. However, the past pioneering approaches, often fragmented in many disciplines, did not lead to solutions that are actually exploited in hospitals. Process Mining for Healthcare (PM4HC) is an emerging discipline gaining the interest of healthcare experts, and seems able to deal with many important issues in representing CGs. In this position paper, we briefly describe the story and the state-of-the-art of CGs, and the efforts and results of the past approaches of medical informatics. Then, we describe PM4HC, and we answer questions like how can PM4HC cope with this challenge? Which role does PM4HC play and which rules should be employed for the PM4HC scientific community?

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