Prevalence Of Syphilis, Neurosyphilis And Associated Factors In a Cross-Sectional Analysis Of HIV Infected Patients Attending Bugando Medical Centre Mwanza Tanzania

Abstract BACKGROUND HIV-syphilis co-infection is a combination that enhances rapid progression of early syphilis or late latent syphilis to neurosyphilis and can cause catastrophic neurological complications. In studies in Mwanza, syphilis affects ~8% of healthy outpatients, and older studies have suggested that up to 23.5% of HIV-syphilis co-infected patients also have neurosyphilis

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Prevalence Of Syphilis, Neurosyphilis And Associated Factors In a Cross-Sectional Analysis Of HIV Infected Patients Attending Bugando Medical Centre Mwanza Tanzania

10.21203/rs.2.13375/v2 ◽

2020 ◽

Author(s):

Adeodatus Richard Haule ◽

Betrand Msemwa ◽

Evarista Mgaya ◽

Peter Masikini ◽

Samuel Kalluvya

Keyword(s):

Associated Factors ◽

Neurological Complications ◽

Medical Centre ◽

Rapid Progression ◽

Cross Sectional ◽

Early Syphilis ◽

Bugando Medical ◽

Sectional Analysis ◽

Bugando Medical Centre ◽

Latent Syphilis

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Prevalence Of Syphilis, Neurosyphilis And Associated Factors In a Cross-Sectional Analysis Of HIV Infected Patients Attending Bugando Medical Centre Mwanza Tanzania

10.21203/rs.2.13375/v1 ◽

2019 ◽

Author(s):

Adeodatus Richard Haule ◽

Evarista Mgaya ◽

Peter Masikini ◽

Betrand Msemwa ◽

Samuel Kalluvya

Keyword(s):

Lumbar Puncture ◽

Associated Factors ◽

Medical Center ◽

Treponema Pallidum ◽

Neurological Complications ◽

Cross Sectional Study ◽

Rapid Progression ◽

Cross Sectional ◽

Bugando Medical ◽

High Prevalence

Abstract Background: HIV-syphilis co-infection is a combination that enhances rapid progression of early syphilis or late latent syphilis to neurosyphilis and can cause catastrophic neurological complications. In studies in Mwanza, syphilis affects ~8% of healthy outpatients, and older studies have suggested that up to 23.5% of HIV-syphilis co-infected patients also have neurosyphilis. The study aimed at determining the prevalence of syphilis, neurosyphilis and associated factors among HIV infected patients attending Bugando Medical Center.Methods: This was a cross sectional study in which HIV infected patients who were hospitalized or attending the outpatient Care and Treatment Clinic (CTC) were interviewed using structured questionnaire and screened for syphilis using serum Treponema Pallidum hemagglutination assay (TPHA). We included all HIV-infected persons aged 18 years and above who consented. Blood was also taken for CD4+ T cells and viral load. Those who were found to have syphilis underwent neurological examination for any neurologic deficit and offered lumbar puncture.Results: The prevalence of syphilis in HIV infected patients was found to be 9.6%. The majority of these were female (72.5%) and median age was 42 years [interquartile range, 32-50]. Most patients were on ART (99.4%).The majority of participants with syphilis (89.2%) reported not knowing that they had syphilis, and had not previously been treated. One hundred forty one participants with syphilis had neurological examinations performed, 4 of whom had abnormal findings that necessitated that they undergo lumbar puncture. One of these had confirmed neurosyphilis.Conclusion: The high prevalence of syphilis in HIV infected patients indicates that there is a need to increase efforts in targeting this population to reduce sexually transmitted infections. Screening for syphilis should be done for all HIV patients given the high prevalence of the infection and the risk that aggressive forms of neurosyphilis can occur despite recovery of CD4+Tcell counts in untreated syphilis.

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Prevalence of syphilis, neurosyphilis and associated factors in a cross-sectional analysis of HIV infected patients attending Bugando Medical Centre, Mwanza, Tanzania

BMC Public Health ◽

10.1186/s12889-020-09984-9 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Adeodatus Haule ◽

Betrand Msemwa ◽

Evarista Mgaya ◽

Peter Masikini ◽

Samuel Kalluvya

Keyword(s):

