scholarly journals Pengaruh P53 Dan YY1 Terhadap Terjadinya Kanker Serviks

Medicinus ◽  
2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Jacobus Jeno Wibisono
Keyword(s):  
Cervical Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Gene Activation ◽  
P53 Gene ◽  
Suppressor Gene ◽  
E6 Oncoprotein ◽  
P53 Activation ◽  
Ubiquitination Pathway ◽  
E6 And E7

<p><em>Cervical cancer is one of the most prevalent cancer in the world and caused by Human Papilloma Virus (HPV). The pathogenesis of cancer as whole (50%) is caused by gene mutation. HPV stimulates carcinogenesis on cervix epitel cells by HPV-Encoded viral oncoproteins, E6 and E7, which will inhibit tumor suppressor gene activation, such as p53 gene. HPV-encoded E6 oncoprotein  is able to directly attached on p53 causing degeneration via E6-AP-mediated ubiquitination pathway. Moreover, overexpression on YY1 gene has significant role on the progression of HPV on cervical cancer. YY1 inhibits p53 activation dan inhibits apoptosis on cells infected by HPV. Overexpression of YY1 induces reduction of endogenous p53, which will inhibit p53 function as tumor suppressor gene.</em></p><p><strong><em>Keywords: cervical cancer, HPV, P53, YY1</em></strong></p>

Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer

2007 ◽  
Vol 17 (4) ◽  
pp. 868-871 ◽  
Author(s):  
L.-S. YEH ◽  
Y.-Y. HSIEH ◽  
J.-G. CHANG ◽  
W.W.-C. CHANG ◽  
C.-C. CHANG ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Mutation Analysis ◽  
Suppressor Gene ◽  
Human Cervical Cancer

scholarly journals miR‑218 functions as a tumor suppressor gene in cervical cancer

2019 ◽  
Author(s):  
Zhen Liu ◽  
Lin Mao ◽  
Linlin Wang ◽  
Hong Zhang ◽  
Xiaoxia Hu
Keyword(s):  
Cervical Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene

scholarly journals Chemical selectivity of nucleobase adduction relative to in vivo mutation sites on exon 7 fragment of p53 tumor suppressor gene

2015 ◽  
Vol 6 (10) ◽  
pp. 5554-5563 ◽  
Author(s):  
Spundana Malla ◽  
Karteek Kadimisetty ◽  
You-Jun Fu ◽  
Dharamainder Choudhary ◽  
Ingela Jansson ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
P53 Gene ◽  
Suppressor Gene ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene ◽  
Chemical Selectivity

A 32-bp fragment of P53 gene reacted with benzo[a]pyrene metabolite BPDE was analyzed by LC-MS/MS. Chemically reactive sites were similar to frequently mutated codons in tumors.

A 700-kb physical and transcription map of the cervical cancer tumor suppressor gene locus on chromosome 11q13

Genomics ◽  
2005 ◽  
Vol 85 (6) ◽  
pp. 704-714 ◽  
Author(s):  
Kayvan Zainabadi ◽  
Payam Benyamini ◽  
Rita Chakrabarti ◽  
Mysore S. Veena ◽  
Settara C. Chandrasekharappa ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Gene Locus ◽  
Suppressor Gene ◽  
Chromosome 11Q13 ◽  
Cancer Tumor ◽  
Transcription Map

scholarly journals Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer

2020 ◽  
Vol 19 (1) ◽  
pp. 42-47
Author(s):  
Yuri Park ◽  
Seunghan Baik ◽  
Charles Ho ◽  
Chin-Yo Lin ◽  
Sang-Hyuk Chung
Keyword(s):  
Cervical Cancer ◽  
Tumor Suppressor ◽  
Progesterone Receptor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene

scholarly journals Relevance of miR-21 in regulation of tumor suppressor gene PTEN in human cervical cancer cells

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Oscar Peralta-Zaragoza ◽  
Jessica Deas ◽  
Angélica Meneses-Acosta ◽  
Faustino De la O-Gómez ◽  
Gloria Fernández-Tilapa ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Cervical Cancer Cells ◽  
Human Cervical Cancer Cells ◽  
Human Cervical Cancer

scholarly journals Nucleic acid probe based on DNA-templated silver nanoclusters for turn-on fluorescence detection of tumor suppressor gene p53

RSC Advances ◽  
2018 ◽  
Vol 8 (45) ◽  
pp. 25611-25616 ◽  
Author(s):  
Dan Han ◽  
Chunying Wei
Keyword(s):  
Nucleic Acid ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Fluorescence Detection ◽  
P53 Gene ◽  
Suppressor Gene ◽  
Silver Nanoclusters ◽  
Turn On ◽  
Ag Ncs ◽  
Tumor Suppressor Gene P53

“Turn-on” fluorescence detection for p53 gene based on target-triggered opening of hairpin DNA probe and synthesis of DNA-Ag NCs.

scholarly journals Immunohistochemical Detection of Tumor Suppressor Gene p53 Protein in Feline Injection Site-associated Sarcomas

2001 ◽  
Vol 38 (2) ◽  
pp. 236-238 ◽  
Author(s):  
P. R. Nambiar ◽  
M. L. Jackson ◽  
J. A. Ellis ◽  
B. J. Chelack ◽  
B. A. Kidney ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Cell ◽  
Injection Site ◽  
Tumor Suppressor Gene ◽  
P53 Protein ◽  
P53 Gene ◽  
Suppressor Gene ◽  
Immunohistochemical Detection ◽  
Cell Nuclei ◽  
P53 Tumor Suppressor Gene

Sarcomas associated with injection sites are a rare but important problem in cats. Immunohistochemical detection of p53 protein may correlate to mutation of the p53 tumor suppressor gene, a gene known to be important in oncogenesis. The expression of nuclear p53 protein in 40 feline injection site-assocated sarcomas was examined by immunohistochemical staining. In 42.5% (17/40), tumor cell nuclei were stained darkly; in 20% (8/40), tumor cell nuclei were stained palely; and in 37.5% (15/40), tumor cell nuclei were unstained. Immunohistochemical detection of p53 protein in a proportion of injection site-associated sarcomas suggests that mutation of the p53 gene may play a role in the pathogenesis of these tumors.

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