Prevention and Treatment of Methotrexate-induced Hepatotoxicity: Potential of Natural Phytobioactive Compounds

Mapping Intimacies ◽

10.20944/preprints202108.0328.v1 ◽

2021 ◽

Author(s):

Michael Adu-Frimpong ◽

James Abugri ◽

Bridget Osei Henewaah Annor

Keyword(s):

Adverse Effects ◽

Treatment Strategies ◽

Clinical Findings ◽

Folate Supplementation ◽

Recent Advances ◽

Prevention And Treatment ◽

Life Threatening ◽

Potent Drug

Methotrexate (MTX) is a potent drug for the treatment of various diseases globally amidst being a chemotherapeutic and immunosuppressant agent. However, hepatotoxicity induced by MTX could be life-threatening if left untreated. Folate supplementation is concurrently applied to reduce the adverse effects of MTX, albeit efficacy compromise. Therefore, there is the need to understand the process for the prevention and treatment strategies for MTX induced hepatotoxicity (MIH). In recent times, preliminary preclinical and clinical findings indicate the potential of natural phytobioactive compounds for MIH prevention and treatment. This mini review therefore summarizes proposed mechanisms of MIH and recent advances in the prevention and treatment prospects of natural phytobioactive compounds on MIH.

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Update on Infections in the Immunocompromised Host

Journal of Pharmacy Practice ◽

10.1177/089719009100400502 ◽

1991 ◽

Vol 4 (5) ◽

pp. 282-294

Author(s):

C. Randall Marchbanks ◽

Karen A. Rowley

Keyword(s):

Bone Marrow ◽

Medical Care ◽

Treatment Strategies ◽

Immunocompromised Host ◽

Immunocompromised Patients ◽

Novel Treatment ◽

Recent Advances ◽

Life Threatening ◽

Immunocompromised State ◽

Novel Treatment Strategies

Recent advances in medical care have provided more effective therapies for the treatment of various malignancies and increased the number of successful bone marrow and organ transplantations. However, these advances often place the patient in a severely immunocompromised state for several days or weeks resulting in one or more life-threatening infections. This article discusses some general principles, current pharmacotherapeutic strategies, and novel treatment strategies for the management of immunocompromised patients.

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A Review of the Therapeutic Benefits of Moringa oleifera in Controlling High Blood Pressure (Hypertension)

Current Traditional Medicine ◽

10.2174/2215083805666190208163441 ◽

2019 ◽

Vol 5 (3) ◽

pp. 232-245

Author(s):

Chuku Okorie ◽

Kola Ajibesin ◽

Adekunle Sanyaolu ◽

Adeena Islam ◽

Selciya Lamech ◽

...

Keyword(s):

Blood Pressure ◽

High Blood Pressure ◽

Moringa Oleifera ◽

Kidney Diseases ◽

Treatment Strategies ◽

Secondary Hypertension ◽

Therapeutic Benefits ◽

Northern Regions ◽

Long Time ◽

Life Threatening

Moringa oleifera (M. oleifera) is an angiosperm plant that is a member of the Moringaceae family. It is a natural plant that is native to the sub-Himalayan northern regions of India, Bangladesh, Pakistan, and Afghanistan. The plant grows abundantly throughout tropical and subtropical areas of the world. For several centuries, many cultures have utilized various parts of the moringa plant as traditional medicine to treat common illnesses and control life-threatening conditions such as hypertension (HTN), diabetes, hyperlipidemia, inflammation, etc. This article reviewed the current literature on the therapeutic benefits of M. oleifera on hypertension, primarily focusing on identifying the plant’s key components and its roles in hindering the common pathophysiological pathways associated with hypertension. The number of people living with HTN has been predicted to increase to 1.56 billion worldwide by 2025 in spite of the myriads of preventive and treatment strategies available today. Therefore, it would be of great value to explore alternative complementary ways of controlling high blood pressure. HTN is commonly defined as blood pressure equal to or higher than 140/90 mm Hg. HTN itself is not a disease condition and does not elicit specific symptoms, however, if left untreated for a long time, it can lead to complicated cardiovascular diseases such as angina, congestive heart failure, myocardial infarction as well as stroke and chronic kidney diseases. Primary hypertension is diagnosed when there is no known identifiable underlying cause for the onset of the condition. Secondary hypertension is diagnosed when there is evidence of a disease or disorder triggering the onset of the condition. It is apparent that understanding the role of M. oleifera in the management of hypertension would expand the valuable strategies for the control of this condition.

