scholarly journals Molecular disorders of erythrocyte and platelet membranes in vascular complications of type 1 diabetes mellitus

2006 ◽  
Vol 5 (4) ◽  
pp. 33-41
Author(s):  
Ye. B. Kravets ◽  
N. V. Ryazantseva ◽  
N. M. Yakovleva ◽  
V. N. Butusova ◽  
O. M. Choudakova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Vascular Complications ◽  
Platelet Membranes

scholarly journals Interplay between Type 1 Diabetes Mellitus and Celiac Disease: Implications in Treatment

2018 ◽  
Vol 36 (6) ◽  
pp. 399-408 ◽  
Author(s):  
Navchetan Kaur ◽  
Sanjay K. Bhadada ◽  
Ranjana W. Minz ◽  
Devi Dayal ◽  
Rakesh Kochhar
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Prevalence Rate ◽  
Vascular Complications ◽  
Complex Situation ◽  
Disease Etiology ◽  
Organ Specific

Background: A complex interplay between genetic and environmental factors contributes to disease etiology of most of the autoimmune disorders. Type 1 diabetes mellitus (T1DM) and celiac disease (CD) are polygenic autoimmune diseases that have high propensity to coexist due to shared etiological factors like genetics and clinico-pathological overlaps. Summary: The mean prevalence rate for coexistence of these diseases is 8%, and this value is a gross underestimation as reported from biopsy-proven symptomatic cases. The prevalence rate will rise when studies will excavate bottom layers of the “celiac iceberg” to detect potential and silent celiac cases. The concomitant presence of both these disorders is a complex situation immunologically as well as clinically. There is an accentuated breakdown of tolerance and proinflammatory cytokine storm that leads to the progression of organ-specific autoimmunity to systemic. No immunomodulating drugs are advocated as exogenous insulin supplementation and gluten exclusion are recommended for T1DM and CD respectively. Nevertheless, these pose certain challenges to both the clinicians and the patients, as gluten free diet (GFD) has been described to have an impact on glycemic control, bone health, and vascular complications. Also intermittent gluten intake by these patients due to non-compliance with GFD also stimulates the autoreactive immune cells that result in an augmented immune response. Key Messages: Large public health studies are needed to estimate the prevalence of all forms of CD in T1DM patients. Strict global guidelines need to be formulated for the disease management and prognosis, and there is also a need for an extensive research on each front to thoroughly understand the co-occurrence of these diseases.

Endothelial monocyte activating polypeptide II in children and adolescents with type 1 diabetes mellitus: Relation to micro-vascular complications

Cytokine ◽  
2015 ◽  
Vol 76 (2) ◽  
pp. 156-162 ◽  
Author(s):  
Amira A.M. Adly ◽  
Eman A. Ismail ◽  
Lamis M. Tawfik ◽  
Fatma S.E. Ebeid ◽  
Asmaa A.S. Hassan
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Vascular Complications

scholarly journals A new strategy for vascular complications in young people with type 1 diabetes mellitus

2019 ◽  
Vol 15 (7) ◽  
pp. 429-435 ◽  
Author(s):  
M. Loredana Marcovecchio ◽  
◽  
R. Neil Dalton ◽  
Denis Daneman ◽  
John Deanfield ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Young People ◽  
Type 1 Diabetes Mellitus ◽  
Vascular Complications ◽  
New Strategy

scholarly journals Type 1 Diabetes Mellitus Presenting as Distal Renal Tubular Acidosis (RTA Type 1)

2019 ◽  
Vol 3 (2) ◽  
pp. 49-52 ◽  
Author(s):  
Mohit Garg ◽  
Ravi Kant
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Renal Tubular Acidosis ◽  
Vascular Complications ◽  
Tubular Damage ◽  
Insulin Deficiency ◽  
Renal Tubular ◽  
Type 1 Dm

Background: Type 1 Diabetes Mellitus (DM) is an autoimmune process which causes destruction of b-cells and absolute insulin deficiency. This insulin deficiency prone patient to hyperglycemia and resultant early micro-vascular and macro-vascular complications. Macro-vascular complication seen early in diabetes are CAD, CVA and PAD. In micro-vascular complications, we have retinopathy, neuropathy and nephropathy. In diabetic nephropathy, usually glomerular injury is widely described in literature but little is known about the tubular changes. We report a case which has tubular damage in the form of distal tubular damage causing renal tubular acidosis. Patient has classical bilateral nephrocalcinosis, normal anion gap acidosis and persistently low HCO3. This entity in type 1 DM is not reported in literature. Case: Patient S, 42 yr Male with Type 1 DM for 15 years on Inj. Insulin mixtard presented to emergency with swelling of bilateral lower limb associated with pain/tingling and numbness for 3 months. Conclusion: In a patient with type 1 DM, acidosis can occur due to causes other than DKA and workup should be done if acidosis persists even after treatment.

scholarly journals Estrogen receptor α gene polymorphism and vascular complications in girls with type 1 diabetes mellitus

2017 ◽  
Vol 437 (1-2) ◽  
pp. 153-161 ◽  
Author(s):  
Bartosz Słomiński ◽  
Jolanta Myśliwska ◽  
Monika Ryba-Stanisławowska ◽  
Maria Skrzypkowska ◽  
Małgorzata Myśliwiec
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Estrogen Receptor ◽  
Gene Polymorphism ◽  
Type 1 Diabetes Mellitus ◽  
Vascular Complications ◽  
Estrogen Receptor Α ◽  
Estrogen Receptor Α Gene

scholarly journals TNF-alpha and homocysteine levels in type 1 diabetes mellitus

2001 ◽  
Vol 7 (4-5) ◽  
pp. 679-688
Author(s):  
M. T. Abdel Aziz
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Vascular Complications ◽  
Endothelial Damage ◽  
Tnf Alpha ◽  
Diabetic Patients ◽  
Beta Cell Apoptosis ◽  
Necrosis Factor Alpha

The role of homocysteine as an independent risk factor for vascular endothelial damage, and the possible link between homocysteine and tumour necrosis factor-alpha [TNF-alpha] as two synergistic risk factors for beta-cell apoptosis in type 1 diabetes mellitus was studied. Plasma homocysteine levels were significantly elevated in all diabetic patients compared with controls and diabetic patients with vascular complications showed higher elevations. Furthermore, homocysteine levels showed significant positive correlation with the degree of microalbuminuria. TNF-alpha levels were elevated in all diabetic patients compared with controls. These results may have therapeutic implications.

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