scholarly journals Nucleic acid probe based on DNA-templated silver nanoclusters for turn-on fluorescence detection of tumor suppressor gene p53

RSC Advances ◽  
2018 ◽  
Vol 8 (45) ◽  
pp. 25611-25616 ◽  
Author(s):  
Dan Han ◽  
Chunying Wei
Keyword(s):  
Nucleic Acid ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Fluorescence Detection ◽  
P53 Gene ◽  
Suppressor Gene ◽  
Silver Nanoclusters ◽  
Turn On ◽  
Ag Ncs ◽  
Tumor Suppressor Gene P53

“Turn-on” fluorescence detection for p53 gene based on target-triggered opening of hairpin DNA probe and synthesis of DNA-Ag NCs.

Mutational analysis of a dominant oncogene (c-Ki-ras-2) and a tumor suppressor gene (p53) in hamster lung tumorigenesis

1992 ◽  
Vol 6 (3) ◽  
pp. 199-202 ◽  
Author(s):  
Victor I. C. Oreffo ◽  
Hsiu-Wei Lin ◽  
Paul H. Gumerlock ◽  
Susan A. Kraegel ◽  
Hanspeter Witschi
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Mutational Analysis ◽  
Suppressor Gene ◽  
Lung Tumorigenesis ◽  
Tumor Suppressor Gene P53

scholarly journals Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma

2002 ◽  
Vol 59 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Brano Topic ◽  
Nebojsa Stankovic ◽  
Dragutin Savjak ◽  
Slavko Grbic
Keyword(s):  
Prognostic Factors ◽  
Breast Carcinoma ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Tumor Size ◽  
Primary Tumor ◽  
Suppressor Gene ◽  
Nodal Status ◽  
Primary Tumor Size ◽  
Tumor Suppressor Gene P53

Correlation of standard path morphological prognostic parameters, primary tumor size and axillary nodal status with new prognostic factor in breast carcinoma: tumor suppressor gene p53 was analyzed. The studied sample included 65 women who underwent surgery for breast carcinoma at the Surgical Clinic of Clinical Center Banja Luka, from January 1st 1997 till January 1st 1999. Statistical data analysis was performed and correlation of prognostic factors was determined. The majority of authors in this field agree that the primary tumor size and axillary nodal status are the two most important prognostic factors. These factors are the best predictors of prognosis and survival of women who had the tumor and were operated on. Tumor markers were immunohistochemically determined in the last ten years and, according to the majority of authors, are still considered the additional or relative prognostic factors in breast carcinoma. Their prognostic value and significance increase almost daily. Most frequently determined tumor markers are bcl-2, pS2, Ki-67 and p53. There was a positive, directly proportional relationship between primary tumor size and tumor suppressor gene p53, but there was no positive correlation between the axillary nodal status and tumor suppressor gene p53. Significance of determination of new tumor markers as the prognostic factors was emphasized. These markers represent a powerful tool in the early detection and prevention of breast carcinoma.

scholarly journals Chemical selectivity of nucleobase adduction relative to in vivo mutation sites on exon 7 fragment of p53 tumor suppressor gene

2015 ◽  
Vol 6 (10) ◽  
pp. 5554-5563 ◽  
Author(s):  
Spundana Malla ◽  
Karteek Kadimisetty ◽  
You-Jun Fu ◽  
Dharamainder Choudhary ◽  
Ingela Jansson ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
P53 Gene ◽  
Suppressor Gene ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene ◽  
Chemical Selectivity

A 32-bp fragment of P53 gene reacted with benzo[a]pyrene metabolite BPDE was analyzed by LC-MS/MS. Chemically reactive sites were similar to frequently mutated codons in tumors.

A Novel Antioxidant Function for the Tumor-Suppressor Gene p53 in the Retinal Ganglion Cell

2008 ◽  
Vol 49 (10) ◽  
pp. 4237-4244 ◽  
Author(s):  
J. C. O'Connor ◽  
D. M. Wallace ◽  
C. J. O'Brien ◽  
T. G. Cotter
Keyword(s):  
Tumor Suppressor ◽  
Ganglion Cell ◽  
Tumor Suppressor Gene ◽  
Retinal Ganglion Cell ◽  
Suppressor Gene ◽  
Retinal Ganglion ◽  
Antioxidant Function ◽  
Tumor Suppressor Gene P53

A synergistic polyphosphoester-based co-delivery system of the anticancer drug doxorubicin and the tumor suppressor gene p53 for lung cancer therapy

2018 ◽  
Vol 6 (20) ◽  
pp. 3262-3273 ◽  
Author(s):  
Jie Liu ◽  
Jinlin He ◽  
Mingzu Zhang ◽  
Guoqiang Xu ◽  
Peihong Ni
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Anticancer Drug ◽  
Delivery System ◽  
Suppressor Gene ◽  
Polymeric Prodrug ◽  
Lung Cancer Therapy ◽  
Tumor Suppressor Gene P53

Hybrid micelles composed of polymeric prodrug and gene carrier were constructed by polyphosphoester-based co-delivery system for lung cancer therapy.

Expression and Mutation of the Tumor Suppressor Gene p53 in AIDS-Associated Kaposi's Sarcoma

1997 ◽  
Vol 19 (4) ◽  
pp. 373-378 ◽  
Author(s):  
Jian J. Li ◽  
Yao-Q Huang ◽  
Clay J. Cockerell ◽  
Wei G. Zhang ◽  
Alexander Nicolaides ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Suppressor Gene ◽  
Tumor Suppressor Gene P53
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