scholarly journals HIV-free survival among breastfed infants born to HIV-positive women in northern Uganda: a facility-based retrospective study.

2020 ◽  
Author(s):  
Irene Aguti ◽  
Charles Kimbugwe ◽  
Patricia Apai ◽  
Siraji Munyaga ◽  
Richard Nyeko
Keyword(s):  
Survival Rate ◽  
Statistical Significance ◽  
Resource Poor Setting ◽  
P Value ◽  
Northern Uganda ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Free Survival ◽  
Breastfed Infants ◽  
Mother To Child

Abstract Background: Without interventions, the risk of mother-to-child transmission of HIV is 25% during pregnancy, labour and delivery with an additional risk of 5-20% during the breastfeeding, leading to an overall risk of 45%. The effectiveness of interventions towards prevention of mother-to-child transmission of HIV in any setting is measured by its HIV-free survival rate. We carried out a study to determine the HIV-free survival among breastfed infants enrolled by 2 months of age in a resource-poor setting. Methods: We conducted a cross-sectional survey of early infant diagnosis registers at two tertiary facilities in northern Uganda and retrospectively reviewed records of exposed infants enrolled from 2014 to 2016. We used simple random sampling and analyzed data using SPSS v16 software package. The chi-square and Student t-tests were used to compare factors among HIV-free survivors (HIV-uninfected and alive at 18 months) and those who became HIV-infected or died. Multivariate analysis using logistic regression was used to determine the factors that were independently associated with HIV-free survival. Odds ratios with 95% confidence interval were used to measure the strength of association between the outcome and predictor variables. P-value <0.05 was considered for statistical significanceResults: The mean age at enrolment of the 317 infants was 1.57 (SD 0.23), majority of whom were males 55.5% (176/317). All except two infants were initiated on Nevirapine prophylaxis. Less than one third, 29.3% (93/317) of the infants were exclusively breastfed for at least 6 months, while the breastfeeding status of 30 infants could not be ascertained. The overall HIV-free survival rate in the current study was 94.6% (300/317), while 2.5% (8/317) were HIV-infected and 2.8% (9/317) died. Gender and treatment facility were the factors independently significantly associated with HIV-free survival. Conclusions: Our study estimates that the HIV-free survival rate in the study setting for breastfed infants enrolled by 2 months of age was 94.6%, below the WHO goal of >95% HIV-free rate in breastfeeding population for virtual elimination of HIV. A further prospective study would be necessary to assess a more accurate HIV-free survival rate given the limitations of retrospective data.

scholarly journals HIV-free survival among breastfed infants born to HIV-positive women in post-conflict northern Uganda: a perspective from two tertiary health facilities

2019 ◽  
Author(s):  
Richard Nyeko ◽  
Irene Aguti ◽  
Charles Kimbugwe ◽  
Patricia Apai ◽  
Siraji Munyaga
Keyword(s):  
Survival Rate ◽  
Low Income ◽  
World Health ◽  
Northern Uganda ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Free Survival ◽  
Breastfed Infants ◽  
Post Conflict ◽  
Mother To Child

Abstract Background Without interventions, the risk of mother-to-child transmission of HIV is up to 25% during pregnancy, labour and delivery with an additional risk of 5-20% during breastfeeding period, leading to an overall rate of up to 45%. Giving anti-retroviral therapy to the mother and anti-retroviral prophylaxis to the infant has been shown to significantly reduce the risk of HIV transmission through breastfeeding to less than 5%. According to the World Health Organization standard, the effectiveness of interventions towards prevention of mother-to-child transmission of HIV in any setting is measured by its HIV-free survival rate. We therefore carried out a study aimed at determining the HIV-free survival among breastfed infants in a resource poor setting in relation breastfeeding duration. Methods A cross-sectional retrospective study using routine clinical data and involving 365 HIV exposed infants followed up in two tertiary facilities in northern Uganda between 2014 and 2016. Data was analysed using Statistical Package for Social Scientists version 16 software package. Results Of the three hundred and sixty five (365) infants sampled for this study, 86.8% (317/365) were enrolled within the first 2 months of life, 12.1% (44/365) between 3-12 months of age and 1.1% (4/365) enrolled after 12 months of age. Almost all the infants (98.4%) were initiated on Nevirapine prophylaxis, 97.5% (356/365) of whom were initiated within 72 hours. The overall HIV-free survival rate in the current study was 93.7% (342/365), while 6.3% (23/365) were either HIV-infected (2.7%) or died (3.6%). The infants’ age at enrolment was the single most important factor significantly associated with HIV-free survival. The overall duration of breastfeeding did not significantly affect the HIV-free survival: 98.1% (304/310) for children breastfed > 12 months versus 100% (15/15) for those breastfed ≤12 months, though exclusive breastfeeding for at least 6 months was protective. Conclusions Adherence to current approaches to prevention of mother-to-child transmission of HIV with support to breastfeeding in low income countries can greatly enhance HIV-free survival for breastfed infants, and supports the current infant and young child feeding recommendations. Key words: HIV-free survival, Mother-to-child transmission, Breastfeeding, Antiretroviral therapy

scholarly journals Antenatal HIV-1 RNA load and timing of mother to child transmission; a nested case-control study in a resource poor setting

2010 ◽  
Vol 7 (1) ◽  
Author(s):  
Kerina Duri ◽  
Felicity Z Gumbo ◽  
Knut I Kristiansen ◽  
Nyaradzi E Kurewa ◽  
Munyaradzi P Mapingure ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Resource Poor Setting ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Resource Poor ◽  
Nested Case Control ◽  
Mother To Child ◽  
Hiv 1 ◽  
Control Study

