scholarly journals Pregnancy Outcomes in Takayasu Arteritis Patients

2021 ◽  
Author(s):  
Shiping He ◽  
Zhi Li ◽  
Yijun Song ◽  
Yunjiao Yang ◽  
Jing Li ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Stable State ◽  
Adverse Pregnancy Outcomes ◽  
Maternal Complications ◽  
Chi Square ◽  
Healthy Women ◽  
Before And After ◽  
Obstetrical Complication ◽  
Chi Square Test ◽  
Adverse Pregnancy

Abstract BackgroundsTakayasu Arteritis (TAK) is a chronic inflammatory autoimmune disease with a high prevalence in women of child-bearing age. We aim to investigate the maternal complications and pregnancy outcomes in patients with TAK and identify the related factors.MethodsA total of 110 pregnancies in 80 TAK patients in a Chinese TAK patient cohort and 440 matched pregnancies in healthy women between 2000 to 2020 were included. The maternal complications and pregnancy outcomes between TAK patients and matched controls were compared by chi-square test. The logistic regression analysis was used to identify the risk factors of maternal complications and adverse pregnancy outcomes in patients with TAK.ResultsMaternal complications and adverse pregnancy outcomes were more frequent in pregnancies with TAK than that in healthy women (P<0.001). In pregnancies with TAK, the most common maternal complication was new-onset or worsening of hypertension (18.2% [20/110]) and the most prevalent obstetrical complication was spontaneous abortion (32.7% [36/110]). Hypertension (OR 5.01, 95% CI 1.61 to 16.01), heart disease (OR 15.83, 95% CI 1.99 to 125.99), and active TAK (OR 7.54, 95% CI 1.85 to 30.72) before pregnancy were independently associated with increased maternal complications. The disease duration (OR 1.12, 95% CI 1.02 to 1.23) and active disease during pregnancy (OR 14.59, 95% CI 1.81 to 117.49) were correlated with adverse pregnancy outcomes. ConclusionTAK disease itself is a risk factor for adverse pregnancy outcomes. Treating the disease to a stable state before and after pregnancy, and close collaboration between rheumatologists and obstetricians are important measures to reduce maternal complications and reach favorable pregnancy outcomes.

scholarly journals Influence of maternal occupation on adverse pregnancy outcomes in a Nigerian tertiary health facility

2021 ◽  
Vol 8 (7) ◽  
pp. 3262
Author(s):  
Hope O. Nwoga ◽  
Miriam O. Ajuba ◽  
Chukwuma P. Igweagu
Keyword(s):  
Health Facility ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Bivariate Analysis ◽  
P Value ◽  
Chi Square ◽  
Still Birth ◽  
Chi Square Test ◽  
Maternal Occupation ◽  
Adverse Pregnancy

Background: There is accumulating evidence that the type of work and environmental exposures in the work environment during pregnancy may have adverse effects on fetal development and pregnancy outcome. The objective was to determine the influence of maternal occupation on adverse pregnancy outcomes.Methods: The study was a prospective hospital based study conducted at the obstetrics and gynecology department of a tertiary health facility in Nigeria. All the data were retrieved from the ante natal and delivery card of all the women that delivered at the unit within the time of data collection. Data was analyzed using SPSS version 25 and variables were presented as frequencies, percentages, means, and standard deviation. Bivariate analysis was done using chi-square test. The level of significance was set at p value ≤ 0.05.Results: Maternal occupation did not significantly affect the gestational age at delivery (X2=10.143, p=0.428) and birth weight (X2=16.807, p=0.079) however, it significantly affected the still birth (X2=28.134, p=0.002). Agricultural, forestry and fishery workers and plant and machine operators were about 8 times and 17 times more likely to have still birth than the unemployed respectively.Conclusions: There were substantial differences in the risk of adverse pregnancy outcomes between the different occupational groups.

scholarly journals Maternal Complications and Adverse Pregnancy Outcomes among Pregnant Women who Acquired Asymptomatic Bacteriuria in Addis Ababa, Ethiopia

