Impaired Fasting Glucose Rate by Diabetes Family History

Abstract Background: Lipid accumulation product (LAP) is considered to be a new convenient useful indicator to assess the visceral fat. However, the association between LAP and family history of diabetes remains an undetermined concept. Therefore, we aimed to evaluate the risk factors of impaired fasting glucose (IFG) and diabetes, and explore the possible interacting influences of LAP with other factors on the risk of IFG and diabetes among Chinese normotension adults.Methods: A multistage stratified cluster sampling method was conducted to select urban residents aged 45-86 years in Bengbu, China. For each eligible participant, data on questionnaire survey, anthropometric measurements and laboratory tests were obtained. LAP was calculated and divided into four categories according to quartile. The effects of body mass index (BMI), waist circumference (WC), waist to height ratio (WHtR) and LAP for predicting IFG and diabetes were performed by multiple logistic regressions and receiver operating characteristic (ROC) analyses. The interaction effects were evaluated by relative excess risk of interaction (RERI), attributable proportion due to interaction (AP) and synergy index (SI). If the 95% CI of RERI and AP do not include 0, the 95% CI of SI do not include 1, the interactions are statistically significant. Results: 6467 normotension subjects (2695 men and 3772 women) were enrolled in our study, the prevalence of IFG and diabetes were 9.37% and 14.33%, respectively. It was revealed that the prevalence rates of IFG and diabetes were gradually increased according to increasing LAP quartiles (P for trend <0.001). When assessed using ROC curve analysis, LAP exhibited higher diagnostic accuracy for identifying IFG and diabetes than BMI, the area under the AUC curve was 0.650 (95% CI: 0.637 to 0.662). After adjustment for age, sex, educational level and other confounding factors, multivariate logistic regression analyses indicated that subjects with the fourth quartile of LAP were more likely to develop IFG (adjusted OR: 2.735, 95% CI: 1.794-4.170) and diabetes (adjusted OR: 1.815, 95% CI: 1.297-2.541) than those with the first quartile. A significant interaction between LAP and family history of diabetes was observed in participants (RERI=1.538, 95%CI: 0.167 to 3.612; AP=0.375, 95%CI: 0.118 to 0.631; SI=1.980, 95%CI: 1.206 to 3.251), but there is no statistically significant difference between LAP and general obesity. However, a significant interaction between LAP and abdominal obesity was indicated by the value of RERI (1.492, 95%CI: 0.087 to 3.723) and AP (0.413, 95%CI: 0.014 to 0.756), but not the value of SI (1.824, 95%CI: 0.873 to 3.526). Conclusion: LAP significantly associates with IFG and diabetes risk in the study population, it has better performance than BMI, WC and WHtR. Apart from that, our results also demonstrated that there might be synergistic effect between LAP and family history of diabetes on the risk of IFG and diabetes.

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Type-2 Diabetes Family History Delays the Onset of Type-1 Diabetes

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.87.7.8649 ◽

2002 ◽

Vol 87 (7) ◽

pp. 3192-3196 ◽

Cited By ~ 6

Author(s):

P. A. Zalloua ◽

H. Shbaklo ◽

G. Halaby ◽

H. Terwedow ◽

X. Xu ◽

...

Keyword(s):

Type 2 Diabetes ◽

Type 1 Diabetes ◽

Family History ◽

Diabetes Family History ◽

Diabetes Family

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Low profilin 1 serum levels are associated with diabetes, family history and multivessel lesions in patients with coronary artery disease

Advances in Interventional Cardiology ◽

10.5114/aic.2021.109159 ◽

2020 ◽

Author(s):

Elżbieta Paszek ◽

Wojciech Zajdel ◽

Krzysztof Plens ◽

Krzysztof Żmudka ◽

Jacek Legutko ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Family History ◽

Serum Levels ◽

Artery Disease ◽

Diabetes Family History ◽

Diabetes Family

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Undiagnosed diabetes mellitus and associated factors among adults in Ethiopia: a systematic review and meta-analysis

Scientific Reports ◽

10.1038/s41598-021-03669-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Getachew Yideg Yitbarek ◽

Gashaw Walle Ayehu ◽

Sintayehu Asnakew ◽

Ermias Sisay Chanie ◽

Wubet Alebachew Bayih ◽

...

