scholarly journals Synthesis and Characterization of 3 - Substituted Coumarin

2016 ◽  
Vol 13 (1) ◽  
pp. 89-96
Author(s):  
Baghdad Science Journal
Keyword(s):  
Acetic Acid ◽  
Schiff Bases ◽  
1H Nmr ◽  
Acetyl Chloride ◽  
Aromatic Aldehydes ◽  
Synthesis And Characterization ◽  
Carbonyl Chloride ◽  
Ft Ir

The reaction of(2-oxo-2H-chromen-3-Carbonyl chloride)(k1) with hydrazine in boiling ethanol gives the hydrazide(K2).When compound (k2) reacts with various aromatic aldehydes ,the corres ponding Schiff bases(k3–k4) achieve new series of thiazotidines (k5–k6) and azetidinones (k7–k8) obtained from the reactions of appropriate Schiff bases with mercapto acetic acid and chloro acetyl chloride respectively. All the compounds are characterized by FT-IR,1H-NMR and GC-Ms.

scholarly journals Synthesis and characterization of some heterocyclic including oxazoles,Thiazoles, Pyridazines, phthalizines and Pyrazoles with evaluating of biological activity.

2013 ◽  
Vol 10 (3) ◽  
pp. 818-827
Author(s):  
Baghdad Science Journal
Keyword(s):  
Acetic Acid ◽  
Biological Activity ◽  
Nmr Spectroscopy ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Acid Hydrazide ◽  
Synthesis And Characterization ◽  
Ft Ir ◽  
New Compounds

A series of new compounds including p-bromo methyl pheno acetate [2]. N-( aminocarbonyl)–p-bromo pheno acetamide [3] , N-( aminothioyl) -p-bromo phenoacetyl amide [4], N-[4-(p-di phenyl)-1,3-oxazol-2-yl]-p-bromopheno acetamide [5],N-[4-p-di phenyl]-1,3-thiazol-2-yl-p-bromo phenoacet amide [6], p-bromopheno acetic acid hydrazide [7] , 1-N-(p-bromo pheno acetyl)-1,2-dihydro-pyridazin-3,6- dione [8], 1-N-(p-bromo pheno acetyl)-1,2-dihydro-phthalazin-3,8- dione[ 9], 1-(p-bromo pheno acetyl)-3-methylpyrazol-5-one [10] and 1-(p-bromo phenol acetyl)- 3,5-dimethyl pyrazole [11] have been synthesized. The prepared compounds were characterized by m.p.,FT-IR and 1H-NMR spectroscopy. Also ,the biological activity was evaluated .

scholarly journals Synthesis and Bioinformatic Characterization of New Schiff Bases with Possible Applicability in Brain Disorders

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4160
Author(s):  
Speranta Avram ◽  
Ana Maria Udrea ◽  
Diana Camelia Nuta ◽  
Carmen Limban ◽  
Adrian Cosmin Balea ◽  
...  
Keyword(s):  
Schiff Bases ◽  
Neurodegenerative Disorders ◽  
Aromatic Aldehydes ◽  
Brain Disorders ◽  
Ir And Nmr Spectroscopy ◽  
Bioinformatics Tools ◽  
Ft Ir ◽  
New Treatments ◽  
New Compounds

(1) Background: The research aims to find new treatments for neurodegenerative diseases, in particular, Alzheimer’s disease. (2) Methods: This article presents a bioinformatics and pathology study of new Schiff bases, (EZ)-N′-benzylidene-(2RS)-2-(6-chloro-9H-carbazol-2-yl)propanehydrazide derivatives, and aims to evaluate the drug-like, pharmacokinetic, pharmacodynamic and pharmacogenomic properties, as well as to predict the binding to therapeutic targets by applying bioinformatics, cheminformatics and computational pharmacological methods. (3) Results: We obtained these Schiff bases by condensing (2RS)-2-(6-chloro-9H-carbazol-2-yl)propanehydrazide with aromatic aldehydes, using the advantages of microwave irradiation. The newly synthesized compounds were characterized spectrally, using FT-IR and NMR spectroscopy, which confirmed their structure. Using bioinformatics tools, we noticed that all new compounds are drug-likeness features and may be proposed as potentially neuropsychiatric drugs (4) Conclusions: Using bioinformatics tools, we determined that the new compound 1e had a high potential to be used as a good candidate in neurodegenerative disorders treatment.

scholarly journals Synthesis and Characterization of Some Novel Oxazine, Thiazine and Pyrazol Derivatives

2016 ◽  
Vol 13 (2) ◽  
pp. 244-252
Author(s):  
Baghdad Science Journal
Keyword(s):  
Acetic Acid ◽  
Ir Spectra ◽  
Glacial Acetic Acid ◽  
Basic Medium ◽  
Synthesis And Characterization ◽  
Pyrazole Derivatives ◽  
Phenyl Hydrazine ◽  
H Nmr ◽  
Ft Ir

