scholarly journals The Role of Divalent Transition Metal Ions in the Binding of Fur Dimer to DNA: Binding of Mn2+ and Co2+ to EC Fur dimer-DNA Complex

2020 ◽  
Author(s):  
Mazen Hamed ◽  
Salih Jabour
Keyword(s):  
Dna Binding ◽  
Transition Metal ◽  
Metal Ions ◽  
Conformational Changes ◽  
Metal Ion ◽  
Transition Metal Ions ◽  
Rich Region ◽  
Repressor Protein ◽  
Dna Complex

Ferric uptake regulation protein is a repressor protein which binds an AT rich region of DNA (the iron box). Fur binds as a dimer in a helix turn helix mode and it is activated by iron(II) and other divalent transition metal ions at elevated concentrations in a process to regulate the ion uptake. Each transition metal ion induces certain conformational changes to aid the Fur binding, both the N-terminal and C-terminal domains take part in binding to DNA in addition to His 88 and His 86 residues. The process is discussed in view of experimental reports. Fe(II), Mn(II) and Co(II) activate Fur to bind DNA experimentally but Zinc plays a structural role and does not activate Fur to bind DNA.

scholarly journals The Role of Divalent Transition Metal Ions in the Binding of Fur Dimer to DNA: Binding of Mn2+ and Co2+ to EC Fur dimer-DNA Complex

2020 ◽  
Author(s):  
Mazen Hamed
Keyword(s):  
Dna Binding ◽  
Transition Metal ◽  
Metal Ions ◽  
Conformational Changes ◽  
Metal Ion ◽  
Transition Metal Ions ◽  
Rich Region ◽  
Repressor Protein ◽  
Dna Complex

Ferric uptake regulation protein is a repressor protein which binds an AT rich region of DNA (the iron box). Fur binds as a dimer in a helix turn helix mode and it is activated by iron(II) and other transition metal ions at elevated concentrations. Each transition metal ion induces certain conformational changes to aid the Fur binding, both the N-terminal and C-terminal domains take part in binding to DNA in addition to His 88 and His 86. The process is discussed in view of experimental reports. Fe(II), Mn(II) and Co(II) activate Fur to bind DNA but Zinc plays a structural role and does not activate Fur to bind DNA.

scholarly journals The Role of Divalent Transition Metal Ions in the Binding of Fur Dimer to DNA: Binding of Mn2+ and Co2+ to EC Fur dimer-DNA Complex

2020 ◽  
Author(s):  
Mazen Hamed ◽  
Salih Jabour
Keyword(s):  
Dna Binding ◽  
Transition Metal ◽  
Metal Ions ◽  
Conformational Changes ◽  
Metal Ion ◽  
Transition Metal Ions ◽  
Rich Region ◽  
Repressor Protein ◽  
Dna Complex

Ferric uptake regulation protein is a repressor protein which binds an AT rich region of DNA (the iron box). Fur binds as a dimer in a helix turn helix mode and it is activated by iron(II) and other transition metal ions at elevated concentrations. Each transition metal ion induces certain conformational changes to aid the Fur binding, both the N-terminal and C-terminal domains take part in binding to DNA in addition to His 88 and His 86. The process is discussed in view of experimental reports. Fe(II), Mn(II) and Co(II) activate Fur to bind DNA but Zinc plays a structural role and does not activate Fur to bind DNA.

scholarly journals The Role of Divalent Transition Metal Ions in the Binding of Fur Dimer to DNA: Binding of Mn2+ and Co2+ to EC Fur dimer-DNA Complex

2020 ◽  
Author(s):  
Mazen Hamed ◽  
Salih Jabour
Keyword(s):  
Dna Binding ◽  
Transition Metal ◽  
Metal Ions ◽  
Conformational Changes ◽  
Metal Ion ◽  
Transition Metal Ions ◽  
Rich Region ◽  
Repressor Protein ◽  
Dna Complex

Ferric uptake regulation protein is a repressor protein which binds an AT rich region of DNA (the iron box). Fur binds as a dimer in a helix turn helix mode and it is activated by iron(II) and other transition metal ions at elevated concentrations. Each transition metal ion induces certain conformational changes to aid the Fur binding, both the N-terminal and C-terminal domains take part in binding to DNA in addition to His 88 and His 86. The process is discussed in view of experimental reports. Fe(II), Mn(II) and Co(II) activate Fur to bind DNA but Zinc plays a structural role and does not activate Fur to bind DNA.

