scholarly journals Neuroendocrine Carcinoma of the Cervix: Clinicopathologic Study and Review of the Literature

2021 ◽  
Author(s):  
Xiaobo Zhang ◽  
Yougui Xu ◽  
Danhua Shen ◽  
MingZhu LI
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Medical Records ◽  
Detection Rate ◽  
Hpv Infection ◽  
Immunohistochemical Examination ◽  
Clinicopathologic Study ◽  
Peking University ◽  
Hybrid Capture 2 ◽  
High Risk Hpv

Abstract BackgroundNeuroendocrine carcinoma of the cervix (CNECC) is a rare variant of cervical cancer. The prognosis of women with CNECC is poor and there is no standardized therapy for this type of malignancy. To discuss the clinical and pathological features and prognosis of CNECC.MethodsTwenty one patients diagnosed as CNECC of cervix from May 2008 to September 2021 were retrospectively analyzed at Peking University people's hospital, were analyzed retrospectively including hematoxylin-eosinstaining （HE）slides review, immunohistochemistry results,Thinprep cytology test(TCT) and human papillomavirus (HPV) Hybrid Capture 2(HC2) assay. and their data were analyzed retrospectively. Telephone and medical records were followed up for 3-160 months with an average follow-up time of 49.8 month.ResultsThe patient's average age was 48.6 years old (range: 33–69 years). The first symptoms of 11 cases had vaginal bleeding, 2 cases had vaginal discharge, and the others were asymptomatic. Among the 21 patients, 17 cases were diagnosed as neuroendocrine carcinoma by biopsy. There were 9 cases with TCT examination and HC2 tests before biopsy, TCT results of 4 cases were positive. High-risk HPV of 7 cases were positive. The morphology of cancer cells were relatively consistent, the cytoplasm was sparse, the nuclei were obviously blue stained, and accompanied by extensive neoplastic necrosis. 13 cases were pure CNECC(61.9%), 8 cases were mix types of CNECC(38.1%).There were 3 cases accompanied by squamous cell carcinoma,5 cases accompanied by adenocarcinoma.The positive detection rate of Syn, CgA, CD56,p16 and TTF1 were 85.7%(18/21), 42.9%(9/21), 85.7% (18/21), 81%(17/21) 52.4%(11/21),respectively.The overall survival rate of 21 NECC cases was 71.4%(15/21).ConclusionsCNECC was a extremely rare primary tumor.The tumor was associated with HPV infection. Combined examination of TCT and HPV could significantly improve the detection rate of neuroendocrine carcinoma before biopsy.Pthology diagnosis was based on histological and immunohistochemical examination. It was considered to be highly aggressive malignancy with very poor prognosis.

scholarly journals Comparison of detection rate of high risk HPV infection between self-collected HPV testing and clinician-collected HPV testing in cervical cancer screening

2019 ◽  
Vol 58 (4) ◽  
pp. 477-481 ◽  
Author(s):  
Pattiya Nutthachote ◽  
Shina Oranratanaphan ◽  
Wichai Termrungruanglert ◽  
Surang Triratanachat ◽  
Arkom Chaiwongkot ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
High Risk ◽  
Cervical Cancer Screening ◽  
Detection Rate ◽  
Hpv Infection ◽  
Hpv Testing ◽  
High Risk Hpv

scholarly journals Temporal changes in the vaginal microbiota in self-samples and its association with persistent HPV16 infection and CIN2+

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Malin Berggrund ◽  
Inger Gustavsson ◽  
Riina Aarnio ◽  
Julia Hedlund Lindberg ◽  
Karin Sanner ◽  
...  
Keyword(s):  
Hpv Infection ◽  
Vaginal Microbiota ◽  
Single Type ◽  
Vaginal Fluid ◽  
Confounding Variables ◽  
Single Positive ◽  
Baseline Test ◽  
High Risk Hpv ◽  
Hpv16 Infection