Lumbar Puncture ◽

Treponema Pallidum ◽

Neurological Complications ◽

Cross Sectional Study ◽

Rapid Progression ◽

Cross Sectional ◽

Sexually Transmitted ◽

Cell Counts ◽

High Prevalence ◽

Sectional Analysis

Abstract Background HIV-syphilis co-infection can enhance the rapid progression of early or late latent syphilis to neurosyphilis and can cause catastrophic neurological complications. In studies in Mwanza, syphilis affects ~ 8% of healthy outpatients and studies done in the 1990s have suggested that up to 23.5% of HIV-syphilis co-infected patients also have neurosyphilis. Methodology This was a cross sectional study in which adult HIV infected patients who were hospitalized or attending the outpatient Care and Treatment Clinic (CTC) were interviewed using a structured questionnaire and screened for syphilis using serum Treponema Pallidum Hemagglutination Assay (TPHA). Blood was also taken for CD4+ T cells and viral load. Those who were found to have syphilis underwent neurological examination for any neurologic deficit and were offered a lumbar puncture. Results The prevalence of syphilis in HIV infected patients was found to be 9.6%. The majority of patients were female (72.5%) and median age was 42 years [interquartile range, 32–50]. Most patients were on ART (99.4%). In the study population of 1748 participants, 9.6% were TPHA positive; the majority (89.2%) reported not knowing their syphilis status and not previously been treated. One hundred and forty-one participants with syphilis had neurological examinations performed. Four of these had abnormal findings that necessitated a lumbar puncture. Neurosyphilis was confirmed in one patient (0.7%). Conclusion The high prevalence of syphilis in HIV infected patients indicates that there is a need to increase efforts in targeting this population to reduce sexually transmitted infections. Screening for syphilis should be done for all HIV patients given the high prevalence of the infection and the risk that aggressive forms of neurosyphilis can occur despite recovery of CD4+ T cell counts in untreated syphilis.

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Predictors of foeto-maternal outcome of patients with abruptio placenta at Bugando Medical Centre, Tanzania

Tanzania Journal of Health Research ◽

10.4314/thrb.v18i1.3 ◽

2015 ◽

Vol 18 (1) ◽

Author(s):

Dismas Matovelo ◽

Kelvin Nandonde ◽

Anthony Massinde ◽

Richard Rumanyika

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Birth Asphyxia ◽

Cross Sectional Study ◽

Adverse Outcomes ◽

Medical Centre ◽

Cross Sectional ◽

Bugando Medical ◽

Abruptio Placenta ◽

Bugando Medical Centre

Background: Abruptio placenta (AP) is one of the life-threatening obstetric complications for both the foetus and mother. We conducted this study to determine the incidence and predictors of adverse outcomes of abruptio placenta at Bugando Medical Centre (BMC) in northwest Tanzania.Methods: This descriptive cross-sectional study was conducted from October 2012 to April 2013. Women with clinical features of abruptio placenta attending BMC were recruited. Data were collected using a structured checklist and analysed with STATA 11.Results: A total of 3,800 deliveries occurred during study period. The incidence of AP was 2.5% (95/3800). Among patients with AP, 49 (51.6%) delivered by Caesarean section. Three (3.2%) maternal deaths occurred. These deaths were strongly associated with the presence of maternal anaemia (p<0.05), and postpartum haemorrhage (p<0.05). The foetal adverse outcomes were prematurity 78 (82.1%), foetal distress 65 (68.4%), low birth weight 46 (48.4%) and intrauterine foetal deaths 30 (31.6%). Perinatal deaths occurred in 52 (54.7 %) of the cases, and were predicted by low birth weight (p<0.001), vaginal delivery (p=0.001), birth asphyxia (p<0.001), and retroplacental clot (>700ml) (p<0.001).Conclusion: The incidence of AP at BMC is high and characterised by poor maternal and foetal outcomes. Patients with AP should be delivered promptly to improve their survival.

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Prevalence of bacterial vaginosis and associated factors among pregnant women attending at Bugando Medical Centre, Mwanza, Tanzania

Tanzania Journal of Health Research ◽

10.4314/thrb.v14i3.3 ◽

2012 ◽

Vol 14 (3) ◽

Cited By ~ 1

Author(s):

Anthony N. Massinde ◽

Prosper A. Shayo ◽

Albert Kihunrwa ◽

Miriam Mirambo ◽

Richard N. Rumanyika ◽

...

