scholarly journals Theta Oscillation and Functional Connectivity Alterations Related to Cerebral Small Vessel Disease with Working Memory Impairment

Author(s):  
Yumeng Gu ◽  
Qi Dong ◽  
Xiaoshuang Xia ◽  
Xin Tian ◽  
Xin Li

Abstract Background Impaired working memory (WM) is an important clinical symptom of cognitive dysfunction associated with cerebral small vessel disease (CSVD). Theta oscillations play an important role in the regulation of learning, WM and synaptic plasticity. Therefore, we speculate that theta oscillation may play an important role in the process of working memory impairment in CSVD. Methods Seventy-eight patients with CSVD (mean age 66.18 ± 1.42) and 49 healthy controls (HCs) (mean age 66.53 ± 1.3) were recruited to perform the WM task. Neural oscillations and functional connectivity during the encoding, maintenance, and retrieval phases of WM were evaluated during performance of WM test. Results Compared with the control group, the working memory behavior of the CSVD group showed a significantly longer reaction time and lower accuracy rate. The energy density and functional connection (FC) strength of the theta band in frontal region of the CSVD group were significantly lower than those of the control group, and the theta oscillation in the retrieval phase was significantly higher than that in the coding phase. However, there was no significant change in FC strengths among three phases. Both in the two groups, the FC was significantly positively correlated with accuracy and negatively correlated with reaction time (RT). Conclusion Our results indicated that CSVD patients have significant working memory impairment, and the lack of theta oscillation in the frontal region and the abnormal functional connection of the brain network may be one of its potential neurophysiological mechanisms.

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Yuan Wang ◽  
Haiqing Song ◽  
Kai Dong ◽  
Ran Meng ◽  
Shuying Wang ◽  
...  

Objective: To evaluate the preliminary efficacy of remote ischemic conditioning (RIC) on patients with cerebral small vessel disease (SVD). Methods: Thirty patients diagnosed with symptomatic SVD within 30 days of onset were enrolled in this prospectively randomized controlled study for 1 year. All patients received routine medical treatment including treating vascular risk factors according to the guideline. Patients in the experimental group (n=14) were administered 5 cycles consisting of ischemia followed by reperfusion for 5 minutes on bilateral upper limbs twice daily for 1 year. Those in the control group (n=16) underwent sham ischemia-reperfusion cycles. Primary outcome was the change of cognitive function measured by mini-mental state examination (MMSE) and montreal cognitive assessment scale (MoCA), and secondary outcomes were changes of plasma biomarkers, cerebral hemodynamic parameters measured by vascular ultrasound and brain lesions measured by MRI FLAIR both at baseline and at the end of 1 year visit. Results: Compared with patients in the control group, patients in the RIC group had higher flow velocity (FV), and lower pulsatility index (PI), but without statistical difference. Patients in the RIC group had improvement in visuospatial and executive abilities (3.86±1.03 vs. 4.43±0.85, p=0.026), reduced plasma triglyceride (1.60±0.74 vs. 1.25±0.38, p=0.019), low density lipoprotein (2.89±0.81 vs. 2.26±0.67, p=0.003) and homocysteine (15.66±10.11 vs. 13.66±9.80 p=0.017). Similarly in the RIC group, the diastolic flow velocity (DFV) of middle cerebral artery (MCA) (right: 33.93±7.67 vs. 36.93±6.12, p=0.032; left: 33.93±7.67 vs. 36.93± 6.12, p=0.032) and the mean flow velocity (MFV) of left MCA (35.00±5.04 vs. 39.50±5.59, p=0.003) increased, and the PI of MCA (right: 1.11±0.19 vs. 1.02±0.14 p=0.030; left: 1.10±0.22 vs. 0.99±0.14, p=0.037) decreased. Conclusion: RIC appears to be potentially effective for improving cognition, enhancing cerebral perfusion, and modifying vascular risk factors in SVD patients. Further studies focusing on long-term neurological outcomes and potential mechanisms underlying RIC on SVD patients are needed.


2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Fanny Quandt ◽  
Felix Fischer ◽  
Julian Schröder ◽  
Marlene Heinze ◽  
Iris Lettow ◽  
...  

