scholarly journals Purtscher-like retinopathy presented a honeycomb-like pattern in optical coherence topography angiography

2019 ◽  
Author(s):  
Bing Li ◽  
Youxin Chen ◽  
Donghui Li
Keyword(s):  
Blood Flow ◽  
Vision Loss ◽  
Acute Onset ◽  
Pathological Process ◽  
Optical Coherence ◽  
Cotton Wool Spots ◽  
Before And After ◽  
Retinal Oedema ◽  
Hypointense Signal ◽  
The Right

Abstract Background: To report a case of Purtscher-like retinopathy (PUR) and the optical coherence tomography (OCT) and OCT angiography (OCT-A) findings before and after treatment. Case presentation: A 65-year-old male presented with acute onset of vision loss for 2 weeks. Fundus examination revealed cotton-wool spots, retinal haemorrhage, and Purtscher flecken spread around the optic disc in the right eye. He was diagnosed with Purtscher-like retinopathy because he lacked any traumatic medical history. OCT presented some band-like hyperreflective lesions at the inner nuclear layer, which are indicative of paracentral acute middle maculopathy (PAMM). OCT-A revealed apparent reduction in blood flow signal at the deep retina and choriocapillaris layers with a honeycomb-like hypointense signal pattern. After 3 months of follow-up, OCT revealed resolution of retinal oedema, but PAMM lesions remained visible. Based on OCT-A, the honeycomb-like pattern turned into a homogeneous reduction in blood flow with small patches of hypointense signal areas in the choriocapillaris. Conclusion: This case presented a new OCT-A sign in PUR with a honeycomb-like hypointense signal at the choriocapillaris layer, indicating the involvement and ischaemia of the choroid during the pathological process.

scholarly journals Purtscher-like retinopathy presented a honeycomb-like pattern in optical coherence topography angiography

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Bing Li ◽  
Donghui Li ◽  
Youxin Chen
Keyword(s):  
Blood Flow ◽  
Vision Loss ◽  
Acute Onset ◽  
Pathological Process ◽  
Optical Coherence ◽  
Cotton Wool Spots ◽  
Before And After ◽  
Retinal Oedema ◽  
Hypointense Signal ◽  
The Right

Abstract Background To report a case of Purtscher-like retinopathy (PUR) and the optical coherence tomography (OCT) and OCT angiography (OCT-A) findings before and after treatment. Case presentation A 65-year-old male presented with acute onset of vision loss for 2 weeks. Fundus examination revealed cotton-wool spots, retinal haemorrhage, and Purtscher flecken spread around the optic disc in the right eye. He was diagnosed with Purtscher-like retinopathy because he lacked any traumatic medical history. OCT presented some band-like hyperreflective lesions at the inner nuclear layer, which are indicative of paracentral acute middle maculopathy (PAMM). OCT-A revealed apparent reduction in blood flow signal at the deep retina and choriocapillaris layers with a honeycomb-like hypointense signal pattern. After 3 months of follow-up, OCT revealed resolution of retinal oedema, but PAMM lesions remained visible. Based on OCT-A, the honeycomb-like pattern turned into a homogeneous reduction in blood flow with small patches of hypointense signal areas in the choriocapillaris. Conclusion This case presented a new OCT-A sign in PUR with a honeycomb-like hypointense signal at the choriocapillaris layer, indicating the involvement and ischaemia of the choroid during the pathological process.

scholarly journals Purtscher-like retinopathy presented a honeycomb-like pattern in optical coherence topography angiography

2019 ◽  
Author(s):  
Bing Li ◽  
Youxin Chen ◽  
Donghui Li
Keyword(s):  
Blood Flow ◽  
Vision Loss ◽  
Acute Onset ◽  
Pathological Process ◽  
Optical Coherence ◽  
Cotton Wool Spots ◽  
Before And After ◽  
Retinal Oedema ◽  
Hypointense Signal ◽  
The Right

