scholarly journals CXCL9: a biomarker for the coronary slow flow phenomenon in patients with coronary artery disease

2019 ◽  
Author(s):  
youfeng Liang ◽  
xianhe Lin ◽  
yuanyuan Xu ◽  
chunmiao Wang ◽  
Qi Zhou
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Multivariate Logistic Regression Analysis ◽  
Serum Levels ◽  
Slow Flow ◽  
Flow Phenomenon ◽  
Coronary Slow Flow ◽  
Ifn Γ ◽  
Artery Disease ◽  
Coronary Slow Flow Phenomenon

Abstract Background: Atherosclerosis is a chronic inflammatory disease. The pathology underlying the disease consists of accumulation of the extracellular matrix, lipid and inflammatory cells. Coronary Slow Flow Phenomenon (CSFP) is closely related to inflammatory responses, while chemokines play an important role in the progression of atherosclerosis. However, the relationship between chemokines and CSFP is unclear. In this study, our aims were to evaluate the association between CXC Chemokines 9 (CXCL9) levels and CSFP in patients with coronary artery disease. Methods: We studied 46 patients diagnosed with CSFP and classed them as the CSFP group. 50 patients with normal coronary angiography (CAG) were randomly selected as the no-CSFP group in our study. The mean TIMI frame count was used to measure coronary blood flow velocity. The clinical and biochemical index, including serum levels of IL1, IL-6, IL-10, CXCL9, CD40L and interferon-γ (IFN-γ), were analyzed in all subjects. Results: The serum levels of IL-1, IL-6, IL-10, CXCL9, CD40L, IFN-γ and CXCL9 in the CSFP group were significantly higher than those in the no-CSFP group, with the differences being statistically significant (p<0.001). Furthermore, Pearson's correlation analysis reflected a significant positive correlation (r=0.171, p=0.01) in CXCL9 levels. Multivariate logistic regression analysis showed that CXCL9 are important risk factors for CSFP (β=1.795, P=0.000). Subsequent ROC curve analyses indicated that the serum CXCL9 levels demonstrated a high diagnostic value in differentiating patients with CSFP from that of normal controls (Area Under the Curve = 0.758) and the serum CXCL9 level of 131.915 mg/L was a predictor of CSFP, with a sensitivity of 54.3% and a specificity of 96.0%. Conclusions: Our findings are indicative of the potential clinical implications of CXCL9 in the occurrence and development of CSFP.

scholarly journals CXCL9: a biomarker for the coronary slow flow phenomenon in patients with coronary artery disease

2019 ◽  
Author(s):  
youfeng Liang ◽  
xianhe Lin ◽  
yuanyuan Xu ◽  
chunmiao Wang ◽  
Qi Zhou
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Inflammatory Responses ◽  
Multivariate Logistic Regression Analysis ◽  
Area Under The Curve ◽  
Serum Levels ◽  
Chronic Inflammatory Disease ◽  
Timi Frame Count ◽  
Ifn Γ ◽  
Artery Disease

Abstract Background: Atherosclerosis is a chronic inflammatory disease. The pathology underlying the disease consists of accumulation of the extracellular matrix, lipid and inflammatory cells. Coronary s low f low p henomenon (CSFP) is closely related to inflammatory responses, while chemokines plays an important role in the progression of atherosclerosis. However, the relationship between chemokines and CSFP is still unclear. In this study, our aims were to evaluate the association between CXC Chemokines 9 (CXCL9) levels and CSFP in patients with coronary artery disease. Methods: We studied 46 patients diagnosed with CSFP and classifyed them as the CSFP group. 50 patients with normal coronary angiography (CAG) were randomly selected as the no-CSFP group in our study. The mean TIMI frame count (TFC) was used to measure coronary blood flow velocity. The clinical and biochemical index, including serum levels of IL1, IL-6, IL-10, CXCL9, CD40L and interferon- γ (IFN- γ ), were analyzed in all subjects. Results: The serum levels of IL-1, IL-6, IL-10, CXCL9, CD40L, IFN- γ and CXCL9 in the CSFP group were significantly higher than those in the no-CSFP group, with the differences being statistically significant (p<0.001). Furthermore, Pearson's correlation analysis reflected a significant positive correlation (r=0.171, p=0.01) in CXCL9 levels. Multivariate logistic regression analysis showed that CXCL9 is an important risk factor for CSFP ( β =1.795, P =0.000). Subsequent ROC curve analyses indicated that the serum CXCL9 levels demonstrated a high diagnostic value in differentiating patients with CSFP from that of normal controls (Area Under the Curve = 0.758) and the serum CXCL9 level of 131.915 mg/L was a predictor of CSFP, with a sensitivity of 54 . 3 % and a specificity of 96.0%, respectively. Conclusions: Our findings are indicative of the potential clinical implications of CXCL9 in the occurrence and development of CSFP.