Abstract Cerebral small vessel disease is a common disease in the older population and is recognized as a major risk factor for cognitive decline and stroke. Small vessel disease is considered a global brain disease impacting the integrity of neuronal networks resulting in disturbances of structural and functional connectivity. A core feature of cerebral small vessel disease commonly present on neuroimaging is white matter hyperintensities. We studied high-resolution resting-state EEG, leveraging source reconstruction methods, in 35 participants with varying degree of white matter hyperintensities without clinically evident cognitive impairment in an observational study. In patients with increasing white matter lesion load, global theta power was increased independently of age. Whole-brain functional connectivity revealed a disrupted network confined to the alpha band in participants with higher white matter hyperintensities lesion load. The decrease of functional connectivity was evident in long-range connections, mostly originating or terminating in the frontal lobe. Cognitive testing revealed no global cognitive impairment; however, some participants revealed deficits of executive functions that were related to larger white matter hyperintensities lesion load. In summary, participants without clinical signs of mild cognitive impairment or dementia showed oscillatory changes that were significantly related to white matter lesion load. Hence, oscillatory neuronal network changes due to white matter lesions might act as biomarker prior to clinically relevant behavioural impairment.


2019 ◽  
Vol 47 (1-2) ◽  
pp. 55-67 ◽  
Author(s):  
Renyuan Liu ◽  
Wenhui Wu ◽  
Qing Ye ◽  
Yucheng Gu ◽  
Junhui Zou ◽  
...  

Objective: To explore the within- and between-network patterns of the default mode network (DMN), the frontoparietal control network (FPCN), and the dorsal attention network (DAN) in cerebral small vessel disease (CSVD) with and without cognitive impairment (CI). Methods: Twenty CSVD with CI subjects, 21 CSVD without CI subjects, and 25 healthy elderly controls were recruited. The within- and between-network patterns of the networks were identified based on resting-state functional magnetic resonance imaging data. Results: Compared with the control group, both the CSVD with CI group and the CSVD without CI group displayed decreased within-network function of the DMN and lower negative connectivity between the DMN and other networks (i.e., DMN and DAN, DMN and FPCN), whereas the CSVD with CI group additionally showed within- and between-network alterations of the FPCN (i.e., increased within-network function of the FPCN and lower negative connectivity between the FPCN and the DMN). Furthermore, these alterations of the FPCN were correlated with the cognitive function of CSVD subjects. Interestingly, the between-network connectivity of the FPCN and the DMN was negatively correlated with deep white matter hyperintensities (DWMH) volume in CSVD subjects. Conclusion: These findings suggest that cognitive alterations of CSVD subjects may be mainly regulated by the FPCN that correlates with DWMH burden, and shed light on the investigation of surrogate markers of CSVD.


2017 ◽  
Vol 37 (2) ◽  
Author(s):  
Fei Wang ◽  
Zhi-Rong Zou ◽  
Dong Yuan ◽  
Yi Gong ◽  
Li Zhang ◽  
...  

The present study was designed to explore the correlation between serum S100β levels and cognitive dysfunction in patients with cerebral small vessel disease (SVD). A total of 172 SVD patients participated in the study, and they were assigned to patients with no cognitive impairment (NCI group) and those with vascular cognitive impairment no dementia (VCIND group). In total, 105 people were recruited into the normal control group. Serum S100β protein level was detected by ELISA. A receiver operating characteristic (ROC) curve was employed for the predictive value of serum S100β in diagnosing SVD with cognitive dysfunction. Pearson correlation analysis was used to examine the association of S100β level with mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) and the association of S100β levels with hypertension. Logistic regression analysis was used to analyze risk factors of SVD. The serum S100β levels in the VCIND group were higher than those in the NCI and normal control groups. Logistic regression analysis revealed that a high serum S100β protein level, hypertension, and high low density lipoprotein-cholesterol (LDL-C) level were the independent risk factors for SVD. In addition, hypertension patients showed higher S100β levels than those with normal blood pressure and the normal control group, and there was a positive correlation between S100β level and blood pressure. The concentration of serum S100β level was related to impairment of cognition function of VCIND patients, therefore, early detection of serum S100β was of great value for diagnosis of SVD.


