scholarly journals Prevalence Of Syphilis, Neurosyphilis And Associated Factors In a Cross-Sectional Analysis Of HIV Infected Patients Attending Bugando Medical Centre Mwanza Tanzania

2020 ◽  
Author(s):  
Adeodatus Richard Haule ◽  
Betrand Msemwa ◽  
Evarista Mgaya ◽  
Peter Masikini ◽  
Samuel Kalluvya
Keyword(s):  
Lumbar Puncture ◽  
Treponema Pallidum ◽  
Neurological Complications ◽  
Cross Sectional Study ◽  
Rapid Progression ◽  
Cross Sectional ◽  
Sexually Transmitted ◽  
Cell Counts ◽  
High Prevalence ◽  
Sectional Analysis

Abstract Background: HIV-syphilis co-infection can enhance the rapid progression of early or late latent syphilis to neurosyphilis and can cause catastrophic neurological complications. In studies in Mwanza, syphilis affects ~8% of healthy outpatients and studies done in the 1990s have suggested that up to 23.5% of HIV-syphilis co-infected patients also have neurosyphilis.Methodology: This was a cross sectional study in which adult HIV infected patients who were hospitalized or attending the outpatient Care and Treatment Clinic (CTC) were interviewed using a structured questionnaire and screened for syphilis using serum Treponema Pallidum Hemagglutination Assay (TPHA). Blood was also taken for CD4+ T cells and viral load. Those who were found to have syphilis underwent neurological examination for any neurologic deficit and were offered a lumbar puncture. Results: The prevalence of syphilis in HIV infected patients was found to be 9.6%. The majority of patients were female (72.5%) and median age was 42 years [interquartile range, 32-50]. Most patients were on ART (99.4%). In the study population of 1748 participants, 9.6% were TPHA positive; the majority (89.2%) reported not knowing their syphilis status and not previously been treated. One hundred and forty-one participants with syphilis had neurological examinations performed. Four of these had abnormal findings that necessitated a lumbar puncture. Neurosyphilis was confirmed in one patient (0.7%).Conclusion: The high prevalence of syphilis in HIV infected patients indicates that there is a need to increase efforts in targeting this population to reduce sexually transmitted infections. Screening for syphilis should be done for all HIV patients given the high prevalence of the infection and the risk that aggressive forms of neurosyphilis can occur despite recovery of CD4+ T cell counts in untreated syphilis.

scholarly journals Prevalence of syphilis, neurosyphilis and associated factors in a cross-sectional analysis of HIV infected patients attending Bugando Medical Centre, Mwanza, Tanzania

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Adeodatus Haule ◽  
Betrand Msemwa ◽  
Evarista Mgaya ◽  
Peter Masikini ◽  
Samuel Kalluvya
Keyword(s):  
Lumbar Puncture ◽  
Treponema Pallidum ◽  
Neurological Complications ◽  
Cross Sectional Study ◽  
Rapid Progression ◽  
Cross Sectional ◽  
Sexually Transmitted ◽  
Cell Counts ◽  
High Prevalence ◽  
Sectional Analysis