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Gender and Impulse Control Disorders

10.1093/oxfordhb/9780195389715.013.0136 ◽

2012 ◽

Author(s):

Alexea Takacs ◽

Sonia Madrid ◽

Marc N. Potenza

Keyword(s):

Impulse Control ◽

Treatment Strategies ◽

Impulse Control Disorders ◽

Treatment Interventions ◽

Prevention And Treatment

Although women and men (and girls and boys) share similarities, they also exhibit differences that may contribute to the etiology and development of impulse control disorders. Such differences may hold significant implications for the generation of optimal prevention and treatment strategies. In this chapter, we review data on gender-related differences in impulse control disorders, considering epidemiological, clinical, biological, and therapeutic perspectives. Implications for improving prevention and treatment interventions are discussed.

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BK Virus Associated Haemorrhagic Cystitis. A systematic review of current prevention and treatment strategies

International Journal of Surgery ◽

10.1016/j.ijsu.2019.01.019 ◽

2019 ◽

Vol 63 ◽

pp. 34-42 ◽

Cited By ~ 2

Author(s):

M. Aldiwani ◽

T. Tharakan ◽

A. Al-Hassani ◽

N. Gibbons ◽

J. Pavlu ◽

...

Keyword(s):

Systematic Review ◽

Treatment Strategies ◽

Bk Virus ◽

Haemorrhagic Cystitis ◽

Prevention And Treatment

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Lidocaine: A Local Anesthetic, Its Adverse Effects and Management

Medicina ◽

10.3390/medicina57080782 ◽

2021 ◽

Vol 57 (8) ◽

pp. 782

Author(s):

Entaz Bahar ◽

Hyonok Yoon

Keyword(s):

Adverse Effects ◽

Local Anesthetic ◽

Local Anesthetics ◽

Adverse Reactions ◽

Rapid Diagnosis ◽

Diagnosis And Treatment ◽

Allergic Reactions ◽

Life Threatening

The most widely used medications in dentistry are local anesthetics (LA), especially lidocaine, and the number of recorded adverse allergic responses, particularly of hazardous responses, is quite low. However, allergic reactions can range from moderate to life-threatening, requiring rapid diagnosis and treatment. This article serves as a review to provide information on LA, their adverse reactions, causes, and management.

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Management of ST Elevation Myocardial Infarction (STEMI) in Different Settings

International Journal of Angiology ◽

10.1055/s-0041-1723944 ◽

2021 ◽

Author(s):

Rod Partow-Navid ◽

Narut Prasitlumkum ◽

Ashish Mukherjee ◽

Padmini Varadarajan ◽

Ramdas G. Pai

Keyword(s):

Myocardial Infarction ◽

Treatment Strategies ◽

Management Process ◽

St Segment Elevation ◽

Segment Elevation Myocardial Infarction ◽

Multiple Factors ◽

St Segment ◽

Threatening Condition ◽

Life Threatening ◽

St Elevation

AbstractST-segment elevation myocardial infarction (STEMI) is a life-threatening condition that requires emergent, complex, well-coordinated treatment. Although the primary goal of treatment is simple to describe—reperfusion as quickly as possible—the management process is complicated and is affected by multiple factors including location, patient, and practitioner characteristics. Hence, this narrative review will discuss the recommended management and treatment strategies of STEMI in the circumstances.

