scholarly journals Effect of Joule Heating on Cell Viability and Device Reliability

2021 ◽  
Author(s):  
Mohamed Yousuff Caffiyar ◽  
Kashif Irshad ◽  
Vineet Tirth ◽  
Mohamed Zackria Ansar B.I ◽  
Ali Algahtani ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Joule Heating ◽  
Threshold Value ◽  
Cell Loss ◽  
Cell Types ◽  
Microfluidic Channels ◽  
Biological Entity ◽  
Heating Effects ◽  
Device Reliability ◽  
Micro Channels

The application of electrode-based microfluidic devices in biological entity often imposes a problem due to joule heating. The strong applied potentials or micro channels having narrow cross sections generate undesirable temperature inside the microfluidic channels leading to strong thermal distribution inside the micro channel. When intrinsic distribution of temperature, if not fix with threshold value, causes device damage or cell loss. In this work, we investigate the effects of temperature generated due to joules heating effects and we attempt to address the design constraints for minimizing the joule heating effects in the microfluidic device for developing effective microfluidic device. The device reliability was analyzed under different parametric constraints for various types of substrate materials (PDMS, PMMA, Polyimide and glass). We also attempt to investigate the effects of cell reliability due to strong temperature gradients generated through different applied potentials on different cell types. Furthermore, the response of the device performance due to different electrode configuration and different conductivity of the medium was also studied. Our investigation will eventually provide guidelines for microfluidic researchers to fabricate efficient electrode based microfluidic device which will ultimately help to choose a critical channel dimensions, threshold potentials, and conductivity of solutions in order to avoid device damage and cell loss.

scholarly journals Numerical Study of Joule Heating Effects on Microfluidics Device Reliability in Electrode Based Devices

Materials ◽  
2021 ◽  
Vol 14 (19) ◽  
pp. 5819
Author(s):  
Caffiyar Mohammed Yousuff ◽  
Vineet Tirth ◽  
Mohamed Zackria Ansar Babu Irshad ◽  
Kashif Irshad ◽  
Ali Algahtani ◽  
...  
Keyword(s):  
Cross Sections ◽  
Joule Heating ◽  
Electrode Materials ◽  
Separation Efficiency ◽  
Numerical Study ◽  
Microfluidic Devices ◽  
Cell Loss ◽  
Heating Effects ◽  
Device Reliability ◽  
Micro Channels

In electrode-based microfluidic devices, micro channels having narrow cross sections generate undesirable temperature inside the microfluidic device causing strong thermal distribution (joule heating) that eventually leads to device damage or cell loss. In this work, we investigate the effects of joule heating due to different electrode configuration and found that, electrodes with triangular arrangements produce less heating effect even at applied potential of 30 V, without compromising the performance of the device and separation efficiency. However, certain electrode materials have low thermal gradients but erode the channel quickly thereby affecting the reliability of the device. Our simulation also predicts optimal medium conductivity (10 mS/m with 10 V) for cells to survive inside the channel until they are selectively isolated into the collection outlet. Our investigations will aid the researchers in the designing of efficient and reliable microfluidic devices to overcome joule heating inside the microchannels.

JOULE HEATING INDUCED HEAT TRANSFER IN ELECTROKINETIC FLOW THROUGH MICROFLUIDIC CHANNELS

Equipment ◽  
2006 ◽  
Author(s):  
C. Yang ◽  
G. Y. Tang ◽  
D. G. Yan ◽  
H. Q. Gong ◽  
John C. Chai ◽  
...  
Keyword(s):  
Heat Transfer ◽  
Joule Heating ◽  
Microfluidic Channels ◽  
Electrokinetic Flow ◽  
Flow Through

scholarly journals Entropy Generation of MHD Poiseuille Flow with Hall and Joule Heating Effects

2020 ◽  
Vol 14 ◽  
Keyword(s):  
Entropy Generation ◽  
Joule Heating ◽  
Poiseuille Flow ◽  
Hall Current ◽  
Coupled System ◽  
Bejan Number ◽  
Electrically Conducting ◽  
Heating Effects ◽  
Adomian Decomposition ◽  
Ion Slip

In this article investigation has been conducted on the effects of Hall parameter, rotation parameter and Joule heating on the entropy generation of fully developed electrically conducting Poiseuille flow. The coupled system of ordinary differential equations for the flow are obtained, non-dimensionalised and solutions are constructed by Adomian decomposition technique. The effects of Hall current, Ion-slip, Joule heating and magnetic parameters on the velocity, temperature, entropy generation and Bejan number are explained and shown graphically. The results indicate that fluid entropy generation is induced by increase in Hall current, rotation and Joule heating parameters. Furthermore Bejan number is accelerated by Hall current, rotation, Magnetic and Joule heating parameters which signifies that heat transfer irreversibility dominates entropy generation.

Two-dimensional numerical simulations of electrothermal behaviour in very large scale integrated contacts and vias

1989 ◽  
Vol 67 (4) ◽  
pp. 212-217 ◽  
Author(s):  
W. Allegretto ◽  
A. Nathan ◽  
K. Chau ◽  
H. P. Baltes
Keyword(s):  
Electrical Conductivity ◽  
Joule Heating ◽  
Large Scale ◽  
Two Dimensional ◽  
Dimensional Model ◽  
Heating Effects ◽  
Two Dimensional Model ◽  
Potential Gradients ◽  
Metallization Process ◽  
Temperature Equation

We present results of electrothermal interactions in fine geometry contacts and vias. The results have been obtained using a two-dimensional model based on the finite-box procedure. For the contact geometry, large electric potential gradients and consequently high Joule-heating effects develop at the interface, which is relatively low in electrical conductivity. In the case of the via, however, temperature escalations result from singularities in the electric field at geometrically imperfect locations, owing to inadequate step coverage in the metallization process. In particular, we discuss the treatment of boundary conditions for the temperature equation.

scholarly journals Parameter Screening in Microfluidics Based Hydrodynamic Single-Cell Trapping

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
B. Deng ◽  
X. F. Li ◽  
D. Y. Chen ◽  
L. D. You ◽  
J. B. Wang ◽  
...  
Keyword(s):  
Single Cell ◽  
Microfluidic Device ◽  
Single Cell Analysis ◽  
Fine Tuning ◽  
Trapping Efficiency ◽  
Cell Analysis ◽  
Cell Trapping ◽  
Micro Channels ◽  
Single Cell Trapping ◽  
Trapping Sites

Microfluidic cell-based arraying technology is widely used in the field of single-cell analysis. However, among developed devices, there is a compromise between cellular loading efficiencies and trapped cell densities, which deserves further analysis and optimization. To address this issue, the cell trapping efficiency of a microfluidic device with two parallel micro channels interconnected with cellular trapping sites was studied in this paper. By regulating channel inlet and outlet status, the microfluidic trapping structure can mimic key functioning units of previously reported devices. Numerical simulations were used to model this cellular trapping structure, quantifying the effects of channel on/off status and trapping structure geometries on the cellular trapping efficiency. Furthermore, the microfluidic device was fabricated based on conventional microfabrication and the cellular trapping efficiency was quantified in experiments. Experimental results showed that, besides geometry parameters, cellular travelling velocities and sizes also affected the single-cell trapping efficiency. By fine tuning parameters, more than 95% of trapping sites were taken by individual cells. This study may lay foundation in further studies of single-cell positioning in microfluidics and push forward the study of single-cell analysis.

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