scholarly journals Assessment of serum BDNF levels in complex rehabilitation of patients with ischemic stroke using traditional approaches to the restoration of motor functions

2021 ◽  
Vol 20 (3) ◽  
pp. 38-45
Author(s):  
S. D. Kazakov ◽  
E. S. Koroleva ◽  
N. G. Brazovskaya ◽  
A. A. Zaytsev ◽  
S. A. Ivanova ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Functional Activity ◽  
Recovery Period ◽  
Medical Rehabilitation ◽  
Stage Ii ◽  
Bdnf Level ◽  
Early Recovery ◽  
Group Ii ◽  
Early Recovery Period ◽  
Serum Bdnf

Aim. To assess the relationship between changes in serum brain-derived neurotrophic factor (BDNF) level, regression of motor deficiency, and restoration of functional activity in patients with ischemic stroke after stage II of medical rehabilitation.Materials and methods. The study included 49 patients with ischemic stroke in the middle cerebral artery after stage I of medical rehabilitation. Group I (n = 32) went through stage II of rehabilitation in the early recovery period, group II (n = 17) was discharged for outpatient monitoring at the place of residence. Observation points: day 14 and day 90. Evaluation scales: National Institute of Health Stroke Scale (NIHSS), Fugle – Meyer Scale (FMA), Modified Rankin Scale (mRS). Serum BDNF levels were determined using a MAGPIX multiplex analyzer (Luminex, USA).Results. A comparative analysis of the studied population showed that patients who underwent motor rehabilitation in the early recovery period had greater regression of neurologic deficit according to the ΔNIHSS scale (pgr.I–II = 0.043), a more pronounced increase in the functional activity on the ΔmRS scale (pgr.I–II = 0.047), and positive dynamics according to the FMA scale (pday14–90 = 0.003) in comparison with patients who received outpatient follow-up. The concentration of BDNF was significantly reduced by the end of the early recovery in the group II (pday14–90_gr.II = 0.002). On the contrary, there was no decrease in the level of the BDNF (pday14–90_gr.I = 0.613) in the group of patients undergoing rehabilitation.Conclusion. The results of the study demonstrated the clinical effectiveness of stage II of the comprehensive rehabilitation of patients in the early period of stroke recovery. We can suggest that the success of neurorehabilitation is closely associated with an increase of the BDNF level against the background of its performance. This makes BDNF a potential marker of evaluating the effectiveness of ongoing rehabilitation treatment.

Neurorehabilitation in the Early Recovery Period of Ischemic Stroke. Pharmacology Support

2021 ◽  
Vol 63 (1) ◽  
pp. 22-25
Author(s):  
Denys N. Khramtsov ◽  
Olexandr N. Stoyanov ◽  
Tetiana N. Muratova ◽  
Olexandr R. Pulyk
Keyword(s):  
Ischemic Stroke ◽  
Acute Stroke ◽  
Recovery Period ◽  
Rehabilitation Medicine ◽  
Neuroprotective Agents ◽  
Early Recovery ◽  
National Medical ◽  
Cholinergic Agents ◽  
Early Recovery Period ◽  
Medical University

Aim: The aim of the study was to evaluate the clinical outcome in the use of neuroprotective agents in the acute period of ischemic stroke. Material and Methods: The study was performed on the basis of the stroke of the Center for Reconstructive and Rehabilitation Medicine (University Clinic) of the Odessa National Medical University. A retrospective analysis of clinical outcomes of 115 patients with acute stroke was conducted. Results: An average NIHSS score at discharge was 4.1±0.1 points when treated with no refinery, then it reached 3.6±0.1 points when using peptidergic drugs, and 3.4±0.1 when using D-fdf. 3.1±0.1 points. When using D-FDF, the MMSE score was 3.5±0.1 points, whereas when using cholinergic agents, this index did not exceed 26.9±1.5 points, and when using peptidergic agents - 26.8±1.4 points. Conclusion: The use of neuroprotective agents positively affects the effectiveness of neuro-rehabilitation in patients with acute stroke. The best results in three months after the hospitalization were obtained for peptidergic agents and D-fructose-1,6-diphosphate.

