scholarly journals Evaluation of anti-inflammatory and anti-angiogenesis effects of naloxone in the rat air pouch model of inflammation

10.19082/7685 ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 7685-7693
Author(s):  
Tahereh Eteraf-Oskouei ◽  
Atefeh Zabiholahi ◽  
Moslem Najafi ◽  
Bohlool Habibi-Asl
Keyword(s):  
Air Pouch ◽  
Anti Inflammatory ◽  
Air Pouch Model

Investigations of Anti-Inflammatory Activity of a Peptide-Based Hydrogel Using Rat Air Pouch Model

2018 ◽  
Vol 11 (3) ◽  
pp. 2849-2859 ◽  
Author(s):  
Pramod K. Gavel ◽  
Hamendra S. Parmar ◽  
Versha Tripathi ◽  
Narendra Kumar ◽  
Ankan Biswas ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Air Pouch ◽  
Anti Inflammatory ◽  
Air Pouch Model

The Anti-Inflammatory Effect of Bee Venom Stimulation in a Mouse Air Pouch Model Is Mediated by Adrenal Medullary Activity

2003 ◽  
Vol 15 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Y.-B. Kwon ◽  
H.-W. Kim ◽  
T.-W. Ham ◽  
S.-Y. Yoon ◽  
D.-H. Roh ◽  
...  
Keyword(s):  
Bee Venom ◽  
Air Pouch ◽  
Anti Inflammatory ◽  
Air Pouch Model ◽  
Inflammatory Effect

scholarly journals Anti-inflammatory and anti-angiogenesis effect of bee pollen methanolic extract using air pouch model of inflammation

2020 ◽  
Vol 15 (1) ◽  
pp. 66
Author(s):  
Tahereh Eteraf-Oskouei ◽  
Ayda Shafiee-Khamneh ◽  
Fariba Heshmati-Afshar ◽  
Abbas Delazar
Keyword(s):  
Methanolic Extract ◽  
Air Pouch ◽  
Bee Pollen ◽  
Anti Inflammatory ◽  
Air Pouch Model

Evaluation of Anti-inflammatory and Anti-arthritic Activity of Ajmodadi Churna- A Polyherbal Formulation

2016 ◽  
Vol 6 (5) ◽  
pp. 72
Author(s):  
Srivastava Neeraj ◽  
Dashora Nipun ◽  
Menaria Jyoti ◽  
Kumar Neeraj
Keyword(s):  
Chronic Inflammation ◽  
Acute Phase ◽  
Aqueous Extract ◽  
Adjuvant Arthritis ◽  
Paw Edema ◽  
Local Inflammation ◽  
Air Pouch ◽  
Polyherbal Formulation ◽  
Anti Inflammatory ◽  
Air Pouch Model

Anti-inflammatory and anti- arthritic activity of aqueous extract of Ajmodadi Churna (AJM) were evaluated by three methods namely, Carrageenan paw edema, Carrageenan induced Air Pouch Model in Rats and Freunds’ complete adjuvant Arthritis. The Carrageenan paw edema was carried out to test the effect of the extract on acute phase of inflammation. Carrageenan induced Air Pouch Model was used for local inflammation and Freunds’ complete adjuvant Arthritis was used for evaluation of chronic inflammation. Results showed that AJM have significant anti-inflammatory activity and Anti-arthritic Activity in both the doses (200 mg/kg and 400 mg/kg) when compared to the Diclofenac but higher dose was found more effective.Key Words: Anti-inflammatory, Anti-arthritic Activity, Freunds’ complete adjuvant Arthritis, Ajmodadi churna.

scholarly journals Suppressions of Serotonin-Induced Increased Vascular Permeability and Leukocyte Infiltration byBixa orellanaLeaf Extract

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Yoke Keong Yong ◽  
NurShahira Sulaiman ◽  
Muhammad Nazrul Hakim ◽  
Gwendoline Ee Cheng Lian ◽  
Zainul Amirudin Zakaria ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
Inflammatory Activity ◽  
Blue Dye ◽  
Leukocyte Infiltration ◽  
Permeability Model ◽  
Air Pouch ◽  
Rat Paw Edema ◽  
Anti Inflammatory ◽  
Pharmacological Screening ◽  
Air Pouch Model