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Family History ◽

Impaired Fasting Glucose ◽

Associated Factors ◽

Fasting Glucose ◽

Undiagnosed Diabetes ◽

Family History Of Diabetes ◽

History Of ◽

Undiagnosed Diabetes Mellitus

AbstractDiabetes has become a major public health problem, with 4.6 million deaths annually. The number of people living with undiagnosed diabetes is on the rise and has a diverse prevalence. Thus, this systematic review and meta-analysis was aimed to synthesize the pooled estimate prevalence of undiagnosed diabetes mellitus, impaired fasting glucose and its associated factors in Ethiopia. The databases Medline, Hinari, Google Scholar, and Google search were used to find potential studies published from January 2013 until January 2021. Extracted data were entered into the excel spreadsheet. The random effects model with Der Simonian-Laird weights was used to assess the pooled estimate of prevalence of undiagnosed diabetes, impaired fasting glucose, and its associated factors. The Cochrane Q-test and I2 statistics were used to screen for statistical heterogeneity. A funnel plot and Egger's statistical test were also used to search for any publication bias (small study effect). After extensive searching of articles on different databases, a total of nine studies were included for this systematic review and meta-analysis. In random effects model, the pooled prevalence of undiagnosed diabetes mellitus and impaired fasting glucose was 5.75%, 95% CI (3.90–7.59%), and 8.94%, 95% CI (2.60–15.28%), respectively. Regarding the associated factors, participants family history of diabetes was significantly associated with diabetes status. The pooled odds of developing diabetes mellitus among participants with a family history of diabetes mellitus were about 3.56 times higher than those without a family history of diabetes mellitus (OR = 3.56, 95% CI (2.23, 5.68)). In this review, the higher prevalence of undiagnosed diabetes mellitus and impaired fasting glucose was observed among adults in Ethiopia. Family history of diabetes was found to have an association with increased risk of diabetes mellitus. Our finding highlights the need of screening at the community level, with special focus on adults with family history of diabetes mellitus.

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Impaired glucose homeostasis in non-diabetic Greek hypertensives with diabetes family history. Effect of the obesity status

Journal of the American Society of Hypertension ◽

10.1016/j.jash.2013.02.007 ◽

2013 ◽

Vol 7 (4) ◽

pp. 294-304 ◽

Cited By ~ 1

Author(s):

Gregory P. Vyssoulis ◽

Charalampos I. Liakos ◽

Eva A. Karpanou ◽

Athanasios I. Triantafyllou ◽

Andreas P. Michaelides ◽

...

Keyword(s):

Family History ◽

Glucose Homeostasis ◽

Obesity Status ◽

History Effect ◽

Diabetes Family History ◽

Diabetes Family

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The Risk and Influencing Factors of Hypertension in Jinchang Cohort

American Journal of Hypertension ◽

10.1093/ajh/hpaa220 ◽

2021 ◽

Vol 34 (5) ◽

pp. 563-563

Author(s):

Qian Miao ◽

Shan Zheng ◽

Yan Luo ◽

Ming-zhen Wang ◽

Wen-zhi Zhu ◽

...

Keyword(s):

Blood Pressure ◽

Family History ◽

Influencing Factors ◽

Baseline Blood Pressure ◽

High Salt Diet ◽

Salt Diet ◽

History Of ◽

Family History Of Hypertension ◽

Diabetes Family History ◽

Diabetes Family

Abstract Background To investigate the incidence and influencing factors of hypertension in Jinchang cohort. Methods A prospective cohort study was conducted to collect the baseline and follow-up information of 22,826 employees from 2011 to 2015 based on the Jinchang cohort platform. The incidence of hypertension in the cohort was calculated and the influencing factors were analyzed by Cox proportional risk model. Results The subjects were followed up for an average of 22 years, and the incidence density of hypertension was 56.31/1000 person-years. Multivariate Cox regression results showed that the main risk factors for hypertension in the population included age ≥40 years, alcohol consumption, high-salt diet, history of diabetes, family history of hypertension, overweight and obesity, baseline systolic blood pressure ≥110 mm Hg and diastolic blood pressure ≥75 mm Hg, and higher education levels (middle school, high school, and above) were a protective factor. The incidence of grade 1 hypertension was related to age, drinking, history of diabetes, family history of hypertension and baseline blood pressure levels, and the incidence of grades 2 and 3 hypertension was related to high-salt diet, family history of hypertension, overweight or obesity, and baseline blood pressure levels. Conclusions The Jinchang cohort has a higher risk of hypertension. Age, unhealthy lifestyle, history of diabetes, family history of hypertension, obesity, and baseline blood pressure are strongly associated with the onset of hypertension. There are differences in the risk factors for the occurrence of grades 1, 2, and 3 hypertension.

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