The Effects of Computer-Based Cognitive Rehabilitation and Traditional Cognitive Training on the Working Memory and Executive Function in Patients with Mild Traumatic Brain Injury

2019 ◽  
Vol 13 (6) ◽  
pp. 277-286
Author(s):  
Jong-Hoon Moon ◽  
Seung-Bum Yang ◽  
Min-Jae Jeon
Keyword(s):  
Traumatic Brain Injury ◽  
Working Memory ◽  
Executive Function ◽  
Brain Injury ◽  
Cognitive Training ◽  
Mild Traumatic Brain Injury ◽  
Cognitive Rehabilitation ◽  
Computer Based

scholarly journals Executive Function Training in Chronic Traumatic Brain Injury Patients: Study Protocol

2019 ◽  
Author(s):  
Daniel Krawczyk ◽  
Kihwan Han ◽  
David Martinez ◽  
Jelena Rakic ◽  
Matthew Kmiecik ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Working Memory ◽  
Executive Function ◽  
Brain Injury ◽  
Executive Functions ◽  
Inhibitory Control ◽  
Cognitive Rehabilitation ◽  
Daily Life ◽  
Chronic Phase ◽  
Post Injury

Abstract Background: Some individuals who sustain traumatic brain injuries (TBIs) continue to experience significant cognitive impairments chronically (months-to-years post-injury). Many tests of executive function are insensitive to these executive function impairments, as such impairments may only appear during complex daily life conditions. Daily life often requires us to divide our attention and focus on abstract goals. In the current study, we compare the effects of two one-month electronic cognitive rehabilitation programs for individuals with chronic TBI. The active program (Expedition: Strategic Advantage) focuses on improving goal-directed executive functions including working memory, planning, long-term memory, and inhibitory control by challenging participants to accomplish life-like cognitive simulations. The challenge level of the simulations increase in accordance with participant achievement. The control intervention (Expedition: Informational Advantage) is identical to the active; however, the cognitive demand level is capped preventing participants from advancing beyond a set level. We will evaluate these interventions with a military veteran TBI population. Methods: One hundred individuals will be enrolled in this double-blinded clinical trial (all participants and testers are blinded to condition). Each individual will be randomly assigned to one of two interventions. The primary anticipated outcomes are improvement of daily life cognitive function skills and daily life functions. These are measured by a daily life performance task, which tests cognitive skills, and a survey that evaluates daily life functions. Secondary outcomes are also predicted to include improvements in working memory, attention, planning, and inhibitory control as measured by a neuropsychological test battery. Lastly, neuroimaging measures will be used to evaluate changes in brain networks supporting cognition pre-intervention and post-intervention. Discussion: We will test whether electronically delivered cognitive rehabilitation aimed at improving daily life functional skills will provide cognitive and daily life functional improvements for individuals in the chronic phase of TBI recovery (greater than three months post-injury). We aim to better understand the cognitive processes involved in recovery and the characteristics of individuals most likely to benefit. This study will also address the potential to observe generalizability, or transfer, from a software-based cognitive training tool toward daily life improvement. Trial Registration: ClinicalTrials.gov Identifier: NCT03704116 (retrospectively registered) https://clinicaltrials.gov/ct2/show/NCT03704116?term=tbi+krawczyk&rank=1 Keywords: Cognitive rehabilitation, traumatic brain injury, executive functions, daily life functions, memory, attention, planning. Support: Joint Warfighter Program; U. S. Dept. of Defense W81XWH-16-1-0053

Cognitive Rehabilitation for Military Service Members With Mild Traumatic Brain Injury

2017 ◽  
Vol 32 (3) ◽  
pp. E1-E15 ◽  
Author(s):  
Douglas B. Cooper ◽  
Amy O. Bowles ◽  
Jan E. Kennedy ◽  
Glenn Curtiss ◽  
Louis M. French ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Military Service ◽  
Cognitive Rehabilitation ◽  
Service Members ◽  
Military Service Members

scholarly journals Altered Relationship between Working Memory and Brain Microstructure after Mild Traumatic Brain Injury

