scholarly journals Preparation and Characterization some New of Naproxen Drug Derivatives

2017 ◽  
Vol 14 (3) ◽  
pp. 564-574 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Nmr Spectroscopy ◽  
Schiff Bases ◽  
Aromatic Aldehydes ◽  
13C Nmr Spectroscopy ◽  
Second Step ◽  
The Third ◽  
Ft Ir ◽  
Fourth Step ◽  
Derivatives Of ◽  
Tetrazole Derivatives

In this research four steps of the new derivatives of Naproxen drug have been made which are known as a high medicinal effectiveness; the first step involved converting Naproxen into the corresponding ester (A) by reaction Naproxen with methanol absolute in presence H2SO4. While the second step involved treatment methyl Naproxen ester (A) with hydrazine hydrate 80% in presence of ethanol .The third reaction requires synthesis of Schiff bases (C1-C10) by condensation. of Naproxen hydrazide (B) with many substituted aromatic aldehydes . Finally, the fourth step synthesized new tetrazole derivatives ( D1- D10) by the reaction of the prepared Schiff bases (in the third step) with Sodium azide in THF as a solvent .The prepared compounds were characterized by physical properties ,(FT-IR) ,UV, and somewhat of them by 1H-NMR, 13C-NMR spectroscopy.

scholarly journals Synthesis of substituted (oxazepine, Diazepine, tetrazde) via Schiff Bases for 2- Aminobenzo Thaizole Derivatives

2013 ◽  
Vol 10 (3) ◽  
pp. 736-748 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Nmr Spectroscopy ◽  
Schiff Bases ◽  
13C Nmr ◽  
Sodium Azide ◽  
Aromatic Amines ◽  
13C Nmr Spectroscopy ◽  
Aldehydes And Ketones ◽  
Primary Aromatic Amines ◽  
Ft Ir ◽  
Tetrazole Derivatives

This work includs synthesis of several Schiff bases by condensation of 6- methoxy – 2- amino benzothiazole with some aldehydes and ketones (2- hydroxyl benzaldehyde, 4- hydroxyl benzaldehyde, 4- N,N –dimethy amino acetophenone, benzophenone) to abtain schiff bases (1-5). These schiff bases were found to react with phthalate anhydride to give oxazepine derivatives (6-10) that were reacted with primary aromatic amines to give Diazepine derivatives (11-15). Besides, we prepared new tetrazole derivatives (16-20) from the reaction of the prepared Schiff bases with sodium azide in the prepared compounds that were characterized by physical properties, FT-IR and some of the 1H-NMR and 13C –NMR spectroscopy.

scholarly journals Synthesis of Some New Nucleoside Analogues Containing Seven Membered Ring and Studying Their Biological Activity

2016 ◽  
Vol 13 (3) ◽  
pp. 531-546
Author(s):  
Baghdad Science Journal
Keyword(s):  
Antibacterial Activity ◽  
Membered Ring ◽  
Nucleoside Analogues ◽  
Second Step ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
The Third ◽  
Ft Ir ◽  
Fourth Step ◽  
Propiolic Acid

In this work, a series of new Nucleoside analogues (D-galactopyranose linked to oxepanebenzimidazole moiety) was synthesized via multisteps synthesis. The first step involved preparation of two benzimidazoles 2-styrylbenzimidazole and 2-(phenyl ethynyl) benzimidazole via reaction of phenylenediamine with cinnamic acid or ?-phenyl propiolic acid. Electrophilic addition of the prepared benzimidazoles by three anhydrides in the second step afforded (4-6) and (14-16) which in turn were treated with 1,2,3,4-di-O-isopropylidene galactopyranose in the third step to afford a series of the desirable protected nucleoside analogues (7-9) ,(17-19)which after hydrolysis in methanolic sodium methoxidein the fourth step afforded the free nucleoside analogues (10-12) and (20-22) .The synthesized compounds were identified by FT-IR and some of them by 1H-NMR and13C-NMR. The synthesized oxepane nucleoside analogues were screened for their antibacterial activity against three types of bacteria including Staphylococcusaureus ,Bacillus(gram positive) andE.coli (gram negative) bacteria repectively.