Abstract Background The vaginal microbiota has been reported to be associated with HPV infection and cervical cancer. This study was performed to compare the vaginal microbiota at two timepoints in women performing self-sampling and had a persistent or transient HPV16 infection. The women were tested for 12 high-risk HPV (hrHPV) types but only women with single type (HPV16) were included to reduce confounding variables. Methods In total 96 women were included in this study. Of these, 26 were single positive for HPV16 in the baseline test and HPV negative in the follow-up test and 38 were single positive for HPV16 in both tests and diagnosed with CIN2+ in histology. In addition, 32 women that were negative for all 12 HPV tested were included. The samples of vaginal fluid were analyzed with the Ion 16S™ Metagenomics Kit and Ion 16S™ metagenomics module within the Ion Reporter™ software. Results K-means clustering resulted in two Lactobacillus-dominated groups, one with Lactobacillus sp. and the other specifically with Lactobacillus iners. The two remaining clusters were dominated by a mixed non-Lactobacillus microbiota. HPV negative women had lower prevalence (28%) of the non-Lactobacill dominant cluster in the baseline test, as compared to women with HPV16 infection (42%) (p value = 0.0173). Transition between clusters were more frequent in women with persistent HPV16 infection (34%) as compared in women who cleared the HPV16 infection (19%) (p value = 0.036). Conclusions The vaginal microbiota showed a higher rate of transitioning between bacterial profiles in women with persistent HPV16 infection as compared to women with transient infection. This indicate an instability in the microenvironment in women with persistent HPV infection and development of CIN2+.

scholarly journals Incidence of cervical high-grade squamous intraepithelial lesions in HIV-1-infected women with no history of cervical pathology: up to 17 years of follow-up

2018 ◽  
Vol 30 (1) ◽  
pp. 56-63 ◽  
Author(s):  
Sebastián Videla ◽  
Antoni Tarrats ◽  
Arelly Ornelas ◽  
Roger Badia ◽  
Eva Castella ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
High Risk ◽  
Hpv Infection ◽  
High Grade ◽  
Papanicolaou Smear ◽  
Papanicolaou Smears ◽  
High Risk Hpv ◽  
Intraepithelial Lesions ◽  
Hiv 1

Currently, Papanicolaou smears are proposed at three-year intervals for cervical screening to all women living with HIV. The aim of this retrospective cohort study was to provide data on the incidence of cervical high-grade squamous intraepithelial lesions (HSIL) in cervical smear confirmed by histology in HIV-1-infected women (two consecutive normal Papanicolaou smears at baseline) after a long-term follow-up. Sixty-seven women (recruited between March 1999 and January 2003) were analyzed. The median period of follow-up was 13.2 years (range: 7.4–17.1 years) with a total of 583 Papanicolaou smears. Twenty-seven percent of these HIV-1-infected women had poorly-controlled HIV. Cumulative incidence of HSIL was 18% (12/67; 95%CI: 11–29%) of which one was an invasive squamous cell carcinoma and two were carcinoma in situ. These women had not been well-engaged with the annual Papanicolaou smear screening program and had poor adherence to antiretroviral therapy. Development of HSIL was associated with high-risk-HPV infection (OR: 14.9; 95%CI: 3.0, 75.1). At last Papanicolaou smear, prevalence of high-risk-HPV infection was 30% (20/66, 95%CI: 21–42%). In conclusion, the incidence of cervical HSIL in HIV-1-infected women with poor antiretroviral therapy adherence or poor immunological status reinforces the need to identify those HIV-1-infected women at risk of developing cervical cancer.

scholarly journals The Value of Partial HPV Genotyping After Conization of Cervical Dysplasias

2017 ◽  
Vol 77 (08) ◽  
pp. 887-893 ◽  
Author(s):  
Kristin Friebe ◽  
Rüdiger Klapdor ◽  
Peter Hillemanns ◽  
Matthias Jentschke
Keyword(s):  
Intraepithelial Neoplasia ◽  
Hpv Testing ◽  
Hpv 16 ◽  
Hybrid Capture ◽  
Recurrence Prediction ◽  
Hpv Status ◽  
Hpv Test ◽  
Hybrid Capture 2 ◽  
High Risk Hpv