The aim of the present study was to evaluate the anti-inflammatory activities of aqueous extract ofBixa orellana(AEBO) leaves and its possible mechanisms in animal models. The anti-inflammatory activity of the extract was evaluated using serotonin-induced rat paw edema, increased peritoneal vascular permeability, and leukocyte infiltrations in an air-pouch model. Nitric oxide (NO), indicated by the sum of nitrites and nitrates, and vascular growth endothelial growth factor (VEGF) were measured in paw tissues of rats to determine their involvement in the regulation of increased permeability. Pretreatments with AEBO (50 and 150 mg kg−1) prior to serotonin inductions resulted in maximum inhibitions of 56.2% of paw volume, 45.7% of Evans blue dye leakage in the peritoneal vascular permeability model, and 83.9% of leukocyte infiltration in the air-pouch model. 57.2% maximum inhibition of NO and 27% of VEGF formations in rats’ paws were observed with AEBO at the dose of 150 mg kg−1. Pharmacological screening of the extract showed significant (P<0.05) anti-inflammatory activity, indicated by the suppressions of increased vascular permeability and leukocyte infiltration. The inhibitions of these inflammatory events are probably mediated via inhibition of NO and VEGF formation and release.

scholarly journals Anti-Inflammatory Activity of the Essential Oil Citral in Experimental Infection withStaphylococcus aureusin a Model Air Pouch

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Hellen Braga Martins ◽  
Nathan das Neves Selis ◽  
Clarissa Leal Silva e Souza ◽  
Flávia S. Nascimento ◽  
Suzi Pacheco de Carvalho ◽  
...  
Keyword(s):  
Essential Oil ◽  
Blood Cells ◽  
Mutual Influence ◽  
White Blood Cells ◽  
Local Treatment ◽  
Inflammatory Activity ◽  
Air Pouch ◽  
Qpcr Array ◽  
Anti Inflammatory ◽  
Air Pouch Model

This study proposes to implement an alternative and effective strategy for local treatment of disease provoked byS. aureus. For the analysis of possible anti-inflammatory activity of essential oil, after establishing an air pouch model, 48 male mice of Balb/c were treated, infected, and euthanized at 4 and 8 h. Thus, the total and differential white blood cells were counted in the animal’s blood, and cytokines IL-1β, IL-6, and TNF-αwere titrated using ELISA in the air pouch lavage. Moreover, TNF-α, IL-1β, and IL-6 gene expression was analyzed through an RT-qPCR array, andS. aureuswas quantified using qPCR. Our results,p<0.05, showed that EOC reduced the quantity of microorganisms. The group of mice treated with essential oil citral showed a significant decrease in TNF-αlevels in tests demonstrating anti-inflammatory activity. There is no data about the mutual influence of the air pouch model, essential oil citral, andS. aureus. Thus, considering the interaction of these variables and the anti-inflammatory activity of the essential oil citral, we demonstrated, by alternative local treatment, a new antimicrobial agent that is not an antibiotic.

Anti-Inflammatory Role of Thyroid Hormones on Rat Air Pouch Model of Inflammation

2016 ◽  
Vol 14 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Bhagyashree Nijampurkar ◽  
Farheen Qureshi ◽  
Neha Jain ◽  
Tushar Banerjee ◽  
Anil Kumar ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Air Pouch ◽  
Anti Inflammatory ◽  
Air Pouch Model

scholarly journals Anti-inflammatory effects of DhHP-6 in LPS-induced RAW264.7 macrophages and carrageenan-induced air pouch model in rat

2021 ◽  
Author(s):  
Fanwei Meng ◽  
Junfeng Ke ◽  
Jia Xu ◽  
Jinze Li ◽  
Liping Wang
Keyword(s):  
Nuclear Translocation ◽  
Raw264.7 Cells ◽  
Total Proteins ◽  
Air Pouch ◽  
Inflammatory Agent ◽  
Raw264.7 Macrophages ◽  
Peptide Mimic ◽  
Anti Inflammatory ◽  
Air Pouch Model ◽  
Pro Inflammatory Cytokines

Abstract DhHP-6 (Deuterohemin-Ala-His-Thr-Val-Glu-Lys) is a novel peptide mimic of peroxidases that was previously designed in our laboratory. Here, we explored the anti-inflammatory potential of DhHP-6 against lipopolysaccharide(LPS)stimulated inflammatory response in RAW264.7 cells and carrageenan-induced air pouch model rats. DhHP-6 treatment dramatically attenuated the production of nitric oxide (NO), IL-6, andTNF-α in LPS induced RAW264.7 cells. Also, it blocked phosphorylation and degradation of IκBα and suppressed the nuclear translocation of p65. DhHP-6 (0.2, 0.6, and 2.0 mg/kg) significantly reduced the levels of total proteins and WBC counts in the exudates of the air pouch model rats. Moreover, MDA contents in the plasma of rats were reduced and SOD activities were enhanced in the DhHP-6-treatment group. Our results strongly show the effectiveness of DhHP-6 as an anti-inflammatory agent. The mechanism could be related to the reduction of Reactive oxygen species(ROS), inhibition of NF-κB nuclear translocation, and reduction of pro-inflammatory cytokines.

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