Abstract Background HIV-syphilis co-infection can enhance the rapid progression of early or late latent syphilis to neurosyphilis and can cause catastrophic neurological complications. In studies in Mwanza, syphilis affects ~ 8% of healthy outpatients and studies done in the 1990s have suggested that up to 23.5% of HIV-syphilis co-infected patients also have neurosyphilis. Methodology This was a cross sectional study in which adult HIV infected patients who were hospitalized or attending the outpatient Care and Treatment Clinic (CTC) were interviewed using a structured questionnaire and screened for syphilis using serum Treponema Pallidum Hemagglutination Assay (TPHA). Blood was also taken for CD4+ T cells and viral load. Those who were found to have syphilis underwent neurological examination for any neurologic deficit and were offered a lumbar puncture. Results The prevalence of syphilis in HIV infected patients was found to be 9.6%. The majority of patients were female (72.5%) and median age was 42 years [interquartile range, 32–50]. Most patients were on ART (99.4%). In the study population of 1748 participants, 9.6% were TPHA positive; the majority (89.2%) reported not knowing their syphilis status and not previously been treated. One hundred and forty-one participants with syphilis had neurological examinations performed. Four of these had abnormal findings that necessitated a lumbar puncture. Neurosyphilis was confirmed in one patient (0.7%). Conclusion The high prevalence of syphilis in HIV infected patients indicates that there is a need to increase efforts in targeting this population to reduce sexually transmitted infections. Screening for syphilis should be done for all HIV patients given the high prevalence of the infection and the risk that aggressive forms of neurosyphilis can occur despite recovery of CD4+ T cell counts in untreated syphilis.

scholarly journals Prevalence Of Syphilis, Neurosyphilis And Associated Factors In a Cross-Sectional Analysis Of HIV Infected Patients Attending Bugando Medical Centre Mwanza Tanzania

2019 ◽  
Author(s):  
Adeodatus Richard Haule ◽  
Evarista Mgaya ◽  
Peter Masikini ◽  
Betrand Msemwa ◽  
Samuel Kalluvya
Keyword(s):  
Lumbar Puncture ◽  
Associated Factors ◽  
Medical Center ◽  
Treponema Pallidum ◽  
Neurological Complications ◽  
Cross Sectional Study ◽  
Rapid Progression ◽  
Cross Sectional ◽  
Bugando Medical ◽  
High Prevalence

Abstract Background: HIV-syphilis co-infection is a combination that enhances rapid progression of early syphilis or late latent syphilis to neurosyphilis and can cause catastrophic neurological complications. In studies in Mwanza, syphilis affects ~8% of healthy outpatients, and older studies have suggested that up to 23.5% of HIV-syphilis co-infected patients also have neurosyphilis. The study aimed at determining the prevalence of syphilis, neurosyphilis and associated factors among HIV infected patients attending Bugando Medical Center.Methods: This was a cross sectional study in which HIV infected patients who were hospitalized or attending the outpatient Care and Treatment Clinic (CTC) were interviewed using structured questionnaire and screened for syphilis using serum Treponema Pallidum hemagglutination assay (TPHA). We included all HIV-infected persons aged 18 years and above who consented. Blood was also taken for CD4+ T cells and viral load. Those who were found to have syphilis underwent neurological examination for any neurologic deficit and offered lumbar puncture.Results: The prevalence of syphilis in HIV infected patients was found to be 9.6%. The majority of these were female (72.5%) and median age was 42 years [interquartile range, 32-50]. Most patients were on ART (99.4%).The majority of participants with syphilis (89.2%) reported not knowing that they had syphilis, and had not previously been treated. One hundred forty one participants with syphilis had neurological examinations performed, 4 of whom had abnormal findings that necessitated that they undergo lumbar puncture. One of these had confirmed neurosyphilis.Conclusion: The high prevalence of syphilis in HIV infected patients indicates that there is a need to increase efforts in targeting this population to reduce sexually transmitted infections. Screening for syphilis should be done for all HIV patients given the high prevalence of the infection and the risk that aggressive forms of neurosyphilis can occur despite recovery of CD4+Tcell counts in untreated syphilis.

scholarly journals Prevalence of urogenital, anal, and pharyngeal infections with Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium: a cross-sectional study in Reunion island

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
A. Calas ◽  
N. Zemali ◽  
G. Camuset ◽  
J. Jaubert ◽  
R. Manaquin ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Neisseria Gonorrhoeae ◽  
Mycoplasma Genitalium ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Transmitted Infection ◽  
Cross Sectional ◽  
Sexually Transmitted ◽  
Urogenital Infection ◽  
High Prevalence