Relationship between Movement Stereotype and Focus Location in the Early Recovery Period after Mild Ischemic Stroke

2019 ◽  
Vol 50 (2) ◽  
pp. 149-155
Author(s):  
I. A. Belayeva ◽  
M. Yu. Martynov ◽  
Ya. G. Pehova ◽  
A. A. Vershinin ◽  
A. P. Rachin ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Recovery Period ◽  
Early Recovery ◽  
Early Recovery Period

Dynamics of recovery of cognitive deficit in patients in the early recovery period of ischemic stroke

2021 ◽  
Vol 121 (11) ◽  
pp. 26
Author(s):  
S.V. Kotov ◽  
V.A. Borisova ◽  
E.V. Slyunkova ◽  
E.V. Isakova ◽  
A.V. Kiselev ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Deficit ◽  
Recovery Period ◽  
Early Recovery ◽  
Early Recovery Period

scholarly journals Impact of the physical rehabilitation onset time in early recovery period of ischemic stroke (second stage of medical rehabilitation) on the level of daily activity and independence

2021 ◽  
Vol 13 (6) ◽  
pp. 41-47
Author(s):  
S. V. Kotov ◽  
L. H. Kodzokova ◽  
E. V. Isakova ◽  
A. S. Kotov
Keyword(s):  
Ischemic Stroke ◽  
Recovery Period ◽  
Onset Time ◽  
Medical Rehabilitation ◽  
Treatment Result ◽  
Early Recovery ◽  
Second Stage ◽  
Number Of Patients ◽  
Group 2 ◽  
Group 1

Ischemic stroke (IS) is the leading cause of neurological inpatient care, readmission, and long-term disability. Until now, there is no single point of view on when the second stage of medical rehabilitation after an IS should be started and the amount of the rehabilitation activities.Objective: to compare the effectiveness of the course of motor rehabilitation during the first 30–90 days and 91–180 days after IS.Patients and methods. The patients were divided into two groups: group 1 included 44 patients in whom ≤3 months passed from IS onset, and group 2–39 patients in whom >3 but <6 months have passed since the IS onset. All patients included in the study received physiotherapy exercises, simulator exercises, robotic mechanotherapy, physiotherapy, massage, speech therapy, cognitive training, and secondary IS prevention.Results and discussion. In both groups patients got a positive treatment result: a significant increase in muscle strength, gait stability, quality, and speed. The number of patients who achieved independence (≤2 points on the Rankin scale) before the start of the rehabilitation course among patients of group 1 was 9.4%, after the end of the course – 40.6%. More initially independent patients were included in the group 2 – 28.6%; after a course of rehabilitation, the proportion of independent patients increased to 35.7%.Conclusion. Rehabilitation courses are effective in patients who have had IS, both in the first three months and in the period from the 4th to the 6th month. It is advisable to conduct the second stage of medical rehabilitation earlier after a stroke.

scholarly journals Comparative Characterization of Candidate Molecular Markers in Ischemic and Hemorrhagic Stroke

2021 ◽  
Vol 17 (5) ◽  
pp. 23-34
Author(s):  
A. M. Golubev ◽  
A. V. Grechko ◽  
V. E. Zakharchenko ◽  
M. M. Kanarsky ◽  
M. V. Petrova ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Molecular Markers ◽  
Neurotrophic Factor ◽  
Hemorrhagic Stroke ◽  
Recovery Period ◽  
Control Group ◽  
Early Recovery ◽  
Acute Period ◽  
S 100 ◽  
Early Recovery Period