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Ketema Bizuwork Gebremedhin ◽  
Haile Alemayehu ◽  
Girmay Medhin ◽  
Wondwossen Amogne ◽  
Tadesse Eguale
Keyword(s):  
Pregnant Women ◽  
Correlation Coefficient ◽  
Gestational Age ◽  
Pregnancy Outcomes ◽  
Perinatal Death ◽  
Addis Ababa ◽  
Asymptomatic Bacteriuria ◽  
Adverse Pregnancy Outcomes ◽  
Maternal Complications ◽  
Adverse Pregnancy

In this study, we aimed to document adverse pregnancy outcomes and maternal complications among pregnant women who acquired asymptomatic bacteriuria in Addis Ababa, Ethiopia. We used hospital-based prospective cohort study design in which we followed 44 pregnant women with asymptomatic bacteriuria confirmed by urine culture result of ≥105cfu/ml of urine. We documented adverse pregnancy outcomes and maternal complications in terms of frequency, percentage, mean, and standard deviation. Additionally, we used Pearson’s correlation coefficient to investigate associations of selected variables with perinatal death as one of adverse pregnancy outcomes. Of the 44 pregnant women enrolled in the study, complete data was collected from 43 participants with one lost to follow-up. Six (14%) of women developed fever and were treated with antibiotic during pregnancy, 26 (60.5%) delivered with cesarean section, two (4.3%) perinatal deaths within seven days of delivery, one miscarriage, and 4 (9.3%) newborns were found underweight. The mean birth weight of the newborns was 3.1   kg ± 0.60 . Almost half 21(48.8%) were born before 37 weeks of gestational age. Fourteen (32.6%) of newborns were born asphyxiated. Twenty-two (51.2%) of newborns developed early neonatal fever within 48 hours of delivery and treated with antibiotic. Correlation coefficient analysis revealed that weight and gestational age of newborns at birth, Apgar score at 1st and 5th minutes of birth and miscarriage were positively correlated and significantly associated with perinatal death. The occurrence of unsought pregnancy outcomes were frequent, and substantial number of pregnant women developed maternal complications. Therefore, screening pregnant women for asymptomatic bacteriuria and treating may reduce the possible maternal complications and adverse pregnancy outcomes.

Pregnancy Outcomes in Women with Incidentally Detected Unicornuate Uteri

2019 ◽  
Vol 37 (01) ◽  
pp. 025-029
Author(s):  
Kathy C. Matthews ◽  
Stephen T. Chasen
Keyword(s):  
Pregnancy Outcomes ◽  
Preterm Births ◽  
Spontaneous Preterm Birth ◽  
Chi Square ◽  
Exact Test ◽  
Unicornuate Uterus ◽  
Gestational Age At Delivery ◽  
Chi Square Test ◽  
Adverse Pregnancy ◽  
Work Up

Abstract Objective To estimate the incidence of adverse pregnancy outcomes in women with incidentally detected unicornuate uteri. Study Design This is a descriptive study. Database review identified patients with unicornuate uteri and singleton pregnancies at ≥12 weeks' gestation. Patients were excluded if the diagnosis of unicornuate uterus was made after a midtrimester loss or preterm delivery. Records were reviewed to obtain clinical outcomes. Chi-square test, Fisher's exact test, and Mann–Whitney U-test were used for statistical analysis. Results Forty patients with 67 pregnancies were included. Most diagnoses were made during infertility work-up (76.2%). There was one midtrimester loss (1.5%). In the remaining 66 pregnancies, median gestational age at delivery was 38 weeks. There were 20 (30.3%) preterm births, 9 (13.6%) spontaneous preterm births, and 11 (16.7%) indicated preterm births. Women with indicated preterm births were more likely to have placental abnormalities. Of the available placental pathology, 45.2% had histological lesions of malperfusion. Cesarean delivery was performed in 77.3% of cases. Conclusion Most women with incidentally detected unicornuate uteri gave birth at term. More than half the preterm births were indicated, with relatively high rates of placental abnormalities. In patients without a poor obstetrical history, rates of midtrimester loss and spontaneous preterm birth were lower than previously described.