Abstract Background: To report a case of Purtscher-like retinopathy (PUR) and the optical coherence tomography (OCT) and OCT angiography (OCT-A) findings before and after treatment. Case presentation: A 65-year-old male presented with acute onset of vision loss for 2 weeks. Fundus examination revealed cotton-wool spots, retinal haemorrhage, and Purtscher flecken spread around the optic disc in the right eye. He was diagnosed with Purtscher-like retinopathy because he lacked any traumatic medical history. OCT presented some band-like hyperreflective lesions at the inner nuclear layer, which are indicative of paracentral acute middle maculopathy (PAMM). OCT-A revealed apparent reduction in blood flow signal at the deep retina and choriocapillaris layers with a honeycomb-like hypointense signal pattern. After 3 months of follow-up, OCT revealed resolution of retinal oedema, but PAMM lesions remained visible. Based on OCT-A, the honeycomb-like pattern turned into a homogeneous reduction in blood flow with small patches of hypointense signal areas in the choriocapillaris. Conclusion: This case presented a new OCT-A sign in PUR with a honeycomb-like hypointense signal at the choriocapillaris layer, indicating the involvement and ischaemia of the choroid during the pathological process.

scholarly journals Purtscher-like retinopathy presented a honeycomb-like pattern in optical coherence topography angiography

2019 ◽  
Author(s):  
Bing Li ◽  
Youxin Chen ◽  
Donghui Li
Keyword(s):  
Blood Flow ◽  
Vision Loss ◽  
Acute Onset ◽  
Pathological Process ◽  
Optical Coherence ◽  
Cotton Wool Spots ◽  
Before And After ◽  
Retinal Oedema ◽  
Hypointense Signal ◽  
The Right

Abstract Background: To report a case of Purtscher-like retinopathy (PUR) and the optical coherence tomography (OCT) and OCT angiography (OCT-A) findings before and after treatment. Case presentation: A 65-year-old male presented with acute onset of vision loss for 2 weeks. Fundus examination revealed cotton-wool spots, retinal haemorrhage, and Purtscher flecken spread around the optic disc in the right eye. He was diagnosed with Purtscher-like retinopathy because he lacked any traumatic medical history. OCT presented some band-like hyperreflective lesions at the inner nuclear layer, which are indicative of paracentral acute middle maculopathy (PAMM). OCT-A revealed apparent reduction in blood flow signal at the deep retina and choriocapillaris layers with a honeycomb-like hypointense signal pattern. After 3 months of follow-up, OCT revealed resolution of retinal oedema, but PAMM lesions remained visible. Based on OCT-A, the honeycomb-like pattern turned into a homogeneous reduction in blood flow with small patches of hypointense signal areas in the choriocapillaris. Conclusion: This case presented a new OCT-A sign in PUR with a honeycomb-like hypointense signal at the choriocapillaris layer, indicating the involvement and ischaemia of the choroid during the pathological process.

scholarly journals Purtscher-like retinopathy presented a honeycomb-like pattern in optical coherence topography angiography

2019 ◽  
Author(s):  
Bing Li ◽  
Youxin Chen ◽  
Donghui Li
Keyword(s):  
Blood Flow ◽  
Vision Loss ◽  
Retinal Hemorrhage ◽  
Acute Onset ◽  
Pathological Process ◽  
Optical Coherence ◽  
Cotton Wool Spots ◽  
Before And After ◽  
Hypointense Signal ◽  
The Right

Abstract Background To report a case of Purtscher-like retinopathy (PUR) and his optical coherence tomography (OCT) and OCT-angiography (OCT-A) findings before and after treatment. Case presentation A 65-year-old male presented with acute onset of vision loss for 2 weeks. Fundus examination revealed cotton-wool spots, retinal hemorrhage, and purtscher flecken spreading around the optic disc in the right eye. He was diagnosed with Purtscher-like retinopathy because of the absent reports of any traumatic medical history. OCT presented some band-like hyperreflective lesions at the layer of inner nuclear layer known as paracentral acute middle maculopathy (PAMM). OCT-A revealed apparent reduction of blood flow signal at the layers of deep retina and choriocapillaris with a pattern of honeycomb-like hypointense signal. After 3-month follow-up, OCT scan showed a resolution of retinal edema, but the PAMM lesions were still visible. OCT-A presented the honeycomb-like pattern turned into a homogeneous reduction of blood flow with small patches of hypointense signal areas in choriocapillaris. Conclusion This case presented a new OCT-A sign in Purtscher-like retinopathy with a honeycomb-like hypointense signal at the layer of choriocapillaris indicates the involvement and the ischemia condition of the choroid in its pathological process.

