The paper presents a general overview of deep drilling in unstable formations at the Semyrenky gas condensate field of the Dnipro-Donetsk Trough, including well design, bottom hole assemblies (BHA), drilling conditions, and drilling muds. Problems encountered during drilling for production casing of Wells 72- and 75-Semyrenky using high-speed drilling methods are analyzed. The relationships between the rate of penetration and disturbed rock stability, volume excess and depth, as well as consistent empirical patterns in changes in mud properties and depth are established. With these technical and economic performance indicators for well drilling are given, elements of a borehole stability management strategy were defined, the principles of mud selection for drilling through problem zones are validated. The paper discusses the requirements to a mud hydraulics program to reduce the erosion of borehole walls, specific borehole preparation techniques, such as reaming and gauging, for drilling in problem zones, and alternative options to ensure borehole stability. Keywords: borehole stability; statistical models; hole gauging; hole geometry; drilling mud; BHA.