The Role of Transition Metal Ions in Ascorbate-Induced Cytotoxicity in Pancreatic Cancer

2014 ◽  
Vol 76 ◽  
pp. S124
Author(s):  
Juan Du ◽  
Brett A Wagner ◽  
Garry R Buettner ◽  
Joseph J Cullen
Keyword(s):  
Pancreatic Cancer ◽  
Transition Metal ◽  
Metal Ions ◽  
Transition Metal Ions

scholarly journals The role of transition metal ions on HO<sub>x</sub> radicals in clouds: a numerical evaluation of its impact on multiphase chemistry

2004 ◽  
Vol 4 (1) ◽  
pp. 95-110 ◽  
Author(s):  
L. Deguillaume ◽  
M. Leriche ◽  
A. Monod ◽  
N. Chaumerliac
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Aqueous Phase ◽  
Numerical Evaluation ◽  
Transition Metal Ions ◽  
Cloud Chemistry ◽  
Sensitivity Tests ◽  
Fe Speciation ◽  
Deposition Processes

Abstract. A new modelling study of the role of transition metal ions on cloud chemistry has been performed. Developments of the Model of Multiphase Cloud Chemistry (M2C2; Leriche et al., 2001) are described, including the transition metal ions reactivity emission/deposition processes and variable photolysis in the aqueous phase. The model is then applied to three summertime scenarios under urban, remote and marine conditions, described by Ervens et al. (2003). Chemical regimes in clouds are analyzed to understand the role of transition metal ions on cloud chemistry and especially, on HxOy chemistry, which consequently influences the sulphur and the VOCs chemistry in droplets. The ratio of Fe(II)/Fe(III) exhibits a diurnal variation with values in agreement with the available measurements of Fe speciation. In the urban case, sensitivity tests with and without TMI chemistry, show an enhancement of OH concentration in the aqueous phase when TMI chemistry is considered.

scholarly journals The Role of Metals in the Reaction Catalyzed by Metal-Ion-Independent Bacillary RNase

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Yulia Sokurenko ◽  
Vera Ulyanova ◽  
Pavel Zelenikhin ◽  
Alexey Kolpakov ◽  
Dmitriy Blokhin ◽  
...  
Keyword(s):  
Metal Ions ◽  
Rna Structure ◽  
Metal Ion ◽  
Extracellular Enzymes ◽  
Bacillus Pumilus ◽  
Transition Metal Ions ◽  
The Body ◽  
Intestinal Microbiome ◽  
Phosphodiester Bond

Extracellular enzymes of intestinal microbiota are the key agents that affect functional activity of the body as they directly interact with epithelial and immune cells. Several species of theBacillusgenus, likeBacillus pumilus, a common producer of extracellular RNase binase, can populate the intestinal microbiome as a colonizing organism. Without involving metal ions as cofactors, binase depolymerizes RNA by cleaving the 3′,5′-phosphodiester bond and generates 2′,3′-cyclic guanosine phosphates in the first stage of a catalytic reaction. Maintained in the reaction mixture for more than one hour, such messengers can affect the human intestinal microflora and the human body. In the present study, we found that the rate of 2′,3′-cGMP was growing in the presence of transition metals that stabilized the RNA structure. At the same time, transition metal ions only marginally reduced the amount of 2′,3′-cGMP, blocking binase recognition sites of guanine at N7 of nucleophilic purine bases.

2,2î-Bipyridine Catalyzed Bleaching of Cotton Fibers with Peracetic Acid

1988 ◽  
Vol 58 (4) ◽  
pp. 198-210 ◽  
Author(s):  
James W. Rucker ◽  
David M. Cates
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Peracetic Acid ◽  
Metal Ion ◽  
Solution Treatment ◽  
Transition Metal Ions ◽  
Ferrous Ion ◽  
Cotton Fibers ◽  
Lauryl Sulfate ◽  
Ferrous Ions

Peracetic acid can be catalyzed to bleach cotton fibers at temperatures as low as 30°C by incorporating 2,2î-bipyridine in the bleach solution. Treatment of the fibers with HCl prior to bleaching reduces bleaching effectiveness by removing trace transition metal ions from the fibers. Sorption of individual ions (Cr+3 Mn+2, Fe+2, Fe+3 Co+2, Ni+2, Cu+2, and Zn+2) by HCl treated cotton fibers prior to bleaching indicates that the ferrous ion produces the greatest catalytic effect, and it is only effective when the metal ion is in the fiber as opposed to in solution. Ferrous ions in the fibers sorb 2,2î-bipyridine from solution to form the tris-2,2î-bipyridine ferrous ion complex that is associated with the fibers, and it is the trischelate associated with the fibers that catalyzes bleaching. The effects of pH, temperature, and concentrations of 2,2î-bipyridine, sodium lauryl sulfate, and transition metal ions (in the fibers and in solution) on bleaching effectiveness and peracetic acid decomposition have been studied, and a bleaching mechanism is proposed.

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