Operational effectiveness and 36 week HIV-free survival in the South African programme to prevent mother-to-child transmission of HIV-1

AIDS ◽  
2007 ◽  
Vol 21 (4) ◽  
pp. 509-516 ◽  
Author(s):  
Debra J Jackson ◽  
Mickey Chopra ◽  
Tanya M Doherty ◽  
Mark SE Colvin ◽  
Jonathan B Levin ◽  
...  
Keyword(s):  
South African ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
The South ◽  
Operational Effectiveness ◽  
Free Survival ◽  
Mother To Child ◽  
Hiv 1

scholarly journals Factors influencing the utilisation of prevention of mother-to-child transmission (PMTCT) services by pregnant women in the Eastern Cape, South Africa

2005 ◽  
Vol 10 (1) ◽  
Author(s):  
Karl Peltzer ◽  
Donald Skinner ◽  
Sakhumzi Mfecane ◽  
Olive Shisana ◽  
Ayanda Nqeketo ◽  
...  
Keyword(s):  
South Africa ◽  
Pregnant Women ◽  
Full Text ◽  
Resource Poor Setting ◽  
Eastern Cape ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Factors Influencing ◽  
Resource Poor ◽  
Mother To Child

The aim of the study was to identify factors influencing the utilisation of Prevention of Mother-to-Child Transmission (PMTCT) in a resource poor setting in South Africa. Opsomming Die doel van die studie was om faktore te identifiseer wat die benutting van die Voorkoming van Moeder-tot-Kind Oordrag (VMTKO) beïnvloed in ‘n omgewing in Suid-Afrika wat arm is aan hulpbronne. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

scholarly journals HUBUNGAN DUKUNGAN BIDAN DENGAN PEMERIKSAAN PMTCT (PREVENTION MOTHER TO CHILD TRANSMISSION) PADA IBU HAMIL DI PUSKESMAS KASIHAN II BANTUL

2020 ◽  
Vol 3 (1) ◽  
pp. 6-12
Author(s):  
Esitra Herfanda ◽  
Indah Pratiwi
Keyword(s):  
Pregnant Women ◽  
Health Center ◽  
Health Care Facilities ◽  
Hiv And Aids ◽  
P Value ◽  
Mother To Child Transmission ◽  
Primary Health Center ◽  
Child Transmission ◽  
Primary Health ◽  
Mother To Child

HIV and AIDS transmission to infants can be prevented by comprehensive and effective PMTCT (Prevention Mother to Child Transmission) efforts in health care facilities. The role of the midwife in encouraging pregnant women to conduct PMTCT examinations is to provide support in the form of information, appreciation, instrumental and emotional information about HIV and AIDS thoroughly to the client until the client understands and gives the permission to conduct PMTCT examinations. The purpose of this study was to determine the correlation between midwife’s support and PMTCT examinations of pregnant women at Kasihan II Primary Health Center of Bantul. This research was conducted using observational analytic methods with cross sectional approach. Data collection techniques employed accidental sampling as many as 40 pregnant women as the respondents. The research instrument was a questionnaire with chi square as data analysis. The results of the study obtained showed that 80% among 40 respondents received good support, and 82.5% conducted PMTCT examinations. There was a correlation between midwife’s support and PMTCT examinations for pregnant women in Kasihan II Primary Health Center of Bantul with p value = 0.000 (p <0.05). Thus, it can be concluded that there was a correlation between midwife’s support and PMTCT examination for pregnant women at Kasihan II Primary Health Center of Bantul.   Keywords: Midwife, Support, PMTCT.

scholarly journals Predictors of Unmet Need for Family Planning among HIV Positive Women in Care in Federal Teaching Hospital Gombe, Nigeria

2020 ◽  
pp. 26-33
Author(s):  
A. Mohammed ◽  
D. Chiroma ◽  
C. H. Laima ◽  
M. A. Danimoh ◽  
P. A. Odunze
Keyword(s):  
Family Planning ◽  
Unmet Need ◽  
Hiv Care ◽  
Hiv Positive ◽  
P Value ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Hiv Positive Women ◽  
History Of ◽  
Mother To Child

Background: Elimination of mother-to-child transmission (EMTCT) of Human Immunodeficiency Virus (HIV) requires adequate and continuous use of family planning commodities among women of reproductive age. This can be made possible by reducing the proportion of HIV positive women with unmet need for family planning. The study aims to determine the factors associated with having unmet need among women in HIV care. Methods: A cross sectional study was conducted using an interviewer administered questionnaire to study 325 women on HIV care. Cluster sampling technique was used to select the study respondents from the clinic. Results: Less than half of the respondents (40%) were currently using family planning, 35% had unmet need for family planning with 53.6% having unmet need for spacing while 46.4% having unmet need for limiting. Women with no history of previous use of family planning were fifteen times more likely to have unmet need for family planning than those with history of previous use of family planning (p value <0.001, CI 2.511-15.770). Also women with more than five deliveries were eight times more likely to have unmet need for family planning (p value 0.004, CI 0.001-0.279) while women with 2-5 deliveries are four times likely to have unmet need for family planning (p value 0.035, CI 0.005-0.832). Conclusion: A high proportion of women receiving ART care still have unmet need for family planning despite incorporating this service in HIV care. It is therefore important to target high risk groups to reduce the proportion of women with unmet need for family planning which will invariable reduce mother to child transmission of HIV.

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