scholarly journals Radiological screening of maternal periodontitis for predicting adverse pregnancy and neonatal outcomes

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ju Sun Heo ◽  
Ki Hoon Ahn ◽  
Jung Soo Park
Keyword(s):  
Preterm Birth ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Neonatal Outcomes ◽  
Chronic Hypertension ◽  
Radiological Staging ◽  
Extremely Preterm ◽  
Before And After ◽  
Adverse Pregnancy ◽  
Periodontal Probing

AbstractIt is well known that periodontitis, diagnosed mainly by periodontal probing, is associated with adverse pregnancy outcomes. However, periodontal probing is time-consuming, highly discomforting, inaccurate, and invasive. We aimed to assess whether periodontitis severity based on radiological staging in accordance with the 2017 new consensus classification was related to adverse pregnancy and neonatal outcomes. The medical records of 165 mothers who underwent panoramic radiography within 5 years before and after the time of delivery and of their singleton neonates were retrospectively reviewed. Twenty-two mothers (13.3%) had severe periodontitis (SP), and 143 (86.7%) had mild or moderate periodontitis (MP). In relation to adverse pregnancy outcomes, uterine leiomyoma (18.2% vs. 4.2%, P = 0.029), chronic hypertension (9.1% vs. 0.7%, P = 0.047), and preeclampsia (13.6% vs. 2.1%, P = 0.032) occurred significantly more frequently in the SP group than in the MP group. The incidences of very preterm birth (13.6% vs. 1.4%, P = 0.017), extremely preterm birth (9.1% vs. 0.7%, P = 0.047), and small for gestational age (22.7% vs. 5.6%, P = 0.017) were also significantly higher in the SP group than in the MP group. Radiological screening of maternal periodontitis could be useful for predicting adverse pregnancy and neonatal outcomes as well as diagnosing SP in pregnant women.

Association between Thiopurines Use and Pregnancy Outcomes in Female Patients with Inflammatory Bowel Disease: A Meta-analysis

2020 ◽  
Vol 26 ◽  
Author(s):  
Yang Zhang ◽  
Dandan Li ◽  
Heng Guo ◽  
Weina Wang ◽  
Xingang Li ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Preterm Birth ◽  
Spontaneous Abortion ◽  
Bowel Disease ◽  
Pregnancy Outcomes ◽  
Congenital Malformations ◽  
Meta Analysis ◽  
Adverse Pregnancy Outcomes ◽  
Inflammatory Bowel ◽  
Adverse Pregnancy

Background: Conflicting data exist regarding the influence of thiopurines exposure on adverse pregnancy outcomes in female patients with inflammatory bowel disease (IBD). Objective: The aim of this study was to provide an up-to-date and comprehensive assessment of the safety of thiopurines in pregnant IBD women. Methods: All relevant articles reporting pregnancy outcomes in women with IBD received thiopurines during pregnancy were identified from the databases (PubMed, Embase, Cochrane Library, and ClinicalTrials.gov) with the publication data up to April 2020. Data of included studies were extracted to calculate the relative risk (RR) of multiple pregnancy outcomes: congenital malformations, low birth weight (LBW), preterm birth, small for gestational age (SGA), and spontaneous abortion. The meta-analysis was performed using the random-effects model. Results: Eight studies matched with the inclusion criteria and a total of 1201 pregnant IBD women who used thiopurines and 4189 controls comprised of women with IBD received drugs other than thiopurines during pregnancy were included. Statistical analysis results demonstrated that the risk of preterm birth was significantly increased in the thiopurine-exposed group when compared to IBD controls (RR, 1.34; 95% CI, 1.00-1.79; p=0.049; I 2 =41%), while no statistically significant difference was observed in the incidence of other adverse pregnancy outcomes. Conclusion: Thiopurines’ use in women with IBD during pregnancy is not associated with congenital malformations, LBW, SGA, or spontaneous abortion, but appears to have an association with an increased risk of preterm birth.

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