Antibodies to N-homocysteinylated albumin as a marker for earlyonset coronary artery disease in men

2005 ◽  
Vol 93 (02) ◽  
pp. 346-350 ◽  
Author(s):  
Anetta Undas ◽  
Milosz Jankowski ◽  
Magdalena Twardowska ◽  
Agnieszka Padjas ◽  
Hieronim Jakubowski ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Multivariate Logistic Regression Analysis ◽  
Mthfr C677t ◽  
Serum Levels ◽  
Autoimmune Response ◽  
Mthfr C677t Polymorphism ◽  
Protein Levels ◽  
Reactive Protein ◽  
Artery Disease

Summary N-homocysteinylated (Nε-Hcy) proteins and corresponding antibodies have recently been discovered in humans and animals. Increased autoimmune response to Nε -Hcy-proteins has been reported in stroke patients. The aim of the present study was to investigate whether antibodies against N-homocysteinylated albumin are associated with coronary artery disease (CAD).We studied 88 male patients aged 50 years or under with angiographically documented CAD and 100 age-matched apparently healthy men as controls. Serum levels of IgG antibodies against Nε-Hcy-albumin were determined using an enzymelinked immunosorbent assay. Seropositivity to anti-Nε -Hcy-albumin antibodies was 5-fold more frequent in CAD patients than in controls (52.3 % vs 10.0 %; p<0.0001). Plasma Hcy levels in CAD patients were also significantly higher in the former than in the latter group (medians, 13.0 μ M vs 12.1 μ M; p=0.026). Importantly, 41.2% of subjects with plasma total Hcy >14.5 mM were seropositive compared with 25.5 % of normohomocysteinemic individuals (p=0.048).There was a weak correlation between anti-Nε-Hcy-albumin antibodies and Hcy levels (r=0.16; p=0.03). By multivariate logistic regression analysis, seropositivity to anti-Nε-Hcy-albumin antibodies was an independent predictor of early CAD (OR, 14.82; 95% CI, 4.47 to 49.19; p=0.00002). Interestingly, anti-Nε-Hcy-albumin antibodies were associated with C-reactive protein levels (r=0.24; p=0.002). Seropositivity to anti-Nε-Hcy-albumin antibodies showed no association with the MTHFR C677T polymorphism. Our results suggest that seropositivity to antibodies against Nε-homocysteinylated albumin is associated with early-onset CAD. An autoimmune response to Nε-Hcy-albumin may represent a novel mechanism involved in the early development of CAD.

scholarly journals Evaluation of prevalence, clinical presentation and risk factors of coronary slow flow phenomenon: a single-center study

2021 ◽  
Vol 9 (4) ◽  
pp. 1106
Author(s):  
Shaileshkumar Patil ◽  
Achyut Sarkar ◽  
Manisha Patil ◽  
Imran Ahmed ◽  
Arindam Pande
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Unstable Angina ◽  
Clinical Presentation ◽  
Slow Flow ◽  
Flow Phenomenon ◽  
Vessel Disease ◽  
Coronary Slow Flow ◽  
Group 3 ◽  
Coronary Slow Flow Phenomenon

Background: The coronary slow flow phenomenon has been revealed to be associated with life-threatening arrhythmias and sudden cardiac death. Currently, clinical features and risk factors of patients with the coronary slow flow phenomenon are incompletely understood. The present study aimed to evaluate the prevalence, clinical presentation, risk factors and evidence of ischemia in patients with coronary slow flow.Methods: This observational study was conducted at a tertiary-care center in India between February 2013 and August 2014.  A total of 60 consecutive patients whose coronary angiogram revealed coronary slow flow were included in the study. According to the number of blood vessels involved, patients were divided into group-1 (29 patients with single-vessel disease), group-2 (22 patients with double-vessel disease), and group-3 (9 patients with triple-vessel disease). Clinical presentation and risk factors were compared among groups.Results: Prevalence of coronary slow flow was 2.97% with greater prevalence amongst male patients (p=0.030). Unstable angina was the most common presentation (p=0.030). Among the traditional risk factors, there was a significantly higher prevalence of smoking (p=0.036), family history of coronary artery disease (p=0.049) and dyslipidemia (p=0.045) in group-3 patients compared to other groups. Among all groups, triglycerides (p=0.020), low-density lipoprotein cholesterol (p=0.046), highly sensitive C-reactive protein (p=0.007) levels, homocysteine (p=0.481), and patterns of ECG abnormalities were significantly different between the three groups. In addition, mean frame counts with coronary slow flow phenomenon in left anterior descending artery (p<0.001), left circumflex artery (p<0.001) and right coronary artery (p=0.005) increased significantly with increase in number of vessels involved.Conclusions: Coronary slow flow was relatively common among patients who presented with unstable angina. Male sex, smoking, and dyslipidemia can be considered as independent risk factors for this phenomenon.  

