scholarly journals Stressful experiences differentially regulate immediate-early genes and stress hormone receptors in immature and mature dentate gyrus neurons

2017 ◽  
Author(s):  
Evgenia Todorova ◽  
Shaina Cahill ◽  
Timothy O'Leary ◽  
Jason Snyder
Keyword(s):  
Dentate Gyrus ◽  
Hormone Receptors ◽  
Immediate Early Genes ◽  
Immediate Early ◽  
Stress Hormone ◽  
Early Genes ◽  
Stressful Experiences

scholarly journals Global Ischemia Induces Immediate-Early Genes Encoding Zinc Finger Transcription Factors

1996 ◽  
Vol 16 (4) ◽  
pp. 557-565 ◽  
Author(s):  
Jari Honkaniemi ◽  
Frank R. Sharp
Keyword(s):  
Transcription Factors ◽  
Dentate Gyrus ◽  
Neuronal Death ◽  
Immediate Early Genes ◽  
Global Ischemia ◽  
Immediate Early ◽  
Mrna Levels ◽  
Brain Areas ◽  
Ca1 Neurons ◽  
Early Genes

Ischemia induces immediate-early genes (IEGs) in brain. Since prolonged expression of some IEGs may precede neuronal death, some researchers have suggested that these IEGs mediate neuronal death. We therefore examined the effect of 5 and 10 min of global ischemia on the expression of the IEGs NGFI-A, NGFI-B, NGFI-C, egr-2, egr-3, and Nurr1 in gerbil brain. All of the IEGs were induced after 30 min of reperfusion in the hippocampus. Most of them were induced in several other regions as well, including cortex, hypothalamus, thalamus, and amygdala. The acute IEG induction decreased in most brain areas by 2–6 h. However, at 24 h following 5 min of ischemia NGFI-A continued to be expressed in the CA1 region and dentate gyrus. In the dentate gyrus, NGFI-C continued to be expressed for 24 h and egr-3 for as long as 72 h. In other brain areas, all of the IEGs returned to control levels by 72 h except in CA1, where most messenger RNA (mRNA) levels were decreased; this decrease correlated with marked neuronal loss. The persistent expression of NGFI-A in CA1 neurons destined to die and the persistent expression of NGFI-A, NGFI-C, and egr-3 genes in dentate granule cell neurons that survive may indicate that some transcription factors modulate cell death whereas others support cell survival when expressed for prolonged periods. The protein products of several transcription factors, including c- fos, are known to downregulate their own expression. The persistent expression of NGFI-A in the CA1 neurons destined to die could therefore be due to ischemia-induced transcriptional activation caused by, e.g., increased intracellular calcium levels plus a lack of negative feedback caused by the blockade of the translation of NGFI-A mRNA into protein.

scholarly journals Object-Place Recognition Learning Triggers Rapid Induction of Plasticity-Related Immediate Early Genes and Synaptic Proteins in the Rat Dentate Gyrus

2008 ◽  
Vol 2008 ◽  
pp. 1-12 ◽  
Author(s):  
Jonathan Soulé ◽  
Zsuzsa Penke ◽  
Tambudzai Kanhema ◽  
Maria Nordheim Alme ◽  
Serge Laroche ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Immediate Early Genes ◽  
Synaptic Proteins ◽  
Immediate Early ◽  
Pcr Analysis ◽  
Long Term Memory ◽  
Place Recognition ◽  
Early Genes ◽  
Recognition Learning

Long-term recognition memory requires protein synthesis, but little is known about the coordinate regulation of specific genes. Here, we examined expression of the plasticity-associated immediate early genes (Arc, Zif268, and Narp) in the dentate gyrus following long-term object-place recognition learning in rats. RT-PCR analysis from dentate gyrus tissue collected shortly after training did not reveal learning-specific changes in Arc mRNA expression. In situ hybridization and immunohistochemistry were therefore used to assess possible sparse effects on gene expression. Learning about objects increased the density of granule cells expressing Arc, and to a lesser extent Narp, specifically in the dorsal blade of the dentate gyrus, while Zif268 expression was elevated across both blades. Thus, object-place recognition triggers rapid, blade-specific upregulation of plasticity-associated immediate early genes. Furthermore, Western blot analysis of dentate gyrus homogenates demonstrated concomitant upregulation of three postsynaptic density proteins (Arc, PSD-95, andα-CaMKII) with key roles in long-term synaptic plasticity and long-term memory.

Angiotensin II Type 1 Receptor Blockade Inhibits the Expression of Immediate-Early Genes and Fibronectin in Rat Injured Artery

Circulation ◽  
1995 ◽  
Vol 92 (1) ◽  
pp. 88-95 ◽  
Author(s):  
Shokei Kim ◽  
Masaki Kawamura ◽  
Hideki Wanibuchi ◽  
Kensuke Ohta ◽  
Akinori Hamaguchi ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Immediate Early Genes ◽  
Immediate Early ◽  
Receptor Blockade ◽  
Early Genes ◽  
Injured Artery

The effect of adrenalectomy on immediate early genes induction by electroconvulsive shock in rat brain

1995 ◽  
Vol 15 (1-2) ◽  
pp. 63
Author(s):  
K.S. Ha ◽  
U.G. Kang ◽  
H.Y. Jung ◽  
J.B. Park ◽  
I.W. Chung ◽  
...  
Keyword(s):  
Rat Brain ◽  
Electroconvulsive Shock ◽  
Immediate Early Genes ◽  
Immediate Early ◽  
Early Genes

Use of intron and exon probes to characterize the expression of immediate early genes

2007 ◽  
Vol 58 ◽  
pp. S111
Author(s):  
Takeshi Izawa ◽  
Yu Kumode ◽  
Tetsuo Yamamori ◽  
Takeshi Yagi ◽  
Takashi Kitsukawa
Keyword(s):  
Immediate Early Genes ◽  
Immediate Early ◽  
Early Genes
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