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Therapeutic Antibodies for the Treatment of Respiratory Tract Infections—Current Overview and Perspectives

Vaccines ◽

10.3390/vaccines9020151 ◽

2021 ◽

Vol 9 (2) ◽

pp. 151

Author(s):

Alexie Mayor ◽

Adélaïde Chesnay ◽

Guillaume Desoubeaux ◽

David Ternant ◽

Nathalie Heuzé-Vourc’h ◽

...

Keyword(s):

Respiratory Tract Infections ◽

Inflammatory Diseases ◽

Treatment Strategies ◽

Candida Spp ◽

Medical Needs ◽

Life Threatening ◽

Rsv Infection ◽

Syncytial Virus ◽

Tract Infections ◽

Unmet Medical Needs

Respiratorytract infections (RTIs) are frequent and life-threatening diseases, accounting for several millions of deaths worldwide. RTIs implicate microorganisms, including viruses (influenza virus, coronavirus, respiratory syncytial virus (RSV)), bacteria (Pseudomonas aeruginosa, Streptococcus pneumoniae, Staphylococcus aureus and Bacillus anthracis) and fungi (Pneumocystis spp., Aspergillus spp. and very occasionally Candida spp.). The emergence of new pathogens, like the coronavirus SARS-CoV-2, and the substantial increase in drug resistance have highlighted the critical necessity to develop novel anti-infective molecules. In this context, antibodies (Abs) are becoming increasingly important in respiratory medicine and may fulfill the unmet medical needs of RTIs. However, development of Abs for treating infectious diseases is less advanced than for cancer and inflammatory diseases. Currently, only three Abs have been marketed for RTIs, namely, against pulmonary anthrax and RSV infection, while several clinical and preclinical studies are in progress. This article gives an overview of the advances in the use of Abs for the treatment of RTIs, based on the analysis of clinical studies in this field. It describes the Ab structure, function and pharmacokinetics, and discusses the opportunities offered by the various Ab formats, Ab engineering and co-treatment strategies. Including the most recent literature, it finally highlights the strengths, weaknesses and likely future trends of a novel anti-RTI Ab armamentarium.

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Nanotechnology as an Anti-Infection Strategy in Periprosthetic Joint Infections (PJI)

Tropical Medicine and Infectious Disease ◽

10.3390/tropicalmed6020091 ◽

2021 ◽

Vol 6 (2) ◽

pp. 91

Author(s):

Pier Francesco Indelli ◽

Stefano Ghirardelli ◽

Ferdinando Iannotti ◽

Alessia Maria Indelli ◽

Gennaro Pipino

Keyword(s):

Joint Infection ◽

Treatment Strategies ◽

High Morbidity ◽

Treatment Protocols ◽

Joint Infections ◽

Prevention And Treatment ◽

Efficient Control ◽

Cement Joint ◽

Clay Nanotubes

Background: Periprosthetic joint infection (PJI) represents a devastating consequence of total joint arthroplasty (TJA) because of its high morbidity and its high impact on patient quality of life. The lack of standardized preventive and treatment strategies is a major challenge for arthroplasty surgeons. The purpose of this article was to explore the potential and future uses of nanotechnology as a tool for the prevention and treatment of PJI. Methods: Multiple review articles from the PubMed, Scopus and Google Scholar databases were reviewed in order to establish the current efficacy of nanotechnology in PJI preventive or therapeutic scenarios. Results: As a prevention tool, anti-biofilm implants equipped with nanoparticles (silver, silk fibroin, poly nanofibers, nanophase selenium) have shown promising antibacterial functionality. As a therapeutic tool, drug-loaded nanomolecules have been created and a wide variety of carrier materials (chitosan, titanium, calcium phosphate) have shown precise drug targeting and efficient control of drug release. Other nanotechnology-based antibiotic carriers (lipid nanoparticles, silica, clay nanotubes), when added to common bone cements, enhanced prolonged drug delivery, making this technology promising for the creation of antibiotic-added cement joint spacers. Conclusion: Although still in its infancy, nanotechnology has the potential to revolutionize prevention and treatment protocols of PJI. Nevertheless, extensive basic science and clinical research will be needed to investigate the potential toxicities of nanoparticles.

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