In this paper, some chalcone derivatives (C1, C2) were synthesized based on the reaction of equal amount of substituted acetophenone and substituted banzaldehyde in basic medium. Oxazine and thiazine derivatives were prepared from the reaction of chalcones (C1-C2) with urea and thiourea respectively in a basic medium. Pyrazole derivatives were prepared based on the reaction of chalcones with hydrazine mono hydrate or phenyl hydrazine in the presence of glacial acetic acid as a catalyst. The new synthesized compounds were identified using various physical techniques like1 H-NMR and FT-IR spectra.

scholarly journals Synthesis and Characterization of some New 1,3,4-Oxadiazole derivatives based on 4-amino benzoic acid

2016 ◽  
Vol 13 (4) ◽  
pp. 762-769
Author(s):  
Baghdad Science Journal
Keyword(s):  
Schiff Base ◽  
Benzoic Acid ◽  
Spectral Data ◽  
1H Nmr ◽  
Synthesis And Characterization ◽  
Oxadiazole Derivatives ◽  
Ft Ir ◽  
Amino Benzoic Acid

Various of 2,5- disubstituted 1,3,4-oxadiazole (Schiff base, ?- lactam and azo) were synthesized from 2,5-di (4,4?-amino-1,3,4-oxadiazole which usequently synth-esized from mixture of 4- amino benzoic acid and hydrazine arch of polyphosphorus acid. The synthesized compounds were cherecterized by using some spectral data (UV, FT-IR , and 1H-NMR)

Synthesis and Characterization of Some 4- Substituted Thiazolidinone Derivatives

2019 ◽  
Vol 10 (04) ◽  
pp. 631-636
Author(s):  
Zainab Ryad Magtoof ◽  
Mahmood Shakir Magtoof
Keyword(s):  
Schiff Bases ◽  
1H Nmr ◽  
13C Nmr ◽  
Mercaptoacetic Acid ◽  
Spectral Studies ◽  
Synthesis And Characterization

This study is concerned with the synthesis and characterization of 4-thiazolidinone derivatives (3a-3e). These compounds were prepared by reacting mercaptoacetic acid with the appropriate Schiff bases (imines) by heating at 50-60 °C in chloroform with moderate yields (51- 75 %). The structures of these 4-thiazolidinone derivatives were established on the basis of spectral studies using IR, 1H-NMR, 13C-NMR, and13C-NMR DEPT .

Synthesis and Characterization of Novel Poly (aryl ether sulfone ketone) S Containing M-Sulfonylbenzonyl Linkage in the Main Chains

2011 ◽  
Vol 396-398 ◽  
pp. 1518-1522
Author(s):  
Feng Ding ◽  
Da Zhi Wang ◽  
Shao Yin Zhang ◽  
Tian Xing Liu
Keyword(s):  
1H Nmr ◽  
Differential Scanning Calorimeter ◽  
Benzoyl Chloride ◽  
Mechanical Performance ◽  
Synthesis And Characterization ◽  
Aryl Ether ◽  
Ft Ir

A low expense chloro-monomer, 1-(4'-chloro-1-benzoyl)-3-(4'-1-choro-benzene sulfonyl)-benzene(CBCBSB), was synthesized by the Friedel-Crafts reaction of m-chlorosu1fonyl benzoyl chloride with chlorobenzene. A novel poly (aryl ether sulfone ketone)s (PAESK) containing m-sulfonylbenzoyl linkages in the main chains were prepared by copolycondensation of CBCBSB with hydroquinone in N, N-Dimethylacetamide (DMAc). The structure of PAESK was confirmed by FT-IR, 1H-NMR and characterized by XRD. thermogravimetry (TG) and Differential Scanning Calorimeter (DSC) were carried out to demonstrate its good melt processability. The polymer exhibited the better solubility in chloroform, N-methyl-2-pyrrlidone(NMP), dimethylacetamide(DMAC), dimethylformamide (DMF) and dimethylsulfoxide (DMSO) and excellent mechanical performance.

scholarly journals Synthesis and Characterization of Some New Benzimidazole Derivatives

2016 ◽  
Vol 13 (1) ◽  
pp. 82-88
Author(s):  
Baghdad Science Journal
Keyword(s):  
Acetic Acid ◽  
Mannich Base ◽  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
Secondary Amines ◽  
Synthesis And Characterization ◽  
Benzimidazole Derivatives ◽  
Schiff Base Derivatives ◽  
New Compounds

In this paper the new starting material 2-(5-chloro-1H-benzo[d]imidazole-2-yl) aniline (1) was synthesized by the condensation reaction of 4-chloro-o-phenylenediamine and anthranilic acid .The new Mannich base derivatives were synthesized using formaldehyde and different secondary amines to synthesize a new set of benzimidazole derivatives(2-5). Also, the new Schiff-base derivatives (6-10) were synthesized from the reaction of compound (1) with various aromatic aldehydes and the closure-ring was done successfully using mercapto acetic acid to get the new thiazolidine derivatives(11-12).These new compounds were characterized using some physical techniques like:FT-IR Spectra and 1HNMR Spectra.

