scholarly journals Existence Of Right Ventricular Structural And Functional Changes In Essential Hypertension And

2021 ◽  
Vol 17 (21) ◽  
pp. 1
Author(s):  
Ana Minashvili ◽  
Ann Rekhviashvili
Keyword(s):  
Essential Hypertension ◽  
Right Ventricle ◽  
Arterial Hypertension ◽  
Right Ventricular ◽  
Prognostic Value ◽  
Structure And Function ◽  
Systemic Hypertension ◽  
Functional Changes ◽  
The Right ◽  
And Function

The structural and functional changes of left and right ventricles as well as the existence of ventricular interaction in patients with arterial hypertenison (AH) were discussed in many research papers. Therefore, published data regarding right ventricular changes under influence of AH are scarce, non-univocal, and sometimes contradictory. Furthermore, there is a significant lack of clinical trials addressing the influence of circadian BP profile on RV structure and function. The importance of right ventricular function in maintaining global cardiac performance was proven. However, the importance of the right ventricular structure and function for cardiovascular morbidity and mortality is still under debate. Despite the abundance of the study data and high vulnerability of the right ventricle under influence of AH, the world's leading contemporary guidelines of the AH management, right ventricular remodeling, its morphology, function, evaluation, predictive and prognostic value are neither discussed nor mentioned. Hence, we strongly believe that further investigations are needed to determine the exact clinical utility and prognostic value of right ventricular functional and morphological changes in patients with arterial hypertension. Moreover, standardization and improvement of diagnostic methodologies of the RV changes via echocardiography, computed tomography, and Magnetic Resonance Imaging are important, which might have a crucial meaning for professionals involved in AH management. The review article aims to discuss anatomic and physiologic aspects of the right ventricle and their discrepancies according to age, sex, and race, the prognostic meaning of RV remodeling, and review current publications regarding the influence of high blood pressure and its circadian profile on the prevalence of functional and structural changes of RV. Hence, we performed a literature search of the PUBMED database using the medical subject headings "arterial hypertension", "essential hypertension", "systemic hypertension", "circadian BP profile", "remodeling", "right ventricle", "morphology", "anatomy" and "function". A manual search for additional studies was performed using references cited in the original articles.

scholarly journals Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region

2022 ◽  
Author(s):  
Alexey N. Sumin ◽  
Nina S. Gomozova ◽  
Anna V. Shcheglova ◽  
Oleg G. Arkhipov
Keyword(s):  
Arterial Hypertension ◽  
Right Ventricular ◽  
Diastolic Dysfunction ◽  
Ethnic Differences ◽  
Structure And Function ◽  
Right Heart ◽  
Hypertensive Patients ◽  
Factors Associated ◽  
The Right ◽  
And Function

Abstract Objective of this study was to compare right ventricular echocardiography parameters in urbanized hypertensive patients of the Shor and non-indigenous ethnic groups in the Mountain Shoria region. Methods The study included patients with arterial hypertension: 58 Shors and 50 non-indigenous urbanized residents, comparable in age, and divided by ethnicity and gender into 4 groups: Shors men (n = 20), Shors women (n = 38), non-indigenous men (n = 15) and non-indigenous women (n = 35). All underwent echocardiographic examination, and the right heart parameters were studied. Results Shor men with arterial hypertension had the lowest values ​​of the pulmonary artery index, the right atrium dimensions, and the highest values ​​of the blood flow velocity in the right ventricle, et' and st' in comparison with non-indigenous men. Shor women have the lowest values Et and Et/At ratios. RV diastolic dysfunction was detected mainly in women, somewhat more often in Shors. Ethnicity was one of the factors associated with the right ventricular diastolic dysfunction presence. Among the factors associated with the RV diastolic dysfunction were risk factors (smoking, obesity), blood pressure, gender, ethnicity, and left ventricular parameters (diastolic dysfunction and the myocardial mass increase). Conclusion Our study established the influence of ethnic differences on the right heart echocardiographic parameters in Shors and Caucasians with arterial hypertension. The revealed differences should improve the assessment of the right heart structure and function in patients with arterial hypertension from small ethnic groups, which will help to improve the diagnosis and treatment of such patients.

scholarly journals Dynamic pattern in the structural-functional parameters of the heart in children with myocardial pathology, taking into account morphological functional features of the right ventricle

2018 ◽  
pp. 32-36
Author(s):  
T. А. Holovko
Keyword(s):  
Left Ventricle ◽  
Right Ventricle ◽  
Children And Adolescents ◽  
Systolic Dysfunction ◽  
Structure And Function ◽  
Dynamic Pattern ◽  
Functional Features ◽  
The Right ◽  
And Function ◽  
Myocardial Pathology

The purpose of the study was to study the dynamics of changes in morphofunctional heart changes inchildren with non-inflammatory pathology of myocardium on the background of ongoing therapy. There were examined 115 patients (11–18 years old) with various heart diseases.The systolic dysfunction of the myocardium was diagnosedin 50 of them, and treatment was prescribed. In the dynamics, a year later, 40 patients were examined.  It has been established that in children and adolescents, along withpathogenetic and cardiometabolic therapy, in parallel with the improvement of the structure and function of the right ventricle of the heart, morphofunctional indicators ofthe left ventricle are improved.

scholarly journals Genetic Analysis of Right Heart Structure and Function in 40,000 People

2021 ◽  
Author(s):  
James P. Pirruccello ◽  
Paolo Di Achille ◽  
Victor Nauffal ◽  
Mahan Nekoui ◽  
Samuel N. Friedman ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Deep Learning ◽  
Right Ventricular ◽  
Congenital Heart ◽  
Left Ventricular ◽  
Structure And Function ◽  
Right Heart ◽  
Heart Chamber ◽  
The Right ◽  
And Function

