A Review of the Therapeutic Benefits of Moringa oleifera in Controlling High Blood Pressure (Hypertension)

2019 ◽  
Vol 5 (3) ◽  
pp. 232-245
Author(s):  
Chuku Okorie ◽  
Kola Ajibesin ◽  
Adekunle Sanyaolu ◽  
Adeena Islam ◽  
Selciya Lamech ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Moringa Oleifera ◽  
Kidney Diseases ◽  
Treatment Strategies ◽  
Secondary Hypertension ◽  
Therapeutic Benefits ◽  
Northern Regions ◽  
Long Time ◽  
Life Threatening

Moringa oleifera (M. oleifera) is an angiosperm plant that is a member of the Moringaceae family. It is a natural plant that is native to the sub-Himalayan northern regions of India, Bangladesh, Pakistan, and Afghanistan. The plant grows abundantly throughout tropical and subtropical areas of the world. For several centuries, many cultures have utilized various parts of the moringa plant as traditional medicine to treat common illnesses and control life-threatening conditions such as hypertension (HTN), diabetes, hyperlipidemia, inflammation, etc. This article reviewed the current literature on the therapeutic benefits of M. oleifera on hypertension, primarily focusing on identifying the plant’s key components and its roles in hindering the common pathophysiological pathways associated with hypertension. The number of people living with HTN has been predicted to increase to 1.56 billion worldwide by 2025 in spite of the myriads of preventive and treatment strategies available today. Therefore, it would be of great value to explore alternative complementary ways of controlling high blood pressure. HTN is commonly defined as blood pressure equal to or higher than 140/90 mm Hg. HTN itself is not a disease condition and does not elicit specific symptoms, however, if left untreated for a long time, it can lead to complicated cardiovascular diseases such as angina, congestive heart failure, myocardial infarction as well as stroke and chronic kidney diseases. Primary hypertension is diagnosed when there is no known identifiable underlying cause for the onset of the condition. Secondary hypertension is diagnosed when there is evidence of a disease or disorder triggering the onset of the condition. It is apparent that understanding the role of M. oleifera in the management of hypertension would expand the valuable strategies for the control of this condition.

About senile withering of the heart

1902 ◽  
Vol 2 (9) ◽  
pp. 483-484
Author(s):  
A. V. Sivre
Keyword(s):  
Blood Pressure ◽  
Young People ◽  
High Blood Pressure ◽  
Pulse Rate ◽  
Physical Work ◽  
Old People ◽  
Long Time

The author, making parallel experiments on young people and old people (lifting with legs of a certain weight), came to the conclusion that the senile heart is not able to maintain that high blood pressure for a long time, which happens during intense physical work, since such a heart is not in a state to accelerate the pulse rate.

scholarly journals A review on nephrotic syndrome with their causes, complications and epidemiology

2020 ◽  
Vol 3 (01) ◽  
Author(s):  
Monika Semwal
Keyword(s):  
Blood Pressure ◽  
Nephrotic Syndrome ◽  
High Blood Pressure ◽  
Kidney Diseases ◽  
Underlying Mechanism ◽  
Blood Cholesterol ◽  
Salt Diet ◽  
Nephritic Syndrome ◽  
Blood Clots ◽  
Urine Testing

Nephrotic syndrome is a collection of symptoms due to kidney damage. This includes protein in the urine, low blood albumin levels, high blood lipids, and significant swelling. Other symptoms may include weight gain, feeling tired, and foamy urine. Complications may include blood clots, infections, and high blood pressure. Causes include a number of kidney diseases such as focal segmental glomerulosclerosis, membranous nephropathy, and minimal change disease. It may also occur as a complication of diabetes or lupus. The underlying mechanism typically involves damage to the glomeruli of the kidney. Diagnosis is typically based on urine testing and sometimes a kidney biopsy. It differs from nephritic syndrome in that there are no red blood cells in the urine. Treatment is directed at the underlying cause. Other efforts include managing high blood pressure, high blood cholesterol, and infection risk. A low salt diet and limiting fluids is often recommended. About 5 per 100,000 people are affected per year. The usual underlying cause varies between children and adults.

scholarly journals Neurovascular compression of the medulla oblongata, case report. The rare cause of secondary hypertension

2014 ◽  
Vol 155 (21) ◽  
pp. 838-842 ◽  
Author(s):  
Judit Nádas ◽  
Sándor Czirják ◽  
Péter Igaz ◽  
Erika Vörös ◽  
György Jermendy ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
High Blood Pressure ◽  
Medulla Oblongata ◽  
Secondary Hypertension ◽  
Surgical Decompression ◽  
Ventrolateral Medulla ◽  
Left Vertebral Artery ◽  
Neurovascular Compression