2019 ◽  
Author(s):  
S. Chung ◽  
X. Wang ◽  
E. Fieremans ◽  
J.F. Rath ◽  
P. Amorapanth ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Working Memory ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Brain Microstructure

scholarly journals Differential Effects of Pergolide and Bromocriptine on Working Memory Performance and Brain Activation after Mild Traumatic Brain Injury

2020 ◽  
Author(s):  
Laura A. Flashman ◽  
Brenna C. McDonald ◽  
James C. Ford ◽  
Rachel M. Kenny ◽  
Katharine D. Andrews ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Working Memory ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Memory Performance ◽  
Brain Activation ◽  
Differential Effects

scholarly journals Executive function predictors of delayed memory deficits after mild traumatic brain injury

Cortex ◽  
2019 ◽  
Vol 120 ◽  
pp. 240-248 ◽  
Author(s):  
James M. Broadway ◽  
Rebecca E. Rieger ◽  
Richard A. Campbell ◽  
Davin K. Quinn ◽  
Andrew R. Mayer ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Executive Function ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Memory Deficits

scholarly journals Modulation of working memory load distinguishes individuals with and without balance impairments following mild traumatic brain injury

Brain Injury ◽  
2017 ◽  
Vol 32 (2) ◽  
pp. 191-199 ◽  
Author(s):  
Elizabeth J. Woytowicz ◽  
Chandler Sours ◽  
Rao P. Gullapalli ◽  
Joseph Rosenberg ◽  
Kelly P. Westlake
Keyword(s):  
Traumatic Brain Injury ◽  
Working Memory ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Memory Load ◽  
Working Memory Load

Assessment of Executive Function in Patients with Mild Traumatic Brain Injury

1999 ◽  
Vol 46 (1) ◽  
pp. 159-163 ◽  
Author(s):  
Jill Brooks ◽  
Lori A. Fos ◽  
Kevin W. Greve ◽  
Jeffrey S. Hammond
Keyword(s):  
Traumatic Brain Injury ◽  
Executive Function ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury

scholarly journals Effect of Age on Working Memory Performance and Cerebral Activation after Mild Traumatic Brain Injury: A Functional MR Imaging Study

Radiology ◽  
2016 ◽  
Vol 278 (3) ◽  
pp. 854-862 ◽  
Author(s):  
David Yen-Ting Chen ◽  
Hui-Ling Hsu ◽  
Ying-Sheng Kuo ◽  
Changwei Wesley Wu ◽  
Wen-Ta Chiu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Working Memory ◽  
Brain Injury ◽  
Mr Imaging ◽  
Mild Traumatic Brain Injury ◽  
Memory Performance ◽  
Imaging Study ◽  
Cerebral Activation ◽  
Functional Mr Imaging ◽  
Effect Of Age

Cognitive Rehabilitation Interventions for Executive Function: Moving from Bench to Bedside in Patients with Traumatic Brain Injury

2006 ◽  
Vol 18 (7) ◽  
pp. 1212-1222 ◽  
Author(s):  
Keith Cicerone ◽  
Harvey Levin ◽  
James Malec ◽  
Donald Stuss ◽  
John Whyte
Keyword(s):  
Traumatic Brain Injury ◽  
Executive Function ◽  
Brain Injury ◽  
Cognitive Neuroscience ◽  
Cognitive Rehabilitation ◽  
Diffuse Axonal Injury ◽  
Executive Dysfunction ◽  
Distributed Networks ◽  
Neural Mechanisms ◽  
Focal Lesions

Executive function mediated by prefrontally driven distributed networks is frequently impaired by traumatic brain injury (TBI) as a result of diffuse axonal injury and focal lesions. In addition to executive cognitive functions such as planning and working memory, the effects of TBI impact social cognition and motivation processes. To encourage application of cognitive neuroscience methods to studying recovery from TBI, associated reorganization of function, and development of interventions, this article reviews the pathophysiology of TBI, critiques currently employed methods of assessing executive function, and evaluates promising interventions that reflect advances in cognitive neuroscience. Brain imaging to identify neural mechanisms mediating executive dysfunction and response to interventions following TBI is also discussed.

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