Iron metabolism and chronic kidney disease

2020 ◽  
Vol 18 (6) ◽  
pp. 27-34
Author(s):  
N.N. Smirnova ◽  
◽  
N.B. Kuprienko ◽  
V.P. Novikova ◽  
A.I. Khavkin ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Metabolism ◽  
Iron Deficiency Anaemia ◽  
Molecular Mechanisms ◽  
Kidney Injury ◽  
Urinary System ◽  
Dual Nature ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Key Words Iron

Iron is involved in all kinds of metabolism. Iron deficiency, even in the absence of anaemia, promotes the development of many diseases. But in inflammation-associated diseases iron accumulates in the liver, kidneys and macrophages; resulting in impairment of effective erythropoiesis. The review presents modern evidence of the molecular mechanisms of iron metabolism and metabolic changes in most common diseases of the organs of the urinary system – pyelonephritis, glomerulonephritis, acute kidney injury. In most cases, anaemia has a dual nature – true iron deficiency anaemia and anaemia of chronic disease. Key words: iron, erythropoiesis, anaemia, renal pathology

scholarly journals Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hafid O. Al-Hassi ◽  
Oliver Ng ◽  
Rayko Evstatiev ◽  
Manel Mangalika ◽  
Natalie Worton ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Iron Metabolism ◽  
Iron Deficiency Anaemia ◽  
Iron Transport ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Loading ◽  
Deficiency Anaemia ◽  
Iron Treatment

AbstractOral iron promotes intestinal tumourigenesis in animal models. In humans, expression of iron transport proteins are altered in colorectal cancer. This study examined whether the route of iron therapy alters iron transport and tumour growth. Colorectal adenocarcinoma patients with pre-operative iron deficiency anaemia received oral ferrous sulphate (n = 15), or intravenous ferric carboxymaltose (n = 15). Paired (normal and tumour tissues) samples were compared for expression of iron loading, iron transporters, proliferation, apoptosis and Wnt signalling using immunohistochemistry and RT-PCR. Iron loading was increased in tumour and distributed to the stroma in intravenous treatment and to the epithelium in oral treatment. Protein and mRNA expression of proliferation and iron transporters were increased in tumours compared to normal tissues but there were no significant differences between the treatment groups. However, intravenous iron treatment reduced ferritin mRNA levels in tumours and replenished body iron stores. Iron distribution to non-epithelial cells in intravenous iron suggests that iron is less bioavailable to tumour cells. Therefore, intravenous iron may be a better option in the treatment of colorectal cancer patients with iron deficiency anaemia due to its efficiency in replenishing iron levels while its effect on proliferation and iron metabolism is similar to that of oral iron treatment.

scholarly journals Ferritin and iron studies in anaemia and chronic disease

2016 ◽  
Vol 54 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Ying Y Peng ◽  
James Uprichard
Keyword(s):  
Chronic Disease ◽  
Iron Deficiency ◽  
Iron Overload ◽  
Iron Deficiency Anaemia ◽  
Iron Homeostasis ◽  
Red Cells ◽  
Pivotal Role ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Common Causes

Anaemia is a condition in which the number of red cells necessary to meet the body's physiological requirements is insufficient. Iron deficiency anaemia and the anaemia of chronic disease are the two most common causes of anaemia worldwide;1 iron homeostasis plays a pivotal role in the pathogenesis of both diseases. An understanding of how iron studies can be used to distinguish between these diseases is therefore essential not only for diagnosis but also in guiding management. This review will primarily focus on iron deficiency anaemia and anaemia of chronic disease; however, iron overload in anaemia will also be briefly discussed.

Haematology

2012 ◽  
pp. 451-464
Author(s):  
Lesley K Bowker ◽  
James D Price ◽  
Sarah C Smith
Keyword(s):  
Multiple Myeloma ◽  
Chronic Disease ◽  
Iron Deficiency ◽  
Older People ◽  
Myelodysplastic Syndrome ◽  
Iron Deficiency Anaemia ◽  
Macrocytic Anaemia ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Haematopoietic System

The ageing haematopoietic system 452 Investigating anaemia in older people 453 Iron deficiency anaemia: diagnosis 454 HOW TO . . . Investigate iron deficiency anaemia 455 Iron deficiency anaemia: treatment 456 Macrocytic anaemia 457 Anaemia of chronic disease 458 Paraproteinaemias 459 Multiple myeloma 460 Myelodysplasia and myelodysplastic syndrome ...

Iron metabolism in obese children and adolescents

2021 ◽  
Vol 11 (1) ◽  
pp. 44-49
Author(s):  
N.N. Smirnova ◽  
◽  
N.B. Kuprienko ◽  
V.P. Novikova ◽  
A.I. Khavkin ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Iron Metabolism ◽  
Iron Deficiency Anaemia ◽  
Molecular Mechanisms ◽  
Key Words Children ◽  
Low Grade ◽  
Obese Children ◽  
Deficiency Anaemia ◽  
Low Grade Inflammation ◽  
Excessive Accumulation

The review presents new data about the causes and molecular mechanisms of iron metabolism in obesity. Obesity is associated with dysregulated iron metabolism. Three hypotheses of the hypoferremia of obesity have been proposed: nutrition hypothesis, large blood volume hypothesis, and the inflammation hypothesis. The latter has been better supported, it is consistent with the data about low-grade inflammation taking place in excessive accumulation of adipose tissue. The key role in the development of functional hypoferremia belongs to the hepcidin-leptin association. Key words: children, iron deficiency anaemia, iron metabolism, obesity, adolescents

Sign in / Sign up

Export Citation Format

Share Document