scholarly journals Consequences of colectomy: pathogenetic damages and correction outlooks

2003 ◽  
Vol 2 (4) ◽  
pp. 34-41
Author(s):  
S. R. Bashirov
Keyword(s):  
Degenerative Changes ◽  
Ileal Reservoir ◽  
Mucous Coat ◽  
Physical Chemical ◽  
Clinical Investigations ◽  
Investigation Methods

On the base of experimental and clinical investigations there has been found that continent reservoir ileorectostomies after colectomy under the rectal contents effect had been exposed to degenerative and dysplastic mucous changes. These damages prohibit from stool formation and increase the risk of reservoir malignization. A method of continent reservoir ileorectostomy formation with restraining and areflux mechanism has been developed for pathological transformation of ileal structure. Results of morphological and instrumental investigation methods made on 33 dogs and 6 patients after colectomy show that the restraining and areflux mechanism permits to avoid displastic and degenerative changes in ileal reservoir mucous coat and to recover the stool formation due to motor-evacuation function regulation and keeping the constant physical, chemical and bacterial reservoir and rectum properties after colectomy.

scholarly journals RELIABILITY INCREASE OF THREAD CUTTING WITH TAP BORERS IN SUPER-SMALL HOLES

2020 ◽  
Vol 2020 (11) ◽  
pp. 12-17
Author(s):  
Mikhail Kulikov ◽  
Maksim Yagodkin ◽  
Yuriy Kulikov
Keyword(s):  
Aluminum Alloy ◽  
Considerable Increase ◽  
Reliability Theory ◽  
Thread Cutting ◽  
Tool Failure ◽  
Reliability Indices ◽  
Mechanics Of Materials ◽  
Physical Chemical ◽  
Investigation Methods ◽  
Small Holes

The purpose of this work consists in the reliability increase of thread cutting with the use of tap borers in super-small holes of aluminum alloy parts. The investigation methods used are based on classic regulations of the cutting theory, physical-chemical mechanics of materials, reliability theory and methods of statistical analysis. There are revealed the reasons of thread cutting low reliability and tool failure. The effectiveness of edge anode-machining use at thread cutting is researched. On the basis of data obtained there is carried out a calculation of basic indices of thread cutting reliability. A comparative analysis of the processing reliability indices obtained under standard conditions and with the use of the developed circuit of anode-machining is shown, the effectiveness of the latter use is presented. As a result of the investigations carried out there is developed a technology for thread cutting in super-small holes that ensures a considerable increase of reliability and allows excluding hand work during the process.

Transmission Electron Microscopy of Protein Macromolecules

1971 ◽  
Vol 29 ◽  
pp. 424-425
Author(s):  
Henry S. Slayter
Keyword(s):  
Biological Systems ◽  
Metal Vapor ◽  
Resolving Power ◽  
Electron Microscopic ◽  
Chemical Methods ◽  
Molecular Weights ◽  
The Past ◽  
Physical Chemical ◽  
Transmission Electron

Electron microscopic methods have been applied increasingly during the past fifteen years, to problems in structural molecular biology. Used in conjunction with physical chemical methods and/or Fourier methods of analysis, they constitute powerful tools for determining sizes, shapes and modes of aggregation of biopolymers with molecular weights greater than 50, 000. However, the application of the e.m. to the determination of very fine structure approaching the limit of instrumental resolving power in biological systems has not been productive, due to various difficulties such as the destructive effects of dehydration, damage to the specimen by the electron beam, and lack of adequate and specific contrast. One of the most satisfactory methods for contrasting individual macromolecules involves the deposition of heavy metal vapor upon the specimen. We have investigated this process, and present here what we believe to be the more important considerations for optimizing it. Results of the application of these methods to several biological systems including muscle proteins, fibrinogen, ribosomes and chromatin will be discussed.

Electron Microscopic and Isozyme Study of a Case of Ochronosis

1972 ◽  
Vol 30 ◽  
pp. 88-89
Author(s):  
Jay W. Cha ◽  
Perry J. Melnick
Keyword(s):  
Benzene Ring ◽  
Enzyme System ◽  
Homogentisic Acid ◽  
Degenerative Changes ◽  
Acid Oxidase ◽  
Electron Microscopic ◽  
Tyrosine Metabolism ◽  
Collagenous Tissues

Hereditary ochronosis in very few cases has been examined electron microscopically or histochemically. In this disease homogentisic acid, a normal intermediary of tyrosine metabolism, forms in excessive amounts. This is believed to be due to absence or defective activity of homogentisic acid oxidase, an enzyme system necessary to break the benzene ring and to further break it down to fumaric and acetoacetic acids. Ochronotic pigment, a polymerized form of homogentisic acid, deposits mainly in mesenchymal tissues. There has been a question whether the pigment originates from the collagenous tissues, or deposits passively, where in contrast to melanin it induces degenerative changes.