Compression of the rostral ventrolateral medulla oblongata is one of the rarely identified causes of refractory hypertension. In patients with severe, intractable hypertension caused by neurovascular compression, neurosurgical decompression should be considered. The authors present the history of a 20-year-old man with severe hypertension. After excluding other possible causes of secondary hypertension, the underlying cause of his high blood pressure was identified by the demonstration of neurovascular compression shown by magnetic resonance angiography and an increased sympathetic activity (sinus tachycardia) during the high blood pressure episodes. Due to frequent episodes of hypertensive crises, surgical decompression was recommended, which was performed with the placement of an isograft between the brainstem and the left vertebral artery. In the first six months after the operation, the patient’s blood pressure could be kept in the normal range with significantly reduced doses of antihypertensive medication. Repeat magnetic resonance angiography confirmed the cessation of brainstem compression. After six months periodically increased blood pressure returned, but in smaller extent and less frequent. Based on the result of magnetic resonance angiography performed 22 months after surgery, re-operation was considerd. According to previous literature data long-term success can only be achieved in one third of patients after surgical decompression. In the majority of patients surgery results in a significant decrease of blood pressure, an increased efficiency of antihypertensive therapy as well as a decrease in the frequency of highly increased blood pressure episodes. Thus, a significant improvement of the patient’s quality of life can be achieved. The case of this patient is an example of the latter scenario. Orv. Hetil., 2014, 155(21), 838–842.

scholarly journals Chronic Kidney diseases: Role of Vitamin-K and Vitamin-D

2021 ◽  
Vol 4 (03) ◽  
Author(s):  
Vinod Kumar Varapete ◽  
Ravindra B N ◽  
Jerin S Shaji ◽  
Yaseen Mulla ◽  
Jiss P Jose ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
High Blood Pressure ◽  
Vitamin K ◽  
Kidney Diseases ◽  
Elevated Serum

Chronic kidney disease is the most common form of kidney disease and high blood pressure is the most common cause the pressure on the glomeruli increases due to high blood pressure which can prove to be very dangerous. Lack in VITAMIN D isn't restricted to the dynamic chemical, calcitriol (25-hydroxycholecalciferol) is likewise insufficient in many patients with constant kidney sickness (CKD), free of their fundamental renal capacity. Diminishes in calcitriol happen generally right off the bat in the movement of kidney illness and may originate before the increment in PTH. These progressions in calcitriol and PTH add to the upkeep of moderately ordinary serum and calcium fixations until the glomerular filtration rate (GFR) diminishes to <20–25%; nonetheless, the outcome is the potential advancement of bone and vascular sickness. Vitamin K intake and long-term vitamin K status are expressed by a high percentage of undercarboxylated OC (uOC). Vitamin D, which is needed for uOC development, and parathyroid hormone (PTH), which is often elevated in patients with CKD, are also affected by osteocalcin levels. Therefore, elevated serum uOC is present in patients with chronic kidney disease (CKD) with hyperparathyroidism, but this does not generally mean that they are deficient in vitamin K.

A Na+,K+ co-transport assay for essential hypertension

1980 ◽  
Vol 58 (10) ◽  
pp. 1069-1074 ◽  
Author(s):  
Georges Dagher ◽  
Ricardo P. Garay
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Secondary Hypertension ◽  
Kinetic Properties ◽  
Maximal Rate ◽  
Hypertensive Patients ◽  
Transport Assay ◽  
History Of ◽  
Family History Of Hypertension ◽  
Per Se

In erythrocytes from essential hypertensive patients and some of their normotensive offspring, the Na+,K+ co-transport system is unable to transport Na+ in an uphill direction against the electrochemical Na+ gradient. Recent studies of the kinetic properties of this system have permitted us to further characterize the abnormal co-transport in hypertension.Thirty-four essential hypertensive patients were characterized by a two-to three-fold decrease in the maximal rate of the outward Na+,K+ co-transport and a partial uncoupling of this system as compared with 22 normotensive controls. On the other hand, a normal co-transport was found in five secondary hypertensives with no family history of hypertension, thus indicating that the abnormal co-transport is not the consequence of high blood pressure per se. An abnormal co-transport was also found in around 50% of 19 young normotensives born of one hypertensive parent, suggesting genetic transmission.This study allows us to propose the use of a specific Na+,K+ co-transport assay for the differential diagnosis between essential and secondary hypertension and for the detection of those normotensives born of hypertensive parents with a potential risk to develop high blood pressure.

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