Abstract Introduction In this retrospective study partial genotyping of human papilloma viruses (HPV) using the Abbott RealTime HighRisk HPV Test (RealTime) was compared with simple HPV detection (Qiagen Hybrid Capture 2 Test; hc2) for recurrence prediction at the first follow-up examination after conization of cervical intraepithelial neoplasia (CIN). Methods 144 women who had undergone conization for CIN between January 2007 and December 2013 were included. HPV status was determined preoperatively and at first follow-up using hc2 in 103 women and RealTime in 41 women. Recurrent or persistent CIN was assumed when CIN2+ was confirmed histologically or on comparable cytology findings. Results Of the 144 women with complete data 12 (8.3%) had a recurrence after conization. HPV persistence at follow-up correlated significantly with recurrence (hc2: p = 0.003; RealTime: p = 0.003) and both sensitivity and specificity were high (hc2 = 100 and 78.4% respectively; RealTime = 75.0 and 83.9%). Whereas isolated HPV testing had a relatively low positive predictive value for recurrence (hc2 16%; RealTime 54.5%), this rose to 80% with HPV 16 detection at follow-up. Conclusion At follow-up after conization of CIN the combination of high risk HPV detection and partial genotyping of HPV 16 constitutes excellent diagnostic criteria for recurrence/persistence of CIN.

scholarly journals Predictive Role of the p16 Immunostaining Pattern in Atypical Cervical Biopsies with Less Common High Risk HPV Genotypes

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1947
Author(s):  
Daniela Cabibi ◽  
Caterina Napolitano ◽  
Antonino Giulio Giannone ◽  
Maria Carmela Micciulla ◽  
Rossana Porcasi ◽  
...  
Keyword(s):  
High Risk ◽  
Early Stage ◽  
Hpv Infection ◽  
Hpv Dna ◽  
Risk Of Progression ◽  
Positive Immunostaining ◽  
Predictive Role ◽  
Positive Immunoreactivity ◽  
High Risk Hpv

P16 immunostaining is considered a useful surrogate of transcriptionally active high-risk (hr) HPV infection. Only strong and widespread “block-like” immunoreactivity is considered specific, whereas weak/focal p16 positive immunostaining is considered not specific, and follow-up and HPV molecular detection is not indicated. The aim of the study was to evaluate the presence of HPV DNA and Ki67 immunostaining in 40 cervical atypical biopsies (CALs) with mild and focal histological features suggestive of HPV infection—20 cases with weak/focal p16 positive immunoreactivity and 20 cases negative for p16 expression. In 16/20 weak/focal p16 positive CALs (80%), the INNO-LiPA HPV genotyping detected hrHPV genotypes (HPV 31, 51, 56, 59, 26, 53, 66, 73, and 82). Co-infection of two or more hrHPV genotypes was often evidenced. HPV16 and 18 genotypes were never detected. Ki67 immunostaining was increased in 10/20 cases (50%). In 19/20 p16 negative CALs, hrHPV infection was absent and Ki67 was not increased. These results suggest that weak/focal p16 immunostaining represents the early stage of transcriptionally active infection, strongly related to the presence of less common hrHPV genotypes, probably with a slower transforming power, but with a potential risk of progression if the infection persists. HPV DNA genotyping and follow-up could be useful in these cases to verify if they are able to evolve into overt dysplastic changes and to improve knowledge of less common hrHPV genotypes.

Comparison of CerviHPV and Hybrid Capture 2 HPV tests for detection of high‐risk HPV infection in cervical swab specimens

2018 ◽  
Vol 47 (5) ◽  
pp. 439-444 ◽  
Author(s):  
Guodong Zhao ◽  
Yaping Tian ◽  
Yingying Du ◽  
Jinli Sun ◽  
Zhenzhen Wang ◽  
...  
Keyword(s):  
High Risk ◽  
Hpv Infection ◽  
Hybrid Capture ◽  
Cervical Swab ◽  
Hybrid Capture 2 ◽  
High Risk Hpv

scholarly journals Multiple Human Papilloma Virus (HPV) Infections Are Associated with HSIL and Persistent HPV Infection Status in Korean Patients

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1342
Author(s):  
Moonsik Kim ◽  
Nora Jee-Young Park ◽  
Ji Yun Jeong ◽  
Ji Young Park
Keyword(s):  
Human Papilloma Virus ◽  
Hpv Infection ◽  
Vaginal Swab ◽  
Chain Reaction ◽  
Clinicopathologic Characteristics ◽  
Papilloma Virus ◽  
Hpv Types ◽  
Polymerase Chain ◽  
High Risk Hpv