Seeking to uncover biology's chemical roots

2019 ◽  
Vol 3 (5) ◽  
pp. 435-443 ◽  
Author(s):  
Addy Pross
Keyword(s):  
Environmental Changes ◽  
Biological Systems ◽  
Significant Development ◽  
The Road ◽  
Physical Chemical ◽  
Systems Chemistry ◽  
Biological World ◽  
Inanimate Matter ◽  
The Origin Of Life ◽  
Opening Up

Despite the considerable advances in molecular biology over the past several decades, the nature of the physical–chemical process by which inanimate matter become transformed into simplest life remains elusive. In this review, we describe recent advances in a relatively new area of chemistry, systems chemistry, which attempts to uncover the physical–chemical principles underlying that remarkable transformation. A significant development has been the discovery that within the space of chemical potentiality there exists a largely unexplored kinetic domain which could be termed dynamic kinetic chemistry. Our analysis suggests that all biological systems and associated sub-systems belong to this distinct domain, thereby facilitating the placement of biological systems within a coherent physical/chemical framework. That discovery offers new insights into the origin of life process, as well as opening the door toward the preparation of active materials able to self-heal, adapt to environmental changes, even communicate, mimicking what transpires routinely in the biological world. The road to simplest proto-life appears to be opening up.

Clinical Investigations of Drug Effects in Women

1986 ◽  
Author(s):  
Jack H. Mendelson ◽  
◽  
Nancy K. Mello
Keyword(s):  
Drug Effects ◽  
Clinical Investigations

Basic Problems of Logic in Drug Investigations

1974 ◽  
Vol 13 (04) ◽  
pp. 248-253
Author(s):  
H. Röpke
Keyword(s):  
Animal Experiments ◽  
Point Of View ◽  
Applied Logic ◽  
Clinical Investigations

The basic problems of the theory of cognition when extrapolating the results of animal experiments to man and the limitations of inferences from clinical investigations of drugs are discussed from the point of view of applied logic.

MR-derived CT-like Images for the Assessment of Acute Vertebral Fractures and Osseous Degenerative Changes in the Thoracolumbar Spine

2020 ◽  
Author(s):  
Benedikt J. Schwaiger ◽  
Charlotte Schneider ◽  
Sophia Kronthaler ◽  
Christoph Böhm ◽  
Julian Zapf ◽  
...  
Keyword(s):  
Vertebral Fractures ◽  
Thoracolumbar Spine ◽  
Degenerative Changes

State special primary acceleration measurement standard for gravimetry GET 190-2019

2020 ◽  
pp. 3-8
Author(s):  
L.F. Vitushkin ◽  
F.F. Karpeshin ◽  
E.P. Krivtsov ◽  
P.P. Krolitsky ◽  
V.V. Nalivaev ◽  
...  
Keyword(s):  
High Precision ◽  
Free Fall ◽  
Measurement Range ◽  
Measurement Standard ◽  
Acceleration Measurement ◽  
Measurement Systems ◽  
Free Fall Acceleration ◽  
Investigation Methods ◽  
Measurement Results ◽  
Upper Level

The State special primary acceleration measurement standard for gravimetry (GET 190-2019), its composition, principle of operation and basic metrological characteristics are presented. This standard is on the upper level of reference for free-fall acceleration measurements. Its accuracy and reliability were improved as a result of optimisation of the adjustment procedures for measurement systems and its integration within the upgraded systems, units and modern hardware components. A special attention was given to adjusting the corrections applied to measurement results with respect to procedural, physical and technical limitations. The used investigation methods made it possibled to confirm the measurement range of GET 190-2019 and to determine the contributions of main sources of errors and the total value of these errors. The measurement characteristics and GET 90-2019 were confirmed by the results obtained from measurements of the absolute value of the free fall acceleration at the gravimetrical site “Lomonosov-1” and by their collation with the data of different dates obtained from measurements by high-precision foreign and domestic gravimeters. Topicality of such measurements ensues from the requirements to handle the applied problems that need data on parameters of the Earth gravitational field, to be adequately faced. Geophysics and navigation are the main fields of application for high-precision measurements in this field.

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