scholarly journals Comparison of Tumor Necrosis Factor-α Level in Coronary Artery Disease and Coronary Slow Flow of Thrombolysis in Myocardial Infarction

2019 ◽  
Vol 11 (3) ◽  
pp. 299-303
Author(s):  
Muhammad Diah ◽  
Rahmawati Rahmawati ◽  
Aznan Lelo ◽  
Zulfikri Muhktar ◽  
Dharma Lindarto ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Healthy Subjects ◽  
Slow Flow ◽  
Timi Frame Count ◽  
Tnf Α ◽  
Significant Difference ◽  
Coronary Slow Flow ◽  
Artery Disease ◽  
Α Level

BACKGROUND: Tumor necrosis factor (TNF)-α, an important primary pro-inflammatory cytokine, has a crucial role in the pathogenesis of atherosclerosis. Since the pathophysiological mechanism of coronary slow flow (CSF) is not fully understood, we investigated the level of TNF-α in coronary artery disease (CAD), CSF and healthy subjects.METHODS: This study was conducted in cross-sectional design involving 16 CAD, 18 CSF and 18 healthy subjects. Coronary angiography was recorded at the left anterior oblique, cranial, right anterior oblique, caudal, and horizontal positions. The flow in coronary arteries of the subjects were assessed using Thrombolysis in the Myocardial Infarction (TIMI) frame count method. Peripheral blood-derived serum was collected and level of TNF-α was determined by using highly sensitive enzymelinked immunosorbent assay (ELISA).RESULTS: No significant difference in level of TNF-α in CAD, CSF and healthy subjects (2.72±2.64 pg/mL, 1.88±0.8 pg/mL, 1.64±0.35 pg/mL, respectively) (p=0.087). In addition, there was no correlation between the concentration of TNF-α and TIMI frame count (r<0.2, p>0.05).CONCLUSION: There was no significant difference of TNF-α level in CAD, CSF and healthy subjects. In addition, there was no correlation between the TNF-α level with TIMI frame count as well. Nevertheless, further clinical studies with more subjects are needed.KEYWORDS: TNF-alpha, coronary artery disease, coronary slow flow 

scholarly journals Could neutrophil/lymphocyte ratio be an indicator of coronary artery disease, coronary artery ectasia and coronary slow flow?

2016 ◽  
Vol 44 (6) ◽  
pp. 1443-1453 ◽  
Author(s):  
Mücahid Yılmaz ◽  
Hasan Korkmaz ◽  
Mehmet Nail Bilen ◽  
Ökkeş Uku ◽  
Ertuğrul Kurtoğlu
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Slow Flow ◽  
Coronary Artery Ectasia ◽  
Operating Characteristics ◽  
Coronary Anatomy ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Coronary Slow Flow ◽  
Artery Disease

Objective To determine whether neutrophil/lymphocyte ratio (NLR) differed between patients with isolated coronary artery disease (CAD), isolated coronary artery ectasia (CAE), coronary slow flow and normal coronary anatomy. Methods Patients who underwent coronary angiography were consecutively enrolled into one of four groups: CAD, coronary slow flow, CAE and normal coronary anatomy. Results The CAD ( n = 40), coronary slow flow ( n = 40), and CAE ( n = 40) groups had similar NLRs (2.51 ± 0.7, 2.40 ± 0.8, 2.6 ± 0.6, respectively) that were significantly higher than patients with normal coronary anatomy ( n = 40; NLR, 1.73 ± 0.7). Receiver operating characteristics demonstrated that with NLR > 2.12, specificity in predicting isolated CAD was 85% and sensitivity was 75%, with NLR > 2.22 specificity in predicting isolated CAE was 86% and sensitivity was 75%. With NLR > 1.92, specificity in predicting coronary slow flow was 89% and sensitivity was 75%. Multivariate logistic regression analyses identified NLR as an independent predictor of isolated CAE (β = −0.499, 95% CI −0.502, −0.178; P <  0.001), CAD (β = −0.426, 95% CI −1.321, −0.408; P <  0.001), and coronary slow flow (β = −0.430, 95% CI −0.811, −0.240; P = 0.001 Table 2 ). Conclusions NLR was higher in patients with CAD, coronary slow flow and CAE versus normal coronary anatomy. NLR may be an indicator of CAD, CAE and coronary slow flow.

Evaluation of blood rheology in patients with coronary slow flow or non-obstructive coronary artery disease

2013 ◽  
Vol 53 (4) ◽  
pp. 317-326 ◽  
Author(s):  
Muhammet Bilgi ◽  
Hakan Güllü ◽  
İlknur Kozanoğlu ◽  
Hakan Özdoğu ◽  
Nurzen Sezgin ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Obstructive Coronary Artery Disease ◽  
Blood Rheology ◽  
Slow Flow ◽  
Coronary Slow Flow ◽  
Artery Disease
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