Outcomes of Management of Proximal Humeral Fractures with Patient-Specific, Evidence-Based Treatment Algorithms

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Christian Spross ◽  
Vilijam Zdravkovic ◽  
Melanie Manser ◽  
Jan Marino Farei-Campagna ◽  
Matthijs Jacxsens ◽  
...  
Keyword(s):  
Proximal Humeral Fractures ◽  
Humeral Fractures ◽  
Patient Specific ◽  
Evidence Based ◽  
Treatment Algorithms ◽  
Evidence Based Treatment

scholarly journals AGO Algorithms for the Treatment of Breast Cancer: Update 2021

2021 ◽  
Vol 81 (10) ◽  
pp. 1101-1111
Author(s):  
Andreas Schneeweiss ◽  
Peter A. Fasching ◽  
Tanja Fehm ◽  
Bernd Gerber ◽  
Christian Jackisch ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Performance Status ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Treatment Decision ◽  
Evidence Based ◽  
Treatment Algorithms ◽  
Actual Treatment ◽  
Therapy Options ◽  
Evidence Based Treatment

AbstractTherapy options shown in the algorithms are based on the current AGO recommendations, but cannot represent all evidence-based treatment options, since prior therapies, performance status, comorbidities, patient preference, etc. must be taken into account for the actual treatment choice. In individual cases, other evidence-based treatment options may also be appropriate and justified. Regardless of approval status, the algorithms only take into account drugs that were available in Germany at the time the algorithm was last updated. Here we present the 2021 update of AGO treatment algorithms for early and metastatic breast cancer, which are intended to intensify structured treatment decision by providing reproducible and evidence-based treatment paths and may be helpful for a broad treatment landscape.

scholarly journals An Evidence-Based Review of the Pathophysiology, Treatment, and Prevention of Exercise Associated Muscle Cramps

2021 ◽  
Author(s):  
Kevin C. Miller ◽  
Brendon P. McDermott ◽  
Susan W. Yeargin ◽  
Aidan Fiol ◽  
Martin P. Schwellnus
Keyword(s):  
Risk Factors ◽  
Patient Specific ◽  
Evidence Based ◽  
Prevention Strategies ◽  
Extrinsic Factors ◽  
Physically Active ◽  
Muscle Cramps ◽  
Evidence Based Treatment ◽  
Treatment And Prevention ◽  
Exercise Associated Muscle Cramps

ABSTRACT Exercise-associated muscle cramps (EAMC) are common and frustrating for athletes and the physically active. We critically-appraised the EAMC literature to provide evidence-based treatment and prevention recommendations. While the pathophysiology of EAMC appears controversial, recent evidence suggests EAMC are due to a confluence of unique intrinsic and extrinsic factors rather than a singular etiology. The treatment of acute EAMC continues to include self-application or clinician-guided gentle static stretching until EAMC abatement. Once the painful EAMC are alleviated, clinicians can continue treatment on the sidelines by focusing on patient-specific risk factors that the clinician believes may have contributed to the genesis of EAMC. For EAMC prevention, clinicians should first perform a thorough medical history followed by identification of the patients' unique risk factors that could have coalesced to elicit EAMC. Individualizing EAMC prevention strategies will likely be more effective than generalized advice (e.g., drink more fluids).

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