Infections with multiple human papilloma virus (HPV) types have been reported, but their role in cervical carcinogenesis has not been fully elucidated. In this study, 236 cases with multiple HPV infection were examined and compared to 180 cases with single HPV infection. HPV genotyping was performed with cervico-vaginal swab specimens using multiplex (real-time) polymerase chain reaction (PCR). In multiple HPV infection, the most prevalent HPV genotype was HPV 53, followed by HPV 16, 58, 52, and 68. HPV 33, 35, 39, 51, 52, 53, 58, and 68 were high-risk-HPV (HR-HPV) genotypes that were more frequently detected in multiple HPV infection compared to that in single HPV infection. The association between multiple HPV infection and high-grade SIL (HSIL) was significantly stronger compared to that of single HPV infection and HSIL (p = 0.002). Patients with multiple HPV infection displayed persistent and longer duration of the HPV infection compared to patients with single HPV infection. Multiple HPV infections have distinct clinicopathologic characteristics. Since it is associated with persistent HPV infection, HSIL, and different HR-HPV strains in contrast to single HPV infection, the presence of multiple HPV infection should be reported; close follow up is warranted.

scholarly journals Invasive Stratified Mucin-Producing Carcinoma (ISMC) of The Uterine Cervix: A Clinicopathological Study of 8 Cases

2021 ◽  
Author(s):  
Tingting Li ◽  
Sixia Xie ◽  
Yichao Qiu ◽  
Shuang Yuan ◽  
Wei Wang ◽  
...  
Keyword(s):  
High Risk ◽  
Clinical Symptoms ◽  
Hpv Infection ◽  
Vaginal Wall ◽  
Gynecologic Malignancy ◽  
Vaginal Cuff ◽  
Ki67 Expression ◽  
Parametrial Involvement ◽  
High Risk Hpv

Abstract Invasive stratified mucin-producing carcinoma (ISMC) is a rare gynecologic malignancy. Previous studies suggested that ISMC was a morphologic variant of invasive cervical adenocarcinoma. The clinicopathologic features and prognosis of eight cases of ISMC are presented. Clinical symptoms and imaging were atypical. Four cases were pure ISMCs, and four cases were ISMCs mixed with usual-type endocervical adenocarcinomas. The depths of stromal invasion were more than half (5/8), with approximate full-thickness in one case, and there was vascular invasion (5/8), neutral invasion (3/8), uterine segment involvement (3/8), and parametrial involvement (1/8). One of the patients underwent vaginal cuff surgery. Lymph node metastasis was seen in two patients (2/8). All cases were diffusely positive for p16 and high Ki67 expression. These cases had high-risk HPV16,18, 58 infection. All patients were alive after surgery and adjuvant therapy during the 8- to 21-month follow-up, and only one developed vaginal wall recurrence at 15 months. The present data and those obtained from the literature suggest that ISMC is an invasive endocervical adenocarcinoma with high-risk HPV infection, mainly HPV18, and has a risk of recurrence and metastasis.

J 5 — A Data Processing System for Medical Information

1967 ◽  
Vol 06 (01) ◽  
pp. 1-6
Author(s):  
P. Hall ◽  
Ch. Mellner ◽  
T. Danielsson
Keyword(s):  
Medical Records ◽  
Medical Information ◽  
Health Care Systems ◽  
Processing System ◽  
Linear Pattern ◽  
Flexible Form ◽  
Care Systems ◽  
Pattern Recognition Analysis ◽  
Numeric Information

A system for medical information has been developed. The system is a general and flexible one which without reprogramming or new programs can accept any alphabetic and/or numeric information. Coded concepts and natural language can be read, stored, decoded and written out. Medical records or parts of records (diagnosis, operations, therapy, laboratory tests, symptoms etc.) can be retrieved and selected. The system can process simple statistics but even make linear pattern recognition analysis.The system described has been used for in-patients, outpatients and individuals in health examinations.The use of computers in hospitals, health examinations or health care systems is a problem of storing information in a general and flexible form. This problem has been solved, and now it is possible to add new routines like booking and follow-up-systems.

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