scholarly journals Effect of Different Local Vibration Frequencies on the Multiscale Regularity of Plantar Skin Blood Flow

Entropy ◽  
2020 ◽  
Vol 22 (11) ◽  
pp. 1288
Author(s):  
Fuyuan Liao ◽  
Keying Zhang ◽  
Lingling Zhou ◽  
Yanni Chen ◽  
Jeannette Elliott ◽  
...  
Keyword(s):  
Blood Flow ◽  
Skin Blood Flow ◽  
Metatarsal Head ◽  
Structural Features ◽  
Frequency Interval ◽  
Local Vibration ◽  
First Metatarsal ◽  
Before And After ◽  
The Right ◽  
Selection Of

Local vibration has shown promise in improving skin blood flow (SBF). However, there is no consensus on the selection of the best vibration frequency. An important reason may be that previous studies utilized time- and frequency-domain parameters to characterize vibration-induced SBF responses. These parameters are unable to characterize the structural features of the SBF response to local vibrations, thus contributing to the inconsistent findings seen in vibration research. The objective of this study was to provide evidence that nonlinear dynamics of SBF responses would be an important aspect for assessing the effect of local vibration on SBF. Local vibrations at 100 Hz, 35 Hz, and 0 Hz (sham vibration) with an amplitude of 1 mm were randomly applied to the right first metatarsal head of 12 healthy participants for 10 min. SBF at the same site was measured for 10 min before and after local vibration. The degree of regularity of SBF was quantified using a multiscale sample entropy algorithm. The results showed that 100 Hz vibration significantly increased multiscale regularity of SBF but 35 Hz and 0 Hz (sham vibration) did not. The significant increase of regularity of SBF after 100 Hz vibration was mainly attributed to increased regularity of SBF oscillations within the frequency interval at 0.0095–0.15 Hz. These findings support the use of multiscale regularity to assess effectiveness of local vibration on improving skin blood flow.

scholarly journals Steep head-down tilt has persisting effects on the distribution of pulmonary blood flow

2006 ◽  
Vol 101 (2) ◽  
pp. 583-589 ◽  
Author(s):  
A. Cortney Henderson ◽  
David L. Levin ◽  
Susan R. Hopkins ◽  
I. Mark Olfert ◽  
Richard B. Buxton ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pulmonary Blood Flow ◽  
Regional Blood Flow ◽  
Flow Distribution ◽  
Normal Subjects ◽  
Relative Dispersion ◽  
Lung Water ◽  
Before And After ◽  
Capillary Pressures ◽  
The Right

Head-down tilt has been shown to increase lung water content in animals and alter the distribution of ventilation in humans; however, its effects on the distribution of pulmonary blood flow in humans are unknown. We hypothesized that head-down tilt would increase the heterogeneity of pulmonary blood flow in humans, an effect analogous to the changes seen in the distribution of ventilation, by increasing capillary hydrostatic pressure and fluid efflux in the lung. To test this, we evaluated changes in the distribution of pulmonary blood flow in seven normal subjects before and after 1 h of 30° head-down tilt using the magnetic resonance imaging technique of arterial spin labeling. Data were acquired in triplicate before tilt and at 10-min intervals for 1 h after tilt. Pulmonary blood flow heterogeneity was quantified by the relative dispersion (standard deviation/mean) of signal intensity for all voxels within the right lung. Relative dispersion was significantly increased by 29% after tilt and remained elevated during the 1 h of measurements after tilt (0.84 ± 0.06 pretilt, 1.09 ± 0.09 calculated for all time points posttilt, P < 0.05). We speculate that the mechanism most likely responsible for our findings is that increased pulmonary capillary pressures and fluid efflux in the lung resulting from head-down tilt alters regional blood flow distribution.