Abstract Background Recommendations for sexually transmitted infection (STI) screening vary significantly across countries. This study evaluated the prevalence of urogenital and extragenital infections with Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Mycoplasma genitalium (MG) in patients visiting a French STI clinic in the Indian Ocean region to determine whether current STI screening practices should be updated. Methods This cross-sectional study examined all patients who visited the STI clinic between 2014 and 2015. Triplex polymerase chain reaction screening for CT, NG, and MG was performed on urine, vaginal, pharyngeal, and anal specimens (FTD Urethritis Basic Kit, Fast Track Diagnostics, Luxembourg). Results Of the 851 patients enrolled in the study, 367 were women (367/851, 43.2%) and 484 were men (484/851, 56.0%). Overall, 826 urogenital specimens (826/851, 97.1%), 606 pharyngeal specimens (606/851, 71.2%), and 127 anal specimens (127/851, 14.9%) were taken from enrolled patients. The prevalence of urogenital CT and MG was high in women ≤25 years (19/186, 10.21%; 5/186, 2.69%) and in men who have sex with women ≤30 years (16/212, 7.54%; 5/212, 2.36%). Among patients with urogenital CT infection, 13.7% (7/51) had urethritis. All patients with urogenital MG infection were asymptomatic. Men who have sex with men had a high prevalence of pharyngeal CT (2/45, 4.44%) and NG (3/44, 6.81%) and a high prevalence of anal CT (2/27, 7.41%), NG (2/27, 7.40%), and MG (1/27, 3.70%). After excluding patients with concomitant urogenital infection, extragenital infections with at least 1 of the 3 pathogens were found in 20 swabs (20/91, 21.9%) taken from 16 patients (16/81, 19.7%), all of them asymptomatic. Conclusions Routine multisite screening for CT, NG, and MG should be performed to mitigate the transmission of STIs in high-risk sexually active populations.

High Prevalence of Sexually Transmitted Infections and Risk Factors Among HIV-Positive Individuals in Yunnan, China

2021 ◽  
Author(s):  
Wei Tu ◽  
Yu-Ye Li ◽  
Yi-Qun Kuang ◽  
Rong-Hui Xie ◽  
Xing-Qi Dong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sexually Transmitted Infections ◽  
Genital Tract ◽  
Mycoplasma Genitalium ◽  
Cross Sectional Study ◽  
Multiple Infections ◽  
Hiv Positive ◽  
Cross Sectional ◽  
Sexually Transmitted ◽  
High Prevalence

Abstract Background Yunnan has the highest rates of HIV in the country. Other treatable sexually transmitted infections (STIs) are associated with accelerated HIV transmission and poor ART outcomes, but are only diagnosed by syndromic algorithms. Methods We recruited 406 HIV-positive participants for a cross-sectional study (204 ART-naive and 202 ART). Blood samples and first-voided urine samples were collected. Real-time polymerase chain reaction methods were used for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Mycoplasma genitalium (MG). Syphilis and HSV-2 tests were also performed. Results Among 406 participants, the overall prevalence of STI was 47.0% and 45.1% in ART-naive individuals and 49.0% in ART individuals, respectively. Testing frequency was 11.6% (11.8% vs 11.4%), 33.2% (29.4% vs 37.1%), 3.2% (3.4% vs 3.0%), 2.0% (3.4% vs 0.5%) and 4.7% (6.4% vs 3.0%) for active syphilis, HSV-2, chlamydia, gonorrhoeae and genitalium. Percentage of multiple infections in both groups was 10.8% (22/204) in ART-naive participants and 9.9% (20/202) in ART participants. Females, age between 18 to 35 years, ever injected drugs, homosexual or bisexual, HIV/HBV coinfection, and not receiving ART were identified as risk factors. Self-reported asymptom was not eliminating of having a laboratory-diagnosed STI. Conclusions STI prevalence was 47.0% (45.1% vs 49.0%), HSV-2, syphilis and MG were the most common STIs in HIV-infected individuals. We found high prevalence (6.4%) of Mycoplasma genitalium in ART-naive individuals. ART can reduce the diversity of STI-HIV coinfection but not the prevalence. HIV-positive individuals tend to neglect or maybe hide their genital tract discomfort, thus we suggest strengthening STI joint screening and treatment services among HIV-infected individuals whether they describe genital tract discomfort or not.