Synthesis and Characterization of Heterocyclic Compounds Derived from Schiff base Glycerol Triester

2021 ◽  
Vol 19 (9) ◽  
pp. 88-96
Author(s):  
Marwa Abdulameer Mseer ◽  
Khudheyer Jawad ◽  
Yahya Al-Khafaji
Keyword(s):  
Schiff Bases ◽  
Heterocyclic Compounds ◽  
Benzoyl Chloride ◽  
Synthesis And Characterization ◽  
Second Step ◽  
Compound A ◽  
The Third ◽  
Aminobenzoic Acids ◽  
Ft Ir

Heterocyclic compounds were prepared from Schiff bases triester derivatives, the first step was included, p- aminobenzoic acids convert to p-amino benzoyl chloride in the presence of thionyl chloride then glycerol was added to form triesters compound A. second step reaction of triester product with the 4-nitrobenzaldehyde, and 3-amino benzaldehyde to produce M1, and M2. The third step. Involve reacted Schiff bases triester derivatives to give heterocyclic compounds M1S, M1A, M2P, and M2K. The structure of all compounds is monitored by (TLC), and identified by many techniques 1HNMR, FT-IR, and melting point.

scholarly journals Synthesis of New Some Imidazole Derivatives Containing ?-Lactam Ring

2016 ◽  
Vol 13 (2) ◽  
pp. 307-316
Author(s):  
Baghdad Science Journal
Keyword(s):  
Nmr Spectroscopy ◽  
Acetic Anhydride ◽  
Hydrazine Hydrate ◽  
Schiff Bases ◽  
Aromatic Aldehyde ◽  
13C Nmr ◽  
13C Nmr Spectroscopy ◽  
Chloroacetyl Chloride ◽  
Lactam Ring ◽  
Ft Ir

In this work 5-methylene-yl - (2-methy –oxazole-4-one) (1H) imidazole (1) were synthesized from the reaction of L-Histidine with acetic anhydride and which converted to the of 5-methylene-yl-(2-methyl 3-amino imidazole-4-one)-1H-imidazole (2) by reaction with hydrazine hydrate. Schiff bases (3-6) were synthesized from the reaction of compound (2) with different aromatic aldehyde. Reaction of compounds (3-6) with chloroacetyl chloride gives azetidinone one derivatives (7-10). These compounds were characterized by FT-IR and some of them with 1H-NMR and 13C-NMR spectroscopy.

scholarly journals Synthesis of Polyimides derived from 2,6-diamino-4-methyl-1,3,5-triazine

2016 ◽  
Vol 13 (2) ◽  
pp. 196-209
Author(s):  
Baghdad Science Journal
Keyword(s):  
Nmr Spectroscopy ◽  
1H Nmr ◽  
13C Nmr ◽  
13C Nmr Spectroscopy ◽  
Second Step ◽  
Acid Chlorides ◽  
Triethyl Amine ◽  
Ft Ir

This work included synthesis of several new polymers of polyacryloyl chloride in two steps . The first step the included the reaction of N-( sub. or un sub. benzoyl and sub. or un sub. acetyl ) amidyl sub. 2,6- diamino -4-methyl-1,3,5-triazine (1-5) by condensation of many substituted acid chlorides with 2,6- diamino -4-methyl-1,3,5-triazine . While the second step included the reaction of polyacryloyl chloride with the produced compounds (1-5) in step (1) in the presence amount triethyl amine (Et3N) to obtain new polyimides (6-10). The prepared compounds were characterized by UV. , FT-IR, and some of them by 1H-NMR and 13C- NMR spectroscopy.

scholarly journals Synthesis, Characterization of Derivatives Tetrazoles for Trimethoprim Drug

2016 ◽  
Vol 13 (2) ◽  
pp. 266-274
Author(s):  
Baghdad Science Journal
Keyword(s):  
Nmr Spectroscopy ◽  
Physical Properties ◽  
Schiff Bases ◽  
1H Nmr ◽  
13C Nmr ◽  
1H Nmr Spectroscopy ◽  
Second Step ◽  
Direct Reaction ◽  
Ft Ir

The present work involved synthesis of serval new substituted tetrazole via Schiff bases for trimethoprim drug by two steps. The first step involved direct reaction of different ketones and aldehydes with trimethoprim producing the corresponding Schiff bases (1-10), whereas the second step, involved preparation new tetrazoles derivatives (11-20) through reaction of the ready Schiff bases (in the first step) with sodium azidein in dioxin. The prepared compounds were characterized by UV, FT-IR, and some of them by 13C-NMR, 1H-NMR spectroscopy and physical properties.