scholarly journals Optical coherence tomography in assessment chorioretinal blood flow in patients with central serous chorioretinopathy

2016 ◽  
Vol 15 (4) ◽  
pp. 39-47
Author(s):  
S. I. Zhukova ◽  
A. N. Zlobina ◽  
T. N. Iureva ◽  
A. A. Shchuko
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Retinal Detachment ◽  
Central Serous Chorioretinopathy ◽  
Structural Changes ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Pathological Process ◽  
Optical Coherence ◽  
Neurosensory Retinal Detachment

Introduction and purpose. Central serous chorioretinopathy - a disease that manifests itself serous detachment of the neurosensory retina and / or retinal pigment epithelium (RPE). Chronic course of pathological process may be complicated by the development of subretinal neovascularization, and is accompanied by a decrease in visual functions. Despite the large number of studies, there are no pathogenetically oriented and effective methods of treatment of central serous chorioretinopathy today, because there is no consensus on the causes of its origin. To evaluate the accuracy of the information content of chorioretinal blood flow changes in patients with central serous chorioretinopathy, to compare the degree of changes of RPE and hemodynamic disorders in different forms of the disease. Materials and Methods. The study involved 26 patients with central serous chorioretinopathy aged 35 to 54 years. To assess chorioretinal blood flow the optical coherence tomography (OCT) in retinal angiography mode was included in the volume of diagnostic examination. Results. It was demonstrated that the choroidal vessels and RPE are an original target in the realization of the pathological process in central serous chorioretinopathy. The changes in the pigment epithelium and the neurosensory retinal detachment, whose height ranged from 53.4 to 513.0 m (238.3 ± 80.4 - in acute and - 215.5 ± 129.9 - in chronic diseases) were revealed in all patients. In 45 % of cases of acute and 67 % in patients with a chronic form of disease the neurosensory retinal detachment combined with RPE detachment, preventing recovery of macular interface on a background of medical actions. Prolonged existence of ischemia and RPE detachment is accompanied by severe progressive degenerative changes in the retina as a whole, causing resistance to treatment. Conclusions. OCT in angiography mode in the diagnosis of various forms of chorioretinal central serous chorioretinopathy allows visualizing blood flow, evaluating the extent and nature of the structural changes of the retina taking into account hemodynamic disorders. The revealed changes of RPE and choroid, as classification and prognostic criteria of the disease, determine the effectiveness of treatment measures and prognosis of disease.

scholarly journals Effects of Foam Rolling Duration on Tissue Stiffness and Perfusion: A Randomized Cross-Over Trial

2021 ◽  
pp. 626-634
Author(s):  
Jan Schroeder ◽  
Jan Wilke ◽  
Karsten Hollander
Keyword(s):  
Blood Flow ◽  
Near Infrared ◽  
Tissue Perfusion ◽  
Minimal Detectable Change ◽  
Tissue Stiffness ◽  
Foam Rolling ◽  
Beneficial Effects ◽  
Before And After ◽  
The Right ◽  
The Impact

Despite its beneficial effects on flexibility and muscle soreness, there is still conflicting evidence regarding dose-response relationships and underlying mechanisms of foam rolling (FR). This study aimed to investigate the impact of different FR protocols on tissue perfusion and tissue stiffness. In a randomized crossover trial, two FR protocols (2x1 min, 2x3 min) were applied to the right anterior thigh of twenty healthy volunteers (11 females, 25 ± 4 years). Tissue perfusion (near infrared spectroscopy, NIRS) and stiffness (Tensiomyography, TMG and Myotonometry, MMT) were assessed before and after FR application. Variance analyses revealed a significant interaction of FR duration and tissue perfusion (F[1,19] = 7.098, p = 0.015). Local blood flow increased significantly from pre to post test (F[1,19] = 7.589, p = 0.013), being higher (Δ +9.7%) in the long-FR condition than in the short-FR condition (Δ +2.8%). Tissue stiffness (MMT) showed significant main effects for time (F[1,19] = 12.074, p = 0.003) and condition (F[1,19] = 7.165, p = 0.015) with decreases after short-FR (Δ -1.6%) and long-FR condition (Δ -1.9%). However, there was no time*dose-interaction (F[1,19] = 0.018, p = 0.895). No differences were found for TMG (p > 0.05). FR-induced changes failed to exceed the minimal detectable change threshold (MDC). Our data suggest that increased blood flow and altered tissue stiffness may mediate the effects of FR although statistical MDC thresholds were not achieved. Longer FR durations seem to be more beneficial for perfusion which is of interest for exercise professionals designing warm-up and cool-down regimes. Further research is needed to understand probable effects on parasympathetic outcomes representing systemic physiological responses to locally applied FR stimulations.