Neurology ◽  
2021 ◽  
Vol 96 (15) ◽  
pp. e1975-e1986
Author(s):  
Dorothee Schoemaker ◽  
Andreas Charidimou ◽  
Maria Clara Zanon Zotin ◽  
Nicolas Raposo ◽  
Keith A. Johnson ◽  
...  

ObjectiveRelying on tau-PET imaging, this cross-sectional study explored whether memory impairment is linked to the presence of concomitant tau pathology in individuals with cerebral amyloid angiopathy (CAA).MethodsForty-six patients with probable CAA underwent a neuropsychological examination and an MRI for quantification of structural markers of cerebral small vessel disease. A subset of these participants also completed a [11C]-Pittsburgh compound B (n = 39) and [18F]-flortaucipir (n = 40) PET for in vivo estimation of amyloid and tau burden, respectively. Participants were classified as amnestic or nonamnestic on the basis of neuropsychological performance. Statistical analyses were performed to examine differences in cognition, structural markers of cerebral small vessel disease, and amyloid- and tau-PET retention between participants with amnestic and those with nonamnestic CAA.ResultsPatients with probable CAA with an amnestic presentation displayed a globally more severe profile of cognitive impairment, smaller hippocampal volume (p < 0.001), and increased tau-PET binding in regions susceptible to Alzheimer disease neurodegeneration (p = 0.003) compared to their nonamnestic counterparts. Amnestic and nonamnestic patients with CAA did not differ on any other MRI markers or on amyloid-PET binding. In a generalized linear model including all evaluated neuroimaging markers, tau-PET retention (β = −0.85, p = 0.001) and hippocampal volume (β = 0.64 p = 0.01) were the only significant predictors of memory performance. The cognitive profile of patients with CAA with an elevated tau-PET retention was distinctly characterized by a significantly lower performance on the memory domain (p = 0.004).ConclusionsThese results suggest that the presence of objective memory impairment in patients with probable CAA could serve as a marker for underlying tau pathology.Classification of EvidenceThis study provides Class II evidence that tau-PET retention is related to the presence of objective memory impairment in patients with CAA.


Heliyon ◽  
2017 ◽  
Vol 3 (11) ◽  
pp. e00455 ◽  
Author(s):  
Jacek Staszewski ◽  
Renata Piusińska-Macoch ◽  
Bogdan Brodacki ◽  
Ewa Skrobowska ◽  
Katarzyna Macek ◽  
...  

2017 ◽  
Author(s):  
Jacek Staszewski ◽  
Renata Piusińska-Macoch ◽  
Bogdan Brodacki ◽  
Ewa Skrobowska ◽  
Katarzyna Macek ◽  
...  

Background and PurposeNatural course of cerebral small vessel disease (CSVD) has not yet been thoroughly studied. The aim of the single center study was to establish risk of vascular events or death in different manifestations of CSVD.Methods150 consecutive, functionally independent patients with marked MRI features of CSVD and with recent lacunar stroke (n=52, LS), 20 with deep hemorrhagic stroke (HS), 28 with vascular parkinsonism (VaP), 50 with vascular dementia (VaD) and 55 controls (CG) with high atherothrombotic risk free of cerebrovascular events were prospectively recruited and followed for 24 months.ResultsMean age and sex distribution were similar in CSVD and CG but patients with CSVD were less likely to have CAD (19% vs 40%, p=0,02) and tended to have higher prevalence of diabetes (54% vs 37%, p=0,11). The risk of vascular events or death was increased in any patients with moderate to severe white matter lesions at baseline MRI (HR 2,0; 95%CI 0,85-7,2), in CSVD (4,56; 95%CI 1,3-14,9) vs CG, regardless of its clinical manifestation: LS or HS (HR 4,70; 95%CI 1,3-16,2) and VaD or VaP (HR 4,59; 95%CI 1,3-15,7).ConclusionsPatients with symptomatic CSVD regardless of the clinical (acute or chronic) manifestation had more than fourfold the risk of vascular events or death in 24 months of observation compared with controls with high atherothrombotic risk free of cerebrovascular events.


2020 ◽  
Vol 41 (10) ◽  
pp. 2629-2641
Author(s):  
Benno Gesierich ◽  
Anil Man Tuladhar ◽  
Annemieke Telgte ◽  
Kim Wiegertjes ◽  
Marek J. Konieczny ◽  
...  

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