A sensitivity analysis of the New Zealand standard model of foot and mouth disease

2011 ◽  
Vol 30 (2) ◽  
pp. 513-526 ◽  
Author(s):  
K. OWEN ◽  
M. STEVENSON ◽  
R.L. SANSON
2014 ◽  
Vol 50 (10) ◽  
pp. 751-755 ◽  
Author(s):  
Rebecca Hayman ◽  
Michael Shepherd ◽  
Claire Tarring ◽  
Emma Best

2010 ◽  
Vol 53 (5) ◽  
pp. 529-544 ◽  
Author(s):  
I. Traulsen ◽  
G. Rave ◽  
J. Krieter

Abstract. A spatial and temporal Monte-Carlo simulation model was developed to analyse the epidemiology and control of foot and mouth disease (FMD). Animal, people and vehicle contacts as well as airborne and local spread represented the FMD virus transmission between farms housing cattle, pigs or sheep. Contacts were explicitly modelled by routes, airborne transmission by the Gaussian Dispersion model and local spread by distance dependent transmission probabilities. Control measures were implemented according to the EU Directive (2003/85/EG). A sensitivity analysis with a two-level fractional factorial design was used to examine the robustness of the simulation model to extreme input values. The influence of eleven input parameters and interactions between them were estimated: ability of airborne spread, duration of the incubation period, time from infection until infectivity, time from onset of clinical signs until diagnosis, farm density, type of index case, number of farms visited per route, visiting interval, type of the animal sales, control strategy, and delay until start of control strategies. The considered parameters as well as certain two-factor interactions between them showed a significant impact on the epidemic duration and the number of infected and culled farms. Particularly, the parameter airborne spread, farm density, number of farms visited per route and control strategy influenced the course of the epidemic. The consideration of airborne spread as well as the implementation of contacts between farms with routes allowed a detailed analysis of these transmission paths.


1993 ◽  
Vol 41 (1) ◽  
pp. 21-28 ◽  
Author(s):  
R.L. Sanson ◽  
G. Struthers ◽  
P. King ◽  
J.F. Weston ◽  
R.S. Morris

2019 ◽  
Vol 45 (1) ◽  
Author(s):  
Astri Adelia ◽  
Windy Keumala Budianti ◽  
Evita Halim Effendy

Eczema coxsackium merupakan spektrum hand, foot, and mouth disease (HFMD) yang disebabkan oleh coxsackievirus A6 (CVA6). Terdapat beberapa perbedaan pendapat di antara para klinisi mengenai definisi eczema coxsackium hingga saat ini, sehingga data epidemiologi penyakit sulit didapatkan. Telah dipublikasikan beberapa laporan mengenai kasus endemik HFMD yang disebabkan oleh CVA6 di Amerika Serikat (AS), New Zealand, beberapa negara di Eropa, dan Asia. Beberapa klinisi sering mengkaitkan penyakit ini dengan kejadian dermatitis atopik, meskipun hal tersebut belum ada penjelasannya. Patogenesis eczema coxsackium hingga saat ini belum diketahui dengan pasti. Manifestasi klinis yang timbul sangat bervariasi, lebih berat, dan luas, baik pada lesi kulit maupun mukosa dibandingkan dengan HFMD pada umumnya, sehingga lebih dikenal sebagai HFMD atipikal. Penegakan diagnosis eczema coxsackium tidak mudah karena dapat menyerupai penyakit lain dan harus dapat dibuktikan bahwa penyakit tersebut disebabkan oleh CVA6. Prinsip tatalaksana adalah rehidrasi. Prognosis eczema coxsackium adalah baik dan jarang menimbulkan komplikasi yang serius.  Kata kunci: eczema coxsackium, coxsackievirus A6, HFMD atipikal


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