scholarly journals The Role of CD44 Cancer Stem Cell Marker in the Development and Progression of Lymph Node Metastasis in Oral Squamous Cell Carcinoma

2021 ◽  
pp. 4917-4922
Author(s):  
Enas M. Omar ◽  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Node Metastasis

Role of cancer stem-cell marker doublecortin-like kinase 1 in head and neck squamous cell carcinoma

Oral Oncology ◽  
2017 ◽  
Vol 67 ◽  
pp. 109-118 ◽  
Author(s):  
Lorenz Kadletz ◽  
Dietmar Thurnher ◽  
Robert Wiebringhaus ◽  
Boban M. Erovic ◽  
Ulana Kotowski ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

scholarly journals EXPRESSION OF THE CANCER STEM CELL MARKER ALDH1 IS INCREASED IN THE BUDDING AREA OF ORAL SQUAMOUS CELL CARCINOMA

2019 ◽  
Vol 128 (1) ◽  
pp. e39
Author(s):  
Dr. Giovanna Ribeiro Souto ◽  
Dr. HelvÉcio Marangon Junior ◽  
Ms. VictÓria Vasconcellos Moreira Melo ◽  
Ms. Ângela Braga Caixeta ◽  
Dr. Paulo Eduardo Alencar Souza ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Oral Squamous Cell Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

scholarly journals Expression Pattern of the Cancer Stem Cell Marker “Nestin” in Leukoplakia and Oral Squamous Cell Carcinoma

2019 ◽  
Vol 10 (4) ◽  
pp. e0024
Author(s):  
Kushbu Narender Singh ◽  
Madhavan Nirmal Ramadas ◽  
Veeravarmal Veeran ◽  
Murali Radhakrishnan Naidu ◽  
Thamarai Selvi Dhanaraj ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Oral Squamous Cell Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Expression Pattern ◽  
Squamous Cell ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma

2003 ◽  
Vol 290 (2) ◽  
pp. 289-302 ◽  
Author(s):  
Daisuke Uchida ◽  
Nasima-Mila Begum ◽  
Ammar Almofti ◽  
Koh-ichi Nakashiro ◽  
Hitoshi Kawamata ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Stromal Cell ◽  
Cxcr4 Signaling ◽  
Node Metastasis ◽  
Stromal Cell Derived Factor

scholarly journals ROLE OF MYOFIBROBLASTS IN THE PRIMARY LESIONS AND LYMPH NODE METASTASIS OF ORAL SQUAMOUS CELL CARCINOMA

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Hagar El-naggar ◽  
Manal El Nouaem ◽  
Zeinab Darwish ◽  
Gamal Swaify ◽  
Marwa Essawy
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Node Metastasis

scholarly journals SOX7 Blocks Vasculogenic Mimicry in Oral Squamous Cell Carcinoma

2020 ◽  
Author(s):  
Kyoung-Ok Hong ◽  
Kyu-Young Oh ◽  
Hye-Jung Yoon ◽  
Neeti Swarup ◽  
Minjung Jung ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Vasculogenic Mimicry ◽  
Channel Formation ◽  
Node Metastasis

Abstract Background: Vasculogenic mimicry (VM) is the formation of an alternative circulatory system by aggressive tumor cells. The characteristics of VM and its underlying mechanism in oral squamous cell carcinoma (OSCC) remain unclear. This study aims to determine the relationship between VM channels in OSCC tissues and clinical outcomes and to investigate the biological role of SOX7 in VM in OSCC cells.Methods: CD31/PAS double staining was performed to evaluate VM status in OSCC tissue. The relationships between VM and clinicopathological variables, and VM and SOX7 levels were analyzed. The correlation between SOX7 levels and head and Neck cancer corhorts were investigated using in silico analysis.VM channel formation assay was performed to observe VM channels in the OSCC cell lines. To investigate the role of SOX7 in VM channel formation, SOX7 was transiently over-expressed in SCC-9 cells. VM-modulating genes were identified by Western blotting.Results: We confirmed the presence of VM channels in OSCC tissue and several cell lines and found a positive correlation between VM and lymph node metastasis and patient survival in OSCC (P = 0.003). In silico analysis from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database showed that down-regulation of SOX7 expression was significantly correlated with head and neck squamous cell carcinoma (HNSCC) patient cohorts (P = 0.0187) and lymph node metastasis (P = 0.0017). We also found that the presence of VM channels in OSCC tissue was inversely associated with SOX7 expression (P = 0.020). We observed that overexpression of SOX7 impaired VM channel formation by reducing the expression of VE-cadherin, thereby inhibiting cell migration and invasion.Conclusion: These results suggest that SOX7 plays an important role in the regulation of VM channel formation and may inhibit OSCC metastasis.

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