scholarly journals Prevalence Of Syphilis, Neurosyphilis And Associated Factors In a Cross-Sectional Analysis Of HIV Infected Patients Attending Bugando Medical Centre Mwanza Tanzania

2020 ◽  
Author(s):  
Adeodatus Richard Haule ◽  
Betrand Msemwa ◽  
Evarista Mgaya ◽  
Peter Masikini ◽  
Samuel Kalluvya
Keyword(s):  
Associated Factors ◽  
Neurological Complications ◽  
Medical Centre ◽  
Rapid Progression ◽  
Cross Sectional ◽  
Early Syphilis ◽  
Bugando Medical ◽  
Sectional Analysis ◽  
Bugando Medical Centre ◽  
Latent Syphilis

Abstract BACKGROUND HIV-syphilis co-infection is a combination that enhances rapid progression of early syphilis or late latent syphilis to neurosyphilis and can cause catastrophic neurological complications. In studies in Mwanza, syphilis affects ~8% of healthy outpatients, and older studies have suggested that up to 23.5% of HIV-syphilis co-infected patients also have neurosyphilis

scholarly journals Infeções sexualmente transmissíveis na população carcerária de Alfenas-MG: estudo de prevalência e intervenção educacional

2020 ◽  
Vol 4 (1) ◽  
pp. 23
Author(s):  
Victor Hugo Tomazela ◽  
Rafael Clemente ◽  
Sara Reis De Paula ◽  
Luisa Patrícia Fogarolli De Carvalho
Keyword(s):  
Prison Population ◽  
Cross Sectional Study ◽  
Unprotected Sex ◽  
Hiv Positive ◽  
Cross Sectional ◽  
Sexually Transmitted ◽  
High Prevalence ◽  
Post Test ◽  
Risk Practices ◽  
Anti Hiv

INTRODUCTION: Sexually Transmitted Infections (STIs) are transmitted primarily through unprotected sex and by sharing of piercings. It is a delicate subject when treated in the context of prisons and the Associations of Protection and Assistance to the Convicted (APACs). OBJECTIVES: The overall objective was to analyze the relationships between: the prisoner, his knowledge about STIs and his condition of vulnerability. METHODOLOGY: This is a cross-sectional study and educational intervention. In the analysis of the promptuaries, serologies (FTAabs-IgG, HbsAg, Anti-HCV and Anti-HIV) were researched. The intervention study was carried out in 3 stages: 1st pre-test questionnaire; 2nd lecture; and 3rd post-test questionnaire. RESULTS: From 151 promptuaries, 3 HIV positive, 4 HCV positive, and 8 FTAabs-IgG positive were identified. In APAC, 1 FTAabs-IgG positive was identified. Of the 58 APAC students, 34.5% did not access high school and 37.5% always use condoms. In the pre-test, the majority signalled that the STIs transmission was due to the sharing of punctures and unprotected sex. In the post-test we noted a gain of knowledge in most of the questions. CONCLUSION: The literature and our results showed a higher prevalence of STIs in prisons. It is noted that low schooling is related to risk practices. In addition, the sharing of tools for the drug consumption, the realization of tattoos and the unprotected sex is remarkable. Other setbacks contributing to the high prevalence of STIs have also been observed. Finally, it is necessary to increase the investments in policies directed to the prison population health.

scholarly journals Prevalence Of Syphilis, Neurosyphilis And Associated Factors In a Cross-Sectional Analysis Of HIV Infected Patients Attending Bugando Medical Centre Mwanza Tanzania

