scholarly journals Acute on chronic liver failure in non-alcoholic fatty liver and alcohol associated liver disease

2019 ◽  
Vol 4 ◽  
pp. 74-74 ◽  
Author(s):  
Ashwani K. Singal ◽  
Patrick S. Kamath
Keyword(s):  
Liver Disease ◽  
Liver Failure ◽  
Fatty Liver ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Alcoholic Fatty Liver

Non-alcoholic fatty liver disease in HIV-positive patients predisposes for acute-on-chronic liver failure: two cases

2006 ◽  
Vol 18 (1) ◽  
pp. 101-105 ◽  
Author(s):  
Alisan Kahraman ◽  
Michael Miller ◽  
Robert K. Gieseler ◽  
Guido Gerken ◽  
Michael J. Scolaro ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Failure ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Chronic Liver ◽  
Hiv Positive ◽  
Chronic Liver Failure ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Metabolic associated fatty liver disease and acute-on-chronic liver failure

2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jacqueline Córdova-Gallardo ◽  
Andrew P. Keaveny ◽  
Xingshun Qi ◽  
Nahum Méndez-Sánchez
Keyword(s):  
Liver Disease ◽  
Liver Failure ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Chronic Liver ◽  
Chronic Liver Failure

scholarly journals Impact of compensated cirrhosis on survival in patients with acute-on-chronic liver failure

2021 ◽  
Author(s):  
Kessarin Thanapirom ◽  
Tongluk Teerasarntipan ◽  
Sombat Treeprasertsuk ◽  
Ashok Choudhury ◽  
Manoj K. Sahu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Failure ◽  
Mortality Rates ◽  
Chronic Liver ◽  
Hbv Reactivation ◽  
Chronic Liver Failure ◽  
Alcoholic Fatty Liver ◽  
Compensated Cirrhosis ◽  
Research Consortium ◽  
Clinical Trials Registry

Abstract Background and aims Acute-on-chronic liver failure (ACLF) is considered a main prognostic event in patients with chronic liver disease (CLD). We analyzed the 28-day and 90-day mortality in ACLF patients with or without underlying cirrhosis enrolled in the ACLF Research Consortium (AARC) database. Methods A total of 1,621 patients were prospectively enrolled and 637 (39.3%) of these patients had cirrhosis. Baseline characteristics, complications and mortality were compared between patients with and without cirrhosis. Results Alcohol consumption was more common in cirrhosis than non-cirrhosis (66.4% vs. 44.2%, p < 0.0001), while non-alcoholic fatty liver disease/cryptogenic CLD (10.9% vs 5.8%, p < 0.0001) and chronic HBV reactivation (18.8% vs 11.8%, p < 0.0001) were more common in non-cirrhosis. Only 0.8% of patients underwent liver transplantation. Overall, 28-day and 90-day mortality rates were 39.3% and 49.9%, respectively. Patients with cirrhosis had a greater chance of survival compared to those without cirrhosis both at 28-day (HR = 0.48; 95% CI 0.36–0.63, p < 0.0001) and 90-day (HR = 0.56; 95% CI 0.43–0.72, p < 0.0001), respectively. In alcohol CLD, non-cirrhosis patients had a higher 28-day (49.9% vs. 23.6%, p < 0.001) and 90-day (58.4% vs. 35.2%, p < 0.001) mortality rate than cirrhosis patients. ACLF patients with cirrhosis had longer mean survival than non-cirrhosis patients (25.5 vs. 18.8 days at 28-day and 65.2 vs. 41.2 days at 90-day). Exaggerated systemic inflammation might be the reason why non-cirrhosis patients had a poorer prognosis than those with cirrhosis after ACLF had occurred. Conclusions The 28-day and 90-day mortality rates of ACLF patients without cirrhosis were significantly higher than those with cirrhosis in alcoholic CLD. The presence of cirrhosis and its stage should be evaluated at baseline to guide for management. Thai Clinical Trials Registry, TCTR20191226002.

Acute on chronic liver failure from nonalcoholic fatty liver disease: a growing and aging cohort with rising mortality

Hepatology ◽  
2020 ◽  
Author(s):  
Vinay Sundaram ◽  
Rajiv Jalan ◽  
Parth Shah ◽  
Ashwani K. Singal ◽  
Arpan A Patel ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Failure ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Nonalcoholic Fatty Liver

Global Burden of Non‐alcoholic Fatty Liver Disease (NAFLD) and chronic liver disease (CLD) Among Adolescents and Young Adults

Hepatology ◽  
2021 ◽  
Author(s):  
James M. Paik ◽  
Khaled Kabbara ◽  
Katherine E Eberly ◽  
Youssef Younossi ◽  
Linda Henry ◽  
...  
Keyword(s):  
Young Adults ◽  
Liver Disease ◽  
Fatty Liver ◽  
Chronic Liver Disease ◽  
Fatty Liver Disease ◽  
Chronic Liver ◽  
Adolescents And Young Adults ◽  
Global Burden ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Imaging Software-Based Sarcopenia Assessment in Gastroenterology: Evolution and Clinical Meaning

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Giovanni Marasco ◽  
Sinan Sadalla ◽  
Giulio Vara ◽  
Rita Golfieri ◽  
Davide Festi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Liver Disease ◽  
Liver Failure ◽  
Chronic Liver Disease ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Cross Sectional ◽  
Cross Sectional Imaging ◽  
Sectional Imaging

Sarcopenia is gaining attention as a negative prognostic factor in different fields of medicine, including chronic liver failure. However, the assessment of sarcopenia in patients with liver diseases is often neglected due to unawareness of reliable tools and methods and thus is limited to research studies. Cross-sectional imaging is a diffuse diagnostic tool and is commonly performed in patients with chronic liver failure. The last advancements in radiology image analysis using dedicated software allow an easy and standardized method to assess skeletal muscle volume. Several measures can be obtained from cross-sectional imaging analysis to evaluate sarcopenia in patients affected by chronic liver disease. We aimed to review the recent advances in imaging-based sarcopenia assessment, in particular in patients with chronic liver diseases. As a result, we found that the skeletal muscle index (SMI) seems to be a reliable method to assess sarcopenia in cirrhotic patients. Even if further studies are needed to validate proper cut-offs for each clinical endpoint, physicians are invited to consider the assessment of sarcopenia in the work-up of patients with chronic liver disease.

Acute Liver Failure

2019 ◽  
pp. 264-269
Author(s):  
James Y. Findlay ◽  
Eelco F. M. Wijdicks
Keyword(s):  
Liver Disease ◽  
Liver Function ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Underlying Liver Disease ◽  
Rapid Deterioration ◽  
Uncommon Condition ◽  
Acute Insult

Acute liver failure (ALF) is an uncommon condition in which an acute insult results in a rapid deterioration of liver function, encephalopathy, and coagulopathy in the absence of prior underlying liver disease. It is differentiated from rapid deterioration in the setting of underlying liver disease (acute on chronic liver failure) and from the gradual deterioration in liver function that can occur in chronic liver failure.

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