scholarly journals EFFICACY AND SAFETY OF AMLODIPINE MALEATE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND BRONCHIAL ASTHMA WITH CONCOMITANT ARTERIAL HYPERTENSION

2010 ◽  
Vol 6 (2) ◽  
pp. 173-178 ◽  
Author(s):  
N. A. Karoli ◽  
A. P. Rebrov ◽  
A. A. Roshchina ◽  
V. A. Sergeeva ◽  
E. E. Arkhangelskaya
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Arterial Hypertension ◽  
Pulmonary Disease ◽  
Bronchial Asthma ◽  
Chronic Obstructive ◽  
Efficacy And Safety ◽  
Obstructive Pulmonary Disease

Comparative study of the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease

2015 ◽  
Vol 26 (5) ◽  
Author(s):  
Dushyant Lal ◽  
Sachin Manocha ◽  
Arunabha Ray ◽  
V.K. Vijayan ◽  
Raj Kumar
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Comparative Study ◽  
Pulmonary Disease ◽  
Bronchial Asthma ◽  
Clinical Symptoms ◽  
Chronic Obstructive ◽  
Efficacy And Safety ◽  
Obstructive Pulmonary Disease ◽  
Beneficial Effects ◽  
Copd Patients

AbstractBronchial asthma and chronic obstructive pulmonary disease (COPD) are the major obstructive disorders that may contribute to the severity in individual patients. The present study was designed to compare the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and COPD.A total of 60 patients, 30 each with bronchial asthma and COPD, were enrolled for the study. Each group of 30 patients received standard treatment for asthma and COPD. Each group was again subdivided into two with 15 patients each, who received theophylline or doxofylline in addition to standard therapy, for a period of 2 months. Each patient was followed up fortnightly for the assessment of efficacy parameters using a pulmonary function test (PFT), clinical symptoms and emergency drug use, and safety was assessed by recording adverse drug reactions.Both theophylline and doxofylline produced enhancements in PFT at different time intervals in both asthma and COPD patients. The maximum beneficial effects were seen at 6 weeks for asthma patients and at 8 weeks for COPD patients for both theophylline and doxofylline.The comparative study showed that doxofylline was more effective as evidenced by improvement in PFT as well as clinical symptoms, and reduced incidence of adverse effects and emergency bronchodilator use.

scholarly journals The effects of climate in patients with arterial hypertension, including in combination with chronic obstructive pulmonary disease and/or bronchial asthma

2013 ◽  
Vol 10 (4) ◽  
pp. 59-65
Author(s):  
I E Chazova ◽  
L G Ratova ◽  
Y A Dolgusheva ◽  
B M Nazarov ◽  
O Y Agapova ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Arterial Hypertension ◽  
Pulmonary Disease ◽  
Bronchial Asthma ◽  
Climatic Factors ◽  
Winter Period ◽  
Chronic Obstructive ◽  
Health State ◽  
Significant Deterioration ◽  
Obstructive Pulmonary Disease

Objective: to examine the characteristics of the regulation mechanisms of the cardiovascular system under the influence of climatic factors of the patients with arterial hypertension (AH) without comorbidity compared to the patients with AH and associated pathology (chronic obstructive pulmonary disease and/or bronchial asthma).Conclusion: during the spring of 2012 – winter of 2013 abnormal summer heat and abnormally low temperatures in winter in the central region of Russian Federation were not observed. Against this background, patients with AH, including with BOD did not have any significant changes of BP and HR in summer compared to those in spring. The increase of the daily average temperature in summer was followed by a significant increase of ventricular extrasystoles. In assessing of the endothelial dysfunction it was proved that it showed a significant deterioration due to hot weather. The best estimation of general health state was noted in winter period according to the VAS. The spirometric parameters of the patients with AH and BOD were significantly better at this time of the year.

Clinical and functional peculiarities at patients with bronchial asthma, chronic obstructive pulmonary disease and overlap of asthma-chronic obstructive pulmonary disease

2020 ◽  
Vol 24 (4) ◽  
pp. 80-86
Author(s):  
V. I. Trofimov ◽  
D. Z. Baranov
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Bronchial Asthma ◽  
Blood Test ◽  
Chronic Obstructive ◽  
Inflammation Markers ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Functional Features ◽  
Lower Airways

BACKGROUND: a comparative analysis of laboratory and instrumental tests at patients with bronchial obstructive diseases seems very actual due to the wide prevalence of these diseases. THE AIM: to evaluate characteristics of spirometry as well as allergic (total IgE, sputum eosinophils) and infectious (blood and sputum leucocytes, ESR, CRP, fibrinogen) inflammation markers at patients with bronchial obstructive diseases. PATIENTS AND METHODS: 104 case histories of patients with bronchial asthma, chronic obstructive pulmonary disease and overlap were analyzed including age, duration of smoking (pack-years), laboratory (clinical blood test, biochemical blood test, general sputum analysis, sputum culture) and instrumental (spirometry, body plethysmography, echocardiography) tests. Data were processed statistically with non-parametric methods. RESULTS: COPD patients were older than other groups’ patients, had the highest pack-years index. ACO patients were marked with maximal TLC and Raw, minimal FEV1, FEF25-75, FEV1/FVC. Patients with COPD had the highest inflammation markers (leucocyte count, CRP, fibrinogen). CONCLUSION: high active inflammation may cause severe lower airways possibility disorders at patients with COPD. Data related to a possible role of K. pneumoniaе in the pathogenesis of eosinophilic inflammation in lower airways are of significant interest. Patients with ACO occupy an intermediate position between asthma and COPD patients based on clinical and functional features.

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