Internationally the research of low permeability oil reservoir is a difficult point in the exploration and development of oil and gas field. This thesis, based on the research methods of low permeability reservoirs at home and abroad, summaries several major problems encountered in the process of low permeability oil exploration and development under the current technical conditions as well as the corresponding, but more effective technical measures that need to be constantly improved. And that exploration and development of low permeability of the reservoir will be the main battle field for some time in the future of oil exploration and development.