According to epidemiological studies, the leading cause of morbidity, disability and mortality are cerebrovascular diseases, in particular ischemic and hemorrhagic strokes. In recent years considerable attention has been given to the study of molecular markers of ischemic and hemorrhagic strokes. These studies are relevant because brain-specific protein biomarkers of neurons and glial cells can provide valuable and timely diagnostic information necessary for clinical decision-making.The aim of the study was to reveal the differences in the serum level of molecular markers in acute, subacute and early recovery periods of ischemic and hemorrhagic strokes.Material and methods. The study included 59 patients. Twenty patients were diagnosed with hemorrhagic stroke and 39 had ischemic stroke. The control group included 20 volunteers. Serum levels of molecular CNS markers were determined in acute, subacute, and early recovery stages of stroke. The serum levels of CNS molecular markers of patients with ischemic and hemorrhagic stroke was measured quantitatively by enzyme immunoassay. Statistical analysis was performed by nonparametric Mann-Whitney method.Results. The level of brain-derived neurotrophic factor (BDNF) in the control volunteers was 574.5 [455.5; 615] pg/ml. Significant differences were found for acute and subacute periods of hemorrhagic stroke: it was 674 [560; 749] pg/ml (P=0.003) and 664 [616; 762] pg/ml (P=0.0001).The level of neuron-specific enolase was significantly increased in all periods of the study: it was 4.15 [3.53; 4.8] ng/ml in the control group, 5.4 [4.4; 6.4] ng/ml in acute period of ischemic stroke (P<0.001), 5.4 [4.4; 6.4] ng/ml in early recovery period of ischemic stroke (P=0.001), 5.1 [4.6; 6.4] ng/ml in acute period of hemorrhagic stroke (P=0.014), 664 [616; 762] ng/ml in subacute period of hemorrhagic stroke (P=0.003).In the control group, the serum S-100 protein level was 4.5 [3.8; 5.4] ng/ml. In the acute and early recovery periods of ischemic stroke, S-100 protein level has significantly fallen down to 4.1 [3.4; 4.6] ng/ml (P<0.031) and 3.9 [3.4; 6] ng/ml (P=0.014), respectively. Glial-cell derived neurotrophic factor level was 1.98 [1.64; 2.1] ng/ml in the controls and increased up to 2.4 [2.2; 5] ng/ml (P=0.002) in the acute period and 2.4 [2.3; 2.6] ng/ml (P<0.001) in the subacute period of hemorrhagic stroke.The vascular endothelial growth factor receptor-1 (VEGFR-1) was significantly lower in the subacute period of hemorrhagic stroke: 485 [211; 945] pg/ml in the subacute period vs 903.5 [626; 1115] pg/ml in the controls (P=0.001).Conclusion. We found differences in the serum level of molecular markers in patients with ischemic and hemorrhagic strokes. In the acute period, early recovery period of ischemic stroke, and subacute period of hemorrhagic stroke, there was an increase in the serum level of neuron-specific enolase. The level of brain-derived neurotrophic factor increased significantly in the acute and subacute periods of hemorrhagic stroke. In the acute and early recovery periods of ischemic stroke, the level of S-100 protein decreased. The level of glial cell-derived neurotrophic factor increased in the acute and subacute periods of hemorrhagic stroke. In the subacute period of hemorrhagic stroke, the level of endothelial growth factor receptor-1 significantly decreased. Moreover, there was significant difference between values of this parameter in the subacute period of hemorrhagic stroke and in the early recovery period of ischemic stroke.

Features of prognostic function in patients with ischemic stroke of frontal localization in the early recovery period

2021 ◽  
Vol 26 (4) ◽  
pp. 31-38
Author(s):  
E. I. Nikishina ◽  
A. E. Danilova ◽  
V. B. Nikishina ◽  
I. V. Zapesotskaya ◽  
T. V. Nedurueva ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Recovery Period ◽  
Time Estimation ◽  
Total Sample ◽  
Practical Significance ◽  
Research Subjects ◽  
Early Recovery ◽  
Preliminary Orientation ◽  
Incomplete Images ◽  
Early Recovery Period

The article presents the results of the research of the features of the anticipation and prognostic function in patients with ischemic stroke of frontal localization in the early recovery period.Material and methods. The total sample group was represented by 60 patients who had suffered an ischemic stroke of frontal or parietal localization. The average age of the research subjects was 53.00 ± 5.44 years. The study was conducted with the use of functional neuropsychological tests (by A.R. Luria, L.S. Tsvetkova), methods of predictive function research (time estimation test, spatial anticipation test, Maze test, London Tower test, “incomplete images” test), as well as statistical methods of quantitative and qualitative data processing.Results. In patients with prefrontal localization of ischemic stroke a specific impairment of prognostic function and a non-specific decrease in anticipation were revealed. It is due to disorders of mental activity purposefulness and preliminary orientation in the conditions of the task. When the lesion was localized in the premotor areas, a less significant decrease in the rate and accuracy of the prognostic function due to the inertia of the mental processes was revealed. In the localization of ischemic stroke in the associative parietal cortex, a specific decrease in the rate and accuracy of sensorimotor, perceptual, and temporal anticipation was revealed, as well as a non-specific decrease in the rate of planning, while maintaining its accuracy of implementation.Conclusion. In terms of practical significance, taking into account the features of prognostic function that have arisen in a particular form of brain damage can serve as a basis for restoring other gnostic or motor impaired functions, increasing the effectiveness of correctional and rehabilitation measures.

The efficacy of divasa in the early recovery period of ischemic stroke

2016 ◽  
Vol 116 (3. Vyp. 2) ◽  
pp. 48 ◽  
Author(s):  
O. A. Mudrova ◽  
N. B. Schekolova ◽  
F. A. Borikov
Keyword(s):  
Ischemic Stroke ◽  
Recovery Period ◽  
Early Recovery ◽  
Early Recovery Period
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