Synthesis and Characterization of (1, 4)-4-benzylidene-1-(1- phenylethylidene) thiosemicarbazide and their Antifungal Activities

10.26524/sa2 ◽  
2018 ◽  
Vol 7 (3) ◽  
pp. 08-19
Author(s):  
L Ilavarasan ◽  
A Ravi ◽  
M Ganapathi ◽  
R Sapthagiri ◽  
K Mohanraj ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Schiff Bases ◽  
1H Nmr ◽  
Conventional Method ◽  
Research Work ◽  
Synthesis And Characterization ◽  
Antifungal Activities ◽  
Aryl Aldehydes ◽  
Anti Fungal

The Present research work is aimed to synthesize a serious of various substituted Schiff bases compounds of 1-(1-phenylethylidene)thiosemicarbazide form (1,4)-4-benzylidene-1-(1-phenylethylidene)Thiosemicarbazide condenses with Four different substituted aryl aldehydes under Microwave irradiation and conventional method. The structure for compounds has been determined by UV, FTIR, 1H-NMR and Mass s spectroscopy. All the compounds are evaluated for its anti-fungal activity.

scholarly journals Synthesis and Characterization of Five, Sevene Heterocyclic Membered Rings

2013 ◽  
Vol 10 (3) ◽  
pp. 803-817
Author(s):  
Baghdad Science Journal
Keyword(s):  
Biological Activity ◽  
Schiff Bases ◽  
13C Nmr ◽  
Starting Material ◽  
Synthesis And Characterization ◽  
Melting Points ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
New Compounds

New compounds containing heterocyclic units have been synthesized. These compounds include 2-amino 5- phenyl-1,3,4-thiadiazole (1) as starting material to prepare the Schiff bases 2N[3-nitrobenzylidene -2 hydroxy benzylidene and 4-N,N-dimethyl aminobenzylidene] -5-phenyl-1,3,4-thiadiazole (2abc) , 2N[3-nitrophenyl, 2-hydroxyphenyl or 4-N,N-dimethylaminophenyl] 3-]2-amino-5-phenyl-1,3,4-thiadiazole]-2,3-dihydro-[1,3]oxazepine-benzo-4,7-dione] (3abc), 2N[3-nitrophenyl,2-hydroxyphenyl,4-N,N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine-4,7-dione[(4abc), 2-N-[3-nitrophenyl, 2-hydroxyphenyl or 4-N,N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2yl]-1,2,3-trihydro-benzo-[1,2-e][1,3] diazepine-4,7-dione (5abc) ,2N[2-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)]-4-oxo-1,3-thiazolidine-3-yl]-2-amino-5-phenyl-1,3,4-thiadiazole (6abc), 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-tetrazolo-1-yl]-2-amino-5-phenyl-1,3,4-thiadiazole (7abc) , 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine-benzo-4,7-dithione (8abc) , 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine -4,7-dithione -5-ene (9abc) and 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl] -1,2,3-trihydro-benzo-[1,2-e][1,3] diazepine -4,7-dithione - (10abc) . the structures of these compounds were characterized by FT-IR, 1H,13C-NMR,Uv/vis spectroscopy and the melting points were determined besides the evaluation of its biological activity.

Synthesis and Characterization of Heterocyclic Compounds Derived from Schiff base Glycerol Triester

2021 ◽  
Vol 19 (9) ◽  
pp. 88-96
Author(s):  
Marwa Abdulameer Mseer ◽  
Khudheyer Jawad ◽  
Yahya Al-Khafaji
Keyword(s):  
Schiff Bases ◽  
Heterocyclic Compounds ◽  
Benzoyl Chloride ◽  
Synthesis And Characterization ◽  
Second Step ◽  
Compound A ◽  
The Third ◽  
Aminobenzoic Acids ◽  
Ft Ir

Heterocyclic compounds were prepared from Schiff bases triester derivatives, the first step was included, p- aminobenzoic acids convert to p-amino benzoyl chloride in the presence of thionyl chloride then glycerol was added to form triesters compound A. second step reaction of triester product with the 4-nitrobenzaldehyde, and 3-amino benzaldehyde to produce M1, and M2. The third step. Involve reacted Schiff bases triester derivatives to give heterocyclic compounds M1S, M1A, M2P, and M2K. The structure of all compounds is monitored by (TLC), and identified by many techniques 1HNMR, FT-IR, and melting point.

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