Keyword(s):

Bacterial Vaginosis ◽

Pregnant Women ◽

Associated Factors ◽

Medical Centre ◽

Bugando Medical ◽

Bugando Medical Centre

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Prevalence Of Syphilis, Neurosyphilis And Associated Factors In a Cross-Sectional Analysis Of HIV Infected Patients Attending Bugando Medical Centre Mwanza Tanzania

10.21203/rs.2.13375/v4 ◽

2020 ◽

Author(s):

Adeodatus Richard Haule ◽

Betrand Msemwa ◽

Evarista Mgaya ◽

Peter Masikini ◽

Samuel Kalluvya

Keyword(s):

Lumbar Puncture ◽

Treponema Pallidum ◽

Neurological Complications ◽

Cross Sectional Study ◽

Rapid Progression ◽

Cross Sectional ◽

Sexually Transmitted ◽

Cell Counts ◽

High Prevalence ◽

Sectional Analysis

Abstract Background: HIV-syphilis co-infection can enhance the rapid progression of early or late latent syphilis to neurosyphilis and can cause catastrophic neurological complications. In studies in Mwanza, syphilis affects ~8% of healthy outpatients and studies done in the 1990s have suggested that up to 23.5% of HIV-syphilis co-infected patients also have neurosyphilis.Methodology: This was a cross sectional study in which adult HIV infected patients who were hospitalized or attending the outpatient Care and Treatment Clinic (CTC) were interviewed using a structured questionnaire and screened for syphilis using serum Treponema Pallidum Hemagglutination Assay (TPHA). Blood was also taken for CD4+ T cells and viral load. Those who were found to have syphilis underwent neurological examination for any neurologic deficit and were offered a lumbar puncture. Results: The prevalence of syphilis in HIV infected patients was found to be 9.6%. The majority of patients were female (72.5%) and median age was 42 years [interquartile range, 32-50]. Most patients were on ART (99.4%). In the study population of 1748 participants, 9.6% were TPHA positive; the majority (89.2%) reported not knowing their syphilis status and not previously been treated. One hundred and forty-one participants with syphilis had neurological examinations performed. Four of these had abnormal findings that necessitated a lumbar puncture. Neurosyphilis was confirmed in one patient (0.7%).Conclusion: The high prevalence of syphilis in HIV infected patients indicates that there is a need to increase efforts in targeting this population to reduce sexually transmitted infections. Screening for syphilis should be done for all HIV patients given the high prevalence of the infection and the risk that aggressive forms of neurosyphilis can occur despite recovery of CD4+ T cell counts in untreated syphilis.

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Blood transfusion practice in surgery at Bugando Medical Centre in northwestern Tanzania

Tanzania Journal of Health Research ◽

10.4314/thrb.v18i1.2 ◽

2015 ◽

Vol 18 (1) ◽

Author(s):

Phillipo L Chalya ◽

Fidelis Mbunda ◽

Joseph B Mabula ◽

Anthony N Massinde ◽

Albert Kihunrwa ◽

...

Keyword(s):

Blood Transfusion ◽

Cross Sectional Study ◽

Transfusion Practice ◽

Medical Centre ◽

Cross Sectional ◽

Emergency Operations ◽

Bugando Medical ◽

Blood Utilization ◽

Bugando Medical Centre ◽

Cross Matching

Background: Preoperative over-ordering of blood for surgical intervention, in excess of the actual and anticipated needs is a common practice in many developing countries. This can be decreased by simple means of changing the blood cross matching and ordering schedule depending upon the type of surgery performed. The aim of this study was to assess the blood transfusion practice in surgery at Bugando Medical Centre in northwestern Tanzania.Methods and Patients: This was a prospective cross sectional study among patients undergoing major operations at Bugando Medical Centre. We evaluated blood ordering and transfusion practices in emergency and elective surgical procedures at our centre and calculated different indices such as cross-match to transfusion ratio (C/T ratio), transfusion probability (% T) and transfusion index (TI). Next Maximal Surgical Blood Ordering System (MSBOS) was estimated for each procedure.Results: The overall blood utilization was only 28.2% at our centre, consisting of 17.1% in the elective operations and 26.9% in the emergency operations. Significant blood utilization was nil in most of the routine elective cases suggesting cross-matching of blood to be a culture than necessity. Generally, the overall blood transfusion of the requested blood as indicated by indices of C/T ratio, %T, TI and MSBOS were 3.5, 28.7%, 0.33 and 0.45, respectively. The overall CT ratio, %T, Ti and MSBOS in the elective operations were 5.8, 15.9%, 0.2 and 0.3, respectively. In the emergency operations, the overall CT ratio, %T, Ti and MSBOS were 3.7, 22%, 0.32 and 0.48, respectively.Conclusion: This study demonstrated that over-ordering of blood in excess of the actual needs is a common practice in our setting. Blood ordering pattern needs to be revised and over-ordering of blood should be minimized. This can be possible by the estimation of MSBOS for each procedure and requisition as calculated.

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