2020 ◽  
Author(s):  
Adeodatus Richard Haule ◽  
Betrand Msemwa ◽  
Evarista Mgaya ◽  
Peter Masikini ◽  
Samuel Kalluvya
Keyword(s):  
Associated Factors ◽  
Neurological Complications ◽  
Medical Centre ◽  
Rapid Progression ◽  
Cross Sectional ◽  
Early Syphilis ◽  
Bugando Medical ◽  
Sectional Analysis ◽  
Bugando Medical Centre ◽  
Latent Syphilis

Abstract BACKGROUND HIV-syphilis co-infection is a combination that enhances rapid progression of early syphilis or late latent syphilis to neurosyphilis and can cause catastrophic neurological complications. In studies in Mwanza, syphilis affects ~8% of healthy outpatients, and older studies have suggested that up to 23.5% of HIV-syphilis co-infected patients also have neurosyphilis

scholarly journals Serological Profile of Syphilis in Patients Attending the STI / RTI Clinic at Government General Hospital, Guntur, Andhra Pradesh – A Cross Sectional Study

2021 ◽  
Vol 8 (17) ◽  
pp. 1122-1126
Author(s):  
Suneetha Devi Chappidi v ◽  
Sowmya Srirama ◽  
Syam Sundar Junapudi
Keyword(s):  
High Risk ◽  
Sexually Transmitted Infections ◽  
Risk Group ◽  
Treponema Pallidum ◽  
Cross Sectional Study ◽  
High Risk Group ◽  
Age Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Sexually Transmitted

BACKGROUND Sexually transmitted infections (STI) are ancient and are as old as human existence. They are closely interlinked with the human sexual behaviour. Syphilis well known for its systemic complications in the pre-antibiotic era is described as the ‘great imitator’ by Sir William Osler, the father of modern medicine. In the present era of human immuno deficiency virus disease / acquired immuno deficiency syndrome, STI control has been made as first priority, because of their close association and interaction. Syphilis caused by Treponema pallidum is diagnosed most often on clinical suspicion supplemented by laboratory diagnosis, where serological tests for syphilis play a key role / main role. METHODS This study is a hospital based cross sectional study that consisted of 416 cases among which, 276 were females, 140 were males who had attended the STI / RTI clinic. The study period was from July 2011 to September 2012. Blood samples were drawn from all the patients (who were willing to be included in the study) attending the RTI / STI clinic, GGH, Guntur after taking consent. All the sera were tested by rapid plasma reagin (RPR) test and the sera was screened simultaneously for human immunodeficiency virus (HIV). Those sera which were tested reactive for RPR were further tested in dilutions to know the titres. Later the sera tested reactive for RPR were further tested by a specific test, Treponema pallidum haemagglutination (TPHA). RESULTS Of the total 19 (4.56 %) persons tested reactive for RPR, males were 10 (7.14 %), females were 9 (3.26 %), and these were further tested for TPHA. Of the 19 tested for TPHA, a total of 16 (84.21 %) were positive for TPHA of which males were 9 (90 %) and females were 7 (77.78 %). Among the 16 patients, positive for serological test for syphilis (STS), 13 (81.25 %) fall in the age group of 21 - 40, 2 (12.50 %) in the age group of ≤ 20, and 1 (6.25 %) is above 60 years of age. CONCLUSIONS In this study it was seen that out of the 16 syphilis cases, 9 were HIV reactive, 3 were non-reactive for HIV and 4 were of unknown status, showing that the rate was more among the HIV reactive group. The prevalence rate of syphilis among the 66 tested patients belonging to the high-risk group was 6.06 % and in nonhigh-risk group was 3.12 %, showing that it was more in people belonging to high risk group. KEYWORDS Serological Profile, Syphilis, Treponema pallidum, Sexually Transmitted Infections (STI), People Living with HIV / AIDS (PHLA)

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