Users behaviors: The Heritage of Digital World

2014 ◽  
Vol 13 (7) ◽  
pp. 4675-4682
Author(s):  
Atefeh Danesh Moghadam ◽  
Alireza Alagha
Keyword(s):  
Technology Development ◽  
Second Step ◽  
Information Communication ◽  
The Third ◽  
Digital World ◽  
New Concepts ◽  
Emerging Patterns ◽  
History Of ◽  
Fourth Step ◽  
Communication And Technology

In the advent of information era, not only digital world is going to expand its territories, it is going to penetrate into the traditional notions about the meaning of the words and also valorize new concepts. According to Oxford Dictionary, the word heritage is defined: The history, tradition and qualities that a country or society has had for many years and that are considered an important part of its character. In order to present how emerging patterns, as the consequences of technology development, are going to be considered as the new concept of heritage, we follow four steps. In the first step, we present the convergence of Information, Communication and Technology (ICT) and a concise history of its convergence. In the second step, we argue how convergence has culminated in emerging patterns and also has made changes in digital world. In the third step, the importance of users behaviors and its mining is surveyed. Finally, in the fourth step; we illustrate User Generated Contents (UGC) as the most prominent users behaviors in digital world.

scholarly journals Synthesis and Bioinformatic Characterization of New Schiff Bases with Possible Applicability in Brain Disorders

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4160
Author(s):  
Speranta Avram ◽  
Ana Maria Udrea ◽  
Diana Camelia Nuta ◽  
Carmen Limban ◽  
Adrian Cosmin Balea ◽  
...  
Keyword(s):  
Schiff Bases ◽  
Neurodegenerative Disorders ◽  
Aromatic Aldehydes ◽  
Brain Disorders ◽  
Ir And Nmr Spectroscopy ◽  
Bioinformatics Tools ◽  
Ft Ir ◽  
New Treatments ◽  
New Compounds

(1) Background: The research aims to find new treatments for neurodegenerative diseases, in particular, Alzheimer’s disease. (2) Methods: This article presents a bioinformatics and pathology study of new Schiff bases, (EZ)-N′-benzylidene-(2RS)-2-(6-chloro-9H-carbazol-2-yl)propanehydrazide derivatives, and aims to evaluate the drug-like, pharmacokinetic, pharmacodynamic and pharmacogenomic properties, as well as to predict the binding to therapeutic targets by applying bioinformatics, cheminformatics and computational pharmacological methods. (3) Results: We obtained these Schiff bases by condensing (2RS)-2-(6-chloro-9H-carbazol-2-yl)propanehydrazide with aromatic aldehydes, using the advantages of microwave irradiation. The newly synthesized compounds were characterized spectrally, using FT-IR and NMR spectroscopy, which confirmed their structure. Using bioinformatics tools, we noticed that all new compounds are drug-likeness features and may be proposed as potentially neuropsychiatric drugs (4) Conclusions: Using bioinformatics tools, we determined that the new compound 1e had a high potential to be used as a good candidate in neurodegenerative disorders treatment.

ODACE SLA

2010 ◽  
Vol 1 (3) ◽  
pp. 1-20 ◽  
Author(s):  
Kaouthar Fakhfakh ◽  
Tarak Chaari ◽  
Said Tazi ◽  
Mohamed Jmaiel ◽  
Khalil Drira
Keyword(s):  
Service Providers ◽  
Service Level Agreement ◽  
Service Level ◽  
Second Step ◽  
Technical Knowledge ◽  
Complex Task ◽  
Semantic Matching ◽  
The Third ◽  
Draft Version ◽  
Fourth Step

The establishment of Service Level Agreements between service providers and clients remains a complex task regarding the uninterrupted growth of the IT market. In fact, it is important to ensure a clear and fair establishment of these SLAs especially when providers and clients do not share the same technical knowledge. To address this problem, the authors started modeling client intentions and provider offers using ontologies. These models helped them in establishing and implementing a complete semantic matching approach containing four main steps. The first step consists of generating correspondences between the client and the provider terms by assigning certainties for their equivalence. The second step corrects and refines these certainties. In the third step, the authors evaluate the matching results using inference rules, and in the fourth step, a draft version of a Service Level Agreement is automatically generated in case of compatibility.

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