scholarly journals Analysis of the Pathogenesis of Experimental Autoimmune Optic Neuritis

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Takeshi Kezuka ◽  
Yoshihiko Usui ◽  
Hiroshi Goto
Keyword(s):  
Multiple Sclerosis ◽  
Animal Models ◽  
Optic Neuritis ◽  
Vision Loss ◽  
Strong Association ◽  
Acute Onset ◽  
Advanced Therapies ◽  
Short Period ◽  
Organ Specific ◽  
The Right

Optic neuritis associated with multiple sclerosis has a strong association with organ-specific autoimmune disease. The goal of our research is to establish an optimal organ-specific animal model to elucidate the pathogenetic mechanisms of the disease and to develop therapeutic strategies using the model. This paper is divided into five sections: (1) clinical picture of optic neuritis associated with multiple sclerosis, (2) elucidation of pathogenesis using animal models with inflammation in optic nerve and spinal cord, (3) clinical relevance of concurrent encephalomyelitis in optic neuritis model, (4) retinal damage in a concurrent multiple sclerosis and optic neuritis model, and (5) development of novel therapies using mouse optic neuritis model. Advanced therapies using biologicals have succeeded to control intractable optic neuritis in animal models. This may ultimately lead to prevention of vision loss within a short period from acute onset of optic neuritis in human. By conducting research flexibly, ready to switch from the bench to the bedside and from the bedside to the bench as the opportunity arises, this strategy may help to guide the research of optic neuritis in the right direction.

scholarly journals Iridotrabecular and Iridocorneal Contact Changes after Cataract Surgery and Endothelial Keratoplasty in Bilateral Iridoschisis

2021 ◽  
pp. 198-203
Author(s):  
Takashi Omoto ◽  
Chisato Agata ◽  
Reina Akiyama ◽  
Kohdai Kitamoto ◽  
Tetsuya Toyono ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Surgical Procedures ◽  
Vision Loss ◽  
Anterior Segment ◽  
Corneal Oedema ◽  
Endothelial Keratoplasty ◽  
Laser Iridotomy ◽  
Before And After ◽  
The Right ◽  
Endothelial Decompensation

We report a case of bilateral iridoschisis with corneal oedema and a quantitative evaluation of the changes in iridotrabecular and iridocorneal contact before and after cataract surgery and after Descemet stripping automated endothelial keratoplasty (DSAEK). A 76-year-old woman with iridoschisis and cataracts, previously managed with laser iridotomy, experienced progressive vision loss. The preoperative iridotrabecular contact (ITC) index measured by anterior segment optical coherence tomography was 23.6% in the right eye and 24.4% in the left eye. Preoperative corneal oedema in the right eye was more severe than that in the left eye. Cataract surgery, followed by DSAEK, was performed in the right eye and subsequently in the left eye. Her visual acuity improved postoperatively, and the corneal oedema of both eyes was treated successfully. Moreover, the ITC index improved in both eyes, to 4.7 and 6.9% after cataract surgery and to 0 and 0% after DSAEK in the right and left eyes, respectively. Staged cataract surgery and DSAEK were effective for endothelial decompensation caused by iridoschisis. Additionally, we confirm that iridotrabecular and iridocorneal contacts improved after both surgical procedures not only after cataract surgery but also after DSAEK. This case report showed the clinical usefulness of the ITC index in the detection of changes after different surgical procedures.

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