The heart evolved hundreds of millions of years ago. During mammalian evolution, the cardiovascular system developed with complete separation between pulmonary and systemic circulations incorporated into a single pump with chambers dedicated to each circulation. A lower pressure right heart chamber supplies deoxygenated blood to the lungs, while a high pressure left heart chamber supplies oxygenated blood to the rest of the body. Due to the complexity of morphogenic cardiac looping and septation required to form these two chambers, congenital heart diseases often involve maldevelopment of the evolutionarily recent right heart chamber. Additionally, some diseases predominantly affect structures of the right heart, including arrhythmogenic right ventricular cardiomyopathy (ARVC) and pulmonary hypertension. To gain insight into right heart structure and function, we fine-tuned deep learning models to recognize the right atrium, the right ventricle, and the pulmonary artery, and then used those models to measure right heart structures in over 40,000 individuals from the UK Biobank with magnetic resonance imaging. We found associations between these measurements and clinical disease including pulmonary hypertension and dilated cardiomyopathy. We then conducted genome-wide association studies, identifying 104 distinct loci associated with at least one right heart measurement. Several of these loci were found near genes previously linked with congenital heart disease, such as NKX2-5, TBX3, WNT9B, and GATA4. We also observed interesting commonalities and differences in association patterns at genetic loci linked with both right and left ventricular measurements. Finally, we found that a polygenic predictor of right ventricular end systolic volume was associated with incident dilated cardiomyopathy (HR 1.28 per standard deviation; P = 2.4E-10), and remained a significant predictor of disease even after accounting for a left ventricular polygenic score. Harnessing deep learning to perform large-scale cardiac phenotyping, our results yield insights into the genetic and clinical determinants of right heart structure and function.

scholarly journals State of cardiovascular system in employees with chronic obstructive pulmonary disease in combination with arterial hypertension in terms of exposure to toxic games

2021 ◽  
Vol 38 (1) ◽  
pp. 16-28
Author(s):  
L. A. Panacheva ◽  
L. A. Shpagina
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Arterial Hypertension ◽  
Cardiovascular System ◽  
Structure And Function ◽  
Chronic Obstructive ◽  
Length Of Service ◽  
Obstructive Pulmonary Disease ◽  
The Right ◽  
And Function ◽  
Large Vessels

Objective. Identification of the features of the cardiovascular system damage in chronic obstructive pulmonary disease (COPD) combined with arterial hypertension (AH) in workers exposed to toxic gases (TG). Materials and methods. 132 house painters and paint production workers of the Novosibirsk aviation enterprise were included in 3 strata and examined: I-COPD and TG; II-COPD in combination with AH when exposed to TG; III COPD in combination with AH without exposure to TG. Employees of all strata were divided by length of service less than 10 and more than 10 years. The selection of workers in groups was carried out by a continuous method. Results. The most pronounced changes on the ECG, regardless of the length of service, were observed in workers with COPD in combination with hypertension and contact with TG (levogram and metabolic changes in the myocardium). When exposed to TG for more than 10 years, hypertrophy of the left parts of the heart was also detected. Among workers with COPD in combination with hypertension exposed to TG, the indicators of average pulmonary artery pressure (APAP) and pulmonary vascular resistance (PVR) elevated with increasing work experience; changes in the structure and function of the right and left parts of the heart and signs of remodeling of large vessels were also revealed. The same workers showed more pronounced changes in the daily blood pressure profile (DBPP) of AP with the prevalence of Non-dippers and Night-pickers. Conclusions. Among workers suffering from comorbid pathology, with increasing duration of TG exposure over 10 years, there were observed the most pronounced ECG changes (deviation of electrical axis to the left, metabolic changes in the myocardium, hypertrophy of the left heart); increased APAP and PVR 1.21 and 1.10 times; changes in the structure and function of the right and left chambers of the heart, remodeling of large vessels; increase in the frequency of variants of the DBPP of Non-dippers and Night-pickers.

scholarly journals Right Ventricle Involvement in Hypertrophic Cardiomyopathy and Role of Cardiac Magnetic Resonance in Hypertrophic Cardiomyopathy: Review Article

2021 ◽  
Vol 24 (4) ◽  
pp. E746-E750
Author(s):  
Weihao Ding ◽  
Sandeep Bhushan ◽  
Chen Ma ◽  
Yifan Yan ◽  
Zongwei Xiao
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Magnetic Resonance ◽  
Left Ventricle ◽  
Right Ventricle ◽  
Right Ventricular ◽  
Complex Geometry ◽  
Imaging Modality ◽  
Phenotypic Expression ◽  
The Right ◽  
And Function

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiac disease, and its main characteristic is symmetrical or asymmetrical hypertrophy of the left ventricle and/or right ventricle. Most previous studies mainly include the left ventricle for definition of HCM, thus neglecting the right ventricle. But recently, many studies have reported the right ventricular involvement in HCM. Histopathological results showed that similar pathogenic changes in both the right and left ventricles, which suggests common myopathic processes and sarcomere genetic mutations. Cardiovascular magnetic resonance (CMR) is a gold standard imaging modality to assess heart anatomy and function and provides highly accurate and reproducible measurements. CMR is very useful in characterizing the various phenotypes of right and left ventricles in HCM. CMR also can be useful in detecting early and dominant phenotypic expression of HCM. Due to the complex geometry of the right ventricle and its retrosternal position, echocardiography may not provide accurate measurements. CMR also provides more accurate and repeatable right ventricular measurements. Thus, right ventricle evaluation along with left ventricle should routinely be done for better assessment of HCM patients.

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